Clinical trials: sponsored by University of Oklahoma
Maternal Obesity
Evaluating Pyrroloquinoline Quinone (PQQ) for Improving Obese Pregnancy Outcomes
Maternal obesity (MO) affects 1 in 5 women and is strongly linked to increased birth weight, childhood/adolescent obesity, life-long metabolic and inflammatory disorders, and childhood neuropsychiatric disorders.
- Trial name
- EPyQ (NCT06245083)
- Testing
- Pyrroloquinoline quinone (PQQ)
- Where
- United States
- Sponsor
- University of Oklahoma
Asthma
Spirometric Response to Bronchial Thermoplasty in Patients With Severe Asthma
The investigators hypothesis is that there will be improvement in FEV1 in patients with severe asthma. This is a retrospective data study that reviews preexisting medical records; no patients will be enrolled.
- Trial name
- NCT02241265
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oklahoma
Cholesterol, Elevated, Diabetes Mellitus
Community Intervention to Improve CVD Risk Factor Control in Young American Indians
American Indians are more likely to die from heart disease compared to other people in the United States. High levels of fat (lipids) and sugar (glucose) in the blood are related to heart disease.
- Trial name
- CIRCLE (NCT06230705)
- Testing
- Guided management, Self management
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- University of Oklahoma
Tooth Discoloration, Dentin Sensitivity
Efficacy and Safety Assessment of Experimental Bleaching Agents
Tooth bleaching is widely used to treat the colors of teeth. This study compares the efficiency of two experimental bleaching gels, with and without nanoparticles, and with and without light activation versus two commercial…
- Conditions
- Tooth Discoloration, Dentin Sensitivity, Patient Satisfaction
- Trial name
- NCT06802614
- Testing
- BLEACHING GEL A, 5% NF_TiO2, BLEACHING GEL B
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Covid19
Community-engaged Approaches to Testing in Community and Healthcare Settings for Underserved Populations
The pandemic caused by the novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has resulted in substantial global morbidity and mortality including in Oklahoma and caused unprecedented interruptions…
- Trial name
- CATCH-UP (NCT04870307)
- Testing
- Dissemination and Implementation Research
- Where
- United States
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cigarette Smoking, Nicotine Dependence
Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties
The proposed pilot project is designed to evaluate the feasibility and potential efficacy of offering small financial incentives for the completion of smoking cessation counseling and self-reported abstinence at follow-up among…
- Trial name
- CLIMB (NCT05095779)
- Testing
- Coaching calls, Nicotine replacement therapy, Financial Incentives
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Substance Use Disorders, Mental Health Impairment
Homeless Care Management App
There is a significant revolving door of incarceration among homeless adults, a population with substantial health disparities. Homeless adults who receive the professional coordination of individualized care (i.e., case…
- Conditions
- Substance Use Disorders, Mental Health Impairment, Health Behavior, Adherence, Patient
- Trial name
- Link2Care (NCT03399500)
- Testing
- In-Person Case Management at Homeless Recovery Program, Unlimited Smartphone, Smartphone Based Case Management (SPCM) app
- Where
- 2 sites in United States
- Volunteers
- 403 people
- Sponsor
- University of Oklahoma
Nutrition Poor, Health Behavior
Virtual Technical Assistance for Child and Adult Care Food Program in Family Child Care Home
This study evaluates the effect of a fully virtual nutrition technical assistance training program for family child care home providers on the food they serve young children in their care and the food environment in their home.
- Trial name
- NCT04345874
- Testing
- Nutrition technical assistance, Children's environmental health technical assistance
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Smoking, Cigarette
Perceptions of Cigarette Smoking in Young Adults
This study focuses on menthol (n = 125) and non-menthol (n = 125) smoking young adults (YAs; defined here as ages 18 to 26).
- Trial name
- PRISM (NCT03953508)
- Testing
- Cigarette flavor type
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Asthma in Children, Asthma Attack
Timely Administration of IV Magnesium Sulfate in Patients With a Moderate Asthma Exacerbation
This study aims to identify whether early administration of magnesium sulfate in moderate asthma exacerbations can potentially avoid admission, decrease length of stay in the emergency department (ED), decrease length of stay…
- Trial name
- NCT06137040
- Testing
- Magnesium Sulfate within the first hour, No Magnesium sulfate within the first hour
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Vaginal Prolapse
Sacrocolpopexy With Posterior Repair Obstructed Defecation Symptoms
Participants who undergo laparoscopic sacrocolpopexy (LSCP) plus posterior repair (PR) will demonstrate greater improvement bowel symptom scores compared to participants who undergo LSCP alone at 3 months postoperatively.
- Trial name
- NCT03658395
- Testing
- Laparoscopic Sacrocolopopexy, Posterior repair
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Oklahoma
Post Operative Pain
Effect of Gabapentin on Post-Operative Pain in Minimally Invasive Sacrocolpopexy
Enhanced recovery after surgery (ERAS) has been synonymous with increasing non-opioid multimodal therapies and decreasing opioid therapies after surgery to improve perioperative care.
- Trial name
- GPOP (NCT05609682)
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Oklahoma
Substance Use Disorders, Pregnancy Related
Substance Use Treatment and Access to Resources (STARS) Project
This study is evaluating a randomized clinical trial and a quasi-experimental observational study combined. Pregnant women with substance abuse issues are referred to the Substance Use Treatment and Recovery (STAR) prenatal…
- Conditions
- Substance Use Disorders, Pregnancy Related, Child Neglect
- Trial name
- NCT04459000
- Testing
- STARS + maternal Attachment Biobehavioral Catchup home visiting model, STARs Only
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- University of Oklahoma
Stroke, Mild Cognitive Impairment
tDCS for Post-Stroke Cognitive Impairment
This study will evaluate the effects of a form of non-invasive brain stimulation on brain functioning and memory in participants with post-stroke cognitive impairment (PSCI).
- Trial name
- NCT06516588
- Testing
- Transcranial Dirrect Current Stimulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Oklahoma
Anesthesia
Needle-Free Lidocaine Injection vs Traditional Local Anesthesia in Infant Lumbar Puncture
We hypothesize that the J-Tip needle-free jet-injection system offers comparable pain control and greater provider satisfaction due to its less invasive nature compared to traditional needle infiltration of 1% lidocaine in…
- Trial name
- NCT06552351
- Testing
- Needle-Free Jet Injection of 1 % lidocaine, traditional needle infiltration of 1% lidocaine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Tobacco Cessation, Tobacco Use
Persistent Poverty Counties Pregnant Women With Medicaid
Although many women initially quit smoking during pregnancy, most will return to smoking by the end of pregnancy or during the first 6 months postpartum.
- Conditions
- Tobacco Cessation, Tobacco Use, Tobacco Smoking, Smoking Cessation Financial Incentives
- Trial name
- NCT05415371
- Testing
- Standard Care + Financial Incentives, Standard Care
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cigarette Smoking
Mobile Health Technology for Personalized Tobacco Cessation Support Among Cancer Survivors in Laos
The parent project (1R21CA253600-01, R21 phase: 9/1/2020-8/31/2022, R33 phase: 9/1/2022-8/31/2025) aims to adapt and evaluate the efficacy of our theoretically and empirically based mobile health (mHealth) technology to help…
- Trial name
- SurvLaos (NCT05253573)
- Testing
- Nicotine patch, Self-help materials (to support smoking cessation), Smartphone-based automated treatment for smoking cessation
- Where
- 2 sites in Laos
- Volunteers
- 80 people
- Sponsor
- University of Oklahoma
Pancreatic Cancer
Exercise and Nutrition to Improve Pancreatic Cancer Outcomes
This is a blinded pilot study in which patients scheduled for pancreaticoduodenectomy for pancreatic or related cancers are randomized to dietary counseling and home exercise at high weekly frequency, either with or without…
- Trial name
- NCT03256201
- Testing
- Nutritional Counseling, Standard Exercise, Enhanced Exercise
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- University of Oklahoma
Edentulous Alveolar Ridge
Implant Stability in Autogenous Mineralized and Demineralized Dentin Grafts
The bone grafting materials currently used in dentistry are autografts, allografts, xenografts, and alloplastic grafts. Among these different types of bone graft materials, autografts are considered to have the most predictable…
- Trial name
- NCT05219305
- Testing
- Dental Implant Placement
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Carcinosarcoma, Ovarian
Paclitaxel/Carboplatin + Galunisertib for Patients With Carcinosarcoma of the Uterus or Ovary
This is a Phase 1 B feasibility trial with Galunsertib, a TGFβ inhibitor, in combination with carboplatin/paclitaxel in patients with newly diagnosed, persistent or recurrent carcinosarcoma of the uterus or ovary.
- Trial name
- NCT03206177
- Testing
- Galunisertib, Paclitaxel, Carboplatin
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Oklahoma