Clinical trials: sponsored by University of Miami
Prostate Cancer
Randomized MRI-Guided Prostate Boosts Via Initial Lattice Stereotactic vs Daily Moderately Hypofractionated Radiotherapy
The purpose of this research study is to learn about: 1) improving control of prostate cancer using an extra high dose radiation treatment to the MRI defined high risk tumor areas, in addition to the standard radiation treatment…
- Trial name
- BLaStM (NCT02307058)
- Testing
- LEAD RT, HEIGHT RT
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Miami
Relapsed and Refractory Multiple Myeloma
Selinexor, Venetoclax, and Dexamethasone (XVenD) in t(11;14)-Positive Relapsed/Refractory Multiple Myeloma
The purpose of this research is to determine whether the combination of selinexor, venetoclax, and dexamethasone therapy can increase anti-cancer effects in patients with translocation 11;14-positive (t(11;14))…
- Trial name
- SELVEDge (NCT05530421)
- Testing
- Selinexor, Venetoclax, Dexamethasone
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of Miami
Metastatic Uveal Melanoma, Metastatic Uveal Melanoma in the Liver
Study of Tebentafusp and Radioembolization in the Treatment of Metastatic Uveal Melanoma
The purpose of this study is to determine the effects (good and bad) that Tebentafusp in combination with Yttrium-90 (Y-90) radioembolization has on patients with metastatic uveal melanoma that has spread to the liver.
- Trial name
- NCT06627244
- Testing
- Tebentafusp, TheraSphere™ Yttrium-90 Trans-Arterial Radioembolization
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
Sarcoma
Effect of A Multimodal Exercise Intervention on Chemotherapy Uptake in Newly Diagnosed Pediatric and AYA Sarcoma Patients
The purpose of this study is to determine the effects of a multimodal exercise intervention on chemotherapy uptake in newly diagnosed pediatric, adolescent and young adult (AYA) Sarcoma patients.
- Trial name
- ACTIVE-SARC (NCT07359911)
- Testing
- Exercise Intervention, Usual Care Control, Exit Interview
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Miami
Prostate Cancer
The University of Miami Adapt (UAdapt) Trial
The purpose of this prostate cancer research study is to investigate: 1. For early-stage patients, the use of a single session of high dose stereotactic body radiotherapy (SBRT) delivered to the tumor within the prostate, not to…
- Trial name
- NCT06111313
- Testing
- FTLEAD, Ultra-Short-Term Androgen Deprivation Therapy with Relugolix, HypoLEAD
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Miami
HIV Infections
Comprehensive HIV and Harm Prevention Via Telehealth
The purpose of this study is to test 2 different ways to offer medications to prevent human immunodeficiency virus (HIV), cure hepatitis C virus (HCV) (if applicable) and treat substance use disorder (if desired) in people who…
- Trial name
- CHARIOT (NCT05897099)
- Testing
- Comprehensive Tele-harm Reduction, Off-site Linkage to HIV Prevention
- Where
- 2 sites in United States
- Volunteers
- 350 people
- Sponsor
- University of Miami
Locally Advanced Rectal Cancer
SMART TNT for the Conservative Management of Locally Advanced Rectal Cancer
The purpose of this research study is to find out how safe and effective is treating patients with locally advanced rectal cancer (LARC) with chemotherapy first and then follow with radiation therapy to a higher dose than what is…
- Trial name
- SMART TNT (NCT05412082)
- Testing
- Intensity-modulated radiation therapy, 5-fluorouracil, Leucovorin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Miami
Schizophrenia
C-Cog in Early Course Schizophrenia Study
The purpose of this study is to examine the role of clinical stability in functional recovery. in first episode schizophrenia.
- Trial name
- NCT05662306
- Testing
- Aripiprazole Lauroxil, Computerized cognitive and functional skills training
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Miami
Hip Osteoarthritis, Hip Arthritis
Alexis Retractor in Total Hip Arthroplasty
To determine if there is a difference in wound healing and surgical site infection (SSI) rates using the Alexis wound retractor vs. not using it in longitudinal direct anterior approach total hip arthroplasty.
- Trial name
- NCT07237737
- Testing
- Alexis wound retractor, Standard wound retractor
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- University of Miami
Health Literacy, Nutrition, Healthy
Addressing Food Insecurity: Plant-Based Food Prescription Program
Reduce food insecurity by improving plant-based health food consumption, access, health and nutrition literacy and the health of the food-insecure families we serve.
- Conditions
- Health Literacy, Nutrition, Healthy, Nutrition Poor, Food Insecurity
- Trial name
- NCT06614920
- Testing
- Plant-Based Food Provision (with or without food prescription), Plant-Based Nutrition Education
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Miami
Activity, Motor
Low Versus High Load Training and Parkinson's Disease
This study will compare the effects of high-load resistance training to low-load resistance training, on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease.
- Trial name
- NCT07378813
- Testing
- Low-Load Resistance Training, High-Load Resistance Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Miami
Activity, Motor
Power Training Progression Methods
This study will investigate the impact of two unique progression models for power training in a sample of healthy older adults. The objective is to identify the most practical methodology for implementing power training, which is…
- Trial name
- NCT07378826
- Testing
- RPE-Based Power Training, Power Plateau-Based Power Training
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Miami
Non Hodgkin Lymphoma, Hodgkin Lymphoma
Lifestyle Intervention of Food and Exercise for Lymphoma Survivors
The purpose of this study is to investigate if a mediterranean diet and exercise program for Lymphoma patients during chemotherapy can improve treatment completion and reduce treatment-related side effects.
- Trial name
- LIFE-L (NCT05839210)
- Testing
- LIFE-L Mediterranean Diet, LIFE-L Home-Based Exercise Program, Supportive Materials
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Miami
Tic Disorders
Comprehensive Behavioral Intervention for Tics
The purpose of this protocol is to examine treatment outcomes of youth receiving the Comprehensive Behavioral Intervention for Tics (CBIT) and better understand the predictors, moderators, mediators and/or mechanisms of change…
- Trial name
- CBIT (NCT05370391)
- Testing
- Comprehensive Behavioral Intervention for Tics (CBIT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Miami
Mild Traumatic Brain Injury
Passive Neurosensory Reintegration Training as a Tool to Augment Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) poses a substantial clinical and public health burden, often leading to persistent neurosensory and cognitive symptoms for which diagnostic and therapeutic solutions remain limited.
- Trial name
- PNRT for mTBI (NCT07356167)
- Testing
- Passive neurosensory reintegration training (PNRT)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Miami
Ventilator Associated Pneumonia
The Duration of Antibiotic Therapy for Early (DATE) Ventilator Associated Pneumonia (VAP): 4 vs. 7 Days
The purpose of this study is to see if the amount of antibiotics given for ventilator-associated pneumonia (VAP) can be decreased in order to reduce the risk of adverse effects associated with antibiotics, while at the same time…
- Trial name
- DATE (NCT05545735)
- Testing
- Standard of Care Antibiotic Therapy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Miami
Child Behavior, Parenting
Natural Helpers and PCIT
The purpose of the study is to evaluate the effect of a time-limited (i.e., 18 weeks) community health worker (CHW) intervention, referred to as the Parent Child Interaction Therapy (PCIT) plus natural helper (NH) model, on…
- Trial name
- NCT05400434
- Testing
- Standard Parent-Child Interaction Therapy (PCIT), Natural Helpers (NH)
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Miami
Breast Cancer, ER-positive Breast Cancer
Levels of Circulating Tumor DNA as a Predictive Marker for Early Switch in Treatment for Patients With Metastatic (Stage IV) Breast Cancer
The majority of patients (pts) with breast cancer have hormone receptor positive (HR+) disease, and this holds true for pts with advanced breast cancer (ABC).
- Conditions
- Breast Cancer, ER-positive Breast Cancer, HER2-negative Breast Cancer, Metastatic Breast Cancer
- Trial name
- NCT05826964
- Testing
- AI+CDK4/6i, SERD+CDK4/6i, mTOR inhibitor + AI
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Miami
Leiomyoma
Dexamethasone for Post Uterine Artery Embolization Pain
The purpose of this research is to investigate if administration steroids (anti-inflammatory medication) via the uterine arteries during uterine fibroid embolization (A non surgical procedure for treating uterine fibroids by…
- Trial name
- Dex-Fib (NCT04655144)
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Miami
COVID-19
Coronavirus Disease of 2019 (COVID-19) Health Education Initiative for School Safety
The purpose of this study is to compare COVID-19 knowledge, experiences, and health behaviors between participants who received the health initiative and those who did not.
- Trial name
- NCT06938230
- Testing
- Health Education Initiative
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Miami