Clinical trials: sponsored by University Hospital, Caen
Quality of Life, Cancer
Quality of Life and Cancers in Nursing Homes
Quality of life (QOL) of nursing homes residents with cancer in France is not known. High prevalence of neurodegenerative diseases makes it difficult.
- Conditions
- Quality of Life, Cancer, Nurse's Role
- Trial name
- QUALICE (NCT03343210)
- Testing
- quality of life and pain measurement .
- Where
- 6 sites in France
- Volunteers
- 73 people
- Sponsor
- University Hospital, Caen
Cancer
Pancytopenia Related to PARP Inhibitors (PancytoRIB)
Although PARP inhibitors (PARPi) have proved effective in treating many cancers, few patients receiving PARPi may experience rare but serious adverse events such as pancytopenia. Today, data about pancytopenia are scarce.
- Trial name
- NCT04774627
- Testing
- PARP inhibitor
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Caen
Contact Lens Complication
Observational Study on the Efficacy and Tolerance of EYEBRID Lenses
Technical advances in lenses are continuous and materials are improved. We provide a prospective longitudinal observational study evaluating the efficacy and safety of new EyeBrid Excel hybrid lenses (LCS) in the treatment of…
- Trial name
- EYEBRID (NCT05036954)
- Testing
- EyeBrid Excel hybrid lenses
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Caen
Cerebrovascular Disorders, Ischemic Attack, Transient
Biomarkers for the Diagnosis of Transient Ischemic Attack
A transient ischemic attack (TIA) should be considered an emergency prevention opportunity in order to avoid recurrence as cerebral infarction (CI) serious (fatal or disabling).
- Trial name
- MAESTRO (NCT02799511)
- Testing
- protein expression
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Caen
Urinary Incontinence,Stress, Ultrasound
Ultrasound and Pelvic Floor Muscle Training
The objective is to validate the use of ultrasound measurements (urethral mobility, movement of the ano-rectal angle, elastography measurements) in women with urinary incontiennce before and after pelvic floor muscle training…
- Conditions
- Urinary Incontinence,Stress, Ultrasound, Elastography, Contraction; Pelvic
- Trial name
- ERP (NCT04361890)
- Testing
- perineal ultrasound
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Caen
Urinary Incontinence, Obesity
BUDI (Bariatric UroDynamic Improvement)
In the population of obese women, the prevalence of urinary incontinence (UI) is around 70%. It was shown in the literature that weight loss by bariatric surgery allowed a significant improvement in the symptoms and impact on the…
- Conditions
- Urinary Incontinence, Obesity, Urodynamics, Quality of Life
- Trial name
- BUDI (NCT03509038)
- Testing
- Exploratory pathophysiology Study
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Caen
Digital Nerve Injury
Vitamin D3 in Sensory Recovery After Digital NERVe Suture (D3NERV).
Digital nerve injuries are frequent in a FESUM center (Federation Européenne des Services d'Urgences Mains), and they need to be repaired in order to reduce the risk of hypoesthesia and to prevent painful neuroma.
- Trial name
- D3NERV (NCT04115982)
- Testing
- Cholecalciferol
- Where
- 3 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Caen
Diverticular Disease of Left Side of Colon
Quality of Life (QOL) After Elective Sigmoidectomy for Diverticular Diseases (DIVERTI)
Acute diverticulitis of the left colon is among the most common abdominal disorders. To date, both conservative therapy in uncomplicated stages and emergency surgery in perforated disease with peritonitis are consensual.
- Trial name
- DIVERTI-QDV (NCT04730765)
- Testing
- left elective colectomy (Surgical Experimental Group), antibiotic therapy (medical Control Group)
- Volunteers
- 220 people
- Sponsor
- University Hospital, Caen
Surgical Procedure, Unspecified, Analgesia
Evaluation of Immersive Audiovisual Distraction Impact on Peroperative Opioid Consumption.
This study evaluate the impact of an audiovisual distraction device on the peroperative opioid consumption for outpatient procedures with Remifentanil added to local anesthesia.
- Conditions
- Surgical Procedure, Unspecified, Analgesia, Outpatient
- Trial name
- AmbuCineView (NCT04238572)
- Testing
- Audiovisual distraction device, Analgesia nociception index
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Caen
Hypercalcemia
Search for New Genetic Causes of Hypercalcemia by Massively Parallel Sequencing of a Genes Panel
Hypercalcemia, whether chronic or acute, exposes the patient to potentially serious complications (arrhythmias, nephrolithiasis, nephrocalcinosis, ...).
- Trial name
- HyCaGene (NCT02908542)
- Testing
- genetic analysis with massively parallel sequencing
- Where
- France
- Volunteers
- 185 people
- Sponsor
- University Hospital, Caen
Neonatal Abstinence Syndrome
Actigraphy and Neonatal Abstinence Syndrome of Hospitalized Newborn in Intensive Care Units
The aim of this study is to analyse the correlation between actigraphy and Lipsitz scoring system in neonatal opioid abstinence syndrome of hospitalized newborn in intensive care units
- Trial name
- ACTINEO2 (NCT04983563)
- Testing
- Actigraphy, eTact
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Trisomy 21
Non-invasive Screening of Fetal Trisomy 21 by Digital PCR
In France, as in many countries of the world, trisomy 21 or Down syndrome (DS) is the subject of an antenatal screening based on a risk calculation (R) including the assay of biochemical markers in the maternal blood, and the…
- Trial name
- dPNI-T21 (NCT03687866)
- Testing
- non invasive prenatal testing
- Where
- France
- Volunteers
- 776 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Healthy Volunteers
Bioequivalence of Solid/Crushed/Dissolved Forms of Biktarvy®
Study context: Some HIV-positive patients have difficulties with oral administration of antiretroviral drugs, such as children and adults suffering from ENT cancer.
- Trial name
- SOLUBIC (NCT04244448)
- Testing
- receive dissolved form of BIKTARVY®, receive crushed form of BIKTARVY®, receive solid form of BIKTARVY®
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Covid19
Effect of Tenofovir/Emtricitabine in Patients Recently Infected With SARS-COV2 (Covid-19) Discharged Home
COVID-19 pandemic is currently affecting the globe. To date, there is no effective oral therapy against SARS-CoV2 infection. The investigators propose to test as a repurposing drug combination, a short course of tenofovir…
- Trial name
- AR0-CORONA (NCT04685512)
- Testing
- tenofovir disoproxil and emtricitabine
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Caen
Relapse, Quality of Life
Ingrown Toenails : Surgery Only Versus Surgery + Chemical Cauterization With TCA
Ingrown toenail is a very common disease in the general population that touches young adults. There are lots of treatments from local care of pedicure to surgery with matricectomy.
- Conditions
- Relapse, Quality of Life, Complication, Pain, Postoperative
- Trial name
- NCT04921540
- Testing
- Ingrown toenails with surgery with chemical cauterisation, Ingrown toenails with only surgery
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Caen
Proprioceptive Disorders
Association Between Knee Isokinetic Testing and Lower Limb Functional Performance and Limb Symmetry
This study aimed to evaluate the association between the isokinetic knee strength and/or proprioception performance with the functional performance on the functional Hop-tests and Y-balance test.
- Trial name
- Pro-knee (NCT04885725)
- Testing
- All group
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Neonatal Abstinence Syndrome
Actigraphy and Neonatal Abstinence Syndrome
The aim of our study is to analyse the correlation between actigraphy and Lipsitz scoring system in neonatal opioid abstinence syndrome.
- Trial name
- ACTINEO (NCT03977545)
- Testing
- Actigraphy
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Cerebrovascular Stroke, Thrombolytic Therapy
Thromboelastometry and Ischemic Stroke (ThromboPredict)
In ischemic stroke, the recanalization rate after intravenous thrombolysis has been estimated to be less than 50% in patients with proximal intracranial artery occlusion; this rate is greater than 80% after endovascular…
- Conditions
- Cerebrovascular Stroke, Thrombolytic Therapy, Mechanical Thrombectomy
- Trial name
- NCT04870684
- Testing
- thromboelastometry test
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Caen
Stroke
PREhospital Routage of Acute STroke Patients With Suspected Large Vessel Occlusion: Mothership Versus Drip and Ship
Background: The outcome of ischemic stroke is related to the brain lesion volume and this volume of infarction is directly related to the time to reperfusion, which therefore depends on the time to initiation of therapy.
- Trial name
- PRESTO-F (NCT04121013)
- Testing
- mothership
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Caen
Neonatal Hypotonia, Antidepressant Drug Adverse Reaction
Neonatal Hypotonia Associated With in Utero Exposure to Antidepressant
To better characterize the neonatal hypotonia associated with in utero exposure to antidepressants, so far limited to clinical cases, we will perform an observational retrospective pharmacovigilance study, using two databases.
- Conditions
- Neonatal Hypotonia, Antidepressant Drug Adverse Reaction, Pregnancy Related
- Trial name
- NCT04830241
- Testing
- Antidepressant
- Where
- France
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Caen