Clinical trials: sponsored by University Hospital, Lille
Cystic Fibrosis (CF), Mucoviscidosis
Prevalence of Exercise-induced Ventilatory Limitation and Associated Factors in Patients With Cystic Fibrosis Receiving Elexacaftor-Tezacaftor-Ivacaftor
Cystic fibrosis is a genetic disorder affecting the entire body and associated with respiratory exacerbations, impaired quality of life and reduced life expectancy.
- Trial name
- MUCOLIMEX (NCT07314229)
- Testing
- Measurement of resistance through forced oscillations and continuous measurement of ventilation and inspiratory capacity during TM6
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Lille
Disorder of Endocrine Pancreas
Evaluation of the Efficacy of Intramuscular Islet Autograft After Extensive Pancreatectomy
The liver may not be an optimal site for islet transplantation due to obstacles by an instant blood-mediated inflammatory response, and low revascularization of transplanted islets.
- Trial name
- AUTOGRAFTIM (NCT02872571)
- Testing
- Intramuscular Islet Autograft
- Where
- 4 sites in France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Lille
Bacteremia, Infant, Very Low Birth Weight
Preventing Catheter-related Bacteremia When Administering Injectable Medications in Premature Infants.
This study evaluates the potential interest of a new multi-lumen infusion access device (Edelvaiss® Multiline NEO) in the prevention of catheter-related bacteremia when administering injectable drugs in premature infants.
- Trial name
- MultilineNEO (NCT02633124)
- Testing
- Edelvaiss Multiline NEO, Standard Infusion Set
- Where
- 4 sites in France
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Surgery, Obesity
A Randomized Controlled Study Evaluating Bariatric Surgery as a Treatment for Severe NASH With Advanced Liver Fibrosis in Non-severe Obese Patients
The aim of the study is to demonstrate the superiority of bariatric surgery on the disappearance of NASH without worsening of fibrosis in comparison to medical standard treatment in obese patients (35 kg/m² > BMI ≥ 30 kg/m²) with…
- Conditions
- Surgery, Obesity, NASH - Nonalcoholic Steatohepatitis, Cirrhosis
- Trial name
- NASHSURG (NCT03472157)
- Testing
- Lifestyle therapy, Bariatric surgery
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
Esophageal Atresia
Long Term Outcome of Easophageal Atresia : Transmics Profiles in Adolescence
Oesophageal atresia (OAEA), a malformation of the oesophagus present from birth, is characterized by the interruption of the continuity of the oesophagus, which then ends in a cul-de-sac.
- Trial name
- TransEAsome (NCT05995171)
- Testing
- Questionnaire
- Where
- 33 sites in France, Martinique and 1 more
- Volunteers
- 300 people
- Sponsor
- University Hospital, Lille
Peri-operative Hemorrhage or Hematoma, Surgery
Preventive EXACYL® on Perioperative Bleeding During Orthognathism of Maxillary Surgery
Prospective, randomized, double-blind, placebo-controlled, mono center, Phase III trial to compare EXACYL in preventive with placebo on perioperatory bleeding in orthognathism surgery.
- Conditions
- Peri-operative Hemorrhage or Hematoma, Surgery, Retrognathism
- Trial name
- LEFORTEXACYL (NCT02702128)
- Testing
- Tranexamic Acid, saline solution
- Where
- France
- Volunteers
- 157 people
- Sponsor
- University Hospital, Lille
Febrile Neutropenia, Rule of Clinical Decision, Chemotherapy
Distinction Risk of Severe Infection in Febrile Neutropenia After Chemotherapy
Evaluate the reproducibility and validate a posteriori a new rule of clinical decision on a multi-center population of children with a post-chemotherapy febrile neutropenia
- Trial name
- NCT03434795
- Where
- France
- Volunteers
- 1,900 people
- Sponsor
- University Hospital, Lille
Scleroderma, Systemic
Trichoscopy and Systemic Scleroderma
Few data are available on scalp involvement in systemic scleroderma. Few data are available on the association between scalp abnormalities and features of systemic scleroderma Trichoscopy is a simple, reproducible, noninvasive…
- Trial name
- TRICHLOSCLERO (NCT04804930)
- Testing
- picture
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Lille
SARS-CoV 2
Impact of COVID-19 Infection on the Incidence of Ventilator-acquired Infections
Observational cohort study aiming at comparing the incidence of ventilator-associated lower respiratory tract infections between COVID-19 patients and two control groups: one with influenza pneumonia and the other with no viral…
- Trial name
- COVAPID (NCT04359693)
- Where
- France
- Volunteers
- 1,576 people
- Sponsor
- University Hospital, Lille
Lung Carcinoma Metastatic to the Brain
MRI Perfusion on T1 and T2 Brain Lesion(s)
This study therefore aims to assess current treatment recommended by scientific societies [ 6-13 ] , brain MRI with injection of contrast for the diagnosis and monitoring of brain metastases .
- Trial name
- METAPERF (NCT02250755)
- Testing
- MRI T1 T2 sequences
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Sepsis, Respiratory Physiological Phenomena
Respiratory Variations for Predicting Fluid Responsiveness
Hypovolemia and acute circulatory failure affects more than 60% of patients hospitalized in intensive care or resuscitation. The volume expansion (VE) by fluid replacement therapy is the first treatment improve circulatory…
- Conditions
- Sepsis, Respiratory Physiological Phenomena, Circulatory Failure
- Trial name
- ReVaPreF (NCT03066362)
- Testing
- Echocardiography-Doppler
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Lille
Cardiogenic Shock
Venous Oxygen Saturation During ECMO Support
Extracorporeal veno-arterial membrane oxygenation" (ECMO-VA), are used to manage refractory cardiogenic shocks by replacing the failed "heart-lung" block.
- Trial name
- ECMOxygen (NCT04934566)
- Testing
- ECMO flow
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Lille
Drug Hypersensitivity, DRESS Syndrome
Origin and Function of Eosinophilic Polynuclear During DRESS Syndrome
Drug Hypersensitivity Syndrome or DRESS for "Drug Reaction with Eosinophilia and Systemic Symptoms" is a serious drug allergy which can be life-threatening for patients with serious organ damage.
- Trial name
- DRESSEO (NCT04330118)
- Where
- 11 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Cystocele
Prosthetic Pelvic Organ Prolapse Repair
The cystocele is the most frequent clinical shape of the genital prolapse. It is a frequent pathology in woman which can impair quality of life and generates pelvic, urinary or sexual functional disorders.
- Trial name
- PROSPERE (NCT01637441)
- Testing
- laparoscopic sacropexy, vaginal mesh
- Where
- 12 sites in France
- Volunteers
- 262 people
- Sponsor
- University Hospital, Lille
Basal Cell Carcinoma
Study Evaluating the Interest of Vismodegib as Neo-adjuvant Treatment of Basal Cell Carcinoma (BCC)
Open-label, non-comparative, multicenter, phase II study of Vismodegib in patients with locally advanced BCC.
- Trial name
- VISMONEO (NCT02667574)
- Testing
- ERIVEDGE
- Where
- 17 sites in France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Lille
Cystocele
Trial Comparing Laparoscopic Sacropexy and Vaginal Mesh Surgery for Women Cystocele Repair.
The primary objective of this study is to compare with PFDI-20 questionnaire the functional outcome of laparoscopic sacrocolpopexy and vaginal mesh surgery in the treatment of symptomatic exteriorised cystocele up to 4 years…
- Trial name
- PROSPERE4 (NCT02272361)
- Testing
- laparoscopic sacrocolpopexy, vaginal mesh surgery
- Where
- 12 sites in France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Lille
Esophageal Cancer
Open Versus Laparoscopically-assisted Esophagectomy for Cancer
To compare laparoscopically-assisted gastric mobilization versus open gastric mobilization in Ivor-Lewis esophagectomy for esophageal cancer, with open thoracic approach in the 2 arms.
- Trial name
- NCT00937456
- Testing
- Laparoscopically-assisted esophagectomy
- Where
- 11 sites in France
- Volunteers
- 207 people
- Sponsor
- University Hospital, Lille
Glottic Carcinoma
Comparison of Voice Results at 5 Years of Treatment of Glottic Squamous Cell Carcinoma T1 by Surgery Versus Radiotherapy
Patients with early-stage squamous cell carcinomas of the vocal cord can be treated in an equivalent way in terms of carcinology by surgery or radiotherapy.
- Trial name
- VO Qual (NCT04447456)
- Where
- 2 sites in France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Lille
Fungal Infection, Critical Illness
Fungal Biomarkers to Reduce Duration of Empirical Antifungal Therapy: a Randomized Comparative Study (STAFE)
The investigators hypothesized that the use of biomarkers of invasive fungal infections would increase the percentage of early discontinuation of empirical antifungal therapy and thus reduce the duration of treatment in ICU…
- Trial name
- STAFE (NCT02154178)
- Testing
- Biomarker group
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Lille
Endometriosis, Infertility
Impact of Complete Surgery of Colorectal Deep Infiltrating Endometriosis on Fertility
The ENDOFERT Study is an open, multicenter, randomized, parallel-group, controlled trial. This study includes patients presenting colorectal DIE and infertility.
- Trial name
- ENDOFERT (NCT02948972)
- Testing
- complete surgery, In vitro fertilization without surgery
- Where
- 5 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Lille