Clinical trials: sponsored by University of Pennsylvania
Suicide
Army-SPRING Army-Suicide Prevention Research
Every unit in the Connecticut Army National Guard has a Suicide Intervention Officer to provide suicide intervention education awareness for their unit, monitor for soldiers in crisis and connect soldiers with helping resources…
- Trial name
- NCT06547008
- Testing
- Army-SPRING, Risk Reduction Group (Control)
- Where
- 3 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Primary Progressive Aphasia
Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS
This is a double-blind, sham-controlled, crossover study in which subjects with the non-fluent/agrammatic and logopenic variants of primary progressive aphasia (naPPA and lvPPA, respectively) will undergo language testing and…
- Trial name
- NCT04046991
- Testing
- high-definition transcranial direct current stimulation, modified constraint-induced language therapy
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Pennsylvania
HIV/AIDS
Enhancing the Organizational Social Context to Improve Viral Suppression and Retention in HIV Care
Despite the widespread use of effective antiretroviral therapy (ART), the HIV epidemic continues to impact racial and ethnic minority populations disproportionately.
- Trial name
- NCT06462807
- Testing
- ARC
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- University of Pennsylvania
End Stage Renal Disease
Light Therapy in End Stage Kidney Disease
The goal of this clinical trial is to test light therapy in patients with end stage kidney disease who are receiving hemodialysis. The main aim is to determine if light therapy decreases fatigue severity.
- Trial name
- NCT06310161
- Testing
- Bright light, Dim Light
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Anxiety, Depression
Weighted Blankets for Dental Anxiety
The objective of this project is to determine the effectiveness of weighted blankets as an anxiety-reducing intervention for neurotypical adult patients with dental anxiety undergoing routine dental procedures at the University…
- Trial name
- NCT07879846
- Testing
- Blanket at visit 1., No blanket at visit 1, Blanket at visit 2.
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
HIV, Hypertension
Tracking Income Dynamics and Everyday Health Study
Among adults with chronic illnesses like hypertension, diabetes, or HIV, adherence to daily oral medications is essential but often below 50%.
- Conditions
- HIV, Hypertension, Hypercholerolemia, Type 2 Diabetes
- Trial name
- TIDES (NCT07862452)
- Testing
- Preventative health review invitation early in SNAP cycle, Financial counseling invitation early in the SNAP cycle, Aim 3 follow-up call early in the SNAP period
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Pennsylvania
Autism Spectrum Disorder
Reducing Challenging Behaviors in Children With Autism Through Digital Health
School-based behavioral approaches to managing challenging behaviors in children with ASD are limited by three key factors: 1) children with ASD often have difficulties communicating their emotions; 2) it is challenging to…
- Trial name
- NCT05277194
- Testing
- KeepCalm app
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Pennsylvania
Neurodegenerative Disease
PET Tau - Neurodegenerative Disease Imaging
The purpose of this study is to measure the amount of a protein in the brain known as tau using an imaging procedure called Positron Emission Tomography (PET/CT).
- Trial name
- NCT03143374
- Testing
- 18F-AV-1451
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pulmonary Hypertension
Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass
Patients with pulmonary arterial hypertension (PAH) are at increased risk of muscle loss and decreased physical activity. This study will aim to (1) understand the way in which muscle loss occurs in PAH, particularly the role of…
- Trial name
- MUSCLE UP-PH (NCT07132788)
- Testing
- blood draw, Short Performance Physical Battery, Grip strength test
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Pennsylvania
Obesity, Childhood
Food Genetics Behavior Study
A genetic risk for obesity does not always translate to the development of obesity among children, which points to the presence of risk-modifying factors that likely relate to energy balance behaviors as key behavioral drivers.
- Trial name
- FOODIE (NCT05783765)
- Testing
- Heightened Drive to Eat
- Where
- United States
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Ketosis, Alcohol Drinking
Effects of Ketone Supplement and Alcohol on Brain Metabolism
The research study is being conducted to better understand the effects of ketones and alcohol on brain functioning and brain metabolism.
- Conditions
- Ketosis, Alcohol Drinking, MRI
- Trial name
- NCT06815237
- Testing
- Kenetik, Alcohol beverage
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Urinary Incontinence, Urge
Mobility and Voiding Exercises in Older Women With Urinary Incontinence (MoVEonUp)
A prospective, two-arm randomized clinical trial utilizing a multidimensional intervention to reduce falls in older women with Urinary Urge Incontinence.
- Trial name
- MOVEONUP (NCT05375344)
- Testing
- Exercise Group
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- University of Pennsylvania
Myeloma
Study of Belantamab Mafodotin as Pre- and Post-autologous Stem Cell Transplant and Maintenance for Multiple Myeloma
This is a single-institution, single-arm, phase 2 study in which belantamab mafodotin (GSK2857916), an antibody-drug conjugate targeting B-cell maturation antigen (BCMA), will be administered to patients with multiple myeloma…
- Trial name
- NCT04680468
- Testing
- Belantamab mafodotin
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Pennsylvania
Hypertension, Diabetes
Randomized Clinical Trial to Improve Mobility After Hospitalization
The objective of this study is to test the feasibility of using behavioral economic interventions (gamification with social incentives) to increase physical activity after hospital discharge to reduce incident mobility disability…
- Conditions
- Hypertension, Diabetes, Heart Failure, Ambulatory Difficulty
- Trial name
- MOVE_ON (NCT05736484)
- Testing
- Social Support Gamification
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Pennsylvania
Anxiety
Effect of cTBS on Startle and TMS-evoked BOLD
The right dorsolateral prefrontal cortex (dlPFC) is increasingly being targeted with transcranial magnetic stimulation (TMS) to reduce anxiety expression; however, there is little mechanistic evidence supporting an optimized…
- Trial name
- NCT07415772
- Testing
- Active TMS
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Renal Insufficiency, Chronic
SDCC - Prospective Cohort Study of Chronic Renal Insufficiency
Chronic kidney disease (CKD) is a silent epidemic affecting more than 37 million Americans. The burden of morbidity and mortality associated with CKD derives from its frequent progression to end-stage kidney disease (ESKD) and…
- Trial name
- CRIC (NCT00304148)
- Where
- 12 sites in United States
- Volunteers
- 5,499 people
- Sponsor
- University of Pennsylvania
Liver Diseases
Biomarker-guided Reduction of Immunosuppression in Liver Transplant Recipients (BRITRE)
Researchers are interested in determining whether it is safe to reduce anti-rejection medication by approximately 50% after liver transplantation and whether special blood tests called biomarkers can identify early signs that the…
- Trial name
- BRITRE (NCT07862439)
- Testing
- miRNA Biomarker-Guided Immunosuppression Minimization, Conventional Biochemical Monitoring-Guided Immunosuppression Minimization
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Pennsylvania
Cholangiocarcinoma, Colorectal Cancer
TCR1188-ABC Cells in KRAS-mutated Cancers
This is a Phase I, open-label dose finding study to assess the safety, manufacturing feasibility, and preliminary efficacy of TCR1188-ABC cells in patients with KRAS-mutated cancers.
- Conditions
- Cholangiocarcinoma, Colorectal Cancer, Non-Small Cell Lung Cancer, Pancreatic Adenocarcinoma
- Trial name
- NCT07594067
- Testing
- TCR1188-ABC cells, Fludarabine + Cyclophosphamide combination, Tocilizumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Estrogen Receptor Positive Breast Cancer, Bone Metastases
FDG PET/CT in Breast Cancer Bone Mets
This study will evaluate baseline uptake on a FDG PET/CT scan in patients with breast cancer that has spread to the bones. A repeat FDG PET/CT scan will be done 4 weeks after the start of new breast cancer hormone treatment and…
- Trial name
- NCT01996046
- Testing
- FDG PET/CT scan
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Pennsylvania
Parkinson Disease, Parkinson Disease Dementia
Parkinson's Disease and Movement Disorders Clinical Database
The research database contains demographic and family history information, longitudinal information on the clinical symptoms, neuropsychological profile and treatments, stored biological samples, and brain images of patients with…
- Conditions
- Parkinson Disease, Parkinson Disease Dementia, Lewy Body Parkinson Disease, Lewy Body Dementia With Behavioral Disturbance
- Trial name
- NCT04997642
- Testing
- neuropsychiatric and cognitive testing questionnaires
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Pennsylvania
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