Clinical trials: sponsored by University of Minnesota
Dupuytren's Disease, Dupuytren Contracture
Post-contracture Release Radiation for Dupuytren's Disease
To determine if the clinical impression of clinicians, ie that patients are improving with the current treatment pathway for Dupuytren's (contracture release followed by radiation), can be substantiated with scientific evidence.
- Conditions
- Dupuytren's Disease, Dupuytren Contracture, Dupuytren Disease of Palm and Finger, Dupuytren Disease of Finger
- Trial name
- NCT04122313
- Testing
- Evaluation of Dupuytren's Disease Treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Parkinson Disease
Vestibular and Cortical Contributions to Transitions in Freezing of Gait in Parkinson's Disease
Currently, there is a lack of comprehensive knowledge about the role of vestibulospinal drive and cortical activity during self-initiated movement transitions in older adults and people with PD (both with and without FOG).
- Trial name
- NCT06506058
- Testing
- EVS and EEG
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Parenting
Comparing Web, Group, and Telehealth Formats of a Military Parenting Program
The overarching goal of this study is to advance research on family-based prevention of negative child outcomes for reintegrating Operation Enduring Freedom/Operation Iraqi Freedom personnel by evaluating different formats of a…
- Trial name
- NCT02973906
- Testing
- ADAPT Self Directed web, ADAPT individualized web-facilitated, Group-based ADAPT
- Where
- United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Healthy
High-field Brain Magnetic Resonance Spectroscopy
Magnetic resonance spectroscopy (MRS) allows non-invasive measurement of the concentration of up to 18 metabolites in the brain ("neurochemical profile").
- Trial name
- NCT02053701
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Shisha
Developing and Pilot Testing an Intervention to Reduce Household Shisha Smoke Exposure Within Somali Homes
Previous qualitative research among Somali American adults in Minnesota have identified high levels of hookah or shisha (hereafter shisha) use in Somali households.
- Trial name
- NCT06316947
- Testing
- CHW-delivered intervention
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Clavicle Fracture
Anser Clavicle Pin for Surgical Management of Midshaft Clavicle Fractures
The goals of this multi-site study are to evaluate the union rate, patient satisfaction, and functional results of the Section 510(K) approved Anser Clavicle Pin in a prospective 50 patient clinical trial in a U.S. population.
- Trial name
- NCT05454306
- Testing
- Anser Clavicle Pin
- Where
- United States
- Sponsor
- University of Minnesota
Spinal Cord Injuries, Neuropathic Pain
Brivaracetam to Reduce Neuropathic Pain in Chronic SCI: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Spinal cord injury (SCI) is associated with severe neuropathic pain that is often refractory to pharmacological intervention. Preliminary data suggest brivaracetam is a mechanism-based pharmacological intervention for neuropathic…
- Trial name
- NCT05639946
- Testing
- brivaracetam
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Minnesota
Parkinson Disease
Circuit-Based Deep Brain Stimulation for Parkinson's Disease; Udall Clinical Core
The goal of this project is to provide comprehensive longitudinal assessments of a cohort of PD patients before, during, and after DBS surgery, including neurological, neurophysiological, and neuropsychological data.
- Trial name
- NCT03021031
- Testing
- Observational
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Self-Injurious Behavior, Deliberate Self-Harm
A Study Examining Adolescents With Non-Suicidal Self-Injury
This study will examine longitudinal brain development in young adolescent girls with a history of Non-Suicidal Self-Injury (NSSI).
- Trial name
- RDoC (NCT02947308)
- Where
- 3 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Parkinson Disease
Characterizing the Pathophysiological Role of the Pallido-thalamocortical Motor Pathway in Parkinson's Disease.
When a patient gets DBS surgery, the neurosurgeon makes a hole in the skull through which they can put the DBS lead down in deep parts of the brain that help control movement.
- Trial name
- NCT06692920
- Testing
- DBS stimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Minnesota
Healthy
Observational Study of Exposure to Environmental Toxicants Among Firefighters
Observational, within subject study design with 1 pre and 2 post-fire exposure biomarker samples collected to assess exposure to toxicants from combustion emissions related to fighting a structural fire.
- Trial name
- NCT05643014
- Testing
- Sample collection
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Duchenne Muscular Dystrophy
Trial of Cell Based Therapy for DMD
This is a single-center, single-arm, interventional phase 1 trial to evaluate the safety and tolerability of local injection of induced pluripotent stem cell (iPSC)- derived CD54+ allogeneic muscle progenitor cells in individuals…
- Trial name
- NCT06692426
- Testing
- MyoPAXon, Tacrolimus
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Type 1 Diabetes
FAM (Follower, Action Plan, and Remote Monitoring) Intervention to Reduce Severe Hyperglycemia in Adults With Type 1 Diabetes Mellitus at Risk for Diabetic Ketoacidosis
Diabetic ketoacidosis (DKA) results in significant morbidity and healthcare utilization and is the main contributor to loss of life expectancy in people with diabetes mellitus type 1 (T1DM) <50 years old.
- Trial name
- NCT06114186
- Testing
- FAM intervention consisting of a Follower of glucose data, Action Plan, and Remote Monitoring of glucose data, standard of care
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Minnesota
Tay-Sachs Disease, Sandhoff Disease
A Natural History Study of the Gangliosidoses
Hypothesis: To characterize and describe disease progression and heterogeneity of the gangliosidosis diseases. This research study seeks to develop a quantitative method to delineate disease progression for the gangliosidosis…
- Conditions
- Tay-Sachs Disease, Sandhoff Disease, Late Onset Tay-Sachs Disease, GM1 Gangliosidosis
- Trial name
- NCT00668187
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Minnesota
Deep Brain Stimulation, Parkinson's Disease and Parkinsonism
Sleep-specific DBS Therapy in Parkinson's Disease
Sleep-wake disturbances are a major factor associated with reduced quality of life of individuals with Parkinson's disease (PD), a progressive neurological disorder affecting millions of people in the U.S and worldwide.
- Conditions
- Deep Brain Stimulation, Parkinson's Disease and Parkinsonism, Dystonia
- Trial name
- NCT05962489
- Testing
- Clinically optimized deep brain stimulation
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Minnesota
Suicide, Attempted, Suicide, Ideation
Teen Brain Training (TBT)
A non invasive treatment study including participants at risk for suicide attempts and undergoing neurofeedback training. Neurofeedback is controlling your brain activity in real time inside the scanner.
- Conditions
- Suicide, Attempted, Suicide, Ideation, Depression
- Trial name
- NCT06183580
- Testing
- neurofeedback training involving dACC, neurofeedback training involving amygdala
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Freezing of Gait, Parkinson Disease
Percept Transitions in FOG and PD
The purpose of this research is to examine the possible causes and signs of freezing of gait (FOG) secondary to Parkinson's disease (PD).
- Trial name
- NCT06848205
- Testing
- OFF Parkinson's Medication(s), OFF Deep Brain Stimulation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Parkinson Disease
Udall Project 2 Aim 2A&C
This protocol will leverage the novel (on-label, FDA-approved) local field potential measuring capability of the Medtronic Percept™ PC or RC DBS system to study the effects of globus pallidus internus, globus pallidus externus…
- Trial name
- NCT05656586
- Testing
- observational-- no intervention
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Brain Imaging
A Pilot Study of a Portable Head-Only MRI Scanner
This is a pilot study to demonstrate human brain imaging with a new portable 0.7 Tesla (T) MRI brain scanner recently developed at the CMRR.
- Trial name
- NCT07444034
- Testing
- 0.7 T MRI
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Smoking, Smoking Cessation
Addressing Parental Tobacco Use in Somali Immigrant Families: Adapting an Evidence-Based Intervention in Primary Care
This study will modify an existing evidence-based parental tobacco cessation intervention (the Clinical Effort Against Secondhand Smoke Exposure, or CEASE) delivered in pediatric primary care clinics to address shared tobacco use…
- Trial name
- NCT06839729
- Testing
- CEASE+
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
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