Clinical trials: sponsored by University Hospital, Rouen
Acute Renal Failure
A New Way to Detect Acute Kidney Injury
Acute renal failure after cardiac surgery is a common postoperative complication, affecting approximately 20% of patients. It is associated with an increase in short-term mortality and an increase in hospital stay; but is also…
- Trial name
- VEX-CARDS (NCT07198906)
- Testing
- Determination of VEXUS score and onset of chronic renal failure
- Where
- France
- Sponsor
- University Hospital, Rouen
Vaccination With MenbVac
Evaluation of Immune Response Against the Strain of Neisseria Meningitidis B: 14, P1-7, 16 Patients Vaccinated With MenBVac® (Extension MenbVac)
This study aims to estimate the vaccinal immunity four years after four doses of MenbVac in children aged 4-8 years.
- Trial name
- Exten MenbVac (NCT01565577)
- Testing
- MenbVac
- Where
- France
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Intraventricular Hemorrhage
Research a New Predictive Marker of Intraventricular Hemorrhage in Very Preterm Infants
The most frequent complications in premature infants are neurological complications: intracranial hemorrhages and white matter lesions. In Epipage 2 study the incidence of severe intraventricular hemorrhages remains stable.
- Trial name
- HEMO PREMA (NCT02400853)
- Testing
- Standard cranial echography, Cord blood analysis
- Where
- France
- Volunteers
- 175 people
- Sponsor
- University Hospital, Rouen
Neonatal Screening, Lysosomal Storage Diseases
A Pilot Study for Systematic Neonatal Screening for Lysosomal Storage Diseases Using Tandem Mass Spectrometry
The study will include all newborns in Normandie region for 3 years (about 105,000 births) for whom signed consent by one (or two) parents will be collected.
- Trial name
- LysoNeo (NCT04393701)
- Testing
- Additional blood sampling
- Where
- 2 sites in France
- Volunteers
- 100,000 people
- Sponsor
- University Hospital, Rouen
Urinary Infections
Study of the Pharmacokinetics of Ceftriaxone
Urinary tract infections (UTIs) are the leading cause of community-acquired bacterial infections in adults. They are a common reason for admission to the Emergency Department (ED), particularly when pyelonephritis is suspected.
- Trial name
- Etude PC-IUU (NCT07169097)
- Testing
- free ceftriaxone concentration dosage
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Rouen
Neurocognitive Disorders, Alzheimer's Disease
Evaluation of the Link Between Carotid Arterial Wall Viscosity and Major Neurocognitive Disorders
The mechanical behavior of conductance arteries is viscoelastic. While the elastic component has been extensively studied, the viscous component has often been neglected for methodological reasons and also because it was…
- Trial name
- VISCOG (NCT07205003)
- Testing
- Assessment of carotid wall viscosity in patients with vascular dementia, Assessment of carotid wall viscosity in patients with Alzheimer's disease, Assessment of carotid wall viscosity in patients not presenting dementia.
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Rouen
Kidney Transplant Infection
Evolution of CMV Antiviral T-cell Immunity Over the Next Six Months Initiation of Treatment With Belatacept.
Belatacept inhibits T cell activation by blocking the costimulatory signal. In kidney transplantation, it limits the use of anticalcineurins while ensuring a satisfactory level of immunosuppression.
- Trial name
- VIRABEL (NCT05708534)
- Testing
- Belatacept
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Rouen
Major Abdominal Surgery
Glycocalyx Monitoring in Major Abdominal Surgery
The study of the microcirculation and glycocalyx could be an essential element in the monitoring of our patients undergoing major abdominal surgery.
- Trial name
- GLYCOCHIP (NCT06285526)
- Testing
- Cytoreduction surgery with Hyperthermic Intraperitoneal Chemotherapy, Cephalic DuodenoPancreatectomy
- Where
- France
- Volunteers
- 78 people
- Sponsor
- University Hospital, Rouen
Idiopathic Megarectum
Megarectum in Adults
Severe functional constipation associated with a pathological increase in rectal volume, with or without colonic dilation, is known as megarectum. In the absence of an organic cause, megarectum is called idiopathic.
- Trial name
- MEGA-ORIGINE (NCT07599527)
- Testing
- Idiopathic megarectum group, Constipated patient group
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Rouen
Gastro-Intestinal Disorder
Fructose Effect on Neuroinflammation and Feelings
Fructose is increasingly present in our food. The increase in its consumption is associated with the increase in the prevalence of several pathologies such as metabolic syndrome or hepatic steatosis.
- Trial name
- MOODYFRUCTOSE (NCT05371067)
- Testing
- Fructose respiratory test
- Where
- France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Autoimmune Diseases
Clinical and Immunological Long-term Follow-up of Patients With Pemphigus Included in the "RITUXIMAB 3" Trial
Pemphigus is an autoimmune disease specific to the skin and mucous membranes characterized by the production of IgG4 isotype autoantibodies (AC) directed mainly against two proteins involved in interkeratinocyte adhesion…
- Trial name
- LTFURITUX3 (NCT03790293)
- Testing
- Rituximab, corticosteroids'therapy
- Where
- 25 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Rouen
Cerebral Venous Thrombosis
Thrombin Generation and Thrombus Degradation in Cerebral Venous Thrombosis : Clinical and Radiological Correlations
Cerebral venous thrombosis is considered as a rare type of stroke with an annual incidence of 3 to 4 per million people. It occurs generally in young patients (mean age of occurrence = 40 years) and principally in young females…
- Trial name
- PHRC-TVC (NCT02013635)
- Testing
- Blood samples, Neuroimaging, Clinical assessments
- Where
- 36 sites in France
- Volunteers
- 232 people
- Sponsor
- University Hospital, Rouen
Pregnancy Related
Clitoris Potential Analgesic Function Research by Pregnant Women : Feasibility Study
Assessment of the acceptability by pregnant women on the research of the potential analgesic function of the clitoris.
- Trial name
- FAC (NCT04257318)
- Testing
- Vibrating Relaxation Tool
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Anal Incontinence
Does the Negativation of the Glucose Hydrogen Breath Test Come Along With a Reduction of the Symptoms of Gaz Incontinence ?
The objectives of this work are: 1/to estimate the frequency of a positive glucose breath test in favour of a small intestinal bacterial overgrowth in a population of patients consulting for gaz incontinence by comparison to a…
- Trial name
- NCT01275560
- Testing
- Metronidazole, CArbosylane
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Severe Symptomatic Aortic Stenosis
Evaluation of Length of Stay After TF-TAVI
Transcatheter aortic valve implantation (TAVI) has been rapidly adopted worldwide since the first-in-man TAVI performed in 2002.
- Trial name
- FAST-TAVI (NCT02956915)
- Testing
- Transfemoral Transcatheter aortic valve implantation
- Where
- 5 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Rouen
Hymenoptera Allergy
Determinism of the Mechanism of Action of Specific Immunotherapy in Hymenoptera Venom Allergy
Currently, most of the protocols used for desensitization to Hymenoptera venoms consist of a very rapid increase in doses of venom extracts administered during the SIT in a day without systemic reaction of the patient which is…
- Trial name
- MAISAVEN (NCT02295488)
- Testing
- biological sampling, Desensitization protocol (Alyostall®)
- Where
- France
- Volunteers
- 29 people
- Sponsor
- University Hospital, Rouen
Respiratory Failure
Benefit of Sleep Quality Monitoring by EEG in ICU
The goal of this observational study is to learn about the benefit of monitoring sleep quality using EEG in patients hospitalized in critical care unit for acute respiratory failure.
- Trial name
- REVASOM (NCT07522450)
- Testing
- EEG monitoring
- Where
- France
- Volunteers
- 47 people
- Sponsor
- University Hospital, Rouen
an Initial Order for a Blood Draw and Placement of an IV Line in the Emergency Department
A Brief Intervention by Nurses to Reduce the Prescribing of Occluded Peripheral Venous Catheters in the Emergency Department
Peripheral venous catheters are frequently inserted in hospitals, with approximately 25 million placed annually in France (HAS data, 2005).
- Trial name
- PERFEKTO (NCT07584590)
- Testing
- question for the prescriber
- Where
- 16 sites in France
- Volunteers
- 1,680 people
- Sponsor
- University Hospital, Rouen
Cancer Colon, Colectomy
Is the Distance of Patients From Rouen University Hospital Influencing the Time Between Colectomy and First Chemotherapy Cure for Colon Cancer?
This project has for objective to demonstrate that the increase of the distance "Patient home - center of treatment" may be associated with significant, other noticeable, noted events.
- Conditions
- Cancer Colon, Colectomy, Chemotherapy
- Trial name
- DICHIMIO (NCT03722121)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Rouen
Bacterial Colonization
Bacterial Colonization After Tunneling in Femoral Perineural Catheters
Background: Bacterial colonization of peripheral nerve catheters is frequent, although infection is relatively rare. With central venous catheters, the tunneling of catheter into the subcutaneous tissue significantly decreases…
- Trial name
- Tunnelized KT (NCT01016925)
- Testing
- tunnelized perineural catheter
- Where
- France
- Volunteers
- 338 people
- Sponsor
- University Hospital, Rouen