Clinical trials: sponsored by University of Colorado, Denver
Cerebral Blood Flow, Brain Function
Effects of Acetate and Alcohol on Brain Function
This study plans to learn more about how alcohol and its metabolite, acetate, affect the brain.
- Trial name
- NCT02542150
- Testing
- acetate, alcohol
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Suicide, Emergencies
Assisting in Decisions in Emergency Departments: (ED-AID) Study
This study will test a patient decision aid about safe firearm storage during suicidal crisis. The investigators hypothesize that participants with higher quality decisions after the decision aid will be more likely to change…
- Trial name
- ED-AID (NCT03478501)
- Testing
- Decision Aid
- Where
- 3 sites in United States
- Volunteers
- 49 people
- Sponsor
- University of Colorado, Denver
Obesity
Myeloid to Adipocyte Transdifferentiation in Human Cells
In order to design new programs to help prevent weight gain, promote successful and sustainable weight loss, and help treat diseases related to obesity, the investigators need a better understanding of why accumulating fat in…
- Trial name
- MYTH (NCT02654925)
- Testing
- Adipose Tissue Biopsy
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Sjogren's Syndrome, Neonatal Systemic Lupus Erythematosus
Prospective Maternal Surveillance of SSA (Sjögren Syndrome A) Positive Pregnancies Using a Hand-held Fetal Heart Rate Monitor
The purpose of the research study "Heart Sounds at Home" is for pregnant SSA or SSA/SSB (Sjögren syndrome B) antibody positive mothers to use a Doppler fetal heart rate monitor to detect abnormal heart rates and rhythms in their…
- Conditions
- Sjogren's Syndrome, Neonatal Systemic Lupus Erythematosus, Fetal Heart Block Complete
- Trial name
- NCT02920346
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- University of Colorado, Denver
Obesity
Motivation for Exercise and Physical Activity Adherence
The limited success of our current approaches to increase adoption and maintenance of physical activity in adults with overweight and obesity is a substantial barrier to effectively address the current obesity epidemic.
- Trial name
- MOVE (NCT04937205)
- Testing
- MOVE
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Chronic Kidney Disease
CKDu in Sugarcane Workers in Guatemala
The objective of this research project is to investigate specific behaviors and exposures related to sugarcane work and their association with non-communicable diseases, specifically Chronic Kidney Disease of Unknown Origin…
- Trial name
- NCT03049527
- Testing
- Education, Incentives and Feedback
- Where
- 2 sites in United States, Guatemala
- Volunteers
- 531 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Respiratory Failure, SARS-CoV 2
Stress Related Disorders in Family Members of COVID-19 Patients Admitted to the ICU
Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Conditions
- Respiratory Failure, SARS-CoV 2, Corona Virus Infection, Post Intensive Care Unit Syndrome
- Trial name
- NCT04476914
- Where
- 9 sites in United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Infantile Spasms
Genetic Studies in Patients and Families With Infantile Spasms
Infantile spasms (IIS), a characteristic epilepsy syndrome of infancy with often catastrophic developmental consequences, is known in some patients to have many different genetic, metabolic and structural etiologies.
- Trial name
- NCT01723787
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Colorado, Denver
Congenital Diaphragmatic Hernia
Resuscitation of Infants With Congenital Diaphragmatic Hernia With an Intact Umbilical Cord
Congenital diaphragmatic hernia (CDH) is a severe birth defect, with a prevalence of 1:2000 to 1:3000 live births where a defect in the diaphragm results in, herniation of the abdominal contents into the chest with subsequent…
- Trial name
- NCT03242044
- Testing
- Congenital diaphragmatic hernia resuscitation with an intact umbilical cord
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Fluoride Varnish and Oral Health Promotion, Usual Care
Preventing Caries in Preschoolers: Testing a Unique Service Delivery Model in American Indian Head Start Programs
An intensive intervention of specially trained paraprofessionals, called community oral health specialists (COHS), administering on a quarterly basis for 2 years fluoride varnish and oral health promotion education, compared to…
- Trial name
- NCT01116739
- Testing
- Fluoride varnish, Oral health education, Dental services delivered by the Indian Health Service.
- Where
- United States
- Volunteers
- 2,060 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Multiple Sclerosis
Home Based Infusions for Ocrelizumab
The goal is to assess the safety and effectiveness of home ocrelizumab infusion.
- Trial name
- NCT04650321
- Testing
- Ocrelizumab at home
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Colorado, Denver
Risk Reduction Behavior
Follow-up Evaluation of Home Nurse Visitation Program for Socially Disadvantaged Women and Their Children
This study will evaluate the long-term effects of a prenatal and early childhood home nurse visitation program for socially disadvantaged women and their children.
- Trial name
- NCT00443586
- Testing
- Developmental Screening, Screening plus Transportation, Screening, Transport, Prenatal Visits
- Where
- United States
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Knee Osteoarthritis
Alterations in Muscle After Total Knee Arthroplasty
The overall goals of this work are: 1) to elucidate alterations in gene expression and downstream protein synthesis 2 weeks after Total Knee Arthroplasty (TKA) to better explain quadriceps muscle atrophy after TKA and 2)…
- Trial name
- NCT02281877
- Testing
- Neuromuscular electrical stimulation (NMES), Standard Rehabilitation Protocol
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Covid19
An Observational Cohort Trial of Outcomes and Antibody Responses Following Treatment With COVID19 Convalescent Plasma in Hospitalized COVID-19 Patients
This is an observational study designed to learn more about how COVID19 convalescent plasma works in patients with COVID19 compared to those patients who did not receive convalescent plasma treatment.
- Trial name
- NCT04471051
- Where
- 6 sites in United States
- Volunteers
- 255 people
- Sponsor
- University of Colorado, Denver
Idiopathic Pulmonary Fibrosis (IPF)
Inhaled NAC in Treatment of IPF
This study plans to learn more about the safety and tolerability of inhaled N-Acetylcysteine (NAC) in patients with pulmonary fibrosis.
- Trial name
- NCT03720483
- Where
- United States
- Sponsor
- University of Colorado, Denver
Cardiovascular Diseases
Cardiac Rehabilitation and Sedentary Behavior
This trial randomizes patients who plan to attend cardiac rehabilitation to either a behavioral intervention to specifically reduce sedentary behavior or to usual care which exclusively focuses on increasing exercise.
- Trial name
- Rest-CR (NCT03200756)
- Testing
- Sedentary Group, Exercise Group
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Coronary Arteriosclerosis, Myocardial Infarction
Impact of Daylight on Patients With Acute Myocardial Infarction
The study tests if intense light could be a potential therapy in humans after myocardial infarction by inducing Per2.
- Trial name
- NCT02490397
- Testing
- Day Light, Room Light
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Demineralization
Prevention of Enamel Demineralization Using CPP-ACP-NaF Varnish
Sometimes when people wear braces, the combination of dental plaque and diets high in sugar and acids can lead to white spots on the teeth surrounding the braces.
- Trial name
- CPP-ACP (NCT04002232)
- Testing
- CPP-ACP-NaF varnish
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cognitive Impairment, Estrogen Deficiency
Effects of Ovarian Hormone Suppression on Vascular and Cognitive Function
Complaints about memory and thinking are common in women as they go through menopause. The female hormone estrogen is important for both the health of both the brain and the blood vessels.
- Conditions
- Cognitive Impairment, Estrogen Deficiency, Menopause, Endothelial Dysfunction
- Trial name
- NCT03112226
- Testing
- GnRHant + E2
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pediatric Pulmonary Hypertension
Actigraphy in Pediatric Pulmonary Hypertension
Physical activity is an important factor in understanding how diseases can affect a child. Decreases in physical activity are sometimes the first thing that happens before a child is diagnosed with a disease.
- Trial name
- NCT02909608
- Testing
- No interventions / observations only
- Where
- 2 sites in United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
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