Clinical trials: sponsored by University of Aarhus
Childhood Obesity, Overweight and Obesity
Childhood Obesity - Prevention of Diabetes Through Changed Eating Patterns
The main purpose of the present study is to perform a 10 weeks dietary intervention study with a follow-up for 52 weeks in children from 7-14 years of age with overweight or obesity.
- Conditions
- Childhood Obesity, Overweight and Obesity, Adolescent Obesity, Adolescent Overweight
- Trial name
- COPE (NCT04522921)
- Testing
- Diet with a higher amount of protein (25E% per day), Increased follow-up contact after the 10-week intervention, Diet with a lower amount of protein (15E% per day)
- Where
- 2 sites in Denmark
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Colorectal Cancer, Colorectal Polyp
IMPROVE-pT1: Accurate Allocation of Completion Resection in Early Colorectal Cancer
After introducing a nationwide screening program for colorectal cancer (CRC) in Denmark, more cases of early-stage CRC are being detected.
- Conditions
- Colorectal Cancer, Colorectal Polyp, Colorectal Cancer Stage I
- Trial name
- NCT06040632
- Where
- 9 sites in Denmark
- Volunteers
- 67 people
- Sponsor
- University of Aarhus
Breast Milk Collection, Human Milk/Breastfeeding
Human Milk and Its Effect on Infant's Metabolism and Infant Gut Microbiome
This protocol explains the MAINHEALTH cohort. The study examine the influence of maternal health parameters on human breast milk composition and integrates milk phenotype with infant metabolism and infant gut microbial content…
- Conditions
- Breast Milk Collection, Human Milk/Breastfeeding, Human Milk Microbiome, Infant Gut Microbiome
- Trial name
- MAINHEALTH (NCT05111990)
- Where
- Denmark
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Fuchs' Endothelial Dystrophy
A Comparison of Visual Functions and Side-effects After DSAEK or DMEK for Fuchs' Endothelial Dystrophy
Descemet's stripping automated endothelial keratoplasty (DSAEK) and Descemet's membrane endothelial keratoplasty (DMEK) are becoming increasingly popular as treatments for Fuchs' endothelial dystrophy.
- Trial name
- NCT04417959
- Testing
- Phaco-DSAEK, Phaco-DMEK
- Where
- Denmark
- Volunteers
- 112 people
- Sponsor
- University of Aarhus
Pancreatic Cancer, Pancreatic Neoplasm
Incremental Value of Magnetic Resonance Imaging in Selection of Pancreatic Cancer Patients for Surgery
The aim of the study is to examine the incremental value of using magnetic resonance imaging (MRI) in addition to computed tomography (CT) in the diagnostic workup of pancreatic cancer patients.
- Conditions
- Pancreatic Cancer, Pancreatic Neoplasm, Liver Metastases
- Trial name
- MAGIPAC (NCT05428358)
- Testing
- Preoperative MRI
- Where
- 3 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- University of Aarhus
Vulva Cancer, Vulva Neoplasm
Danish Vulva Cancer Recurrence Study
The overall aim is to investigate different aspects of recurrence detection in women with vulva cancer (VC) to identify optimal treatment- and surveillance programs.
- Conditions
- Vulva Cancer, Vulva Neoplasm, Vulvar Cancer, Vulva Disease
- Trial name
- DaVulvaRec (NCT06495554)
- Testing
- Measurement of circulating tumor-DNA, Collection of patient-reported outcomes, Algorithmically determined telephone interview with a nurse
- Where
- 2 sites in Denmark
- Volunteers
- 1,295 people
- Sponsor
- University of Aarhus
Renovascular Hypertension, Renovascular Hypertension With Renal Failure
Effects of Percutaneous Transluminal Renal Angioplasty of Atherosclerotic Renal Artery Stenosis in High-Risk Patients.
The goal of this clinical trial is to document a beneficial effect of percutaneous transluminal renal angioplasty (PTRA) of atherosclerotic renal artery stenosis in high-risk patients selected according to the criteria used in…
- Conditions
- Renovascular Hypertension, Renovascular Hypertension With Renal Failure, Heart Failure, Renal Artery Stenosis Atherosclerotic
- Trial name
- DAN-PTRAII (NCT05834803)
- Testing
- Optimal medical therapy (OMT), Catheter-based angiography, Measurement of translesional pressure gradients
- Where
- 3 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
Radiotherapy Side Effect
Prospective RegIstry for Oncologic Reirradiation (PRIOR-DK)
The study aims to provide a setup for collecting radiotherapy-related toxicity data, loco-regional control, and overall survival data for all Danish cancer patients undergoing reirradiation with high dose intention or with the…
- Trial name
- PRIOR (NCT07528339)
- Testing
- Reirradiation
- Volunteers
- 500 people
- Sponsor
- University of Aarhus
Migraine With Aura, Migraine Without Aura
Trial Designs for Evaluating Migraine Treatment
The study aims to test interactions between drug and placebo-responses in acute migraine treatment and to assess variation in adverse events according to treatment information provided.
- Conditions
- Migraine With Aura, Migraine Without Aura, Headache, Migraine
- Trial name
- NCT06617832
- Testing
- Active drug for acute migraine treatment
- Where
- 2 sites in Denmark
- Volunteers
- 128 people
- Sponsor
- University of Aarhus
Chronic Pain
Effects of Spinal Cord Stimulation
The goal of this interventional study is to test effects of spinal cord stimulation in patients receiving treatment for their chronic pain.
- Trial name
- NCT05885061
- Testing
- Stimulation OFF, Stimulation ON, Told ON
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- University of Aarhus
Cardiac Arrest (CA), In-Hospital Cardiac Arrest
The Ventilation During In-hospital Cardiac Arrest Study
The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult…
- Conditions
- Cardiac Arrest (CA), In-Hospital Cardiac Arrest, Heart Arrest
- Trial name
- VENT-IHCA (NCT06809309)
- Testing
- Positive pressure ventilation during cardiopulmonary resuscitation
- Where
- 11 sites in Denmark, Norway
- Volunteers
- 900 people
- Sponsor
- University of Aarhus
Healthy Overweight/Obese
Metabolic Effects of the Exercise-metabolite Lac-Phe
The goal of this double-blinded, randomized cross-over clinical trial is to assess the isolated (i.e. outside the context of exercise) effects of Lac-Phe on appetite and glucose concentrations in healthy volunteers with obesity…
- Trial name
- NCT06743009
- Testing
- N-lactoyl-phenylalanine, NaCl
- Where
- Denmark
- Volunteers
- 23 people
- Sponsor
- University of Aarhus
Hypotension
Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia
The optimal vasopressor for ensuring organ blood flow and tissue oxygen delivery during surgery remains undetermined. This study aim to compare the effects of noradrenaline vs.
- Trial name
- IMPACT (NCT06083948)
- Testing
- Noradrenalin, Phenylephrine
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- University of Aarhus
Healthy Overweight/Obese
The Metabolic Effects of Oral Tributyrin Administration
The goal of this double-blinded randomized clinical cross-over trial is to investigate the metabolic and appetite regulating effects of oral tributyrin (a butyrate pro-drug) administration vs placebo.
- Trial name
- TRIMET (NCT07463495)
- Testing
- tributyrin, Control
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Hepatocellular Carcinoma (HCC), Cirrhosis
Biannual Screening for HCC Offered to Patients With Cirrhosis. Introducing Surveillance for Hepatocellular Carcinoma (HCC) in the Central Denmark Region Using Ultrasound and Alpha-Fetoprotein to Reduce HCC-Related Mortality in Patients With Compensated Non-Viral Cirrhosis
This study aims to investigate whether repeated 6-monthly screening for hepatocellular carcinoma (HCC) - called "HCC surveillance" - offered to selected patients with chronic liver disease can reduce HCC-related mortality by…
- Trial name
- BISHOP (NCT07469319)
- Testing
- Ultrasound of the liver and blood sample for alpha-fetoprotein
- Where
- 6 sites in Denmark
- Volunteers
- 617 people
- Sponsor
- University of Aarhus
Facial Palsy, Stroke
Effect of Neuromuscular Electrical Stimulation on Unilateral Central Facial Palsy
Background Central facial palsy (CFP) is a common condition in stroke, with an estimated prevalence of 45%. CFP can lead to facial asymmetry, problems with mouth closure and food processing, bite marks on the cheek, social…
- Trial name
- NCT07325604
- Testing
- Neuromuscular electrical stimulation (NMES), Usual Care
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- University of Aarhus
Aging, Metabolism Disorder
The Metabolic Effects of β-hydroxybutyrate on Working Skeletal Muscle
The goal of this clinical trial is to test ketone bodies in healthy elderly and young individuals. The main question it aims to answer are: Do ketone bodies improve skeletal muscle function? Participants will ingest a ketone…
- Conditions
- Aging, Metabolism Disorder, Ketonemia, Muscle Disorder
- Trial name
- NCT05732909
- Testing
- D-β-hydroxybutyrate/D 1,3 butanediol monoester
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Radiotherapy Side Effect, Radiation Toxicity
Curatively Intended Thoracic Reirradiation
The number of long-term lung cancer (LC) survivors increases, however many patients are diagnosed with recurrent or new thoracic cancers. High-dose reirradiation (reRT) is promising but associated with high severe toxicity rates.
- Conditions
- Radiotherapy Side Effect, Radiation Toxicity, Oncology, Lung Cancer
- Trial name
- CureLung (NCT06950073)
- Testing
- Radiotherapy
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- University of Aarhus
Diarrhea, Systemic Sclerosis
Faecal Microbiota Transplantation Against Chronic Diarrhea in Patients With Systemic Sclerosis
This clinical trial aims to assess the safety and effectiveness of faecal Microbiota Transplantation (FMT) in improving chronic diarrhea symptoms among patients with systemic sclerosis.
- Trial name
- FaeMiCue (NCT06333795)
- Testing
- Faecal Microbiota Transplantation (FMT)
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Eumenorrhea, Intrauterine Devices, Medicated
Effect of Different Sex Hormone Profiles for the Response to Physical Training
The aim of the project is to elucidate the impact of diverse sex hormone profiles on the adaptability of muscle mass to physical training.
- Conditions
- Eumenorrhea, Intrauterine Devices, Medicated, Hormonal Contraception
- Trial name
- NCT07115849
- Testing
- Physical training
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
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