Clinical trials: open to volunteers, sponsored by University of Alabama at Birmingham
Myeloid Malignancy, Hematologic Malignancy
Trial of Novel Anti-leukemia Agents in Flu/Mel RIC Transplant for Myeloid Malignancies
The purpose of this study is to determine the safety of adding Decitabine and Venetoclax to patients undergoing reduced intensity allogenic transplantation for treatment of hematologic malignances with Fludarabine and Melphalan.
- Conditions
- Myeloid Malignancy, Hematologic Malignancy, Acute Myeloid Leukemia, Myelodysplastic Syndromes
- Trial name
- NCT07044544
- Testing
- G-CSF, Decitabine, Venetoclax
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Sickle Cell Disease, Cognitive Impairment
Cognitive Remediation Intervention to Prepare for Transition of Care
Randomized Controlled Trial (RTC) testing the efficacy of a telehealth adaptation of the Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) intervention to prepare adolescents with sickle cell disease for…
- Conditions
- Sickle Cell Disease, Cognitive Impairment, Adolescent Behavior, Self Efficacy
- Trial name
- NCT05336201
- Testing
- CREADY (Cognitive-Remediation of Executive and Adaptive Deficits in Youth)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Alabama at Birmingham
Oncology, Financial Toxicity
Evaluating the Implementation and Impact of Standard-of-care Delivered Oncology Financial Navigation
The purpose of this study is to understand the implementation and impact of a pragmatically-delivered oncology financial navigation program. The main questions it aims to answer are: 1.
- Conditions
- Oncology, Financial Toxicity, Counseling
- Trial name
- NCT07281287
- Testing
- Financial navigation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Opioid Use Disorder, Opioid Overdose
A Bundled Intervention
Opioid overdose deaths have reached historically high records in the United States and are particularly concentrated among patients after emergency department (ED) discharge.
- Trial name
- B-CARE (NCT06593093)
- Testing
- a bundled intervention, control group
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- University of Alabama at Birmingham
CVA (Cerebrovascular Accident), Stroke
Constraint-Induced Movement Therapy for Adults Post-Stroke With Mild Upper Extremity Impairment
Constraint-Induced Therapy (CI Therapy) is a behavioral approach to neurorehabilitation and consists of multi-components that have been applied in a systematic method to improve the use of the limb or function addressed in the…
- Conditions
- CVA (Cerebrovascular Accident), Stroke, Upper Extremity Paresis
- Trial name
- NCT05492513
- Testing
- Grade 1 CI Therapy +Sensory Components
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Alabama at Birmingham
HIV, PrEP
PrOTECT AL: PrEP Optimization Through Enhanced Continuum Tracking
The purpose of this study is to enhance and evaluate the implementation of a PrEP Care Continuum data dashboard across seven distinct clinical sites in Alabama.
- Conditions
- HIV, PrEP, PrEP Uptake, HIV Prevention
- Trial name
- PrOTECT AL (NCT07231640)
- Testing
- PrOTECT AL Implementation Strategy
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Alabama at Birmingham
Sepsis
Predicton of Sepsis Recovery Performance Subtypes Pilot Study
This study addresses critically ill sepsis patients' current literature reports of ongoing post-hospital discharge weakness and hospital readmissions.
- Trial name
- NCT05912413
- Testing
- there is no intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Substance Use Disorders, Hiv
HIV, Equity, and Addiction Training (HEAT) Program
This project is a pilot study to determine the feasibility and acceptability of a telemedicine intervention for substance use disorder service delivery in diverse people living with HIV in Alabama.
- Conditions
- Substance Use Disorders, Hiv, Opioid Use Disorder, Stimulant Use (Diagnosis)
- Trial name
- HEAT (NCT06370481)
- Testing
- Telemedicine, Standard of care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Biliary Atresia, Kasai
The Use of Near-Infrared Fluorescence Cholangiography With Indocyanine Green (ICG) in the Work Up of Neonatal Cholestasis
In infants that present with findings concerning for biliary atresia, along with other cholestatic work up which is standard, they will receive a one-time intravenous (IV) dose of Indocyanine Green (ICG).
- Conditions
- Biliary Atresia, Kasai, Cholestasis in Newborn, Cholestasis in Newborn Infant
- Trial name
- NCT07250854
- Testing
- Indocyanine Green
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Irreversible Pulpitis
Comparative Effectiveness in the Management of Irreversible Pulpitis
This project addresses a central question within the practice of dentistry: Is a pulpotomy procedure effective in the treatment of a tooth with symptomatic irreversible pulpitis and normal periapex? In addition, the project seeks…
- Trial name
- NCT04922229
- Testing
- RCT, Pulpotomy
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Stress Incontinence Female, Pelvic Organ Prolapse
Sequence of Midurethral Sling Placement During Robotic Sacrocolpopexy
This study looks at the best time to place a midurethral sling (MUS), which is a small piece of mesh used to treat stress urinary incontinence (SUI) (leaking urine when you cough, laugh, or exercise).
- Trial name
- NCT07008898
- Testing
- Midurethral sling placed before robotic sacrocolpopexy, Midurethral sling placed after robotic sacrocolpopexy
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Alabama at Birmingham
Natriuretic Peptides, Cardiovascular Diseases
CARBON: UAB Cardiovascular Research Biobank
The UAB Cardiovascular Research Biobank (CARBON) will be a resource that contains biological materials, such as DNA samples, in addition to health and personal information on a large number of people over time.
- Conditions
- Natriuretic Peptides, Cardiovascular Diseases, Hypertension, Diabetes
- Trial name
- CARBON (NCT05067231)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Respiratory Syncytial Virus Infections
Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children
The overarching hypothesis of the ARRC trial is that administration of Azithromycin (AZM) during acute, Respiratory Syncytial Virus (RSV)-induced respiratory failure will be beneficial, mediated through the matrix…
- Trial name
- NCT05026749
- Testing
- AZM Group, Control Group
- Where
- 15 sites in United States
- Volunteers
- 370 people
- Sponsor
- University of Alabama at Birmingham
Central Visual Impairment, Macular Degeneration
Factors in Learning And Plasticity: Macular Degeneration
A greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has the potential to benefit millions of individuals suffering from low vision.
- Trial name
- FLAP (NCT05454124)
- Testing
- Training visual sensitivity, Combination training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Autism, Pervasive Developmental Disorder
The Impact of a Virtual Magic Trick Training Program
The proposed project will attempt to confirm the benefits of a structured magic trick training program (MTTP) experience in adolescents with autism.
- Trial name
- NCT05664841
- Testing
- magic trick training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Cancer
Legal Evaluation for Greater Access to Cancer Care (LEGAL-CARE)
This study aims to help patients with cancer facing legal issues. The investigators noticed that many patients struggle with laws and regulations related to disability benefits, employment rules, health insurance denials, and…
- Trial name
- LEGAL-CARE (NCT07197515)
- Testing
- Legal Navigation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Alabama at Birmingham
Sleep, Circadian Rhythm
Sleep and Circadian Contributions to Nighttime Blood Pressure
Broadly, this study (SCN-BP) seeks to examine sleep and circadian factors that contribute to blood pressure levels at night.
- Conditions
- Sleep, Circadian Rhythm, Blood Pressure, Hypertension
- Trial name
- SCN-BP (NCT05656768)
- Testing
- Constant Routine Protocol
- Where
- United States
- Volunteers
- 1,427 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Heart Failure
Feasibility and Acceptability of Three Component Intervention for the Heart Failure Care for Rural Dwelling Participants
The purpose of this research study is to determine if using remote blood pressure monitoring and video-based consultation is an effective way to help patients in rural communities better manage their heart failure.
- Trial name
- NCT07103239
- Testing
- Video Based Visits, Remote Self-Care Education, Remote Patient Monitoring
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Alabama at Birmingham
Breast Cancer
Positron Emission Tomography (PET) Imaging With Zirconium-89 (89Zr)-Trastuzumab for Prediction of HER2 Targeted Therapy Effectiveness
Our goal is to investigate the use of 89Zr-trastuzumab as a HER2 imaging agent to determine which patients are likely to respond to targeted HER2 agents as single agent therapy.
- Trial name
- NCT03321045
- Testing
- [89Zr]-Df-Trastuzumab, PET/MRI Imaging
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Alabama at Birmingham
Decision Making, Shared, Family Caregiving
A Stakeholder-enhanced Intervention to Improve the Decisional Partnership of Chronic Kidney Disease Dyads (IMPART)
Using a highly innovative methodology, the Multiphase Optimization Strategy (MOST), the purpose of this study is to pilot test, an optimization trial approach to develop and refine the decision partnering skills of persons with…
- Conditions
- Decision Making, Shared, Family Caregiving, Chronic Kidney Disease
- Trial name
- ImPart (NCT06173323)
- Testing
- ImPart - Improving Chronic Kidney Disease Decisional Partnerships
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Alabama at Birmingham