Clinical trials: sponsored by University Hospital, Brest
Cancer, Benign Tumors
Description of the Stroma of Solid Tumors (DISTRO)
This study aims to describe the cellular and non-cellular components of different types of benign and malignant tumors.
- Trial name
- DISTRO (NCT07396740)
- Where
- France
- Volunteers
- 7,000 people
- Sponsor
- University Hospital, Brest
Anterior Cruciate Ligament Rupture With Ligamentoplasty
Evaluation of the Evolution of Proprioceptive Reweighting Abilities Following Anterior Cruciate Ligament Reconstruction Surgery
Anterior cruciate ligament (ACL) injury is the most common knee injury among athletes who play contact sports involving pivoting.
- Trial name
- ReproEVO (NCT07389850)
- Testing
- ReproEVO intervention
- Where
- 3 sites in France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Brest
Algoneurodystrophy, Amputation
Analgesic Amputation for Algodystrophy: Feedback From a Case Series
What is the aim of the research? The study aims to describe the time interval between amputation for post-traumatic complex regional pain syndrome (CRPS) and functional prosthetic fitting of the amputated limb, within a series of…
- Trial name
- AMPUTALGO (NCT07364266)
- Testing
- describe the time interval between amputation for post-traumatic algodystrophy and functional prosthetic fitting of the amputated limb
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Brest
Anatomical Study
Anatomical Assessment of Orbital Contents on Imaging (EACOI)
This is a single-center retrospective study based on existing data. The study focuses on the anatomical content of the orbit, and in particular the anatomy of the oculomotor muscles in the orbit, which are involved in eye…
- Trial name
- EACOI (NCT07360470)
- Where
- France
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Venous Thromboembolism
CoMbination of Data From European Cohorts as Part of the European MORPHEUS Project [HORIZON-HLTH-2022-11-01] - "MC-MORPHEUS".
Combine clinical, biological and morphological data from 14 French and European cohorts into a single database.
- Trial name
- MC-MORPHEUS (NCT07328152)
- Where
- France
- Volunteers
- 20,000 people
- Sponsor
- University Hospital, Brest
Dry Eye, Dry Eye After LASIK-Laser in Situ Keratomileusis
Combined Treatment With Pulsed Light and Photobiomodulation Before Laser Refractive Surgery
Laser corneal refractive surgery is a widely adopted approach for correcting refractive errors, but postoperative dry eye remains a common side effect.
- Trial name
- TEBELID (NCT05803798)
- Testing
- IPL+LLLT
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Children and Adolescents With Neuromotor Impairment, Children and Youth With Special Healthcare Needs
"Healthcare APPlication for Children and Young People With Neuromotor Disabilities": a Digital Tool to Promote Integrated Pediatric Rehabilitation Care for Children and Young People With Disabilities and Their Families: a Mixed-methods Usability-acceptability-impact Study (HAPPY)
The goal of this observational multicentric mixed methods study is to evaluate if the digital application "Deneo Kid", co-designed in France with adolescents, families, rehabilitation providers and researchers, can improve the…
- Trial name
- HAPPY (NCT07307950)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Brest
Autism Disorder, Multiple Disabilities
Impact and Determinants of Success of a Mobile Multidisciplinary Intervention System Specialized in Pain Management for Patients With Moderate to Severe Intellectual Development Disorder, Isolated or Associated With an ASD or Multiple Disability
Pain is described by patients with a Neurodevelopmental Disorder (NDD), including Autism Spectrum Disorder (ASD), Intellectual Development Disorder (IDD) or multiple disabilities, and the family as one of the main associated…
- Conditions
- Autism Disorder, Multiple Disabilities, Pain, Intellectual Developmental Disorder
- Trial name
- MoDIDol (NCT07302048)
- Testing
- MoDIDol intervention
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Brest
Uterine Anteflexion, Parous Women
The Variation in Uterine Flexion Angle Before and After Voiding in Parous Women.
Intrauterine devices (IUDs) account for approximately 25% of contraceptive methods used in France. However, their insertion can be painful for patients and challenging for practitioners, particularly due to the passage through…
- Trial name
- FLEXIMIX 2 (NCT07084766)
- Testing
- ultrasonography, pelvic
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Brest
Infertility, Infertility Unexplained
PMA-FERTITHEQUE Biocollection
Creation of a patient library in Medically Assisted Procreation to allow the implementation of further research with the following objectives: To identify new relevant biomarkers in patients who will carry a pregnancy to term To…
- Trial name
- FERTITHEQUE (NCT05599724)
- Testing
- Biocollection
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Brest
Bronchiolitis Acute
Bronchiolitis Clearance Airways With Seaserum
The objective of this study is to show that the use of electrodialyzed seawater reduces the duration (in days) of symptoms in acute infant bronchiolitis compared with the use of saline solution in infants aged 1 month to less…
- Trial name
- B-CLASS (NCT06177197)
- Testing
- Physiomer, Saline solution
- Where
- 8 sites in France
- Volunteers
- 458 people
- Sponsor
- University Hospital, Brest
Atopic Dermatitis
Comparative Analysis of Filmed Sequences for the Assessment of Discomfort in Atopic Dermatitis of Infants Under 6 Months of Age
Atopic dermatitis (AD) is an frequent chronic and itchy inflammatory dermatitis which concern about 20% of pediatric population with a revelation usually toward 3-6 months of live.
- Trial name
- PRURINEO (NCT03684343)
- Testing
- Filmed consultation with a dermatologist
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Pain, Preterm Newborn
Evaluation of Pain in Preterm Newborn
The purpose of this study is to correlate the composite PIPP-R (Premature Infant Pain Profile-Revised) scale and the parasympathetic nervous system (heart rate variability).
- Trial name
- TRIPAIN (NCT02885051)
- Testing
- Recording of skin conductance and heart rate variability.
- Where
- France
- Volunteers
- 91 people
- Sponsor
- University Hospital, Brest
Cystic Fibrosis
Evaluation of (R)-Roscovitine Safety and Effects in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation
This is a phase II, dose ranging, multicenter, randomized, double-blind, placebo-controlled study. The aim of this study is to assess the safety of increasing doses of roscovitine administered orally for 4 cycles of 4 consecutive…
- Trial name
- ROSCO-CF (NCT02649751)
- Testing
- Roscovitine
- Where
- 11 sites in France
- Volunteers
- 49 people
- Sponsor
- University Hospital, Brest
Shoulder Pain
Impact of Anthropometrics Data and of Physical Activity Level in Closed kineTic Chain Upper Extremity Stability Test
The purpose of this study is to evaluate impact of anthropometric criteria to CKCUEST score.
- Trial name
- EPOLTEST (NCT04090632)
- Testing
- Closed Kinetic Chain Upper Extremity Stability Test
- Where
- France
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Knee Chondral or Osteochondral Defect
Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized Trial
Numerous surgical techniques have been developped for the treatment of chondral and osteochondral defects of the knee. Among those techniques autologous chondrocyte transplantation (ACT) was promising but have potential…
- Trial name
- Cartipatch (NCT00560664)
- Testing
- Autologous chondrocytes transplantation, Mosaicoplasty
- Where
- 12 sites in France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Brest
Bariatric Surgery, Morbid Obesity
Pharmacokinetics of Rivaroxaban After Bariatric Surgery
Data on pharmacokinetics of rivaroxaban after bariatric surgery and in morbid obesity are sparse. The aim of this study is to assess the pharmacokinetic and pharmacodynamic parameters of rivaroxaban, used at a therapeutic…
- Trial name
- ABSORB (NCT04180436)
- Testing
- rivaroxaban 20 mg once daily 8 days
- Where
- France
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Prevention of the Procedural Pain in the Newborn
Prevention of the Procedural Pain in the Newborn
The aim of this study is to compare the impact of two non-medicinal strategies: the breast-feeding and saccharose to measure effects in cerebral cortex during pain using near infrared spectroscopy (NIRS)
- Trial name
- ACTISUCROSE (NCT02109263)
- Testing
- saccharose versus breast-feeding
- Where
- France
- Volunteers
- 114 people
- Sponsor
- University Hospital, Brest
Ulnar Neuropathies
ULnar Nerve ECHographic Observation (ULNECHO)
There is currently no consensus on the normal ultrasound surface of the ulnar nerve at the elbow. The goal of this study is to study the ulnar nerve surface at the elbow in a population of asymptomatic subjects
- Trial name
- ULNECHO (NCT03209947)
- Testing
- Ulnar nerve Ultrasound
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest
Pulmonary Embolism
Ga68 V/Q PET/CT for Pulmonary Embolism Diagnosis: a Diagnostic Accuracy Study vs CT Pulmonary Angiography
This study evaluates the diagnostic accuracy (sensitivity, specificity) of V/Q PET/CT for the diagnosis of pulmonary embolism (PE), using CT pulmonary angiography as a reference standard.
- Trial name
- PETEP (NCT04179539)
- Testing
- V/Q PET/CT, CTPA
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest