Clinical trials: sponsored by University of Toronto
Glycemic Control, Satiety Response
Postprandial Glycemia and Satiety of Meals With Potatoes, With and Without Protein
The proposed study aims to simulate a meal eaten at home, where meals will provide a fixed amount of protein from beef or vegetarian substitute "meat" balls with ad libitum access to one of mashed potatoes, full-fat fries, or…
- Conditions
- Glycemic Control, Satiety Response, Appetite Regulation, Diabetes
- Trial name
- NCT05610124
- Testing
- Ad libitum full-fat French fries with beef meatballs, Ad libitum instant mashed potatoes with beef meatballs, Ad libitum macaroni pasta with beef meatballs
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Anesthesia, Conduction, Arthroplasty, Replacement, Knee
Inter-fascial Plane Between the SArtorius Muscle and FEmoral Artery (ISAFE)
Total knee arthroplasty (TKA) is a frequent performed surgery. Adequate pain management is an important feature. Analgesic duration of single shot nerve blocks is limited to no more than 24h.
- Trial name
- ISAFE (NCT05313269)
- Testing
- ISAFE technique for adductor canal catheter insertion, Conventional technique for adductor canal catheter insertion
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Mobility Limitation, Balance Impairment
TIME™ at Home Feasibility Study: Evaluation of a Virtually Delivered, Community-based, Task-oriented Exercise Program
Balance and mobility limitations can lead to increased difficulty with everyday function and increased dependence on caregivers.
- Trial name
- NCT05369741
- Testing
- TIME™ at Home
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Toronto
Metabolic Disturbance
The Influence of Different At-home Exercise Strategies on 24h Glycemic Control
This study will determine how different at-home exercise strategies influence 24hr glycemic control in women with metabolic dysfunction.
- Trial name
- NCT05490706
- Testing
- Bodyweight interval exercise, Walking
- Where
- Canada
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Breastfeeding, Breastfeeding, Exclusive
Parkdale Infant Nutrition Security Targeted Evaluation Project: Infant Feeding
In Toronto Ontario, the Parkdale Community Health Centre operates a community outreach program entitled Parkdale Parents' Primary Prevention Project (5P's).
- Conditions
- Breastfeeding, Breastfeeding, Exclusive, Infant Nutrition, Vulnerable Population
- Trial name
- PINSTEP-3 (NCT03400605)
- Testing
- Infant feeding questionnaire
- Where
- Canada
- Volunteers
- 203 people
- Sponsor
- University of Toronto
Surgical Education, Virtual Reality
Virtual Reality in Orthopaedic Surgical Education: A Randomized Controlled Trial
Immersive virtual reality (IVR) surgical simulators are increasingly being used for learner education. The aim of this randomized controlled trial is to compare the efficacy of IVR to hands-on orthopaedic workshop sessions (such…
- Conditions
- Surgical Education, Virtual Reality, Orthopaedic Training
- Trial name
- VR-ORS (NCT05830786)
- Testing
- Immersive virtual reality (IVR), Traditional hands on orthopaedic workshop group
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Dietary Proteins, Indicator Amino Acid Oxidation
The Effect of Dairy and Dairy-Free Alternative Beverages on Post-Exercise Anabolism in Active Youth
The growth and development of lean body mass (i.e., muscle and bone) is instrumental to health and performance across the lifespan, especially in youth, as they actively experience growth.
- Trial name
- PBS (NCT05827666)
- Testing
- 2% milk beverage, Almond milk alternative beverage, Soy milk alternative beverage
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Vaccination; Complications, Vaccine Adverse Reaction
Effectiveness of CARD for Improving School-Based Immunizations
Vaccination is estimated to have saved more lives in Canada than any other single intervention and is considered one of the most important advances in the prevention of disease.
- Conditions
- Vaccination; Complications, Vaccine Adverse Reaction, Fear
- Trial name
- NCT03966391
- Testing
- Multi-faceted knowledge translation intervention
- Where
- Canada
- Volunteers
- 8,839 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cardiovascular Diseases, Lipid Disorder
SRMA of the Effect of Soy Milk vs Cow's Milk on Cardiometabolic Outcomes
Dairy consumption has shown associations with decreased incidence of cardiometabolic diseases. With the growing interest in plant-based eating, and the mounting evidence for the cardiovascular benefits of plant forward diets…
- Conditions
- Cardiovascular Diseases, Lipid Disorder, Metabolic Disease, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT05637866
- Testing
- Soy milk
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
HIV
Evaluating a Community-Based Exercise Intervention With Adults Living With HIV: An Interrupted Time Series Study
The primary aim of this research is to evaluate a community-based exercise (CBE) intervention for adults living with HIV within the community with the goal of reducing disability and enhancing health (cardiopulmonary, strength…
- Trial name
- CBE (NCT02794415)
- Testing
- Community-based exercise
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of Toronto
Breast Cancer, Breast Cancer Stage I
Feasibility of a Remotely-Delivered Yoga Intervention on Cognitive Function in Breast Cancer Survivors
The purpose of this pilot study is to assess the feasibility of a remotely-delivered yoga intervention for breast cancer survivors.
- Conditions
- Breast Cancer, Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage III
- Trial name
- NCT05180656
- Testing
- Yoga Intervention
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University of Toronto
Global Health, Education
Can VAST Improve ACLS in Rwanda
Aim The purpose of this study is to determine if the addition of the VAST Course to technical resuscitation skills training enhances healthcare providers' resuscitation performance in a resource-limited setting.
- Conditions
- Global Health, Education, Resuscitation
- Trial name
- NCT05278884
- Testing
- Advanced Cardiac Life Support Training, Vital Anesthesia Simulation Training
- Where
- Rwanda
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Parkinson Disease, Memory Disorders
GPi+NBM DBS in Parkinson's Disease With Mild Cognitive Impairment
This study examines the safety and feasibility of DBS in treating the movement and cognitive dysfunction in Parkinson's disease (PD).
- Trial name
- 2T-DBS (NCT04571112)
- Testing
- NBM stimulation using the Vercise device (Boston Scientific, Marlborough, Massachusetts, US)
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of Toronto
Obesity, Type 2 Diabetes Mellitus
Effect of Pre-meal Serving of Dairy and Dairy Alternatives on Post-meal Satiety and Glycaemia in Healthy Young Adults
Regular consumption of dairy products is found to negatively associated with metabolic diseases and improve body composition in long term studies and has positive effect on acute glycemia control and satiety.
- Trial name
- NCT04600128
- Testing
- Dairy-based greek yogurt, Dairy-based cheddar cheese, Plant-based yogurt
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Toronto
HIV/AIDS, HIV Infections
HIV Self-Testing and Comic Intervention With Refugee Adolescents and Youth
HIV is the leading cause of death for adolescents and young people (AYP) in sub-SaharanAfrica (SSA). Uganda hosts 1.4 million refugees/displaced persons and the Bidi Bidi refugee camp in Northern Uganda is the second-largest…
- Conditions
- HIV/AIDS, HIV Infections, Knowledge, Attitudes, Practice
- Trial name
- NCT05213689
- Testing
- Educational comic book, HIV Self-testing
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cancer
Comprehensive Geriatric Assessment and Management for Canadian Elders With Cancer
A multicentre two-group parallel single-blind (outcome assessor) randomized controlled trial (RCT). A cost effectiveness study alongside a clinical trial using a payer and societal perspective to study the cost-effectiveness of…
- Trial name
- NCT03154671
- Testing
- Geriatric assessment and management
- Where
- 2 sites in Canada
- Volunteers
- 351 people
- Sponsor
- University of Toronto
Dementia
Mortality Risk Prediction Tool in Hospitalized Dementia Patients
The objective of this study is to develop and validate a clinical prediction tool to estimate 1-year mortality among hospitalized patients with dementia.
- Trial name
- NCT05371782
- Volunteers
- 298,576 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Mortality, Oral Health
De-adoption of Oral Chlorhexidine Prophylaxis and Implementation of an Oral Care Bundle (CHORAL)
The objective of the CHORAL study is to evaluate the de-adoption of oral chlorhexidine and the introduction of a bundle of oral care practices on selected outcomes in critically ill mechanically ventilated adults.
- Conditions
- Mortality, Oral Health, Dryness, Mouth, Pain, Orofacial
- Trial name
- CHORAL (NCT03382730)
- Testing
- Chlorhexidine Mouth Rinse, Chlorhexidine Mouth Rinse De-Adoption
- Where
- 5 sites in Canada
- Volunteers
- 3,260 people
- Sponsor
- University of Toronto
Amino Acids, Essential, Metabolism
Impact of Amino Acids to Enhance Anabolism After Home-based Exercise
An adequate quantity of lean body mass is vital for optimal health and performance, and is accrued when net protein balance (NPB) is positive.
- Conditions
- Amino Acids, Essential, Metabolism, Exercise
- Trial name
- B2B (NCT04850820)
- Testing
- Novel essential amino acid supplementation, Branched-chain amino acid supplementation (BCAA), Isocaloric carbohydrate supplementation
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Breastfeeding, Breast Pumping
Parkdale Infant Nutrition Security Targeted Evaluation Project: Focus Groups & Interviews
In Toronto Ontario, the Parkdale Community Health Centre operates a community outreach program entitled Parkdale Parents' Primary Prevention Project (5P's).
- Conditions
- Breastfeeding, Breast Pumping, Infant Nutrition, Vulnerable Population
- Trial name
- PINSTEP-2 (NCT03305406)
- Testing
- Focus groups, Interviews
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Toronto