Clinical trials: sponsored by University of Nottingham
Time Restricted Feeding
Prolonged Overnight Fast, Energy Metabolism and Skeletal Muscle Anabolic Sensitivity
Recent research shows that timing of nutritional intake and daily periods of fasting may have important health effects. In humans, limiting daily food intake to a narrow window (typically ~8 hours) can bring about some beneficial…
- Trial name
- NCT05420181
- Testing
- Short 10hr fast, Long 16h fast
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Old Age, Long Term Care Facility
Co-producing a Novel Model an Outcome Framework for the Implementation of Falls Management in Care Home Settings.
AIM: To co-produce a novel model for implementation of falls management for older people living in care homes SECONDARY OBJECTIVES Component One Objectives: Primary :To co-produce a novel model for the implementation of falls…
- Conditions
- Old Age, Long Term Care Facility, Fall Prevention
- Trial name
- CHAFFINCH (NCT06947915)
- Testing
- Co-design workshop, Survey, Interview
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- University of Nottingham
Parental Imprisonment
Understanding the Impacts and Experiences of Children Currently Experiencing Parental Imprisonment
This research aims to understand the impacts, experiences, and support needs of children who are aged 16 years and above, currently experiencing parental imprisonment from their own perspective, and from the perspective of their…
- Trial name
- NCT07238010
- Testing
- Parental Imprisonment
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University of Nottingham
Dialysis Patients, Dialysis
Protein Supplementation During Dialysis (PROSED)
When a patient has dialysis some nutrients are lost in the process. Nutritional losses include protein, trace elements (i.e. zinc, copper and selenium) and water-soluble vitamins (Vitamins C and B).
- Conditions
- Dialysis Patients, Dialysis, Protein Energy Wasting, Protein Intake
- Trial name
- PROSED (NCT07237997)
- Testing
- High Protein Diet/Modular protein supplements will be used
- Where
- United Kingdom
- Volunteers
- 114 people
- Sponsor
- University of Nottingham
Chronic Pain, Limb Fracture
Chronic Pain Predictors in Major Trauma
The goal of this observational study is to learn about who is at risk of developing chronic pain in a major trauma population with at least one limb fracture.
- Trial name
- COPE: MT (NCT07237152)
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- University of Nottingham
Cerebral Autoregulation, Blood Pressure
Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation
Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically.
- Conditions
- Cerebral Autoregulation, Blood Pressure, Dynamic Cerebral Autoregulation
- Trial name
- RICE-DCA (NCT07179887)
- Testing
- Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Osteoarthritis, Knee
lIfestyle iNterventionS for PaIn ReliEf (INSPIRE)
This is a 2x2 factorial design randomised controlled trial in which participants with knee pain will be grouped into the diet intervention, exercise intervention, diet and exercise intervention or placebo arm.
- Trial name
- INSPIRE (NCT05670314)
- Testing
- Inulin Fibre supplement, Exercise
- Where
- United Kingdom
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Dry AMD, Diabetic Retinopathy (DR)
Microperimetry Changes in Retinal Function in Macular Disorders
The purpose of this study is to measure precisely how sensitive the central part of the retina - the light-sensitive film at the back of the eye, is to light.
- Trial name
- MAIAStud (NCT07170683)
- Testing
- MAIA Microperimetry, Microperimetry, Visual Acuity Measurement (logMAR)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Resilience, Psychological, Burnout, Professional
Impact of a Bespoke Mindfulness Intervention for Registered Dietitians on Resilience, Burnout and Stress
The goal of this randomised control trial is to find out whether a mindfulness based intervention can improve mental well-being for Registered Dietitians (RD) in the UK.
- Conditions
- Resilience, Psychological, Burnout, Professional, Stress, Psychological
- Trial name
- NCT07155512
- Testing
- Mindfulness based intervention
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Aging
Bedside Tests of Cardiorespiratory Fitness
A study of 64 older adults over the age of 65y to assess the utility of patient characteristics and bedside measures of physical function and muscle size to predict cardiorespiratory fitness.
- Trial name
- NCT06062784
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Knee Osteoarthritis, Knee Pain Chronic
Molecular Pathways Involved in Knee Pain
Knee osteoarthritis (OA) is the most common form of arthritis and the most common cause of knee pain in the world. The rate of knee arthritis is as high as that of cardiac disease and is the most common problem in individuals…
- Trial name
- NCT04443452
- Testing
- Quantitative Sensory Testing, Radiographic Evaluation, Ultrasound-guided Aspiration
- Where
- United Kingdom
- Volunteers
- 71 people
- Sponsor
- University of Nottingham
U-VNS, Sham U-VNS
Blinding and Adverse Effects of Ultrasonic Vagus Nerve Stimulation (U-VNS)
The vagus nerve is a large nerve that runs from the gut to the brain. It consists of two main sections, left and right, and comprises a series of branches. One of these branches runs through the ear.
- Trial name
- BLAST (NCT07091812)
- Testing
- Ultrasound Vagus Nerve Stimulation (U-VNS)
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Colorectal (Colon or Rectal) Cancer
An Observational Cohort Study to Assess the Postop Activity of Colorectal Patients Undergoing Elective Surgery (PHYSPAL)
All participants will have a physical activity monitor placed onto the right thigh in the midline which will start collecting data at midnight on the first postoperative day.
- Trial name
- PHYSPAL (NCT05934643)
- Testing
- ActivPAL accelerometer, Hospital Anxiety and Depression Scale (HADS) Questionnaire
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Nottingham
Colorectal Cancer, Colorectal Neoplasms
Supervised Exercise for Post-surgery Colorectal Cancer Patients
Participants will undergo preoperative baseline screening and will be randomised to either normal postoperative care or a 12-week supervised exercise programme comprising of both an aerobic and resistance component They will be…
- Trial name
- POSTEx (NCT05090215)
- Testing
- Aerobic and resistance training 12 week exercise programme, Venous blood sampling, Muscle Ultrasound
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Nottingham
Disorders of Consciousness
What is the Perceived Role of Risk in DOC Healthcare.
Critical ethnography exploring how decisions are made on behalf of people in disorder of consciousness (DOC). Prospective longitudinal case study design including observation, field interview and video reflexive ethnography.
- Trial name
- NCT06647433
- Testing
- Observation
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Hearing Loss, Hearing Loss, Noise-Induced
Understanding the Consequences of Recreational Noise Exposure
The aim of this study is to determine whether measures derived from Magnetic Resonance Imaging (MRI) scans, and clinical and behavioural measures of hearing loss, in the peripheral and central auditory system (ranging from the…
- Trial name
- NCT05076344
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Type 2 Diabetes, Prediabetes
Sweet Sensing in Type 2 Diabetes
Diabetes is a global challenge and the number of people affected by diabetes is expected to rise to 5.5 million by 2030, of which 90% are type 2 diabetes (T2D).
- Trial name
- NCT06804187
- Where
- United Kingdom
- Volunteers
- 505 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy Male Volunteers Over 65
Investigating the Digestibility, Bioavailability and Utilisation of Varied Combined Protein Sources in Older Males Using a Dual Stable Isotope Tracer Technique
By 2020, over 20% of the UK population will be over 65 years of age, dramatically increasing pressure on health and social care. Muscle mass is a strong predictor of healthy ageing and longevity.
- Trial name
- NCT07038655
- Testing
- Randomised 20g Protein Supplement
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Frailty at Older Adults, Pre-Frailty
The Effect of Pectin Supplementation on Geriatric With Frailty: A Randomised Placebo-Controlled Dietary Intervention Study
The study involves the intake of Low-methoxy (LM) pectin (polysaccharides extracted from citrus peels), which are commonly found in the UK diet (not pharmacological agents), to test their effects on systematic inflammation in the…
- Conditions
- Frailty at Older Adults, Pre-Frailty, Frailty, Diet
- Trial name
- GEOFF (NCT06955975)
- Testing
- Pectin, Whey protein
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Parkinson's Disease (PD)
Characterising Physiological Resilience in People With Parkinson's Disease
Parkinson's disease (PD) is a condition that affects movement and gets worse over time. It is more common in older adults. People with PD may have symptoms like shaking, stiff muscles, slow movement, and trouble with balance.
- Trial name
- ParkEx (NCT07013513)
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Nottingham