Clinical trials: sponsored by University of Colorado, Denver
HPV
The HPV 9-10 Trial: Early Initiation of HPV Vaccination
Every year, thousands of Americans die from cancers related to human papillomavirus (HPV). The vast majority of those deaths could be prevented with a safe and effective vaccine, yet many parents choose not have their children…
- Trial name
- NCT04722822
- Testing
- (Intervention) Recommending HPV vaccine for patients 9-10 years of age, (Control) Recommending HPV vaccine for patients 11-12 years of age
- Where
- 2 sites in United States
- Volunteers
- 62,272 people
- Sponsor
- University of Colorado, Denver
Irritable Mood, Temper Tantrum
Parent Management Training to Treat Irritability
The goal of this clinical trial is to see if 12 sessions of a Parent Management Training program can treat irritability in children aged 10-14 years old.
- Conditions
- Irritable Mood, Temper Tantrum, Anger
- Trial name
- PMT (NCT06020261)
- Testing
- Parent Management Training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Obesity, Adolescent Obesity
Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents
The study plans to learn more about what happens to the body after bariatric surgery in people 12 to 24 years old. The study aims to understand why people respond differently to bariatric surgery and how to define success beyond…
- Conditions
- Obesity, Adolescent Obesity, Body-Weight Trajectory, Weight Loss Trajectory
- Trial name
- PRESSURE (NCT06575738)
- Testing
- Injectable semaglutide or injectable tirzepatide, Standard postoperative care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Metastatic Colorectal Cancer
Couple-Based Mindfulness Intervention for Metastatic Colorectal Cancer
The overall objective of this study is to develop a novel couple-based mindfulness intervention aimed at reducing distress in patients with metastatic colorectal cancer (mCRC) and their partners.
- Trial name
- NCT05840263
- Testing
- Qualitative interview, Cognitive Interviews
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Heart Failure With Reduced Ejection Fraction
Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure
An increasing number of guideline-directed medical therapies (GDMT) have been developed for patients with chronic heart failure with reduced ejection fraction (HFrEF).
- Trial name
- IICAPTAIN-HF (NCT06526988)
- Testing
- EPIC-HF Patient-facing Tool, PROMPT-HF Clinician-facing Alert
- Where
- 5 sites in United States
- Volunteers
- 2,200 people
- Sponsor
- University of Colorado, Denver
ACL Tear
Comparison of Methods in Post Operative Knee Arthroscopy Rehabilitation
The aim of this study is to investigate the efficacy of blood flow restriction (BFR) therapy in post-operative rehabilitation following knee arthroscopy for primary ACL reconstruction.
- Trial name
- ACL BFR (NCT05735236)
- Testing
- BFR Cuff
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Colorado, Denver
Ovary Cancer, Peritoneal Cancer
An Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib
The Principal Investigator hypothesizes the combination of MIRV and Olaparib is an effective, and tolerable, maintenance therapy strategy in platinum sensitive recurrent ovarian cancer.
- Conditions
- Ovary Cancer, Peritoneal Cancer, Fallopian Tube Cancer
- Trial name
- NCT05887609
- Testing
- Mirvetuximab Soravtansine-gynx, Olaparib
- Where
- 6 sites in United States
- Volunteers
- 53 people
- Sponsor
- University of Colorado, Denver
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Tendon-Bone Versus All-Soft-Tissue for ACL Reconstruction: A Patient-Blinded Randomized Clinical Trial
In primary pediatric Anterior cruciate ligament (ACL) reconstruction, the quadriceps tendon with either tendon and patellar bone or an all-tendon graft is commonly employed.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT04039971
- Testing
- ACL Reconstruction
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Cancer, Cancer-related Problem/Condition
Virtual Exercise Program to Reduce Cancer Related Fatigue
The objective of this investigation is to establish the feasibility and initial effectiveness of a novel exercise program for rural cancer survivors in Colorado suffering from cancer related fatigue.
- Conditions
- Cancer, Cancer-related Problem/Condition, Fatigue
- Trial name
- NCT04533165
- Testing
- Exercise
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Colorado, Denver
Solid Tumor
The Intersection of Oncology Care and Worker Well-Being
The goals of this study will be a greater understanding of cancer patients' well-being experience through the care/treatment continuum.
- Trial name
- NCT05250284
- Testing
- WellBQ, PROMIS
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Colorado, Denver
Colorectal Cancer
Increasing CRC Screening in Community Health Centers Through Mobile Messaging Optimization
The goal of this interventional study is to create and test a comprehensive and low burden text message program within existing Community Health Centers (CHC) electronic records system to encourage patients to complete at home…
- Trial name
- CoSMMO (NCT07569250)
- Testing
- Personalized Text Message, Screening Concerns Text Message, Message Framing Text Message
- Where
- 4 sites in United States
- Volunteers
- 7,220 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Breast Cancer
Interpretations and Predictions of Patient Reported Outcomes by Breast Cancer Patients
This study will assess how patients' long-term quality of life after different surgical approaches compares to their predicted quality of life.
- Trial name
- NCT05064098
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Non-Hodgkin Lymphoma, B-cell Non-Hodgkin Lymphoma (B-NHL)
Preliminary Safety and Tolerability of CD19x22 CAR T Cells in Adolescent and Adult R/R B-NHL Patients
This open-label, single arm phase 1 trial aims to determine the safety and tolerability of anti-CD19 and anti-CD22 chimeric antigen receptor-expressing (CAR) T cells (CD19x22 CAR T) in adolescents and adults with…
- Conditions
- Non-Hodgkin Lymphoma, B-cell Non-Hodgkin Lymphoma (B-NHL), Mantle Cell Lymphoma (MCL), CNS Lymphoma
- Trial name
- NCT05098613
- Testing
- CD19x22 CAR T Cells
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Colorado, Denver
Cancer Remission
Relationships Between Physical Activity and Different Measures of Fatigue in Cancer Survivors
This is an investigation of possible relationships between daily physical activity (PA) and different measurements of fatigue in cancer survivors participating in a cancer exercise program.
- Trial name
- NCT05073848
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Post-operative Pulmonary Complications
Impact of Prophylactic High Flow Nasal Oxygen in Post-Operative Thoracic Surgical Patients
The Investigators goal was to study the effect of high flow nasal cannula oxygen (HFNC) on the rate of post-operative pulmonary complications in thoracic surgical patients.
- Trial name
- NCT03024112
- Testing
- Heated humified high-flow nasal cannula Oxygen, Standard oxygen therapy
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Colorado, Denver
PARKINSON DISEASE (Disorder)
Vibrotactile Stimulation for Parkinson's Disease
Investigation on whether and how vibrotactile stimulation applied on the fingertips affects beta power in the subthalamic nucleus.
- Trial name
- NCT07687732
- Testing
- Vibrotactile stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Colorado, Denver
Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis
Study to Investigate Vagus Nerve Stimulation Paired With Motor Task for Remyelination and Functional Recovery
The goal of this clinical trial is to learn if stimulating the vagus nerve in combination with a motor task in people with multiple sclerosis can improve motor function.
- Trial name
- NCT06641271
- Testing
- Closed Loop Trans-Auricular Vagus Nerve Stimulation System
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Colorado, Denver
Diabetes, Kidney Disease
MIRACLE-T2D Montelukast Intervention for Renal, Cardiovascular and Eye Health in Type 2 Diabetes
Diabetes mellitus type 2 is associated with significant morbidity and mortality; and identifying new treatments for diabetes complications to be used alone or in combination with other therapies is a high priority.
- Conditions
- Diabetes, Kidney Disease, Vascular Disease, Retinopathy
- Trial name
- MIRACLE-T2D (NCT07685886)
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Colorado, Denver
Obesity/Therapy
Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity
Glucagon-like peptide 1 receptor agonists (GLP-1RA), such as Ozempic and Wegovy, have been rapidly adopted for the treatment of obesity in both youth and adults.
- Trial name
- PLASTIC (NCT07021937)
- Testing
- Semaglutide 1.7mg subcutaneous
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
NT219 Combined With Standard of Care Biologic Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Fixed dose NT219 weekly plus pembrolizumab every 3 weeks or cetuximab weekly to be continued until progression, unacceptable toxicity, or investigator or participant decision.
- Trial name
- NCT06919666
- Testing
- NT219
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- University of Colorado, Denver
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