Clinical trials: sponsored by University of Nottingham
Renal Disease
Renal MR Feasibility in Renal Disease
To use Non-invasive MR Imaging of Renal Physiology and structure to assess patients with Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD).
- Trial name
- REMIND (NCT03578523)
- Testing
- 3 Tesla multiparametric MR, renal histopathology scoring, Blood and urine sampling
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Nottingham
Smoking Cessation
Hospital to Home, Smoker Support Trial
The present study is proposed to build on the investigators demonstration of the effectiveness of default delivery of smoking interventions in hospital inpatients by testing a multi-component intervention to prevent relapse to…
- Trial name
- HTH (NCT02767908)
- Testing
- Intervention
- Where
- United Kingdom
- Volunteers
- 404 people
- Sponsor
- University of Nottingham
Low Back Pain
Predictors of Self-management in Patients With Chronic Low Back Pain
Supported self-management (SM) is one of the key recommendations in management of chronic low back pain (CLBP). SM programmes for patients with CLBP have failed to show clinically meaningful improvement in pain and disability…
- Trial name
- NCT02636777
- Testing
- no intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 270 people
- Sponsor
- University of Nottingham
Stroke
Triple Antiplatelets for Reducing Dependency After Ischaemic Stroke
The risk of recurrence is greatest immediately after stroke or Transient Ischaemic Attack (TIA). Existing prevention strategies (antithrombotic, lipid/blood pressure lowering, endarterectomy) reduce, not abolish, further events.
- Trial name
- TARDIS (NCT01661322)
- Testing
- Aspirin, Dipyradimole, Clopidogrel
- Where
- United Kingdom
- Volunteers
- 3,096 people
- Sponsor
- University of Nottingham
Osteoarthritis of the Knee
Knee Osteoarthritis Risk in Retired Professional Footballers
The OA and Football Study is an epidemiological study designed to establish the prevalence of knee osteoarthritis in retired professional footballers.
- Trial name
- NCT02098044
- Where
- United Kingdom
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Premature Birth
HeartLight Pulse Study: Evaluation of Heart Rate Using an Electronic Stethoscope and Pre Placed ECG in the Delivery Room
This study will evaluate the accuracy of both an electronic stethoscope and electrocardiogram (ECG) to evaluate heart rate in neonatal patients in the delivery suite.
- Trial name
- HLPulseS (NCT02747069)
- Testing
- NICU electronic stethoscope, Newborns <32 weeks and ECG
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Nottingham
Deferred Umbilical Cord Clamping
Physiological Effects of Deferred Cord Clamping
This is an observational study to see if at birth, flow of blood from a placenta to the baby can be estimated non-invasively using Doppler ultrasound and/or cutaneous perfusion measured using a novel PPG sensor.
- Trial name
- DoppCord (NCT01864421)
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Nottingham
Infant, Newborn, Diseases, Fetus or Neonate Affected by Cesarean Section
HeartLight: Heart Rate Monitoring for Newborn Resuscitation
This study will compare a newborn heart rate sensor (HeartLight) that is integrated into a hat with other common forms of heart rate monitoring such as electrocardiography (ECG), stethoscope and pulse oximetry (PO) in newborn…
- Conditions
- Infant, Newborn, Diseases, Fetus or Neonate Affected by Cesarean Section, Infant, Premature, Diseases
- Trial name
- HeartLight (NCT02701920)
- Testing
- HeartLight hat, The HeartLight hat with in-built sensor, HeartLight
- Where
- United Kingdom
- Volunteers
- 184 people
- Sponsor
- University of Nottingham
Immature Newborn, Premature Birth
Gestational Age Assessment Tool
In the UK and worldwide many babies are born without carers knowing their gestation as the mothers will not have had good antenatal care. It is possible to estimate gestation but this requires a detailed clinical exam.
- Trial name
- GestATion (NCT02534194)
- Testing
- Image acquisition
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Liver Cirrhosis, Portal Hypertension
Can MRI Evaluate Beta-blocker Response in Portal Hypertension?
Aim: To test if MRI can detect meaningful changes in portal pressure in the liver to assess whether treatment with beta-blockers has worked. Liver Disease: Most people with liver disease do not have symptoms.
- Conditions
- Liver Cirrhosis, Portal Hypertension, Varix, Esophageal
- Trial name
- B-SMaRT (NCT03114813)
- Testing
- Carvedilol, MRI scan, Hepatic Venous Pressure Gradient (HVPG)
- Where
- 2 sites in United Kingdom
- Volunteers
- 68 people
- Sponsor
- University of Nottingham
Impulsive Behavior, Empathy
Effects of rTMS on Impulsivity and Empathy
Impulsivity describes the tendency to make risky and unplanned decisions, to pick immediate reward over a bigger reward after a period of time or to not be able to resist the urge to do something.
- Trial name
- NCT03200873
- Testing
- repetitive transcranial magnetic stimulation
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Dementia
Digital Reminiscence for People With Dementia
The purpose of this study is to explore the feasibility and acceptability of a digital reminiscence therapy (DRT) intervention for people with dementia (PwD). The objectives of this study include: 1.
- Trial name
- DTR (NCT03429686)
- Testing
- DRT Intervention
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sarcopenia
Characterizing the Incretin Effect of Amino Acids and Defining GLP-1 Role on Skeletal Muscle
This study has two protocols the aims of which are: 1. To identify age-related effects of AA on incretin secretion and whether and to what extent AA exhibit a true incretin effect (gut- mediated increases in plasma insulin) in…
- Trial name
- Incretin (NCT02370745)
- Testing
- GLP-1, Insulin Actrapid, Oral amino acids
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Carcinoma, Basal Cell, Intraoperative BCC Detection by Fast Raman Device
Intraoperative Detection of Residual BCC by Fast Raman
The main objective of this research is to develop a new scanning technology called the Fast Raman device, to accurately check the skin removed by the surgeon and detect any residual cancer cells; if found, additional skin can…
- Trial name
- NCT03482622
- Testing
- Fast Raman
- Volunteers
- 600 people
- Sponsor
- University of Nottingham
Mild Cognitive Impairment
The Effects of Diet on Mood, Cognition and Appetite
A previous study has found that the consumption of a high fat, low carbohydrate meal results in increased feelings of calmness, friendliness and an increase in subjective energy levels in comparison to a low fat, high…
- Trial name
- NCT01201616
- Testing
- High Fat Low Carbohydrate Diet, Low fat High Carbohydrate Diet
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sepsis
Effect of Lipopolysaccharide on Skeletal Muscle Functions
The investigators aim to examine how the skeletal muscles of the human volunteers respond to experimental septic conditions to aid understanding of muscle wasting and its biology..
- Trial name
- LPS (NCT01423968)
- Testing
- Lipopolysaccharide infusion, saline
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Insulin Resistance, Obesity
The Effects of Orange Juice on Plasma Lipids
The aim of this study is primarily to investigate the ability of antioxidants found in orange juice (OJ) to improve the serum lipid profile.
- Conditions
- Insulin Resistance, Obesity, Dyslipidemia
- Trial name
- NCT01350843
- Testing
- Orange Juice
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Obesity, Metabolic Syndrome
Influence of the Constancy of Daily Meal Pattern on Energy Balance, Glucose Profiles an Appetite in Healthy Women
In this study we will compare the health effect of two different meal patterns. In one subjects will consume food according to an 'irregular meal pattern' (3-9 meals/day) and the other 'regular meal pattern' (6 meals/day) for two…
- Trial name
- NCT02052076
- Testing
- Meal pattern
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Insulin Resistance
Meal Pattern and Metabolic Parameters
In this study investigators will compare the health effect of two different meal patterns. In one, participants will consume food according to an 'irregular meal pattern' (minimum 3 meals, maximum 9 meals per day) and in the…
- Trial name
- NCT02582606
- Testing
- Regular meal pattern, Irregular meal pattern
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Type 2 Diabetes
Study Looking at Cardiovascular Effects of Exenatide, Its Blood Pressure Lowering Effect and Its Mechanisms
Exenatide is a new drug which lowers blood sugar (glucose) levels for people with type 2 diabetes. It has significant advantages over other treatments such as insulin as it causes weight loss in a group of people that is…
- Trial name
- NCT01046721
- Testing
- Exenatide, Saline
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Nottingham