Clinical trials: sponsored by University of Utah
Congenital Diaphragmatic Hernia, Pulmonary Hypertension
A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH)
Congenital diaphragmatic hernia (CDH) occurs in approximately 1 in 3000 US live births, similar to the incidence seen within the Utah Birth Defects cohort.
- Trial name
- NCT05201144
- Testing
- Sildenafil Oral Suspension
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Congenital Diaphragmatic Hernia
High Frequency Oscillatory Ventilation Versus High Frequency Jet Ventilation for Congenital Diaphragmatic Hernia
The purpose of this study is to conduct a prospective study of all congenital diaphragmatic hernia (CDH) neonates managed at the University of Utah newborn intensive care unit (NICU) and Primary Children's Hospital NICU that…
- Trial name
- NCT04774848
- Testing
- High Frequency Jet Ventilator, High Frequency Oscillatory Ventilator
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Diabetes Mellitus, Type 2, Insulin Resistance
The Acute T-Rex (Timing of Resistance Exercise) Study
The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Glucose Intolerance, Sleep Disturbance
- Trial name
- NCT06366399
- Testing
- Resistance Exercise Timing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
GTP Cyclohydrolase Deficiency
Study of Kuvan Treatment in Adults With GTPCH Deficiency
The purpose of this study is to identify the dose of Kuvan needed to normalize the levels of tetrahydrobiopterin (BH4) in patients with a Guanosine Triphosphate Cyclohydrolase (GTPCH) deficiency and to asses the potential impact…
- Trial name
- NCT01425528
- Testing
- Sapropterin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Elderly, Frail, Accidental Falls
Reconfiguring the Patient Room to Increase Patient Stability
Despite decades of research into patient falls, falls and the injuries incurred continue to be a serious threat to patient safety. Fall rates continue to be unacceptably high.
- Conditions
- Elderly, Frail, Accidental Falls, Hospitals
- Trial name
- NCT04003779
- Testing
- Room configuration
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Utah
Insomnia
A Novel Wearable Device to Improve Sleep Quality
The purpose of the study is to help determine if a wearable sleep wellness device improves sleep among adults with insomnia. This study will enroll a total of 60 participants for this remotly conducted study and randomize 1:1 for…
- Trial name
- NCT05952297
- Testing
- Sleep Wellness Device (BeCurie)
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Utah
Knee Pain Chronic
SMART Embedded Intervention for Military Postsurgical Engagement Readiness
The overarching objective of this proposal is to conduct a multi-site Sequential Multiple Assignment Randomized Trial (SMART) across multiple Military Health System (MHS) sites to optimize the sequencing and integration of two…
- Trial name
- SEMPER (NCT05050409)
- Testing
- Brief mindfulness, Mindfulness-Oriented Recovery Enhancement (MORE), Standard care
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Utah
Chronic Pain
Brief Mindfulness Intervention for Chronic Pain in Ukraine
This is a pragmatic randomized controlled trial comparing a single 15-minute mindfulness-based intervention to usual care for patients with chronic pain in Ukraine being seen in a pain clinic.
- Trial name
- NCT05383157
- Testing
- Brief mindfulness, Usual care
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- University of Utah
Chronic Pain
Feasibility and Acceptability Study of ACUAWARE
This study aims to gather preliminary feasibility and acceptability data to justify a subsequent trial that would fill a gap in knowledge regarding acupuncture therapy (AT) effects on interoceptive awareness (IA) among those with…
- Trial name
- ACUAWARE (NCT06145997)
- Testing
- Acupuncture therapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Utah
Early Detection of Cancer, Lung Neoplasms
Evaluation of a Scalable Decision Support and Shared Decision Making Tool for Lung Cancer Screening
The purpose of this project is to increase appropriate low-dose computed tomography (LDCT) lung cancer screening through the development and wide dissemination of patient-centered clinical decision support (CDS) tools that (1)…
- Trial name
- NCT04498052
- Testing
- EHR-integrated Shared Decision Making Tool and Clinical Decision Support for Lung Cancer Screening
- Where
- United States
- Volunteers
- 1,855 people
- Sponsor
- University of Utah
Upper Respiratory Tract Infections Due to Influenza or Rhinovirus
Efficacy of Transfer Factor to Prevent Upper Respiratory Tract Infections in Healthy Adults
The goals of our study are to critically evaluate if a healthy population supplemented with Transfer factor experiences fewer incidences of colds and flu, or experience shorter duration of illness compared to an identical…
- Trial name
- NCT01106183
- Testing
- transfer factor
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Utah
Spinal Muscular Atrophy
Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy
This is a multi-center trial to assess safety and efficacy of a combined regimen of oral valproic acid (VPA) and carnitine in patients with Spinal Muscular Atrophy (SMA) 2 to 17 years of age.
- Trial name
- NCT00227266
- Testing
- Valproic Acid and Levocarnitine
- Where
- 6 sites in United States, Canada
- Volunteers
- 94 people
- Sponsor
- University of Utah
Vestibular Schwannoma, Vestibular Disorder
Longitudinal Recovery of Laboratory, Clinical, and Community-Based Measures of Head and Trunk Control in People With Acquired Vestibulopathy
This study is designed to examine the true impact inner-ear dysfunction has on patient head movement kinematics, activity levels, and participation, and (2) to explore the efficacy of rehabilitation on laboratory, clinical, and…
- Trial name
- NCT04594057
- Testing
- Gaze and Postural Retraining Exercise
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Utah
High Risk Pregnancy
Use Of An In-Home Non-Stress Test Device For Remote Fetal Monitoring
Non-stress tests (NSTs) are used to monitor the health of babies during pregnancy. These tests are currently conducted in clinics and hospitals.
- Trial name
- NCT02379351
- Testing
- In-Home Non-Stress Test Device
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Utah
Prematurity, Necrotizing Enterocolitis
Neutrophil Extracellular Trap Formation in Newborn Infants at Risk for Inflammatory Syndromes
The purpose of this study is to characterize the time to maturation of neutrophil extracellular trap(NET) formation capability in polymorphonuclear leukocytes(PMNs) isolated from newborn premature and term infants.
- Trial name
- NCT01106209
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Utah
Tobacco Use Cessation, Tobacco Use
Reach Through Equitable Implementation in Utah
The goal of this pragmatic, multilevel Type III Hybrid Effectiveness-Implementation trial is to increase the reach of existing evidence-based interventions (EBIs) for tobacco cessation and to mitigate the impact of adverse Social…
- Conditions
- Tobacco Use Cessation, Tobacco Use, Tobacco Smoking, Tobacco Chewing
- Trial name
- REI-UT (NCT06881069)
- Testing
- Clinic Level: AAC - SDOH, AAC - Tobacco, Non-Bundled, Bundled
- Where
- United States
- Volunteers
- 1,560 people
- Sponsor
- University of Utah
Coma
Using EEG to Study Coma in the Neurocritical Care Unit
Despite its clinical significance, the pathophysiology of coma is still under investigation and the physiology of emergence from coma remains a mystery.
- Trial name
- NCT01897194
- Volunteers
- 1 people
- Sponsor
- University of Utah
Schizophrenia
Impact of Aripiprazole Once Monthly Medications on Changes in Brain Structure and Metabolism
This is a Phase 4, randomized, open-label, parallel group study designed to assess the clinical and biological effects of 12 months of treatment with long acting intramuscular (IM) aripiprazole (Abilify®) as measured by clinical…
- Trial name
- NCT02237417
- Testing
- Standard of Care Oral antipsychotics, IM aripiprazole once monthly, No Treatment
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Utah
Thoracic Epidural
Effects of Fixation Technique On Thoracic Epidural Catheter Displacement
The purpose of our study is to assess the effectiveness of Dermabond as a thoracic epidural fixation technique compared to both Mastisol and the Grip-Lok fixation bandage, two common, widely used techniques for epidural fixation.
- Trial name
- NCT03976154
- Testing
- Thoracic Epidural Catheter Fixation Techniques
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Utah
Melanoma
Improving Early Detection of Melanoma Recurrence With Circulating Tumor DNA (ctDNA)
This is a non-randomized experimental biomarker study evaluating ctDNA levels in patients with stage IIB/C and stage IIIB/C/D melanoma skin cancer pre and post-surgery Study participants will complete a ctDNA test within 4 weeks…
- Trial name
- NCT05736523
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Utah