Clinical trials: sponsored by University of Minnesota
Cardiac Surgery
Validation and Feasibility of Noninvasive Oxygen Delivery Index Monitoring in Cardiac Surgery Patients
This study will establish the feasibility and preliminary validity of real-time oxygen delivery index (DO₂i) monitoring using noninvasive hemoglobin (SpHb, Masimo) and minimally invasive cardiac output (FloTrac, Edwards) in…
- Trial name
- NCT07573306
- Testing
- SpHb monitor
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Minnesota
Refractory Epilepsy, Deep Brain Stimulation
Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection.
- Trial name
- NCT05493722
- Testing
- Physician-Selected Settings Stimulation, Optimized Settings Stimulation, DBS Setting Optimization
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Memory Loss, Alzheimer Disease
The PorchLight Project
The proposed project is a fully embedded pragmatic trial (R01), following an R61 pilot collaboration with Lutheran Social Service of Minnesota (LSS-MN).
- Conditions
- Memory Loss, Alzheimer Disease, Dementia
- Trial name
- NCT05550727
- Testing
- PorchLight
- Where
- United States
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hip Fractures
Comparison of Cryoablation of Pericapsular Nerve Group (PENG) to Fascia Iliaca Catheter in Patients With a Hip Fracture
The purpose of this study is to determine if patients with hip fractures who undergo cryoablation of the PENG have improved pain control 30 days from surgery when compared to those who have a fascia iliaca catheter.
- Trial name
- NCT06278987
- Testing
- PENG block and cryoablation, fascia iliaca compartment block
- Sponsor
- University of Minnesota
Aging
Technical Development of Multi-Parametric Renocerebral MRI
The purpose of the study is to investigate the associations of the age-related changes in the brain, kidneys and cognitive performance in healthy adults by utilizing multiple anatomic and functional MRI methods along with a…
- Trial name
- NCT02831335
- Testing
- MRI, Group 4
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Patellar Dislocation
The Impact of Tibial Tubercle-trochlear Groove Distance and Patellar Height on the Outcome of Isolated Medial Patellofemoral Ligament Reconstruction
The investigators plan to perform a prospective observational cohort study of patients undergoing MPFL reconstruction for the treatment of episodic patellar instability in the absence of significant degenerative disease.
- Trial name
- TT-TG Outcome (NCT03076008)
- Testing
- Observational
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- University of Minnesota
Low Back Pain
Feasibility of Identifying Brain Mechanisms of Qigong and Behavioral Outcomes After Qigong Practice in People With Chronic Low Back Pain
The long-term objective of this investigation is to identify how Qigong affects brain function in brain areas relevant to patients with chronic low back pain (cLBP), thereby setting a foundation from which to perform further…
- Trial name
- NCT04164225
- Testing
- Qigong Exercise, P.Volve Exercises
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Health Knowledge, Attitudes, Practice, Training
Evaluating the Effects of Reproductive Health Training on Provider Behavior
The goal of this randomized, controlled, single blinded trial is to evaluate the medium to long-term effects of an Afrocentric sexual health curriculum on health professional students' knowledge, attitudes, and clinical skills in…
- Trial name
- THP-2 (NCT06428058)
- Testing
- Comprehensive sexual health curriculum
- Where
- Tanzania
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Parkinson's Disease (PD), Deep Brain Stimulation
Coordinated Reset Deep Brain Stimulation for Parkinson's Disease
Deep brain stimulation (DBS) is a surgical implant procedure for the treatment of Parkinson's Disease (PD) utilizing medical devices approved by the FDA.
- Trial name
- CR DBS PD (NCT07340073)
- Testing
- DBS
- Volunteers
- 24 people
- Sponsor
- University of Minnesota
Cardiac Amyloidosis, Pacemaker
Elevated Rate Pacing of Cardiac Amyloidosis
This study aims to better quantify the improvements in heart failure symptoms and exercise tolerance before and after the heart rate elevation in a cohort of 10 cardiac amyloidosis patients with preexisting pacemakers.
- Trial name
- NCT07583823
- Testing
- Pacemaker Rate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Minnesota
Smoking Cessation, Cigarette Smoking
Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation
This pilot randomized controlled trial will test the feasibility of a smoking cessation intervention using mindful smoking practice and a smartphone-based sensor-band among adults who regularly smoke cigarettes.
- Conditions
- Smoking Cessation, Cigarette Smoking, Tobacco Use, Nicotine Dependence
- Trial name
- NCT07789496
- Testing
- Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Chronic Low Back Pain, Spinal Cord Injury
SERENITY Study of Chronic Pain Interference in Adults
SERENITY is a remote observational study designed to characterize inter-individual differences in chronic pain among adults with chronic low back pain and adults with spinal cord injury-related neuropathic pain.
- Conditions
- Chronic Low Back Pain, Spinal Cord Injury, Neuropathic Pain, Chronic Pain
- Trial name
- SERENITY (NCT07820475)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Minnesota
Preterm Birth, Very Preterm Infant
NICU-to-Home Dyadic Support for Very Preterm Infants and Families
This feasibility study will evaluate delivery of the Supporting Play Exploration and Early Development Intervention after neonatal intensive care unit discharge for very preterm infants and their families.
- Conditions
- Preterm Birth, Very Preterm Infant, Infant Development, Neonatal Intensive Care Unit
- Trial name
- MN-SPEEDI (NCT07820462)
- Testing
- Homebased SPEEDI, Telehealth SPEEDI
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Type 2 Diabetes Mellitus, Acute Kidney Injury
Clinical Decision Support for SGLT2i After AKI in Type 2 Diabetes
This pilot study will evaluate the feasibility of using a clinical decision support(CDS) message to support consideration of SGLT2 inhibitor prescribing in patients with type 2 diabetes who recently had acute kidney injury.
- Conditions
- Type 2 Diabetes Mellitus, Acute Kidney Injury, Chronic Kidney Diseases, SGLT2 Inhibitor Use
- Trial name
- NCT07868666
- Testing
- Clinical Decision Support Message
- Volunteers
- 250 people
- Sponsor
- University of Minnesota
Healthy
State Dependence of Prefrontal Transcranial Magnetic Stimulation
The study will examine whether the benefits of brain stimulation on mental functioning can be enhanced if an individual is actively engaging the target brain networks while receiving brain stimulation.
- Trial name
- NCT05962385
- Testing
- Brain state while receiving TMS
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Congenital Heart Disease, Cardiac Output
UltraTrac for Cardiac Output Monitoring in Congenital Heart Disease
This pilot feasibility study will evaluate UltraTrac, an investigational noninvasive wearable device for continuous cardiac output monitoring, in patients with congenital heart disease.
- Conditions
- Congenital Heart Disease, Cardiac Output, Hemodynamic Monitoring, Pediatric Heart Disease
- Trial name
- UltraTrac (NCT07866573)
- Testing
- UltraTrac
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Minnesota
Kidney Transplant; Complications, CMV
CMVIG Prophylaxis in Belatacept Conversion Kidney Transplant Recipients
The purpose of this study is to study how CMVIG interacts with the body and to see if it might work to prevent kidney transplant patients from becoming infected with CMV.
- Trial name
- NCT07096453
- Testing
- Cytogam
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Lennox Gastaut Syndrome (LGS), Epilepsy
Sleep-Driven Adaptive Neuromodulation in Lennox-Gastaut Syndrome
The goal of this clinical trial is to explore a new type of personalized brain stimulation that works during day time and night time hours using the Medtronic Percept Deep Brain Stimulation (DBS) device in patients with…
- Trial name
- ADAPT LGS (NCT07568860)
- Testing
- Personalized Adaptive Deep Brain Stimulation Therapy, Conventional Non-Personalized Deep Brain Stimulation Therapy
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Grip Strength, Hand Strength
Tyrannosaurus Flex: Finding the "Fair-ly Normal" Grip
The purpose of this study is to evaluate the performance of the Dinomometer and establish normative data to inform clinical standards and benchmarks for therapeutic practice.
- Trial name
- NCT07735195
- Testing
- Dinomometer
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Symptomatic Bradycardia, Cognitive Function
PACE Cognition Proof-of-Concept Study
This proof-of-concept study will evaluate whether physiologic pacemaker programming improves cognitive function and health status in patients with symptomatic bradycardia who require permanent pacemaker implantation.
- Conditions
- Symptomatic Bradycardia, Cognitive Function, Pacemaker, Health Status
- Trial name
- NCT07769424
- Testing
- Physiologic Pacemaker Programming, Standard Pacemaker Programming
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Minnesota