Clinical trials: sponsored by University of Edinburgh
Calcific Aortic Stenosis
Study Investigating the Effect of Drugs Used to Treat Osteoporosis on the Progression of Calcific Aortic Stenosis.
Aortic stenosis is a condition whereby one of the heart valves (aortic valve) becomes narrowed, due to calcium deposition, over time. This can lead to chest pain, heart failure and sudden death.
- Trial name
- SALTIRE II (NCT02132026)
- Testing
- Denosumab, Alendronic Acid
- Where
- United Kingdom
- Volunteers
- 152 people
- Sponsor
- University of Edinburgh
Thrombosis, Atherothrombosis
In-vivo Thrombus Imaging With 18F-GP1, a Novel Platelet PET Radiotracer
To date, the investigators have successfully employed a radiotracer (18F-sodium fluoride) as a marker of necrotic inflammation in human atherosclerosis.
- Conditions
- Thrombosis, Atherothrombosis, Myocardial Infarction, STEMI
- Trial name
- iThrombus (NCT03943966)
- Testing
- 18F-GP1 PET CT
- Where
- United Kingdom
- Volunteers
- 73 people
- Sponsor
- University of Edinburgh
Bronchiectasis, Immunoglobulin Subclass Deficiency
Immunoglobulin Replacement Therapy for Immunoglobulin G Subclass 2 Deficient Patients With Bronchiectasis
Bronchiectasis is a common chronic lung condition where patients have permanent airways damage leading to daily symptoms of cough, sputum production and recurrent respiratory tract infections.
- Trial name
- NCT03737617
- Testing
- Cuvitru 20 % Injectable Solution
- Where
- United Kingdom
- Sponsor
- University of Edinburgh
Endothelial Progenitor Cells, Coronary Artery Disease
Tracking Endothelial Cells in Arterial Injury
We plan to track the migratory behaviour of culture-expanded enothelial outgrowth cells in the context of vascular injury sustained during elective coronary angiography.
- Conditions
- Endothelial Progenitor Cells, Coronary Artery Disease, Vascular Injury, Coronary Angiography
- Trial name
- NCT02975518
- Testing
- Administration of radio labelled endothelial outgrowth cells
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Edinburgh
Acute Coronary Syndrome, Myocardial Infarction
High-Sensitivity Troponin in the Evaluation of Patients With Acute Coronary Syndrome
In patients with chest pain the diagnosis of a heart attack (myocardial infarction) is made where there is evidence of heart muscle damage using a blood test to measure the heart muscle protein troponin.
- Trial name
- High-STEACS (NCT01852123)
- Testing
- High-sensitivity troponin I assay
- Where
- United Kingdom
- Volunteers
- 48,282 people
- Sponsor
- University of Edinburgh
Cancer Induced Bone Pain, Secondary Malignant Neoplasm of Bone
Thermal Testing in Bone Pain (TiBoP)
If cancer spreads to bones it can be very painful, especially when trying to move around. One of the best treatments is radiotherapy, which has to be given in a cancer centre.
- Conditions
- Cancer Induced Bone Pain, Secondary Malignant Neoplasm of Bone, Toxicity Due to Radiotherapy, Pain
- Trial name
- TiBoP (NCT02887833)
- Testing
- Clinical biomarker (thermal sensory testing)
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- University of Edinburgh
Multiple Sclerosis, Fatigue
Self Help for Fatigue in Multiple Sclerosis
The purpose of this study is to determine if cognitive behavioural therapy (CBT) based self help is effective for the management of symptoms of fatigue in Multiple Sclerosis (MS).
- Trial name
- NCT01532037
- Testing
- Cognitive behavioural therapy based self help, Treatment as usual
- Where
- 2 sites in United Kingdom
- Volunteers
- 73 people
- Sponsor
- University of Edinburgh
Stroke
A RCT to Establish the Effectiveness of Intermittent Pneumatic Compression to Prevent Post Stroke DVT
Strokes occur when blood flow to part of the brain is interrupted. Patients are often bedbound for several days or weeks although if they survive, most will make some recovery.
- Trial name
- CLOTS-3 (NCT00789542)
- Testing
- Intermittent Pneumatic compression, Routine care
- Where
- United Kingdom
- Volunteers
- 2,876 people
- Sponsor
- University of Edinburgh
Chronic Depression
Does Disciplined Personal Involvement Precede Change in CBASP?
The purpose of the study is to investigate the process of symptom change in Cognitive Behavioural Analysis System of Psychotherapy (CBASP), and how the individual components of the therapy affect this change in individuals with…
- Trial name
- NCT02470988
- Testing
- Cognitive Behavioural Analysis System of Psychotherapy, CBASP Without DPI
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Edinburgh
Vascular Function
Effect of Woodsmoke on Vascular Function
Exposure to air pollution is a well established risk factor for the development of heart disease. Firefighters are exposed to excess air pollution in the form of wood smoke during the extinguishing of forest or woodland fires.
- Trial name
- FIREWOOD (NCT01495325)
- Testing
- Forearm Vascular Study, Badimon Chamber
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Cardiopulmonary Bypass, Consciousness Monitors
Isoflurane During Cardiopulmonary Bypass
There is no clinical way of assessing the depth of anaesthesia while patients are on the heart-lung machine. A new method of measuring the depth of anaesthesia using brainwaves called the Bispectral index (BIS) has been developed…
- Conditions
- Cardiopulmonary Bypass, Consciousness Monitors, Isoflurane
- Trial name
- NCT02471950
- Testing
- 2.5 % Isoflurane administration
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Edinburgh
Vascular Function, Atherothrombosis
Effect of Real-fire Training on Vascular Function
Fire-fighters are at increased risk of death from heart attacks when compared to other emergency service professionals whose jobs involve similar components such as emergency call-outs and shift work.
- Trial name
- FIREPROOF (NCT01812317)
- Testing
- Forearm Vascular Study, Badimon Chamber Study
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Asthma
Contraceptive Use and Respiratory Conditions Among Scottish Women
Studies examining the sex differences in the epidemiology and morbidity patterns of asthma show that the rates of disease severity, healthcare utilisation, and poor quality of life are considerably higher in women than in men…
- Trial name
- NCT02039102
- Where
- United Kingdom
- Volunteers
- 3,257 people
- Sponsor
- University of Edinburgh
Aortic Aneurysm
Magnetic Resonance Imaging of Aortic Aneurysm Instability
Abdominal aortic aneurysm (AAA) is a progressive enlargement of the aorta, the largest blood vessel in the body. It is at risk of bursting when it is usually fatal.
- Trial name
- NCT00794092
- Testing
- Sinerem administration
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Edinburgh
Coronary Artery Disease
Novel Imaging Approaches To Identify Unstable Coronary Plaques
Cardiovascular disease is the leading cause of death in Scotland and the Western World. Approaches to improve the identification of vulnerable or ruptured coronary atherosclerotic plaques are urgently needed to help risk…
- Trial name
- NCT01749254
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Edinburgh
Vascular Disease, Heart Disease
Gap Junction Potentiation of Endothelial Function With Rotigaptide
Hypothesis - Rotigaptide will improve endothelial function in the context of endothelial dysfunction. The lining of blood vessels (endothelium) can react to hormones in the blood stream causing the blood vessel muscle to relax…
- Trial name
- NCT00901563
- Testing
- Rotigaptide, Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Healthy Volunteer
Cell Tracking Using Superparamagnetic Particles of Iron Oxide (SPIO) and Magnetic Resonance Imaging (MRI) - A Pilot Study
The ability to label specific cells and image their natural movements in vivo would allow researchers to investigate the mechanisms of disease progression.
- Trial name
- NCT00972946
- Testing
- Administration of autologous Endorem-labelled mononuclear cells intravenously, Administration of Endorem
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Coronavirus, Anxiety Depression
When Distance is an Act of Love: Exploring the Use of Video Diaries for Family Members of Intensive Care Patients
Due to Covid-19, intensive care (ICU) patients are not allowed visitors or have severely restricted visiting. After being admitted to ICU most patients are unconscious or extremely weak and therefore cannot speak on a phone or…
- Trial name
- NCT04870450
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Inpatients
Inpatient Distress Tolerance Group Intervention Pilot
Research suggests that a low capacity to tolerate distress is a common underlying factor in the development and maintenance of a range of mental health problems.
- Trial name
- NCT03712332
- Testing
- Distress Tolerance Group
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Edinburgh
Coronary Artery Disease, Acute Coronary Syndrome
Troponin to Risk Stratify Patients for Computed Tomography Coronary Angiography
Most patients presenting to hospital with chest pain are discharged home without further tests once a heart attack has been ruled out.
- Trial name
- PRECISE-CTCA (NCT04549805)
- Testing
- Computed Tomography Coronary Angiography
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- University of Edinburgh