Clinical trials: sponsored by University Hospital, Grenoble
Hepatocellular Carcinoma
Study Investigating the Association of NP137 With Atezolizumab-Bevacizumab Combination in First Line in Unresectable HCC
The study will assess the safety of the association of NP137 with the standard of care Atezolizumab-Bevacizumab in first line setting in patients with unresectable hepatocellular carcinoma.
- Trial name
- Liver-NET1 (NCT05546879)
- Testing
- NP137, Atezolizumab, Bevacizumab
- Where
- 9 sites in France
- Volunteers
- 43 people
- Sponsor
- University Hospital, Grenoble
Crohn Disease (CD)
Qualitative Exploration of Key Symptoms of Stricturing Crohn's Disease: Toward the Development of a Clinical Assessment Score.
The goal of this qualitative study is to identify and better understand the symptoms of stricturing Crohn's disease in order to inform the development of more appropriate clinical evaluation scores.
- Trial name
- SYMCROHNS (NCT07441629)
- Testing
- Semi-structured interview
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Primary Tumor, Colon Tumor
Tumor Immune Microenvironment Involvement in Colorectal Cancer Chemoresistance Mechanisms
Colorectal cancer is the third most common cancer worldwide and its progression-free survival is still low, around 10 months. Thirthy to 50% of patients do not respond to chemotherapy upon initiation of treatment, suggesting that…
- Trial name
- CRC-ORGA2 (NCT05038358)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Pancreatic Ductal Adenocarcinoma
Study Investigating the Association of NP137 With mFOLFIRINOX in Locally Advanced Pancreatic Ductal Adenocarcinoma
The study will assess the safety of the association of NP137 with the standard of care mFOLFIRINOX in the treatment of locally advanced pancreatic ductal adenocarcinoma.The study drug which is tested is the NP137 in association…
- Trial name
- LAP-NET1 (NCT05546853)
- Testing
- NP137, Oxaliplatin, Irinotecan
- Where
- 9 sites in France
- Volunteers
- 43 people
- Sponsor
- University Hospital, Grenoble
Inflammatory Bowel Disease (IBD)
Metabolic Reprogramming of Monocytes in Inflammatory Flares of Inflammatory Bowel Diseases
Inflammatory bowel diseases, Crohn's disease and haemorrhagic rectocolitis, are pathologies that progress in flare-ups, impacting on patients' quality of life and functional or even vital prognosis.
- Trial name
- REPRO-MICI (NCT06944873)
- Testing
- Blood test 4 EDTA tubes
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Chronic Kidney Disease (CKD), Coronary Artery Disease (CAD)
Coronary Artery Disease Screening in Patients With Chronic Kidney Disease
Patients with chronic kidney disease (CKD) have a markedly increased cardiovascular risk, with coronary artery disease being a leading cause of morbidity and mortality.
- Trial name
- EVACKD (NCT07585695)
- Where
- France
- Volunteers
- 283 people
- Sponsor
- University Hospital, Grenoble
SARS-CoV-2 Infection
Evaluation of the Diagnostic Performance of the TestNPass DM-DIV for SARS-CoV-2 Using a Nasopharyngeal Sample
The COVID-19 pandemic has created a major global health crisis that requires a rapid and effective response, particularly in the field of diagnostics.
- Trial name
- TESTOGRAPH (NCT06917261)
- Testing
- nasopharyngeal swab.
- Where
- 2 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Grenoble
Heart Failure, Systolic
Hypoxic Conditioning in Heart Failure
Heart failure impairs quality of life and exercise capacity, despite an optimal medical therapy. Alternative methods, like hypoxic conditioning coupled to exercise training, must be explored and describe
- Trial name
- hypoxheart (NCT03537079)
- Testing
- hypoxia air
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Grenoble
Respiratory Infections in Old Age
Functional Impact of Acute Respiratory Viral Infections in Older Adults
The prevention of infectious diseases in older adults remains a major public health challenge, as acute respiratory infections are a leading cause of hospitalisation, mortality, and functional decline worldwide.
- Trial name
- AFIRI (NCT07388173)
- Where
- 24 sites in United States, France and 3 more
- Volunteers
- 1,600 people
- Sponsor
- University Hospital, Grenoble
Hypoxia, Cerebral Hypoxia
Effect of Hypoxic Conditioning on Cerebrovascular Health in the Elderly
In line with the ever-growing aging of Western populations, the development of preventive strategies to slow down the effects of aging on cardiovascular health represents a major challenge in order to preserve functional…
- Conditions
- Hypoxia, Cerebral Hypoxia, Brain Diseases, Exercise
- Trial name
- HYPOXAGE (NCT05048680)
- Testing
- Hypoxia and/or Exercise
- Where
- France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Anorexia Nervosa
Home-based Adapted Physical Activity in Anorexia Nervosa: a Feasibility Pilot Study
The goal of this pilot clinical trial is to assess a program of Home-based Adapted Physical Activity in Anorexia Nervosa.
- Trial name
- APAMAdom (NCT05803707)
- Testing
- Home-based Adapted Physical Activity
- Where
- 2 sites in France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Grenoble
Alzheimer Disease
Validation of an Alzheimer's Disease Marker by Fecal Assay of Amyloid Peptides and Tau Proteins
Alzheimer's disease (AD) is the leading cause of dementia in humans, currently affecting almost one million people in France. It results from an irreversible degeneration of neurons responsible for a progressive decline in the…
- Trial name
- FecAlz (NCT06481878)
- Testing
- faecal analysis
- Where
- France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Diabetes
Satisfaction of Specific Modes Related to Physical Activity in People Living With Type 1 Diabetes and Using an Hybrid Closed-loop System
The BF-ACT study is a single-center, non-interventional (RIPH3) descriptive study conducted at CHU Grenoble Alpes. It aims to evaluate the satisfaction of adults with type 1 diabetes using closed-loop insulin delivery systems…
- Trial name
- BF-ACT (NCT07567170)
- Testing
- Questionnar
- Where
- France
- Volunteers
- 900 people
- Sponsor
- University Hospital, Grenoble
Frail Elderly
High Intensity Interval Training Versus Moderate Intensity Continuous Training in Frail Elderly
The assessment and systematic integration of physical activity into the care pathway of frail elderly people is essential to prevent loss of independence and improve the quality of life of this population.
- Trial name
- EPAF (NCT07211334)
- Testing
- Exercise Training
- Where
- France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Grenoble
Osteoarthritis
Evaluation of the Safety of LipiodolⓇ Embolization in Symptomatic Digital Osteoarthritis Refractory to Conventional Treatment
The goal of this clinical trial is to evaluate the safety of arterial embolization using Lipiodol® in patients with symptomatic hand osteoarthritis refractory to conventional treatment.
- Trial name
- EMBARDI (NCT06611007)
- Testing
- embolization therapy
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Prostate Cancer
Prostate Interstitial Brachytherapy With I125 Implant With Target Dose Supplementation in the Tumor Volume Guided by TRINITY® PERINE 3D System
The objective of the FOCUS-Boost project is to implant for the first time with a 3D ultrasound image fusion registration system (3D echo) implant of iodine 125 with precision in a target volume determined by positive biopsies.
- Trial name
- FOCUS-BOOST (NCT05322356)
- Testing
- Interstitial Brachytherapy of the Prostate With Iodine 125 Implant With Target Dose Supplementation in the Tumor Volume Guided by the TRINITY® PERINE 3D
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Hereditary Angioedema (HAE)
HAE Burden and Crisis Management
The study has been designed as a French, multicentric survey study to obtain data to describe the burden of on-demand treatment for patients with hereditary angioedema (HAE).
- Trial name
- ECRINS (NCT06806618)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Grenoble
Post-Cesarean Maternal Satisfaction Scale
Translation and Validation Into French of a Maternal Satisfaction Scale Following a Cesarean Section (MSSCS)
Cesarean section is currently the most commonly performed surgical procedure worldwide, accounting for more than one-fifth of all deliveries in France.
- Trial name
- TRANSALPINE (NCT07555353)
- Testing
- Post-Cesarean Maternal Satisfaction Scale Questionnaire
- Volunteers
- 210 people
- Sponsor
- University Hospital, Grenoble
Severe Trauma Patient, Venous Thromboembolism
Intermediate Versus Standard Dose Enoxaparin to Prevent Venous Thromboembolism in Severe Trauma Patients: a Multicenter Double Blind Randomised Controlled Trial
Venous thromboembolism is a frequent issue in severe trauma patients. Guidelines for venous thromboembolism prevention include the use of pharmacological thromboprophylaxis, mainly with low-molecular-weight heparin, and/or…
- Trial name
- HEPTRAUMA (NCT07506473)
- Testing
- Enoxaparin standard dose, Enoxaparin intermediate dose
- Where
- 17 sites in France
- Volunteers
- 540 people
- Sponsor
- University Hospital, Grenoble
Spondyloarthritis (SpA), Rheumatoid Arthritis & Other Inflammatory Polyarthropathies
Ecological Momentary Assessment and Physical Activity in Patients With Inflammatory Rheumatic Diseases
Chronic inflammatory rheumatic diseases (IRDs), such as rheumatoid arthritis and spondyloarthritis, can cause pain, fatigue, and mobility issues, significantly impacting patients' quality of life.
- Trial name
- DYNAMIC (NCT07167784)
- Testing
- Ecological Momentary Assessment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble