Clinical trials: sponsored by University Hospital Heidelberg
Elective Non-cardiac Surgery
Leukocytes and Cardiovascular Perioperative Events-2
The potential use of regulatory T cells as preoperative risk stratification tool is evaluated in order to improve clinical risk stratification and reduce perioperative morbidity and mortality.
- Trial name
- LeukoCAPE-2 (NCT03105427)
- Where
- Germany
- Volunteers
- 233 people
- Sponsor
- University Hospital Heidelberg
Shock, Septic, Sepsis
Anticholium® Per Se
Anticholium® per Se is a randomized, double-blind, placebo-controlled, monocentric trial to assess whether the CAP can be transferred from bench to bedside.
- Conditions
- Shock, Septic, Sepsis, Perioperative Period
- Trial name
- NCT03013322
- Testing
- Physostigmine, Isotonic Saline
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg
Mucopolysaccharidosis Type I, Mucopolysaccharidosis Type II
Parental Coping With Challenging Behavior in Mucopolysaccharidosis Type I-III
The study quantitates behavioral challenges in mucopolysaccharidosis type I-III and parental coping strategies
- Conditions
- Mucopolysaccharidosis Type I, Mucopolysaccharidosis Type II, Mucopolysaccharidosis Type III, Behavior Disorders
- Trial name
- NCT03161171
- Testing
- This is an observational study
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- University Hospital Heidelberg
Chronic Pain in the Extremities, Chronic Abdominal Pain
Screening for Fabry Disease in a Pediatric Population at Risk
The purpose of this study is to assess the frequency of Fabry disease in children with chronic abdominal pain or chronic pain in the extremities
- Conditions
- Chronic Pain in the Extremities, Chronic Abdominal Pain, Fabry Disease
- Trial name
- NCT02152189
- Testing
- Screening for Fabry disease
- Where
- Germany
- Volunteers
- 1,422 people
- Sponsor
- University Hospital Heidelberg
Alteration of Mitochondrial Membrane, Type2 Diabetes
Mitochondrial Effects of C18:0 Supplementation in Humans
The purpose of this crossover study is to determine whether nutritional supplementation of C18:0 in humans has mitochondrial effects as shown in Drosophila and human cell culture.
- Conditions
- Alteration of Mitochondrial Membrane, Type2 Diabetes, Fatty Acid Deficiency
- Trial name
- NCT02957838
- Testing
- C18:0, mock
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Cardiomyopathy, Dilated, Sudden Cardiac Death
Prediction of Sudden Cardiac Death in Dilated Cardiomyopathy
PREDICT-DCM Trial is a multi-centre, prospective observational trial including patients with DCM undergoing cardiac magnetic resonance imaging (CMR) prior to ICD or event recorder implantation.
- Trial name
- PREDICT-DCM (NCT03224156)
- Testing
- Cardiac Magnetic Resonance Imaging
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Heidelberg
Chronic Obstructive Pulmonary Disease (COPD)
Image-Based Structural and Functional Phenotyping of the COSYCONET Cohort Using MRI and CT
The main objective of this trial is to prove that MRI - as the imaging modality without the use of ionizing radiation - can replace CT for structural and functional regional phenotyping of COPD.
- Trial name
- MR-COPD (NCT02629432)
- Where
- 15 sites in Germany
- Volunteers
- 602 people
- Sponsor
- University Hospital Heidelberg
Rheumatoid Arthritis, Periodontitis
Dental Prophylaxis and Rheumatoid Arthritis
This study evaluates the influence of dental prophylaxis on disease activity of Rheumatoid Arthritis. In addition to standard antirheumatic therapy, recently the question has been raised whether or not there is a supplementary…
- Conditions
- Rheumatoid Arthritis, Periodontitis, Gingivitis, Dental Prophylaxis
- Trial name
- PREPARA II (NCT03087240)
- Testing
- Dental Prophylaxis
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- University Hospital Heidelberg
Elective Non-cardiac Surgery
Leukocytes and Perioperative Cardio Vascular Events
To analyze whether non-cardiac surgery in high-risk cardio-vascular patients induces a quantitative change in one or several leukocyte subpopulations and whether such changes are associated with perioperative cardio-vascular…
- Trial name
- LeukoCAPE (NCT02874508)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Heidelberg
Coronary Artery Disease
Procedural Advantages of a Novel Drug-Eluting Coronary Stent
This study sought to compare procedural performance of a new coronary stent generation, that is already available in Germany, with hitherto established current drug-eluting stents.
- Trial name
- NCT02881216
- Testing
- Synergy Stent, Currently common drug-eluting stent (DES)
- Volunteers
- 814 people
- Sponsor
- University Hospital Heidelberg
Acute Ischemic Stroke
Sedation vs. Intubation for Endovascular Stroke TreAtment
Sedation vs Intubation for Endovascular Stroke TreAtment Trial (SIESTA) is a prospective, randomised controlled, monocentric, two-armed, comparative trial.
- Trial name
- SIESTA (NCT02126085)
- Testing
- Endovascular recanalisation
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Heidelberg
Non-specific Chronic Back Pain
Eye Movement Desensitization and Reprocessing (EMDR) in Non-specific Chronic Back Pain
The study explores the feasibility of Eye-Movement-Desensitization and Reprocessing (EMDR) in non-specific chronic back pain.
- Trial name
- LOGIN - EMDR (NCT01850875)
- Testing
- Eye-Movement-Desensitization-Reprocessing
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Heidelberg
CD20+ Aggressive Lymphoma, Mantle Cell Lymphoma
Rituximab Maintenance Therapy in Aggressive CD20 (Cluster of Differentiation Antigen 20) Positive Lymphoma and Mantle Cell Lymphoma
Clinical and pharmacokinetic data suggest that the effect of rituximab could be improved by prolonged exposure to the drug. To test for this hypothesis we performed a prospective randomized trial of rituximab maintenance therapy…
- Trial name
- NCT01933711
- Testing
- rituximab
- Where
- 3 sites in Germany
- Volunteers
- 328 people
- Sponsor
- University Hospital Heidelberg
Healthy
Oxytocin and Resting State fMRI
The goal of the study is to investigate the effects of intranasal oxytocin (OT) or placebo to resting state brain activity in healthy males.
- Trial name
- NCT02689596
- Testing
- Oxytocin
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Unsatisfactory or Defective Restoration of Tooth
Minimal Invasive Rehabilitation of Tooth Loss in the Anterior Segment
Tooth loss can be addressed by different rehabilitative strategies. Implant-supported crowns and conventional bridges (fixed dental prostheses [FDPs]) are well established treatment alternatives.
- Trial name
- MIZE-F (NCT01997827)
- Testing
- metal-ceramic RBFDP, all-ceramic RBFDP
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Atrial Fibrillation
High Sensitivity Cardiac Troponin T in Patients With Atrial Fibrillation Admitted to an Emergency Department (ED)
The purpose of this study was to collect data on the prevalence and clinical significance of elevated cardiac troponin in a large registry of unselected patients with atrial fibrillation presenting to an emergency department.
- Trial name
- NCT02542189
- Volunteers
- 3,037 people
- Sponsor
- University Hospital Heidelberg
Ischemic Stroke, Intracranial Hemorrhage
Registry of Acute Stroke Under New Oral Anticoagulants -Pilot (RASUNOA-Pilot)
The registry of acute stroke under new oral anticoagulants (RASUNOA) is a German multicenter, prospective, observational registry performed at about 50 study centers covering about 50.000 acute ischemic strokes and 6000 acute…
- Trial name
- RASUNOA (NCT01850797)
- Where
- Germany
- Volunteers
- 353 people
- Sponsor
- University Hospital Heidelberg
Coronary Artery Disease
HsTnT in Stable Coronary Artery Disease
Coronary artery disease (CAD) is one of the leading causes of morbidity and mortality worldwide. Life threatening manifestations such as acute myocardial infarction (AMI) and sudden cardiac death are the most important causes of…
- Trial name
- NCT01954303
- Testing
- Progress of CHD
- Volunteers
- 965 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Major Adverse Cardiovascular Events, Troponin T
Pre-discharge vs. Early Post-discharge Stress Testing and GRACE Score for Safe Discharge of ACS-patients With a Negative Hs-troponin T Result
New high-sensitivity cardiac troponin (hs-cTn) assays allow earlier detection of acute myocardial infarction (AMI). Furthermore, elevated values were associated with an increased risk of recurrent AMI or death.
- Conditions
- Major Adverse Cardiovascular Events, Troponin T, GRACE Score
- Trial name
- NCT02072538
- Where
- Germany
- Sponsor
- University Hospital Heidelberg
Ischemic Stroke, Thrombolysis
Hypothermia in Acute Ischemic Stroke - Surface Versus Endovascular Cooling (HAIS-SE)
HAIS-SE is evaluating for the first time ever in a randomized controlled trial efficacy, tolerability, practicability and safety of endovascular versus surface cooling in awake stroke patients.
- Conditions
- Ischemic Stroke, Thrombolysis, Hypothermia
- Trial name
- HAIS-SE (NCT01665885)
- Testing
- ZOLL Thermogard XP, BARD/Medivance Arctic Sun 5000
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Heidelberg