Clinical trials: sponsored by University of Miami
Amyotrophic Lateral Sclerosis
Clinical Research in ALS Study
CRiALS is an umbrella protocol through which people are recruited to participate in a range of research studies being conducted by the ALS Research Collaboration (ARC).
- Trial name
- CRiALS (NCT00136500)
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Miami
Amyotrophic Lateral Sclerosis
The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study
Pre-fALS is a prospective natural history and biomarker study of people not yet affected with ALS, but who are at genetic risk for developing ALS.
- Trial name
- Pre-fALS (NCT00317616)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Miami
Amyotrophic Lateral Sclerosis
PRE-Symptomatic Studies in Amyotrophic Lateral Sclerosis
The goal of PRESS-ALS is to study the earliest manifestations of disease in people with early ALS in whom some areas of the body are not yet affected.
- Trial name
- PRESS-ALS (NCT01508962)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Miami
Mixed Connective Tissue Disease (MCTD), Systemic Lupus Erythematosus (SLE)
Characteristics and Disease Progression of Mixed Connective Tissue Disease and Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD) are long-term autoimmune diseases in which the immune system attacks parts of the body.
- Trial name
- NCT00582881
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Miami
Pain, Inflammatory Response
Association Between Body Composition and Pain in Spinal Cord Injury
The purposes of the study are to quantify and compare relationships among acute changes in inflammatory markers and evoked pain sensitivity after a high-fat meal (HFM) challenge, compared to a moderate-fat meal challenge, and…
- Trial name
- NCT05459207
- Testing
- Moderate Fat Meal, High Fat Meal
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Miami
SCI - Spinal Cord Injury
Nutrition and Pain Study
The purpose of this research is to assess the effectiveness of a nutrition intervention on diet quality in managing pain in individuals with spinal cord injury (SCI).
- Trial name
- NCT07179588
- Testing
- Nutrition Education Program, Nutrition Counseling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
Knee Osteoarthritis, Hip Osteoarthritis
General vs Spinal in Total Joint Arthroplasty (TJA)
The purpose of this research is to compare post-operative outcomes from patients undergoing TJA. The study team wants to learn about outcomes like length of hospital stay, post-operative pain scores, post-operative nausea, deep…
- Trial name
- NCT06747494
- Testing
- General Anesthesia, Spinal Anesthesia
- Where
- United States
- Volunteers
- 2,396 people
- Sponsor
- University of Miami
THA
Duloxetine for Perioperative Pain in Hip Arthroplasty: A RCT
The primary objective of this study is to compare total narcotic intake standardized via milligram morphine equivalents between duloxetine and placebo cohorts after a total hip arthroplasty.
- Trial name
- NCT06807866
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Miami
THA
Bikini vs Longitudinal Incision in Direct Anterior Approach (DAA) Total Hip Arthroplasty (THA)
The study team is conducting this study to see if there is a difference between the wound healing and participant satisfaction rates between two incision types used during a THA done via the DAA technique.
- Trial name
- NCT06831045
- Testing
- Bikini Incision, Longitudinal Incision
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Miami
Chronic Kidney Diseases, Cardiovascular Diseases
BLOOM: Biological Legacy of Origin in Mother-Infant Dyads
Infants born preterm and of low birth weight are known to be at increased risk for early onset of cardiovascular and renal disease in adult life.
- Trial name
- NCT02000895
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Miami
Venous Thromboembolism
Optimal Dosing For Low-Dose Aspirin Chemoprophylaxis For VTE Following Total Joint Arthroplasty
This research study is attempting to answer the question of whether 81 mg aspirin once daily is as effective as 81 mg aspirin twice daily in preventing blood clots after total joint replacement surgery.
- Trial name
- NCT04295486
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 5,478 people
- Sponsor
- University of Miami
Adult T-cell Leukemia-Lymphoma, ATLL
Belinostat Therapy With Zidovudine for Adult T-Cell Leukemia-Lymphoma
The investigators propose to use Belinostat in combination with AZT as consolidation therapy for the treatment of ATLL.
- Trial name
- NCT02737046
- Testing
- Belinostat, Zidovudine, Interferon-Alfa-2b
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Miami
Gastrointestinal Cancer
Dyadic Sleep Study
The purpose of this study is to learn about sleep behaviors and test different ways to help patients with cancer and caregiver partners.
- Trial name
- NCT06569693
- Testing
- My Sleep Our Sleep (MSOS) Program, Brief Behavioral Treatment for Insomnia (BBTI)
- Where
- 2 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Miami
Hidradenitis Suppurativa
A Bioelectric Dressing for Post De-Roofing Treatment of HS
The primary purpose of this study is to test if the use of a bioelectric dressing can improve healing after a surgical procedure called de-roofing.
- Trial name
- NCT05057429
- Testing
- Bioelectric Dressing, Standard Gauze Dressing
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Miami
Glaucoma, Open-Angle Glaucoma
Biomarkers of Ocular Surface Damage in the Setting of Topical Ocular Hypotensive Medication Use
The objective of this study is to evaluate whether reduction in topical medication with the injection of a sustained release capsule (Durysta) leads to a reduction in ocular surface inflammation, indicated by levels of caspase-1…
- Conditions
- Glaucoma, Open-Angle Glaucoma, Ocular Hypertension, Glaucoma Suspect
- Trial name
- NCT07217678
- Testing
- Durysta, Bimatoprost Intracameral Implant 10 µg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
Prostate Cancer
Collection and Measurement of Biomarkers in Prostate Cancer Radiotherapy Patients
The purpose of this research study is to learn about: 1) How standard radiation treatment to prostate (primary radiotherapy) or the pelvis after prostatectomy (postoperative radiotherapy) may cause changes in MRI and PET imaging…
- Trial name
- COMBINE (NCT02997709)
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Miami
Perineal Injury, Pain Vulva
Improving Postoperative Recovery: A Study of Multimodal Perineal Analgesia Protocol (MPAP) After Vaginal Surgery
The purpose of this research is to determine if using perineal ice packs, medicated witch-hazel pads (MAJOR® Medi-Pads), and topical benzocaine spray (Dermoplast®) helps reduce perineal pain after perineorrhaphy and/or posterior…
- Conditions
- Perineal Injury, Pain Vulva, Perineum; Injury
- Trial name
- NCT07401134
- Testing
- Perineal ice packs, medicated witch-hazel pads, and topical benzocaine spray
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Miami
Aging, Alcohol Drinking
The GLUCID Study: Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers
The goal of this pilot study is to explore a combination of two interventions: (1) a behavioral alcohol-reduction intervention using motivational interviewing, and (2) a blinded probiotic microbiome or placebo intervention.
- Trial name
- NCT07415707
- Testing
- Visbiome, Motivational Interviewing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
Infertility, Male
Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI)
This is a study of infertility which often occurs in men with spinal cord injury. Most men with spinal cord injury have a normal sperm count but abnormally low sperm motility - which means that the sperm does not swim well.
- Trial name
- NCT05903859
- Testing
- Probenecid 500 Milligrams (mg), probenecid 250 Milligrams (mg)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Miami
Prostate Cancer
Randomized MRI-Guided Prostate Boosts Via Initial Lattice Stereotactic vs Daily Moderately Hypofractionated Radiotherapy
The purpose of this research study is to learn about: 1) improving control of prostate cancer using an extra high dose radiation treatment to the MRI defined high risk tumor areas, in addition to the standard radiation treatment…
- Trial name
- BLaStM (NCT02307058)
- Testing
- LEAD RT, HEIGHT RT
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Miami