Clinical trials: sponsored by University of Toronto
Change in Serum 25 Hydroxyvitamin D Levels
Mozzarella Cheese Vitamin D and Bioavailability
The purpose of this study is to evaluate the effect of heat on the bioavailability of vitamin D in industrially fortified mozzarella cheese baked with pizza.
- Trial name
- NCT01919905
- Testing
- Vitamin D
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Food Intake Regulation, Substrate Oxidation
Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men
The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.
- Trial name
- NCT01888991
- Testing
- Glucose Preload and Exercise Intervention
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Health, Appetite Regulation
Sodium Alginate in Chocolate Milk, Satiety and Glycemic Control
This study compares the effects of isovolumetric (325 ml) preloads of chocolate milk supplemented with sodium alginates at incremental doses on inter-meal glucose levels, appetite scores and food intake in healthy adult men.
- Conditions
- Health, Appetite Regulation, Glucose Metabolism
- Trial name
- NCT01877460
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Hypercholesterolemia, Cardiovascular Diseases
Low Carbohydrate Portfolio or "Eco-Atkins" Diet
Exchange of the butter, eggs, cheese and meat in the Atkins diet for soy protein foods, other vegetable proteins including gluten and vegetable fats, nuts, avocado, olive and canola oil will result in dramatic rather than modest…
- Trial name
- NCT00256516
- Testing
- Eco-Atkins diet (high vegetable protein and vegetable fat), NCEP diet
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Glycemic Control, Gastrointestinal Hormone Response
Mechanism of Action of Milk and Its Components on Glycemic Control in Healthy Young Men
The investigators hypothesize that the physiological effects of milk on satiety and glycemic control are mediated by the interaction between its macronutrient components by both insulin-dependent and independent mechanisms.
- Conditions
- Glycemic Control, Gastrointestinal Hormone Response, Healthy Young Men
- Trial name
- NCT01812967
- Testing
- Milk Fat, Milk Protein, Lactose
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cardiovascular Disease, Diabetes
The Effect of Continuous Sipping of a Glucose Solution on Markers of Oxidation in Men and Women
The objective of this study is to determine the effect of reducing the rate of glucose absorption on oxidative stress after eating and to compare it with the effects of vitamin C.
- Trial name
- AOGI (NCT01440790)
- Testing
- glucose bolus, Glucose sipping, Glucose bolus plus 1g vitamin C
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes, Gestational
The Effect of a Low Glycemic Index Diet on Blood Sugar Control in Pregnant Women at Risk for Gestational Diabetes
Gestational diabetes mellitus (GDM) is a condition in which high blood sugar levels occur during pregnancy. GDM increases the risk of medical complications during pregnancy which may harm the mother and her baby.
- Trial name
- NCT01105455
- Testing
- Nutrition education
- Where
- Canada
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Obesity
Glucose, Whey Protein and Time to the Next Meal on Mealtime Food Intake in Children
The investigators hypothesize that glucose and whey protein given 30 and 60 min before a pizza meal will exert different effects on food intake in adolescent children, and will depend on pubertal stage.
- Trial name
- NCT01272427
- Testing
- water with glucose, water and whey protein, water with noncaloric sweetener
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetic Macular Edema
Anterior and Posterior Segment Vascular Changes Following Laser and Anti-Vascular Endothelial Growth Factor (VEGF) Treatment of Diabetic Retinopathy
The study will investigate changes in the structure and function of blood vessels in the front and back of the eye following laser and anti-VEGF treatments for sight-threatening diabetic eye disease.
- Trial name
- VEGF (NCT01196325)
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Branch Retinal Artery Occlusion, Central Retinal Artery Occlusion
Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye
Canadians fear loss of vision more than any other disability. Vision loss has an enormous impact on quality-of-life and is extremely costly from a societal and economic perspective.
- Conditions
- Branch Retinal Artery Occlusion, Central Retinal Artery Occlusion, Branch Retinal Vein Occlusion, Central Retinal Vein Occlusion
- Trial name
- NCT01348633
- Where
- Canada
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Age Related Macular Degeneration, Glaucoma
Prospective Study Phase: Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye
Canadians fear loss of vision more than any other disability. Vision loss has an enormous impact on quality-of-life and is extremely costly from a societal and economic perspective.
- Conditions
- Age Related Macular Degeneration, Glaucoma, Diabetic Retinopathy.
- Trial name
- NCT01348672
- Where
- Canada
- Volunteers
- 381 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Pain
Evaluating Lanolin for the Treatment of Nipple Pain Among Breastfeeding Women
The purpose of this study is to evaluate the effectiveness of lanolin for the treatment of painful/damaged nipples among breastfeeding women, and to evaluate if the use of lanolin has an effect on breastfeeding outcomes such as…
- Trial name
- LanP (NCT01420419)
- Testing
- Lanolin, Standard (usual) in-hospital and community postpartum care
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- University of Toronto
Hypertension
Attitudes and Understanding of Sodium Claims on Food Labels
Sodium-related claims on food labels should help people find lower sodium food choices; however consumer attitudes and understanding of such claims are unknown.
- Trial name
- NCT01764724
- Testing
- Mock package questionnaire
- Where
- Canada
- Volunteers
- 987 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 2 Diabetes, Cardiovascular Disease
Effect of Nuts vs. a Wheat Bran Muffin in Type 2 Diabetes
To determine if tree nuts (Almonds, Hazelnuts, Pistachios, Peanuts, Macadamia nuts, Pecans, Walnuts and Cashews) improve glycemic control in type 2 diabetes, as assessed by HbA1c and serum fructosamine, and to assess whether…
- Conditions
- Type 2 Diabetes, Cardiovascular Disease, Diet Therapy
- Trial name
- NCT00410722
- Testing
- Whole wheat and bran muffin, Mixed tree nuts
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Toronto
Immunization
Testing Educational Materials in a Paediatric Setting
Immunization procedures are a common source of iatrogenic pain for infants. A recently developed clinical practice guideline, led by Taddio et al., created evidence-based strategies for management of immunization pain.
- Trial name
- NCT01713322
- Testing
- Pain management education, No pain management education
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Pregnancy, Childbirth and the Puerperium
A Pilot Randomized Controlled Trial of Repeated Hands-and-Knees Positioning During Labour
The investigators designed a pilot randomized controlled trial to assess the feasibility and acceptability of repeated hands-and-knees positioning during labour.
- Trial name
- LPT2 (NCT01720004)
- Testing
- Repeated hands-and-knees positioning during labour
- Where
- 2 sites in United States, Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Food Intake Regulation
The Effects of Ad Libitum Pre-Meal Raisin Snack on Satiety and Food Intake in Children
No studies have reported the effect of pre-meal snacking on raisins compared to other commonly consumed snacks on energy intake in children.
- Trial name
- NCT01712737
- Testing
- Dietary intervention
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Healthy Infants, Immunization
A Study of Two Injection Techniques to Reduce Pain in Infants Undergoing Immunization
Immunization injections are a significant source of pain for infants. Tactile stimulation (rubbing/applying pressure) may be an effective and feasible pain-relieving intervention - it is cost neutral, and has been shown to be…
- Conditions
- Healthy Infants, Immunization, Pain Management
- Trial name
- NCT01601197
- Testing
- Tactile stimulation
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Infertility, In-vitro Fertilization
NuvaRing vs. Oral Contraceptive Pills (OCP) for In-Vitro Fertilization (IVF) Pre-treatment
The newly designed contraceptive ring, Nuvaring has a lower total steroid dose, and medications are delivered locally. It has been proven to be as safe and effective as the combined OCP in ovarian suppression and preventing…
- Trial name
- NCT01298128
- Testing
- NuvaRing, marvelon
- Volunteers
- 70 people
- Sponsor
- University of Toronto
Pressure Ulcers, Multi-disciplinary Wound Care Teams
Pressure Ulcer Multi-disciplinary Teams Via Telemedicine (PUMTT): A Trial in Long Term Care
The purpose of this study is to evaluate the effectiveness of 'enhanced' multi-disciplinary wound care teams (MDTs) vs. 'usual' care teams in Long Term Care (LTC) facilities in Ontario for the treatment of pressure ulcers.
- Conditions
- Pressure Ulcers, Multi-disciplinary Wound Care Teams, Remote Support, Digital Wound Photography
- Trial name
- PUMTT (NCT01232764)
- Testing
- Exposure to multi-disciplinary wound care team
- Where
- Canada
- Volunteers
- 137 people
- Sponsor
- University of Toronto