Clinical trials: sponsored by University of Chicago
COVID-19
Can Vitamin D Reduce the Burden of COVID-19?
The purpose of this study is to compare the risks of COVID-19 in individuals from the Chicagoland area and other communities in the United States randomized to low (400 IU/day) versus moderate (4,000 IU/day) dose vitamin D.
- Trial name
- NCT07128069
- Testing
- Vitamin D 400IU, Vitamin D 4000IU
- Where
- United States
- Volunteers
- 2,093 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Lennox Gastaut Syndrome (LGS)
EEG Dynamics in Lennox-Gastaut Syndrome Patients Undergoing Fenfluramine Treatment
This study plans to learn if certain markers found during electroencephalogram (EEG) analysis could predict fenfluramine responsiveness to give clinicians greater insight into the effectiveness of fenfluramine in people with…
- Trial name
- NCT07555171
- Testing
- fenfluramine HCl
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
HIV, Financial Stress
BIG Chicago: A Trial of Basic Income Guarantee for Young People Living With HIV
The goal of this clinical trial is to compare two interventions - Basic Income Guarantee (BIG) + Treatment as Usual and Treatment as Usual among individuals living with HIV who have experienced financial hardships.
- Trial name
- NCT07502365
- Testing
- Treatment As Usual, BIG + Treatment As Usual
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- University of Chicago
Heart Failure, Cardiogenic Shock
Cardiac Power Output in Cardiogenic Shock Patients
The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.
- Trial name
- NCT05700617
- Testing
- 1:1 Randomization to receive milrinone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Chicago
HIV, Tobacco Use
Optimizing Treatment of Co-occurring Smoking and Unhealthy Alcohol Use Among PWH in Nairobi, Kenya
People with HIV (PWH) smoke tobacco cigarettes and drink alcohol at higher rates than the general population, both in the US and internationally, including low- and middle-income countries.
- Conditions
- HIV, Tobacco Use, Alcohol Use Disorder
- Trial name
- NCT06790342
- Testing
- Cystine, Positively Smoke Free, Standard of Care
- Where
- 2 sites in Kenya
- Volunteers
- 300 people
- Sponsor
- University of Chicago
Obsessive-Compulsive Disorder, Trichotillomania (Hair-Pulling Disorder)
Epidiolex in Obsessive Compulsive Disorder and Related Disorders
The primary objective of the proposed study is to evaluate the safety and efficacy of Epidiolex (cannabidiol) in adults with obsessive compulsive and related disorders (OCRDs).
- Conditions
- Obsessive-Compulsive Disorder, Trichotillomania (Hair-Pulling Disorder), Tourette Syndrome, Hoarding Disorder
- Trial name
- NCT04978428
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Chicago
Borderline Personality Disorder
Caplyta in Borderline Personality Disorder
The primary objective of the proposed study is to evaluate the safety and efficacy of Caplyta (lumateperone) in adults with borderline personality disorder (BPD).
- Trial name
- NCT05356013
- Testing
- Caplyta
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Chicago
Celiac Disease
Tissue Destruction and Healing in Celiac Disease
The purpose of this clinical study is to learn more about celiac disease pathogenesis and clinical symptoms. In particular, this study will examine the interactions between biological factors such as, intestinal epithelial cells…
- Trial name
- NCT05680012
- Testing
- Gluten containing snack bar
- Where
- 3 sites in United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Food Insecurity
CommunityRx-Hunger
CommunityRx-Hunger (CRx-H) is a hospital-based intervention that addresses food insecurity and other health-related social needs such as transportation, housing, utilities, and safety.
- Trial name
- CRx-H (NCT04171999)
- Testing
- Community Rx-Hunger (CRx-H)
- Where
- United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Dementia, Hip Pain
Pragmatic Use of PAIN-Advanced Dementia Scale in Emergency Departments
The purpose of this study is to learn if the Pain in Advanced Dementia (PAINAD) scale can improve emergency pain care in persons living with dementia (PLWD).
- Conditions
- Dementia, Hip Pain, Emergency Department Patient, Pain in Advanced Dementia Scale
- Trial name
- NCT06370572
- Testing
- PAINAD EHR Prompt
- Where
- 2 sites in United States
- Volunteers
- 2,421 people
- Sponsor
- University of Chicago
SARS-CoV-2 Infection
Low vs. Moderate to High Dose Vitamin D for Prevention of COVID-19
The purpose of this study is to compare the risks of COVID-19 in individuals from Chicagoland communities randomized to low (400 IU/day) vs. moderate (4,000 IU/day) or high (10,000 IU/day) dose vitamin D.
- Trial name
- NCT04868903
- Testing
- Vitamin D3
- Where
- 2 sites in United States
- Volunteers
- 1,475 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Invasive Mechanical Ventilation, Children With Medical Complexity
Parent-to-parent Coaching While Awaiting Hospital Discharge With a Child With a Ventilator
The objective of the study is to pilot a parent-to-parent coaching model with experienced family members of children with Invasive Mechanical Ventilation (IMV) as parent coaches.
- Conditions
- Invasive Mechanical Ventilation, Children With Medical Complexity, Home Nursing, Empowerment
- Trial name
- NCT05880953
- Testing
- Parent-to-parent coaching
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Schizoaffective Disorders, Bipolar Disorder With Psychotic Features
Transition Care for FEP
This study is testing a new approach to help people with first episode psychosis transition successfully from the hospital to outpatient mental health care.
- Conditions
- Schizoaffective Disorders, Bipolar Disorder With Psychotic Features, Schizophrenia Disorders, Major Depressive Disorder With Psychotic Features
- Trial name
- TCT FEP (NCT07713849)
- Testing
- Transition Care Team
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of Chicago
Pregnancy, Child Development
Improving Maternal and Child Health Through Prenatal Fatty Acid Supplementation
The purpose of the study is to test whether nutritional supplementation during pregnancy is associated with 1) improved maternal health during pregnancy; 2) improved infant birth and neurodevelopmental outcomes, and 3) whether…
- Trial name
- NAPS (NCT02647723)
- Testing
- DHA, Sugar pill
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Head and Neck Cancer
A Study Comparing Two Immunotherapy Options for Human Papillomavirus Positive HPV-Positive Head and Neck Cancer After Treatment
The goal of this clinical trial is to learn if the combination of cemiplimab and fianlimab can improve outcomes compared to cemiplimab alone in adults with Human Papillomavirus Positive HPV-positive head and neck cancer who have…
- Trial name
- NCT07179315
- Testing
- cemiplimab+fianlimab, Cemiplimab
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Chicago
Healthy Adult
Effect of Monosodium Glutamate on Microbiome-Derived Imidazole Propionate Production in Healthy Volunteers
The goal of this clinical trial is to learn whether dietary monosodium glutamate (MSG), a common food flavor enhancer, increases the blood level of a gut-microbiome-derived compound called imidazole propionate (ImP) in healthy…
- Trial name
- NCT07700368
- Testing
- L-histidine, Monosodium glutamate (MSG), Sodium chloride (NaCl)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Critical Illness, Microbiome
Alterations of the Microbiome During Critical Illness With Short and Long Term Clinical Outcomes
This study is designed to study the variations in the microbiome among critically ill patients and the effect of admission to the medical intensive care unit (MICU) at the University of Chicago.
- Trial name
- NCT04552834
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Chicago
Low Blood Pressure, Delirium
Vasopressor SAT Study
To assess the impact of daily awakening from sedation on the amount of vasoactive medication required in the ICU. The hypothesis of this proposal is that the amount of vasoactive drug required to maintain an adequate mean…
- Conditions
- Low Blood Pressure, Delirium, Critical Illness
- Trial name
- NCT03182335
- Testing
- sedation awakening trial
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Chicago
Critical Illness, Corona Virus Infection
Long Term Outcomes of Patients With COVID-19
The investigators hypothesize that those with respiratory failure due to COVID-19 will have different burdens of mental and physical disability than those with respiratory failure who do not have COVID-19.
- Conditions
- Critical Illness, Corona Virus Infection, Respiratory Failure, Covid-19
- Trial name
- COVID19 LTFU (NCT04360538)
- Testing
- Quality of Life, Impact Event Score, Hospital anxiety and depression scale
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Chicago
Immune Response To Sepsis, Staphylococcus Aureus Infection
Immune Resolution After Staphylococcus Aureus Bacteremia
The purpose of this study is to determine how monocyte HLA-DR and other markers of immune function change with time in patients with and without prior immune dysfunction who survive sepsis from Staphylococcus aureus bacteremia.
- Trial name
- NCT01879761
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Chicago