Clinical trials: sponsored by University of Edinburgh
Myocardial Infarction
Sixth Generation High-sensitivity Cardiac Troponin T for the Early Rule Out of Myocardial Infarction: a Controlled Before and After Study
Cardiac troponin is a protein released into the blood when the heart muscle is damaged. Measuring this protein helps doctors diagnose a heart attack (also called a myocardial infarction).
- Trial name
- STEREO-MI (NCT07636642)
- Testing
- sixth-generation high sensitivity cardiac troponin T assay, fifth-generation high sensitivity cardiac troponin T assay
- Where
- 3 sites in United Kingdom
- Volunteers
- 19,500 people
- Sponsor
- University of Edinburgh
Cachexia; Cancer, Advanced Cancer
Routine Evaluation of People Living With Cancer
People with incurable cancer often have complex individual needs, however there are several common themes encountered when considering this group.
- Conditions
- Cachexia; Cancer, Advanced Cancer, Quality of Life
- Trial name
- REVOLUTION (NCT04406662)
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- University of Edinburgh
Bipolar Affective Disorder, Schizophrenia Disorders
Medical Phenotyping of NHS General Adult Psychiatry (GAP) Inpatients
This observational study will characterise the general psychiatric and general medical phenotypes of 100 adults, sequentially admitted to NHS General Adult Psychiatry (GAP) "mental health" inpatient wards, providing the first…
- Conditions
- Bipolar Affective Disorder, Schizophrenia Disorders, Depression Disorders, Personality Disorders
- Trial name
- NCT07398365
- Testing
- Questionnaires, rating scales, & review of notes
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Paget Disease, Paget Disease of Bone
Genetic Analysis to Predict the Development of Paget's Disease
Paget's disease of the bone (PDB) is a skeletal disorder with a strong genetic component which can be associated with various complications such as pain, bone deformity, arthritis and deafness.
- Trial name
- GAPDPD (NCT05309954)
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Brown Adipose Tissue, Cold Exposure
Intermittent Cold Exposure and Brown Adipose Tissue Hyperplasia
This clinical trial explores how repeated short-term cold exposure impacts the molecular and physiological function of brown adipose tissue (BAT), a thermogenic organ associated with improved cardiometabolic health.
- Conditions
- Brown Adipose Tissue, Cold Exposure, 18F-FDG PET/CT
- Trial name
- ICEBATH (NCT07048405)
- Testing
- Cooling, Biopsies, Injection of 18F-FDG
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
The Edinburgh Lung Fibrosis Molecular Endotyping (ELFMEN) Study
To prospectively study novel blood and lung biomarkers of disease activity in patients with IPF and other interstitial lung disease with the aims of prognostic modelling and disease clustering
- Conditions
- Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease, Asbestosis
- Trial name
- ELFMEN (NCT04016181)
- Volunteers
- 800 people
- Sponsor
- University of Edinburgh
ATTR-CM
Quantitative-imaging in Cardiac Transthyretin Amyloidosis
Transthyretin amyloid cardiomyopathy (ATTR-CM), is a heart muscle disease that's stops the heart muscle working properly. With an ageing population, it is increasingly common but untreated, it has a poor prognosis.
- Trial name
- I-CARE (NCT05776212)
- Testing
- 18F-fluoride PET
- Where
- Netherlands
- Volunteers
- 140 people
- Sponsor
- University of Edinburgh
Sleep Disordered Breathing (SDB), Cerebral Palsy (CP)
Experiences of Managing Sleep Disordered Breathing in Children With Cerebral Palsy.
Cerebral palsy (CP) refers to a non-progressive movement disorder, which occurs due to damage to the developing brain around the time of birth.
- Conditions
- Sleep Disordered Breathing (SDB), Cerebral Palsy (CP), Respiratory Support
- Trial name
- QualSDB_CP (NCT06753370)
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Edinburgh
Near Fatal Asthma
Near Fatal Asthma in Children and Young People
This study will report the frequency, risks factors, clinical care and estimate the future asthma risk of children and young people (aged 5-15 years) experiencing a Delphi defined near fatal asthma (NFA) attacks in the United…
- Trial name
- NCT05632588
- Testing
- Observational study
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Endometriosis
ENDO1000 - A UK-wide Endometriosis Research Project
Approximately 1.5 million people in the UK, and 200 million globally live with endometriosis, and it is estimated to affect 1 in 10 women of reproductive age.
- Trial name
- NCT07240883
- Testing
- Sample and data collection
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University of Edinburgh
Type 2 Diabetes
Pancreas Lipotoxicity in T2D: Edinburgh Diabetes Remission Study (EDRS)
This study aims to investigate how fat accumulation in the pancreas contributes to the development of type 2 diabetes (T2D), and how weight loss may reverse this process.
- Trial name
- EDRS (NCT07364045)
- Testing
- Total Diet Replacement (TDR) Program
- Where
- United Kingdom
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Giant Cell Arteritis (GCA)
Mapping B-cell Biology Across the Cardiovascular Territories of Giant Cell Arteritis: Towards a New Therapeutic Approach (RituxiMAP GCA)
B cells are a component of the immune system which appear be important in causing all forms of cardiovascular disease. Until now, it has not been possible to directly study these cells in living patients (essential to assess…
- Trial name
- RituxiMAP GCA (NCT07269938)
- Testing
- Zirconium Zr 89 labelled rituximab
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Chronic Obstructive Pulmonary Disease
Innate Immunity in COPD
Chronic Obstructive Pulmonary Disease (COPD) causes obstruction to airflow when breathing out. It is a leading cause of chronic lung disease, hospitalization and death.
- Trial name
- NCT05743582
- Testing
- Bronchoscopy for sample collection, Blood donation
- Where
- 2 sites in United Kingdom
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Osteogenesis Imperfecta
Treatment of Osteogenesis Imperfecta With Parathyroid Hormone and Zoledronic Acid
Osteogenesis imperfecta (OI) is an inherited skeletal disorder characterised by increased risk of fragility fractures. Bisphosphonates are frequently prescribed for adult patients with OI with the aim of preventing fractures but…
- Trial name
- TOPaZ (NCT03735537)
- Testing
- Teriparatide Pen Injector, Zoledronic Acid
- Where
- 23 sites in Ireland, United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Edinburgh
Human Papilloma Virus
HPV Equity Study: Exploring Cervical Cancer Control in Scotland for Women With Experience of Priority Risks
Individuals with experience of homelessness, substance use/addiction, transactional sex, and incarceration experience significant health inequities across a wide range of health conditions.
- Trial name
- NCT06414057
- Testing
- Offering opportunistic HPV vaccine during routine sexual health clinic visits
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University of Edinburgh
Atrial Fibrillation
Realistic Computational Electrophysiology Simulations for the Targetted Treatment of Atrial Fibrillation
The aim of this research is to classify patients by the dominant mechanism of continuous atrial electrical activation during atrial fibrillation.
- Trial name
- ReCETT-AF (NCT05057507)
- Testing
- Atrial cardiac magnetic resonance imaging, Atrial electro-anatomic mapping, Atrial fibrillation symptom questionnaire
- Where
- 2 sites in United Kingdom
- Volunteers
- 91 people
- Sponsor
- University of Edinburgh
Abortion Early
Point of Care Tests in the Management of Very Early Medical Abortion
This study will investigate the use of a point of care test in patients who are having an abortion at a gestation of <6 weeks (known as a very early medical abortion).
- Trial name
- POCT VEMA (NCT07417787)
- Testing
- Blood test, Participant Questionnaire
- Where
- 3 sites in Sweden, United Kingdom
- Volunteers
- 130 people
- Sponsor
- University of Edinburgh
Lung Cancer
Visualising c-MET and Activated Neutrophils in Lung Cancer
Lung cancer is currently a major health problem in the UK. Despite being one of the most common cancers, lung cancer has a poor prognosis compared to other types of cancer and is the leading cause of cancer death in the world.
- Trial name
- DUAL (NCT02676050)
- Testing
- Optical Imaging Agents (EMI-137, NAP), Delivery Device Cathetar and Miniaturised imaging fibre, Optical endomicroscopy system
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Edinburgh
Cardiovascular Diseases
Developing a Brief Intervention to Communicate Cardiovascular Risk to Patients Presenting to the Emergency Department With Chest Pain: a Co-Production Approach. Phase 2.
Some patients who come to the emergency department with chest pain and have not had a heart attack, are at an increased risk of having a heart attack in the future.
- Trial name
- ACTION 2 (NCT06903442)
- Testing
- Co-designed cardiovascular brief intervention
- Where
- United Kingdom
- Volunteers
- 118 people
- Sponsor
- University of Edinburgh
Endometriosis
Imaging of Endometriosis With Total-body PET-CT (PET-Endo)
Endometriosis is a disease that affects 1 in 10 women and is associated with debilitating pain and infertility. Endometriosis is where cells similar to those lining the womb (the 'endometrium') grow elsewhere in the body, forming…
- Trial name
- PET-Endo (NCT07523997)
- Testing
- PET/CT, PET/MRI, Buscopan 20 MG/ML Injectable Solution
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh