Clinical trials: sponsored by University of Aarhus
Liver Metastasis Colon Cancer
Improving Survival of COlorectal LIver Metastases by RFA-mediated Immunostimulation
To examine radio frequency ablation as a treatment supplement to stimulate immunogenicity and improve survival for patients undergoing curative-intent surgery for colorectal liver metastases.
- Trial name
- ISCOLIM (NCT04798898)
- Testing
- RFA (radiofrequency ablation)
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- University of Aarhus
Genitourinary Syndrome of Menopause
Vaginal CO2 Laser Therapy for Genitourinary Syndrome in Breast Cancer Survivors
This project will be based on three studies over a period on three years. The first study is a dose response study that includes 30 breast cancer survivors.
- Trial name
- NCT06007027
- Testing
- SmartXIDE2V2LR, Monalisa Touch, DEKA, Florence, Italy
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Pleural Effusion, Pleural Diseases
Strategy for Prompt and Effective Thoracentesis in the Emergency Department
The SPEEDTAP-trial is a prospective, randomised, investigator-initiated, multicenter, clinical superior trial investigating two thoracentesis methods in four emergency departments (ED) in Central Denmark Region.
- Conditions
- Pleural Effusion, Pleural Diseases, Heart Failure
- Trial name
- SPEEDTAP (NCT06180603)
- Testing
- Gravity fluid drainage in the radiology department, Manual drainage in the emergency department
- Where
- 6 sites in Denmark
- Volunteers
- 188 people
- Sponsor
- University of Aarhus
Stroke Not Otherwise Specified
More Steps Towards an Active Life After Stroke - ActForStroke
The main goal of this quasi-experimental study is to prevent the negative consequences of mobility impairments after stroke. These include recurrent strokes, general deconditioning, and overweight on the physical side, and…
- Trial name
- ActForStroke (NCT06715566)
- Testing
- ActForStroke, Standard care
- Where
- 10 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Pediatric Obesity, Psychosocial Well-being
Childhood Obesity, Decided Not to Participate, Lifestyle Intervention and Psychosocial Well-being.
Childhood obesity has been associated with an increased risk of impaired psychosocial well-being and the development of depression and anxiety.
- Trial name
- NCT06705231
- Testing
- The Aarhus-intervention
- Where
- Denmark
- Volunteers
- 403 people
- Sponsor
- University of Aarhus
Pain, Postoperative, Back Pain
Methadone for Spinal Fusion Surgery.
A prospective double-blind, randomized controlled trial investigating the effect of a single-dose of intraoperative methadone in patients undergoing spinal fusion.
- Conditions
- Pain, Postoperative, Back Pain, Opioid Use, Methadone
- Trial name
- METASPINE (NCT04764825)
- Testing
- Methadone, Morphine
- Where
- Denmark
- Volunteers
- 114 people
- Sponsor
- University of Aarhus
Functional Constipation, Fecal Incontinence in Children
Effect of MiniGo As Add-on to Oral Laxatives for Children with Constipation and Fecal Incontinence
The goal of this clinical trial is to compare combination therapy with low volume trans anal irrigation (TAI) and oral laxatives to monotherapy with oral laxatives in children with functional constipation and fecal incontinence.
- Trial name
- NCT05570318
- Testing
- Polyethylene Glycols, Low volume trans anal irrigation
- Where
- 3 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Endometriosis; Peritoneum
Is Laparoscopic Excision for Peritoneal Endometriosis Helpful or Harmful?
The trial seeks to test effect of laparoscopic excision of peritoneal endometriosis on pelvic pain. Data will also be gathered on quality of life and neuropathic pain.
- Trial name
- NCT05162794
- Testing
- Laparoscopy with excision, Laparoscopy without excision, Medical treatment-as-usual
- Where
- 5 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Type 2 Diabetes
High-amylose Barley (HIAMBA) in the Regulation and Prevention of Type 2 Diabetes
In a series of double-blinded randomized cross-over acute studies, the investigators want to study the effects of naturally produced high-amylose barley (Lean-baking barley®) on the postprandial glucose-metabolism in subjects…
- Trial name
- NCT04702672
- Testing
- 100% wheat (control), 100% Lean-baking barley®, 100% regular barley
- Where
- Denmark
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy Infants
HMOs on Infant Gut Microbiota Modulation and Development of the Immune System in Healthy Infants
The goal of this clinical trial is to learn how a mixture of human milk oligosaccharides impacts the development of the infant microbiota, the immune maturation and how the interaction between the microbiota and immune maturation…
- Trial name
- BELIEF (NCT06631937)
- Testing
- Human Milk Oligosaccharides
- Where
- 2 sites in Denmark
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
PCOS
Exogenous Ketone Ester in Women with Polycystic Ovary Syndrome.
Polycystic ovarian syndrome (PCOS) is characterized by elevated androgens such as testosterone. Clinical studies suggest that ketogenic diets lower the levels of androgens.
- Trial name
- NCT05762822
- Testing
- 3-OHB (KE4), water
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Healthy, Lactate Blood Increase
The Lactate Project: Investigating the Impact of Lactate to Preserve Vital Organ Blood Supply and Function in Heart and Brain
The aim of the proposed study is to investigate the effect of increased plasma lactate concentrations on the heart and brain's metabolism of other energy sources, primarily glucose in the brain and glucose and FFA in the heart.
- Trial name
- NCT06665763
- Testing
- Sodium Lactate Solution
- Where
- 2 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Surgical Procedure, Unspecified
Examination of the Blood Supply of the Intestine Before Suturing the Ends of the Intestine.
In this non-interventional, multicenter study in the Central Denmark Region, the potential of assessing blood supply during colorectal surgery will be explored using a recognized and reliable laser technique called Laser Speckle…
- Trial name
- NCT06637176
- Testing
- Laser speckle contrast imaging
- Where
- 3 sites in Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Multiple Sclerosis (MS) - Relapsing-remitting
Deuterium Metabolic Imaging in People with Multiple Sclerosis
The goal of this case-control study is to investigate glucose brain metabolism in people with multiple sclerosis and age- and sex-matched healthy controls.
- Trial name
- NCT06611280
- Testing
- No Interventions
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy, Healthy Nutrition
The BEGIN Study Bifidobacterium Infantis to Newborns: Effects of Modulating the Gut Microbial Composition on Growth, Immune Function and Inflammatory Conditions - a Randomized Placebo-controlled Double-blinded Intervention Trial
The goal of The BEGIN Study, a randomized controlled double-blinded intervention trial, is to learn if probiotics, with Bifidobacterium longum subspecies infantis Bifin02 (B.
- Trial name
- BEGIN (NCT06452199)
- Testing
- B. infantis
- Where
- 2 sites in Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
PreDiabetes, Metabolic Syndrome
Does Co-administration of Lactate to an Oral Glucose Tolerance Test Lower the Glucose Response?
To investigate whether co-administration of lactate with a glucose load affects postprandial glucose levels/handling, gastrointestinal hormones, gastric emptying, and appetite sensations in individuals with pre-diabetes when…
- Conditions
- PreDiabetes, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT06265337
- Testing
- Lactate
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cholestasis, Genetic Liver Disorder
PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Cholestatic Disorders in Patients with Genetic Liver Disorders and Healthy Individuals
Purpose The primary goal is to study liver diseases with defects in bile excretion. Investigators aim to do this using a radioactive tracer that mimics human bile and can be visualized with a PET/CT scanner.
- Trial name
- NCT06610695
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Osteoarthritis, Knee, Arthropathy of Knee
Late-initiated Blood Flow Restricted Rehabilitation Exercises After Total Knee Replacement
This trial will investigate the effectiveness of applying low-load blood flow restricted exercise 12 months after receiving a total knee replacement to achieve a functional capacity-level similar to healthy peers.
- Trial name
- EXKnee2 (NCT05770934)
- Testing
- Blood flow restricted low-load resistance exercise
- Where
- Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Primary Biliary Cholangitis (PBC), Cirrhosis
PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Changes in the Hepatobiliary System in Patients With Primary Biliary Cholangitis Before and After Treatment.
Purpose The primary purpose is to use an imaging diagnostic method to examine how the medication for primary biliary cholangitis (PBC) works.
- Conditions
- Primary Biliary Cholangitis (PBC), Cirrhosis, Cholestasis, Ursodeoxycholic Acid
- Trial name
- NCT06604923
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
Gastroparesis, Vomiting
Mechanisms of Action for the Enterra Medical Gastric Electrical Stimulator
Background: Gastric electrical stimulation applied by a surgically implanted device effectively alleviates upper gastrointestinal symptoms in the majority of individuals with medically refractory gastroparesis.
- Conditions
- Gastroparesis, Vomiting, Nausea
- Trial name
- NCT06582576
- Testing
- Effect of different gastric electrical stimulator stimulation paragdimes on brain, heart, and stomach.
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
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