Clinical trials: sponsored by University Hospital, Grenoble
Atrial Fibrillation Paroxysmal
Pulsed Field Ablation vs Cryoablation In Paroxysmal Atrial Fibrillation
Cryoballoon pulmonary vein isolation (PVI) has emerged as an alternative to radiofrequency in the treatment of drug-resistant atrial fibrillation (AF).
- Trial name
- FACIL AF (NCT05940597)
- Testing
- Pulse field ablation, Cryoballoon pulmonary vein isolation
- Where
- 7 sites in France
- Volunteers
- 354 people
- Sponsor
- University Hospital, Grenoble
Transgender Persons, Pelvic Pain
New-onset Chronic Pelvic Pain in Transgender People Using Testosterone Therapy: an Exploratory Qualitative Study.
This descriptive qualitative study aim to describe the characteristics of pelvic pain in transgender (trans) individuals using testosterone therapy and the impact on their quality of life.
- Conditions
- Transgender Persons, Pelvic Pain, Testosterone, Gender-Affirming Care
- Trial name
- NCT06487754
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Grenoble
Healthy Subjects (HS), Exercise
Methodological Study of Exercise and Hypoxic Conditions in Healthy Subjects
The aim of this protocol is to assess physiological responses during various physical exercise protocols (whole-body exercise such as cycling or treadmill running, or localised exercise such as knee extension) and during…
- Conditions
- Healthy Subjects (HS), Exercise, Hypoxia
- Trial name
- ExHyp (NCT07671638)
- Testing
- Exercise and hypoxia
- Where
- France
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Mild Traumatic Brain Injury
Transcranial Ultrasonography for the Management of Patients With Mild TBI
The investigators hypothesize that patients with mild TBI and normal TCD can be safely discharged home immediately after the ED.
- Trial name
- TRUST (NCT03989999)
- Testing
- Transcranial Doppler (TCD)
- Where
- 12 sites in France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Grenoble
Severe Chest Trauma
EffecT of eARly analGesia With Erector Spinae Plane Block to Reduce Ventilation After Severe Chest Trauma
Blunt chest trauma is commonly associated with rib fractures and early pain management is a key goal after chest trauma. In spontaneous breathing patients, pain limits coughing efficiency and secretion clearance, thereby…
- Trial name
- TARGET (NCT05920109)
- Testing
- ESP block
- Where
- 14 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Grenoble
Patient With an Appointment for an Abdominal CT Scan and Able to Stand up for Height Measurement
Automated and Reliable Estimation of Patient Height From CT Scan Using an Artificial Intelligence Algorithm
The TAILLE study is a single-center, non-interventional (RIPH3), uncontrolled, non-randomized, open-label study.prospective study conducted at CHU Grenoble Alpes.
- Trial name
- TAILLE (NCT07864857)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea
Follow-up of Apneic Patients by Visio-consultation
Prospective multicenter open-label randomized clinical trial comparing videoconsultation to a face-to-face consultation during the follow-up of apneic patients treated by continuous positive pressure (CPAP) .
- Trial name
- VISIOSAS (NCT04547543)
- Testing
- Videoconsultation
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Grenoble
Lung Cancer (NSCLC)
Study of Three Endpoints to Assess the Benefit of Rehabilitation in Patients With Advanced Non-small Cell Lung Cancer Controlled After at Least 6 Months of Systemic Treatment
The objective of this study is to identify an outcome that is relevant for assessing the benefit of rehabilitation in patients with advanced or metastatic non-small cell lung cancer whose disease has been stable or responding for…
- Trial name
- REHAB-CBNPC (NCT07434947)
- Where
- 3 sites in France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Grenoble
Arthrogryposis Multiplex Congenita (AMC)
Technical Feasibility Study of Ultrasound Muscle Imaging in Antenatal Ultrasound
The objective of the study is to evaluate the performance of muscle ultrasound sections on antenatal ultrasound between 21-24 amenorrhea weeks for the screening of muscle atrophy, in a sample of low-risk and high-risk pregnancies…
- Trial name
- FetUS (NCT06130592)
- Testing
- ultrasound muscle imaging technique
- Where
- 2 sites in France
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea (OSA), Insomnia
Study on the Management of COMISA
COMISA, the combination of obstructive sleep apnea (OSA) and insomnia, is a frequent and burdensome condition. Many patients with OSA experience clinically significant insomnia symptoms, and a substantial proportion of…
- Conditions
- Obstructive Sleep Apnea (OSA), Insomnia, COMISA
- Trial name
- COMISA-PEC (NCT07743931)
- Testing
- Daridorexant 50 mg, Continuous Positive Air Pressure (CPAP)
- Where
- 5 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Grenoble
Autism Spectrum Disorder
Flexibility and the Predictive Brain in Autistic Males and Females
The goal of this study is to compare the neural correlates of predictive brain mechanisms during high-level social and non-social flexibility tasks, between autistic and non-autistic males and females.
- Trial name
- FLEX-PREAU (NCT06391684)
- Testing
- Social/non social; predictable vs unpredictable
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Burnout, Caregiver
Evaluation of the CBSM Program Online and in Person to Reduce Caregiver Burnout
Professional burnout is a common syndrome among healthcare workers, impacting both their well-being and the quality of care provided .
- Trial name
- Caregiver-CBSM (NCT06626061)
- Testing
- Cognitive Behavioral Stress management in in person group Format, Cognitive Behavioral Stress management Hybrid Format
- Where
- 2 sites in France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Corticospinal Excitability, Cortical Activation
LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension
Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research.
- Trial name
- LAMI (NCT06478303)
- Testing
- Motor imagery, Action reading, Motor localizer
- Where
- 2 sites in France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
MRI, Sequence Optimization
Development of MRI Protocols and Associated Neuro-physiological Explorations in Healthy and Pathological Subjects
IRMaGe is a Joint Service Unit (UMS) which provides users of brain exploration equipment (clinical MRI and preclinical, TMS, EEG, NIRS and metabolomics).
- Conditions
- MRI, Sequence Optimization, Physiological Measurement
- Trial name
- MAP-IRMaGE (NCT05036629)
- Testing
- MRI Protocol
- Where
- France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
ER+ Breast Cancer, Breast Cancer
Evaluation of Adherence to Cell Cycle Inhibitors Used as Adjuvant Therapy in Patients With Localized Breast Cancer at High Risk of Recurrence.
Hormone receptor-positive (HR+) breast cancers represent the most common histological subtype of breast cancer, accounting for approximately 75% of cases, regardless of HER2 (human epidermal growth factor receptor 2) status (1).
- Conditions
- ER+ Breast Cancer, Breast Cancer, Early Breast Cancer, Endocrine Therapy
- Trial name
- AdheRA (NCT07443774)
- Where
- France
- Volunteers
- 81 people
- Sponsor
- University Hospital, Grenoble
Benzodiazepine Withdrawal
Brief Motivational Intervention (BMI) on the Deprescription of Benzodiazepines and Related Substances in Adult Chronic Drug Users
We hypothesise that a short-term intervention by dispensing pharmacists is feasible and relatively easy to implement, and that it could have an impact on the deprescribing of BZD/Z in adult patients.
- Trial name
- BENZ_HALTE (NCT06446349)
- Testing
- Brief motivational intervention
- Where
- 20 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Grenoble
Digital Technology, Mobile Application
Enabling Women With Parkinson's Disease to Identify and Better Manage Hormonal Triggers of Parkinsonian Symptoms
Forty percent of people living worldwide with Parkinson's disease (PD) are women. Twenty percent of patients have PD onset under the age of 60 years, a time when women may encounter significant caregiving responsibilities along…
- Conditions
- Digital Technology, Mobile Application, Motor Fluctuations, Oestrogen
- Trial name
- Lady-PD (NCT06582212)
- Testing
- Mymovesmatter mobile application
- Where
- 4 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Grenoble
Multiple Sclerosis, Quality of Life (QOL)
Enhancing Self-Esteem in Patients With Multiple Sclerosis: A Randomised Controlled Trial of the Lexical Association Technique
The goal of this clinical trial is to learn whether the Lexical Association Technique (LAT) can improve well-being in people recently diagnosed with multiple sclerosis (MS), either relapsing-remitting (RRMS) or secondary…
- Trial name
- SE-P-MS (NCT07064291)
- Testing
- The Lexical Association Technique (LAT)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Grenoble
Anxiety, Paramedical Consultation
Pre-operative Interventional Paramedical Consultation: What About the Implantable Device?
The placement of implantable ports is carried out at CHUGA by several departments, including the Interventional Radiology Department.
- Trial name
- COPAIN (NCT07559981)
- Testing
- Paramedical consultation
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Grenoble
Aphasia Non Fluent, Stroke
Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia
SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that…
- Trial name
- SEMO (NCT04433351)
- Testing
- Enriched rehabilitation, Simple rehabilitation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Grenoble