Clinical trials: sponsored by University of Utah
Congestive Heart Failure
Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease
Hypothesis: Tissue and serum samples collected from end-stage heart failure patients receiving left ventricular assist device implantation (LVAD) or heart transplantation will provide information regarding the basic science of…
- Trial name
- NCT01099982
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Utah
Respiratory Distress Syndrome, Prematurity
Oscillatory Versus Non-Oscillatory Nasal Continuous Airway Pressure Neonatal Respiratory Support
This study will seek to enroll neonates requiring Nasal Continuous Airway Pressure (NCPAP) respiratory support and randomize them to either oscillatory (Osc-NCPAP, study group) or non-oscillatory (NCPAP, control group) mode.
- Trial name
- NCT01277874
- Testing
- Nasal CPAP, Oscillatory NCPAP
- Where
- 3 sites in United States
- Sponsor
- University of Utah
Foot Injuries, Ankle Injuries
The Safety of Reusing Walking Boot Components for Patients Recovering From Acute Foot and Ankle Injuries
The investigators primary purposes is to determine the safety of reusing a specific durable medical equipment (DME) item (walking boots) components for patients recovering from acute foot and ankle injuries.
- Trial name
- NCT07287969
- Testing
- New durable medical equipment (DME) walking boot, Re-used durable medical equipment (DME) walking boot
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Utah
Secondary Progressive Multiple Sclerosis, Multiple Sclerosis, Secondary Progressive
Novel Imaging Markers in SPMS
This pilot study takes the innovative approach of using ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle enhanced MRI to measure activity of the innate immune system within MS lesions.
- Conditions
- Secondary Progressive Multiple Sclerosis, Multiple Sclerosis, Secondary Progressive, Multiple Sclerosis
- Trial name
- NCT05357833
- Testing
- Ferumoxytol infusion, Gadoteridol, MRI Brain and Cervical Spine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Utah
Femoro Acetabular Impingement
Biomechanical Assessment of Femoroacetabular Impingement
The purpose of this study is to determine the influence of FAI abnormalities on hip joint biomechanics.
- Trial name
- FAI (NCT01575964)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Utah
Obesity & Overweight
Personalizing Financial Incentives
The purpose of this study is to determine the feasibility of providing personalized incentives for dietary self-monitoring and/or interim weight loss to people enrolled in a weight-loss program
- Trial name
- Log2LoseAI (NCT07225426)
- Testing
- personalized financial incentives
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Utah
Bone Metastases
Simulation-Free, Single-Fraction Palliative Radiation Therapy for Treatment of Bone Metastases
The goal of this study is to provide proof that patients can be treated with simulation-free, single-fraction palliative radiation therapy with a single in-person visit.
- Trial name
- SIM-FREE RT (NCT07202273)
- Testing
- simulation-free, single-fraction palliative radiation therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Metastatic Castration-resistant Prostate Cancer
Dose-Escalation Study of Cabozantinib in Combination With Lutetium-177 (177Lu)-PSMA-617 in Patients With Metastatic Castration-Resistant Prostate Cancer
This is an open-label, phase 1b dose-escalation study of cabozantinib in combination with 177Lu-PSMA-617 in subjects with mCRPC.
- Trial name
- CaboLu (NCT05613894)
- Testing
- Cabozantinib
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Utah
Brain Tumor Adult
Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas
This study evaluates the use of specialized magnetic resonance imaging (MRI) techniques including magnetic resonance (MR) perfusion and 2-hydroxyglutarate (2HG) spectroscopy in the surgical treatment of gliomas.
- Trial name
- NCT03542409
- Testing
- MR Perfusion Scan, 2HG Spectroscopy Scan, Standard of Care Intraoperative MRI
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Utah
Central Nervous System Lymphoma
Loncastuximab Tesirine and Rituximab Following Stereotactic Radiosurgery in Patients With Central Nervous System Lymphomas (SOLAR)
The purpose of this clinical trial is to learn if drugs loncastuximab tesirine and rituximab (lonca-R) after stereotactic radiosurgery are safe and effective for treatment of central nervous system lymphomas.
- Trial name
- SOLAR (NCT06607549)
- Testing
- Loncastuximab tesirine and rituximab (Lonca-R)
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Melanoma (Skin), Skin Cancer
Rural Adult and Youth Sun Protection Study
The purpose of this study is to help prevent skin cancer by improving the use of sun protective behaviors among youths living in rural communities in Utah and West Virginia.
- Trial name
- RAYS (NCT06439979)
- Testing
- RAYS Intervention
- Where
- 2 sites in United States
- Volunteers
- 843 people, healthy volunteers welcome
- Sponsor
- University of Utah
Children With Medical Complexity (CMC), Multiple Chronic Conditions
Developing an Innovative Decision Support Tool for Pediatric Neuromuscular Scoliosis
The goal of this pilot hybrid type I efficacy/implementation trial is to assess a newly developed decision support tool patients, parents, and providers to use during surgical treatment decision making for neuromuscular scoliosis…
- Conditions
- Children With Medical Complexity (CMC), Multiple Chronic Conditions, Neuromuscular Scoliosis, Shared Decision Making
- Trial name
- NCT07167927
- Testing
- Decision support tool
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Utah
Substance Use Disorders, Simulation Training
Interprofessional Simulation Program for Clinical Resilience and Empathy: Project INSPIRE
The goal of this clinical trial is to develop and evaluate INSPIRE, an intervention for healthcare teams to improve care for individuals with substance use disorder (SUD) during their peri-delivery care.
- Conditions
- Substance Use Disorders, Simulation Training, Pregnancy Related, Patient-centered Care
- Trial name
- INSPIRE (NCT07707115)
- Testing
- INSPIRE
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Utah
Sleep Apnea, Sleep Disturbance
Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples With Implications for Alzheimer's Disease Risk
The goal of this clinical trial is to learn if the culturally adapted couples sleep health intervention (Nuestro Sueno) improves positive airway pressure use and sleep among Hispanic couples in which one partner was diagnosed…
- Trial name
- NCT06649929
- Testing
- Couples-based treatment- Patient, Couples-based treatment- Partner, Information control- Patient
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Physiological Stress
Physiologic Burden to the Surgeon During Orthopaedic Surgery
The investigator's plan to quantify the physiologic impact of orthopaedic surgery on the surgeon and operating team.
- Trial name
- NCT06180044
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Utah
Neuroendocrine Tumors, Gynecologic Cancer
The Use of Guarana to Treat Fatigue in Patients With Neuroendocrine Tumors and Gynecologic Cancers (Guarana Fatigue)
The purpose of this clinical trial is to learn if the drug guarana improves symptoms of fatigue in patients with neuroendocrine tumors and gynecologic cancers
- Trial name
- NCT07151391
- Testing
- Guarana
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- University of Utah
Borderline Personality Disorder, Sleep Disturbance
Real-time Experiences With Sleep Training Study
Borderline personality disorder (BPD) is a serious mental illness that often first emerges in adolescence. Effective treatments are typically expensive, lengthy, and intense (e.g., Dialectical Behavior Therapy).
- Trial name
- REST (NCT04507308)
- Testing
- Single-session sleep intervention drawn from principles of the TSC-youth protocol
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- University of Utah
Lifestyle Factors, Overweight and Obesity
Effect of Sleep Extension on Ceramides in People With Overweight and Obesity
The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity.
- Conditions
- Lifestyle Factors, Overweight and Obesity, Insulin Sensitivity, Eating Habit
- Trial name
- NCT06180837
- Testing
- Sleep Extension Intervention
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Utah
Cardiometabolic Syndrome, Type 2 Diabetes
Circadian Intervention to Improve Cardiometabolic Health
The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD).
- Conditions
- Cardiometabolic Syndrome, Type 2 Diabetes, Sleep, Time Restricted Feeding
- Trial name
- TOCS (NCT05943626)
- Testing
- Circadian Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Utah
Head and Neck Cancer, Hypoxia
Novel Hypoxia Imaging for Head and Neck Cancer: Imaging Phenotype for Personalized Treatment
Tumor hypoxia is one of the physiological factors for treatment resistance and likely contributes to poor overall survival among patients with head and neck cancer (HNC).
- Conditions
- Head and Neck Cancer, Hypoxia, Magnetic Resonance Imaging, Cancer Neck
- Trial name
- NCT06108089
- Testing
- [18F]MISO-PET/CT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah