Clinical trials: sponsored by University Hospital, Geneva
Glioblastoma Multiforme, Glioblastoma, Adult
Pembrolizumab in Association With the IMA950/Poly-ICLC for Relapsing Glioblastoma
Monocentric randomized phase I/II trial, including 24 patients diagnosed with relapsing glioblastoma (GBM) irrespective of MGMT and IDH gene status.
- Conditions
- Glioblastoma Multiforme, Glioblastoma, Adult, Glioma of Brain, Glioblastoma Multiforme of Brain
- Trial name
- IMA950-106 (NCT03665545)
- Testing
- IMA950/Poly-ICLC, IMA950/Poly-ICLC and pembrolizumab
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- University Hospital, Geneva
Tracheal Intubation
Prehospital Tracheal Intubation Technique Using Initial Direct Laryngoscopy During Videolaryngoscopy
Tracheal intubation using videolaryngoscopy may be required in the prehospital setting, where airway management presents unique technical and logistical challenges.
- Trial name
- NCT06918717
- Testing
- Direct Laryngoscopy-to-VideoLaryngoscopy sequence, Free use of videolaryngoscopy
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Pacing-Induced Cardiomyopathy
His Bundle Pacing Versus Right Ventricular Pacing
This study will randomize cross-over periods of 6 months of right ventricular pacing and His bundle pacing in patients with baseline left ventricular ejection fraction (LVEF)>40%. The primary outcome measure is LVEF.
- Trial name
- His-PACE (NCT04672408)
- Testing
- His bundle pacing, Right ventricular pacing
- Where
- Switzerland
- Volunteers
- 29 people
- Sponsor
- University Hospital, Geneva
Bronchiolitis
Efficacy of Lavender Essential Oil Chest Wraps in Infants With Bronchiolitis
The goal of this clinical trial is to learn if lavender essential oil chest wraps relieve cough in infants with bronchiolitis compared to standard care.
- Trial name
- NCT06108648
- Testing
- Lavender essential oil 10%, diluted in 90% olive oil, Control
- Where
- 2 sites in Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Geneva
Drug Hypersensitivity
Management of Drug Hypersensitivity in Children
The aim of this study is (1) to assess the incidence of suspected drug allergies in a pediatric hospital and the proportion in which these reactions are confirmed to be allergic; (2) to evaluate the diagnostic values of the…
- Trial name
- DHC (NCT02031120)
- Where
- Switzerland
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Hematologic Malignancy, Haplo-identical Stem Cell Transplantation
Prophylactic CD45RA-depleted DLI After Haploidentical Transplantation/RIC
To assess safety of prophylactic escaladed dose of T naïve depleted (CD45RA depleted donor lymphocyte infusion, in patients with malignant hemopathie who received an allogeneic stem cell transplant from an haplo-identical donor…
- Trial name
- NCT05066412
- Testing
- CD45RAneg cells, prepared from mononuclear cell leukapheresis by CliniMACS® technology
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University Hospital, Geneva
Mitral Valve Insufficiency, Coronary Stenosis
Impact of Mitral Regurgitation on Coronary Haemodynamics and Instantaneous Effect of Transcatheter Mitral Valve Repair
In the present study, the investigators aim to use the in-vivo Transcatheter Mitral Valve Repair (TMVR) model to determine how Mitral Regurgitation (MR) affects coronary hemodynamics in patients affected with severe MR and…
- Conditions
- Mitral Valve Insufficiency, Coronary Stenosis, Mitral Regurgitation, Coronary Artery Disease
- Trial name
- MitraFLOW (NCT04245956)
- Testing
- Measure of hemodynamic indices in a stenosed coronary artery using a pressure wire
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- University Hospital, Geneva
Cervical Cancer
Telecytology as a Triage Tool in LMICs
The investigators will collect PAP-test samples from women undergoing colposcopy. Laboratory providers will prepare the samples with a liquid-based cytology method.
- Trial name
- NCT05474404
- Testing
- Cervical smear test
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Alzheimer Disease
Dynamic Response to Probiotics in Context of Alzheimer Disease: a Proof-of-concept Study
proof-of-concept study to adequately design a larger trial to investigate the effect of supplementation of a probiotic (SLAB51) on AD biomarker.
- Trial name
- HISTEPPA (NCT05521477)
- Testing
- SLAB51
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- University Hospital, Geneva
Sleep Apnea, Alveolar Hypoventilation
How Differences in Oximeter Performance May Affect Clinical Decision
In clinical practice discrepancies between overnight SpO2 recordings performed by 2 devices used simultaneously are regularly observed. However, this has not been systematically studied or quantified.
- Conditions
- Sleep Apnea, Alveolar Hypoventilation, Nocturnal Hypoxemia
- Trial name
- NCT04474574
- Testing
- Simultaneous recording of nocturnal SpO2
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Geneva
Cerebral Palsy, Brain Injury
Validation of a 3D Instrumented Serious Game to Evaluate Upper Limb Impairments in Children With Neuromotor Disorders
The goal of this clinical trial is to validate an instrumented 3D serious game to assess upper limb impairments in children with neuromotor disorders.
- Conditions
- Cerebral Palsy, Brain Injury, Neurological; Disorder, Nervous System
- Trial name
- Play2BEAPI (NCT06774456)
- Testing
- instrumented 3D serious game (BE API 3.0)
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
SARS-CoV-2 Infection, Influenza Viral Infections
Mucosal Immunity: Influence on Infectious Viral Load: a Prospective Observational Study
The goal of this observational study is to learn about the influence of pre-existing mucosal immunity, i.e. antibodies and immune cells that are present at the nasal mucosa before infection, on the infectious viral load after…
- Conditions
- SARS-CoV-2 Infection, Influenza Viral Infections, Virus Shedding, Mucosal Immunity
- Trial name
- MIViral (NCT05794412)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Vestibular Schwannoma, Ototoxicity
Radiosurgery Induced Ototoxicity in Patients Treated for a Vestibular Schwannoma
The investigators aim to study the impact of stereotactic radiosurgery, for the treatment of vestibular Schwannoma, on the cochlear, vestibular, gustatory, and facial nerve functions and compare it with a conservatively treated…
- Trial name
- NCT05641441
- Testing
- Stereotactic radiosurgery
- Where
- Switzerland
- Volunteers
- 258 people
- Sponsor
- University Hospital, Geneva
Septic Shock
Muscle Ultrasound Study in Shock Patients
Intensive Care Unit (ICU) patients are known to lose muscle mass and function for many reasons, ranging from prolonged immobilization, to the effects of ICU treatments such as mechanical ventilation (MV), to the critical illness…
- Trial name
- MUSiShock (NCT04550143)
- Testing
- Diaphragm ultrasound (DUS), Peripheral Muscle Ultrasound (PMUS), Airway occlusion pressure (P0.1)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Lean Body Mass
Does Muscle Mass At Intensive Care Unit Admission Determine Mortality: the Memo Study
This retrospective monocentric study aims to investigate whether a low muscle mass at ICU admission and its loss over the ICU stay predicts mortality, and in what proportion we can counteract it by nutritional support.
- Trial name
- MEMO (NCT05834894)
- Testing
- exposure(s) of interest : intensive care unit
- Where
- Switzerland
- Volunteers
- 4,000 people
- Sponsor
- University Hospital, Geneva
Atrial Fibrillation, Persistent, Heart Failure
Atrial Fibrillation Ablation Versus Atrioventricular Nodal Ablation with Conduction System Pacing in Heart Failure
The goal of this clinical trial is to evaluate two treatment strategies in patients with chronic atrial fibrillation and heart failure, who are eligible for atrial fibrillation ablation.
- Trial name
- ABACUS (NCT06207383)
- Testing
- Conduction system pacing, Atrioventricular nodal ablation, Atrial fibrillation ablation
- Where
- 18 sites in Austria, Belgium and 12 more
- Volunteers
- 220 people
- Sponsor
- University Hospital, Geneva
ECMO, Cardiogenic Shock
The ECMOCYP (cytochromes P450 Activity) Study
Prospective open label observational study including patients requiring a tMCS (VA-ECMO or Impella® CP) or in in cardiogenic shock according to the SCAI (Society for Cardiovascular Angiography and Interventions) ESC (European…
- Conditions
- ECMO, Cardiogenic Shock, Temporary Mechanical Circulatory Support
- Trial name
- NCT06662084
- Testing
- phenotype
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- University Hospital, Geneva
Malocclusion, Angle Class I
The Efficacy of Lingual Aligners in Adults.
The goal of this clinical trial is to test the effectiveness of lingual aligners in adults. The main question to answer is: Are lingual aligners effective in achieving desired and predicted tooth movements?
- Trial name
- NCT06050655
- Testing
- Lingual aligners
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Uterine Myoma
Does Preventive Uterine Artery Occlusion During Laparoscopic Myomectomy Impact on Ovarian Reserve Markers?
Hysterectomy is an effective treatment used as a first-line approach for uterine myomas. Several others alternatives to hysterectomy have been developed in recent years for women wishing to retain their uterus: myomectomy…
- Trial name
- ORAM (NCT02563392)
- Testing
- uterine myomectomy with preventive uterine arteries occlusion, laparoscopic uterine myomectomy without preventive uterine arteries occlusion
- Where
- Switzerland
- Volunteers
- 58 people
- Sponsor
- University Hospital, Geneva
Aortic Valve Stenosis
Perioperative Hemodynamic and Microcirculatory Physiological Study During TAVI
The Physiological Study of Haemodynamic and Microcirculatory Evolution before/after Transcatheter Aortic Valve Replacement (TAVI) aims to investigate the physiological changes induced by the implantation of a prosthetic aortic…
- Trial name
- TAVI (NCT06154642)
- Testing
- Determination of arterial compliance using blood pressure waveform analysis, Measurement of plasma Vascular Endothelium Growth Factor, Skin temperature gradient
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- University Hospital, Geneva