Clinical trials: sponsored by University of Colorado, Denver
Trauma, Critical Illness
Pilot Study of Targeted Normoxia in Critically Ill Trauma Patients
The objective of this study is to conduct an observational pre/post study to evaluate the clinical impact oxygen guideline implementation on oxygen utilization and oxygenation in critically ill trauma patients.
- Conditions
- Trauma, Critical Illness, Oxygen Toxicity
- Trial name
- NCT03789396
- Testing
- Targeted Normoxia (oxygen saturation 90-96%), Usual Care Oxygenation
- Where
- United States
- Volunteers
- 572 people
- Sponsor
- University of Colorado, Denver
Glaucoma, Open-Angle
Use of Methazolamide to Lower Intraocular Pressure
The purpose of this study is to evaluate the effect of methazolamide, 25 mg or 50 mg tablets once a day for a week than twice a day for a week, on lowering intraocular pressure and the safety of methazolamide.
- Trial name
- NCT05498103
- Testing
- Methazolamide 25 MG, Methazolamide 50 MG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Eosinophilic Esophagitis
Fibrostenotic Eosinophilic Esophagitis: Assessment Tools
This protocol addresses a central hypothesis that fibrostenotic Eosinophilic Esophagitis (EoE) is characterized by abnormal esophageal structure and compliance compared to non fibrostenotic EoE and that distinctive cellular and…
- Trial name
- NCT02453126
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Colorado, Denver
Surgical Patients
3D Printing for Pre-Surgical Planning
3D printing is emerging as a new diagnostic tool for pre-surgical planning. 3D printed models are extremely advantageous to surgeons in their preoperative planning.
- Trial name
- 3D (NCT05144620)
- Testing
- 3D Mapping
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- University of Colorado, Denver
Port-site Injury Caused by Stray Energy Transfer
Characterizing Stray Energy Injuries During Robotic Surgery
Stray energy transfer during laparoscopic surgery is recognized as a cause of potentially serious complications. This will be the first study to demonstrate clinical evidence of tissue injury due to stray energy transfer during…
- Trial name
- NCT03477201
- Testing
- Laparoscopic robotic DaVinci assisted inguinal hernia repair, Standard laparoscopic inguinal hernia repair
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Colorado, Denver
Dental Phobia, Dental Anxiety
The Impact of Medical Play in the Dental Clinic Setting on the Cooperation of Neurotypical Patients
The purpose of this pilot study is to investigate the efficacy of medical play in the dental setting to improve the behaviors and cooperation of neurotypical patients during dental visits.
- Conditions
- Dental Phobia, Dental Anxiety, Oral Aversion
- Trial name
- NCT05571423
- Testing
- Medical Play, Routine Play
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Ultrasound, Education
Tele-Ultrasound: VIrtual Hands-on Education for Novice Users
This study is intended to perform a comparative analysis of novice ultrasound users when taught in person versus virtually. This study aims to show that students will not demonstrate a statistical difference in scores learning in…
- Conditions
- Ultrasound, Education, Virtual
- Trial name
- NCT05013476
- Testing
- Butterfly handheld ultrasound machine
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetic Foot Ulcer
PHASE 1, OPEN-LABEL SAFETY STUDY OF UMBILICAL CORD LINING MESENCHYMAL STEM CELLS (CORLICYTE®) TO HEAL CHRONIC DIABETIC FOOT ULCERS
Study Objective: The objective of this Phase 1 open-label study is to establish the safety and tolerability of Corlicyte mesenchymal stem cells (MSCs) in the treatment of patients with chronic diabetic foot ulcers (DFUs).
- Trial name
- NCT04104451
- Testing
- Corlicyte
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Down Syndrome, Dysphagia, Oropharyngeal
Pulmonary Health in Children With Down Syndrome
The goal of the study is to learn more about tests that can assess lung health in children with Down syndrome.
- Trial name
- NCT04398862
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Colorado, Denver
Lymphedema of Leg
Establishing Guidelines for Manual Lymphatic Drainage
The purpose of this study is to establish optimal guidelines for Manual Lymphatic Drainage in participants with lower extremity lymphedema.
- Trial name
- MLD (NCT05509062)
- Testing
- Pressure
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Colorado, Denver
Parkinson Disease
NMT for Parkinson's Disease
Parkinson's Disease (PD) is defined by characteristic motor symptoms including slow movements, small movements, difficulty with movement initiation and disruptions in timing.
- Trial name
- NCT03049033
- Testing
- Neurologic Music Therapy, Occupational Therapy, Music Supported Therapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Substance Use, Substance Abuse
Evaluation of Thiwáhe Gluwáš'Akapi Substance Use Prevention Program
Researchers at the Centers for American Indian and Alaska Native Health in the Colorado School of Public Health at the University of Colorado completed an intensive community-engaged process to rigorously adapt the Strengthening…
- Conditions
- Substance Use, Substance Abuse, Suicide
- Trial name
- NCT04222556
- Testing
- Thiwáhe Gluwáš'akapi, Woyute Waśte
- Where
- United States
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic
Pulse Reduction On Beta-blocker and Ivabradine Therapy
Heart failure with reduced left ventricular ejection fraction (HFrEF) is the most common form of chronic heart failure in subjects ≤ 75 years of age.
- Conditions
- Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic, Ventricular Remodeling, Electrical Remodeling
- Trial name
- PROBE-IT (NCT02973594)
- Testing
- Ivabradine
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Colorado, Denver
Alcohol Use Disorder
Facilitating Alcohol Screening and Treatment (FAST)
Alcohol use is the third leading cause of death in the United States. Primary care practices need to implement new research findings that help identify and treat alcohol use disorder.
- Trial name
- FAST (NCT04303676)
- Testing
- Virtual Practice Facilitation with e-Learning, Virtual Practice Facilitation without e-Learning
- Where
- United States
- Volunteers
- 399 people
- Sponsor
- University of Colorado, Denver
Menopause, Obesity, Abdominal
Bioenergetic Effects of Aging and Menopause (BEAM)
The menopause transition is associated with increased risk for weight gain and a shift toward storing fat in the belly region, which may increase risk for cardiovascular disease and diabetes.
- Conditions
- Menopause, Obesity, Abdominal, Aging, Weight Gain
- Trial name
- BEAM (NCT04043520)
- Testing
- GnRH antagonist, Estrogen Product
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Aging
NanoSilk Cosmo: Evaluation of a Novel Silk Complex on Biophysical Parameters Related to Skin Aging
Silk is a naturally occurring protein polymer that is approved for medical use by the U.S Food and Drug Administration (FDA). Silk fibroin fiber biomaterial has shown promising results for tissue regeneration demonstrated through…
- Trial name
- NCT04630418
- Testing
- NanoSilk Cosmo
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Respiratory Failure
The Impact of Age-dependent Haptoglobin Deficiency on Plasma Free Hemoglobin Levels During Extracorporeal Membrane Oxygenation Support
Newborns and children with life-threatening heart and lung failure may require support with ECMO (extracorporeal membrane oxygenation).
- Trial name
- NCT03472768
- Testing
- Plasma Haptoglobin Concentration
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Colorado, Denver
Lung Cancer
Pilot Study of High Risk Lung Cancer Screening
This study is a prospective trial of 200 individuals at high risk for lung cancer who are not eligible for lung cancer screening under current screening guidelines.
- Trial name
- NCT03683940
- Testing
- Screening
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Colorado, Denver
Phantom Limb Pain
Electrical Stimulus Therapy for Chronic Phantom Limb Pain
The goal of this pilot study is to assess the effectiveness of an electrical stimulation therapy option for the treatment of chronic phantom limb pain in upper or lower limb amputees.
- Trial name
- NCT03030079
- Testing
- Experimental Electrical Stimulation Regimen
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
CDKL5, CDKL5 Deficiency Disorder
International CDKL5 Clinical Research Network
Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830), a severe developmental and epileptic encephalopathy associated with cognitive and motor impairments…
- Conditions
- CDKL5, CDKL5 Deficiency Disorder, CDD
- Trial name
- ICCRN (NCT05558371)
- Testing
- No intervention.
- Where
- 9 sites in United States, Australia
- Volunteers
- 1,000 people
- Sponsor
- University of Colorado, Denver
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