Clinical trials: sponsored by University of Edinburgh
Rheumatoid Arthritis, Adrenal Insufficiency
Rheumatoid Arthritis Adrenal Recovery Study
Cortisol is a naturally occurring stress hormone, made by the adrenal glands in response to hormones produced by the pituitary and hypothalamus.
- Trial name
- RAAR (NCT03294876)
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- University of Edinburgh
Cardiac Disease, Delirium
A Study to Identify the Incidence of Post Traumatic Stress Symptoms in Patients With Delirium Following Cardiac Surgery
'Post perfusion syndrome' was a term historically associated to cardiac surgery in view of the transient neuro-cognitive deficits attributed to cardio pulmonary bypass pump.
- Conditions
- Cardiac Disease, Delirium, Stress Disorders, Post-Traumatic
- Trial name
- NCT02954861
- Testing
- No intervention
- Volunteers
- 406 people
- Sponsor
- University of Edinburgh
Covid19
Manganese-Enhanced Magnetic Resonance Imaging of MyOcardial injuRY in COVID 19 (COVID-19)
Our understanding of the clinical manifestations of COVID-19 is growing on a daily basis and there is evidence that increased age, cardiovascular risk factors and cardiac comorbidity are strongly associated with poor outcomes.
- Trial name
- MEMORY-COVID (NCT04625075)
- Testing
- Cardiac MRI, Cardiac CT, Electrocardiogram (ECG)
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Anxiety
Exploring the Effectiveness of a Brief CBT Intervention for Anxious Pregnant Women
Pregnancy is a time of significant adjustment and uncertainty. Anxiety is common among this group and is associated with poor cognitive and physical outcomes for both the mother and child.
- Trial name
- NCT03103217
- Testing
- brief CBT for anxious pregnant women
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Edinburgh
Liver Transplantation, Liver Transplant; Complications
A Study of Novel Biomarkers of Kidney Dysfunction at Liver Transplant
Kidney dysfunction before and immediately after liver transplantation is common and leads to poorer outcomes, including prolonged need for post-operative intensive care, diminished graft survival, and greater risk of permanent…
- Conditions
- Liver Transplantation, Liver Transplant; Complications, Kidney Dysfunction
- Trial name
- NCT03376009
- Testing
- Blood sample for serum and plasma biomarkers:, Urine sample for biomarkers, Cardiac bio-impedance (Cardioscreen Medis)
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- University of Edinburgh
Depression
Attachment Style and Reflective Functioning in CBASP
Cognitive behavioural analysis system of psychotherapy (CBASP) is one of the only psychological models and treatments that has been designed specifically for patients diagnosed with chronic depression.
- Trial name
- NCT02748187
- Testing
- CBASP
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Vascular Function, Atherothrombosis
Comparison of Vascular Function in Emergency Service Professionals
Emergency Service Professionals have an increased risk of death from heart attacks when compared to the general public. All the emergency professions share similar responsibilities such as emergency call-outs and shift work.
- Trial name
- FIRECOP (NCT01813032)
- Testing
- Forearm Vascular Study, Badimon Chamber
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Myocardial Infarction, Inflammation
Inflammatory Cell Trafficking After Myocardial Infarction
Myocardial infarction (heart attack) is usually the consequence of rupture of a fatty 'plaque' in a heart artery. The presence of this fat and debris causes the propagation of a blood clot and blockage of the artery.
- Trial name
- NCT01127113
- Testing
- Infusion of investigational product, Cardiac magnetic resonance imaging
- Where
- United Kingdom
- Sponsor
- University of Edinburgh
Atherosclerosis, Stroke
Metabolic Imaging in Carotid Atherosclerosis
Hardening of the arteries (atherosclerosis) is a common disorder that causes heart attacks and strokes. PET CT and contrast-enhanced MRI scans are two new ways of assessing atherosclerosis.
- Trial name
- MICA (NCT01674257)
- Testing
- USPIO (ferumoxytol)-enhanced MRI scan, 18f-Fluoride PET/CT scan, 18F-Flurodeoxyglucose PET/CT scan
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Edinburgh
Vascular Disease, Heart Disease
Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers (Protocol 2)
Impairment of the heart's pumping capacity (heart failure) remains a major clinical problem with a poor prognosis and the search for novel treatments remains an important area of research.
- Trial name
- NCT01096693
- Testing
- Urocortin 2, Urocortin 3
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Previous Myocardial Infarction
Effect of Omega 3 Fatty Acids on Vascular Function
The mechanisms through which omega-3 fatty acids reduce adverse cardiac events remain uncertain. The aim of the study was to investigate the effect of omega-3 fatty acid supplementation on endothelial vasomotor function…
- Trial name
- NCT01888211
- Testing
- Omega 3 fatty acid supplementation, Olive Oil
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Allergy
Allergy UK Research and Development Nurse Project
The aim of the research project is to develop, deliver and assess the feasibility of a nurse-led allergy clinic in primary care, taking into account population, geographical area and needs of healthcare in the area chosen.
- Trial name
- ALLUKN (NCT03826953)
- Testing
- Nurse Led Allergy Clinic
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Vascular Function, Atherothrombosis
Effect of Fire Suppression and Emergency Duties on Vascular Function
Firefighters are at increased risk of death from heart attacks when compared to other emergencyy service professionals whose jobs involve similar components such as emergency call-outs and shift work.
- Trial name
- NCT01805063
- Testing
- Forearm Vascular Study, Badimon Chamber
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Childhood Pneumonia
Improving Paediatric Pneumonia Diagnosis Using Digital Auscultation
This study aims to evaluate an automated interpretation algorithm of recorded lung sound by a digital stethoscope, name the Smartscope, among rural Bangladeshi children receiving community care in order to improve the diagnosis…
- Trial name
- NCT03959956
- Testing
- Recording lung sound by a Smartscope
- Where
- Bangladesh
- Volunteers
- 990 people
- Sponsor
- University of Edinburgh
Adolescent Development
Parental Cognitions and Children's Wellbeing
The current study aims to address the research limitations in previous studies by adopting a longitudinal design to investigate the associations between parental cognitions (parental expectations, parental beliefs, and parental…
- Trial name
- NCT06159738
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Vasculitis
Endothelin Antagonism in ANCA Vasculitis
Patients with vasculitis commonly develop cardiovascular disease. The reasons for this are not clear and is not adequately treated with current drugs.
- Trial name
- NCT02062346
- Testing
- BQ123, BQ123/788
- Where
- 2 sites in United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Bicuspid Aortic Valve, Thoracic Aortic Aneurysm
Assessment of Risk in Thoracic Aortopathy Using 18F-Sodium Fluoride
Patients with bicuspid aortic valve-related aortopathy are at increased risk of aortic dilatation, dissection and rupture. Currently, risk stratification is largely based on aortic diameter measurements, with those deemed high…
- Conditions
- Bicuspid Aortic Valve, Thoracic Aortic Aneurysm, Aortic Dissection
- Trial name
- AoRTAS (NCT04083118)
- Testing
- clinical evaluation, blood markers, pulse wave analysis, 18F sodium fluoride PET/CT and PET/MRI, Repeat 18F sodium fluoride PET/MRI
- Where
- United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Colorectal Cancer, Vitamin D Deficiency
Vitamin D Supplementation Study
Patients with colorectal cancer will be recruited to undergo vitamin D supplementation in the peri-operative period. Vitamin D levels (25OHD) will be measured to assess response to supplementation.
- Trial name
- NCT05506696
- Testing
- Fultium
- Where
- United Kingdom
- Volunteers
- 122 people
- Sponsor
- University of Edinburgh
Myocardial Infarction
Optimisation and Quantification of Contrast Enhanced Computed Tomography Myocardial Fibrosis Imaging
Detecting scarred heart muscle is important to diagnose and treat of a wide variety of heart conditions. Magnetic resonance imaging (MRI) can assess scarred heart muscle but it is time consuming, contraindicated for some patients…
- Trial name
- NCT02364687
- Testing
- Computed tomography late enhancement imaging
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
Premature Infant, Oxygen Therapy
SCO2T (Servo vs. Servo)
Most premature babies require oxygen therapy. There is uncertainty about what oxygen levels are the best. The oxygen levels in the blood are measured using a monitor called a saturation monitor and the oxygen the baby breathes is…
- Conditions
- Premature Infant, Oxygen Therapy, Hypoxia, Hyperoxia
- Trial name
- NCT04546568
- Testing
- Servo control (closed-loop automatic control of the inspiratory fraction of oxygen (FiO2)) - Leoni plus CLAC, Servo control (closed-loop automatic control of the inspiratory fraction of oxygen (FiO2)) - IntellO2 OAM
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh