Clinical trials: sponsored by University Hospital, Caen
Teenager, Sex Behavior
Quantitative Study of Prevalence and Vulnerability Factors of Active Cyber Sexuality Among Teenagers in West Normandy
This study evaluates prevalence of active cybersexuality among teenagers (15-17 old) in West Normandy and find different factors of vulnerability that could induce this behaviour.
- Trial name
- NCT03662321
- Where
- 14 sites in France
- Volunteers
- 1,208 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Pelvic Organ Prolapse, Symptoms
Evaluation of Functional Outcomes After Laparoscopic Promontofixation (PFL).
Prolapse of the pelvic organs is a common pathology in women with a strong impact on the quality of life. Its prevalence tends to increase due to increased life expectancy and obesity.
- Conditions
- Pelvic Organ Prolapse, Symptoms, Satisfaction, Quality of Life
- Trial name
- PeSuLife (NCT03919123)
- Testing
- Evaluation of laparoscopic promontofixation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Caen
Kidney Transplantation
Therapeutic Drug Monitoring (TDM) of Cyclosporine in Kidney Transplant Patients by Dried Blood Spot Assay. Interest and Feasibility.
Ciclosporin A (CsA) is an immunosuppressive drug used in organs and tissues transplantations (kidney, heart, liver, bone marrow ...) to prevent rejection, and in different autoimmune or inflammatory diseases.
- Trial name
- CICLOSPOT (NCT02830191)
- Volunteers
- 22 people
- Sponsor
- University Hospital, Caen
Cardio-oncology
Prevention and Pharmacological Management of Cardiac Adverse Drug Reactions Induced by Drugs Used in Oncology.
Recently, the medical management of cancer patients has considerably improved the prognosis of these patients and today some cancers are becoming "chronic diseases".
- Trial name
- PICARO (NCT03678337)
- Testing
- observational cohort with plasma samples
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Caen
Stroke
Stroke Observatory of Caen-Normandie Metropole
Stroke Observatory of Caen-Normandy Metropole provides epidemiological data in prospective collection. The primary objective is to determinate incidence of Stroke in this area.
- Trial name
- NORMANDYSTROKE (NCT03684226)
- Where
- France
- Volunteers
- 2,400 people
- Sponsor
- University Hospital, Caen
Cardiac Surgery, Atrial Fibrillation
Spironolactone and Perioperative Atrial Fibrillation Occurrence in Cardiac Surgery Patients.
Study hypothesis : Pre-operative aldosterone receptor blockade may reduce post-operative atrial fibrillation (POAF) occurrence within 5 days after coronary artery bypass graft surgery (CABG) ± aortic valve replacement (AVR)…
- Conditions
- Cardiac Surgery, Atrial Fibrillation, Aldosterone Blockade
- Trial name
- ALDOCURE (NCT03551548)
- Testing
- Spironolactone 25mg
- Where
- 2 sites in France
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Caen
Immune Deficiency
ENCAPSID Study : ENCApsulated Bacterial Infection and Primary, Secondary ImmunoDeficiency
Background : The occurrence of Primary immune deficiencies (PID) is rare in adults. Antibody deficiencies were the first PID to be diagnosed in adulthood and are mainly represented by common variable immune deficiency.
- Trial name
- ENCAPSID (NCT03721146)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Caen
Healthy
Determination of Baseline Thyroid Status Values in French Adult Population
The objective of this study is to establish reference values in the general population from a Beckman Coulter DxI chemiluminescence assay.
- Trial name
- THYRBECK (NCT03748407)
- Testing
- Dosages of Thyroid parameters
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Glioma
Multimodal Imaging of Hypoxia in Gliomas
The imaging of cerebral oxygenation is an extremely important tool in understanding the pathophysiology of the tumor and for adaptation of therapies according to hypoxia.
- Trial name
- GLIOXYMAGE (NCT03716986)
- Testing
- MRI Oxygen Saturation Map
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Chronic Subdural Hematoma
General Anesthesia Versus Locoregional Anesthesia for Evacuation of Chronic Subdural Hematoma
This study compare general anesthesia versus locoregional anesthesia for evacuation of chronic subdural hematoma. Half of participant will be operated under general anesthesia, while the other half will be operated under…
- Trial name
- NCT03666949
- Testing
- All General anesthesia, All Locoregional anesthesia
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Caen
Total Hip Replacement
Study of the Wear of a Highly Cross-linked Polyethylene Acetabular Doped With Vitamin E and Coated With Titanium in Total Hip Replacement
The total hip replacement, with over 120,000 cases per year in France, provides short term, excellent functional results and a significant improvement in quality of life, in almost all cases.
- Trial name
- POLYTITAN (NCT02524587)
- Testing
- standard polyethylene acetabular irradiated at 3 Mrad, radio stereometric analysis (RSA) of the acetabular, acetabular polyethylene vitamys®
- Where
- France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Caen
Blood Sample for Routine Care, Term or Premature Newborns (28 to 44 Amenorrhea Weeks)
TDM of Gentamicin and Vancomycin, in Neonates, Using Dried Blood Spot Sampling.
Gentamicin and vancomycin, widely used in neonatology, are antibiotics with a narrow therapeutic index and a risk of nephrotoxicity and ototoxicity.
- Conditions
- Blood Sample for Routine Care, Term or Premature Newborns (28 to 44 Amenorrhea Weeks), Gentamicin and/or Vancomycin
- Trial name
- MIDOMEN (NCT03651115)
- Testing
- therapeutic drug monitoring
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen
Heart Failure With Reduced Ejection Fraction
Bisoprolol Plasma Residual Concentrations in Chronic Heart Failure
This study evaluate the dosage of bisoprolol plasma residual concentrations in chronic heart failure with mild to reduced ejection fraction adult patients by dose and renal function.
- Trial name
- PREVALENT (NCT03644446)
- Testing
- Bisoprolol plasma residual concentration dosage
- Where
- France
- Volunteers
- 81 people
- Sponsor
- University Hospital, Caen
Hypogonadism
Effects of Replacement Therapy With Sexual Steroid Hormones on the Insulin Sensitivity of Hypogonadal Man
Sexual steroids administered to supra-physiological doses are likely to change the carbohydrate and lipid metabolism. Investigators propose to study in 12 hypogonadal men hypogonadotropic or hypergonadotropic treated with…
- Trial name
- STEROSENS (NCT02847806)
- Testing
- Estradiol (Insulin sensitivity), Testosterone (Insulin sensitivity)
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Caen
SCCHN
Evaluation of the Overall Quality of Life After the Neck Dissection Retro-spinal Sector (IIb), in Squamous Cell Carcinomas Clinical and Radiological N0 VADS
The nodal involvement in squamous cell carcinomas of the upper aerodigestive tract (VADS) is one of the main factors of poor prognosis, justifying the surgical management of neck dissection as a reference treatment.
- Trial name
- QDV2b (NCT02878655)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Caen
Intraoperative Neurophysiological Monitoring
Effect of Perioperative Factors on the Analgesia Nociception Index
The Analgesia Nociception Index (ANI) is a new unitless marker derived from Heart Rate Variability spectral analysis, ranging between 0 and 100 and expressing the parasympathetic tone.
- Trial name
- ANIFACT (NCT02305576)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen
Attention Deficit Hyperactivity Disorder
A Study of Identity Building in Children With ADHD
Context: Attention Deficit Hyperactivity Disorder (ADHD), a major public health issue, is a neurodevelopmental disorder characterized by disturbance of attention, pathological impulsivity and a variable level of psychomotor…
- Trial name
- SID-ADHD (NCT03565250)
- Testing
- self understanding interview
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Pregnancy
Pregnancy and Use of Psychoactive Substances: The Influence of Representations of Care on Care.
It is observed that pregnant women using psychoactive substance (s) have a more random and more accidental pregnancy follow-up than women with no addictive problems.
- Trial name
- ADDGEST (NCT03567070)
- Testing
- qualitative study based on an individual clinical interview
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Caen
Healthy Volunteers
VESTIBULAR EVOKED MYOGENIC POTENTIALS IN ALTERED GRAVITY
Recently, new clinical testing of saccular and utricular function have been developed and validated, the so-called vestibular-evoked myogenic potentials - VEMP (Brantberg et al. 2009, Cornell et al.
- Trial name
- VEMP (NCT03562676)
- Testing
- weightlessness
- Where
- France
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Cancer
Oral Chemotherapy and Quality of Care
PARCOURS is a non-interventional research study evaluating dysfunctions in the continuous city-hospital journey of a patients cohort treated by oral chemotherapy (60 patients followed for 3 months).
- Trial name
- PARCOURS (NCT03561467)
- Testing
- Observational
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Caen