Clinical trials: active, sponsored by University of Utah
Pain, Postpartum Depression
Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery
The purpose of this study is to identify pharmacokinetics of postpartum ketamine infusion. This study will assess ketamine kinetics and metabolism in this setting.
- Trial name
- PREPARE-2 (NCT06767566)
- Testing
- Ketamine (Ketalar)
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Utah
Methamphetamine Use Disorder, Pregnancy
Transcranial Magnetic Stimulation for Methamphetamine Use Disorder During Pregnancy
The goal of this clinical trial is to learn whether transcranial magnetic stimulation, also called TMS, is a practical and acceptable treatment option for methamphetamine use disorder during pregnancy.
- Trial name
- NCT07849530
- Testing
- 4- Week Dual-Target Transcranial Magnetic Stimulation (TMS), Accelerated Dual-Target Transcranial Magnetic Stimulation (aTMS), Treatment as Usual (TAU)
- Volunteers
- 45 people
- Sponsor
- University of Utah
Financial Burden, Health Behavior
Economic Empowerment and Health Promotion of Uganda Grandmother-caregivers.
Background: There are an estimated 163 million children worldwide who are under the care of their grandparents or other relatives.
- Conditions
- Financial Burden, Health Behavior, Social Support
- Trial name
- BAJJAJJA (NCT07011264)
- Testing
- The BAJJAJJA intervention
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Utah
Obesity
Partnership to Reduce Obesity in Community Health Center Patients (SMARTLife Utah)
The long-term objective of SMARTLife Utah is to increase the reach of existing digital EBIs for obesity among patients of Community Health Centers (CHCs).
- Trial name
- NCT07582016
- Testing
- Ask-Advise-Connect (AAC), Text Messaging (TM), Connect Only (CO)
- Where
- United States
- Volunteers
- 5,354 people
- Sponsor
- University of Utah
NSCLC Stage II, NSCLC, Stage III
PILOT for The Precision Exercise Regimen for Cancer Care (PERCC) Study
This study is designed to evaluate whether a precision exercise regimen is feasible to implement within cancer populations, specifically stage II-III primary lung cancer patients receiving multimodal therapy, and delivered…
- Trial name
- PILOT PERCC (NCT06945484)
- Testing
- Precision Exercise Regimen for Cancer Care (PERCC)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Surgery
FOCUS Pre-Post Study
The Facilitating Goal-based Conversations for Understanding Surgery (FOCUS) Guide is a communication intervention designed to support discussion and documentation of the goal for surgery during outpatient surgical consultations.
- Trial name
- NCT07664514
- Testing
- FOCUS Guide
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Utah
Breast Cancer Recurrent
Functional Precision Oncology to Predict, Prevent, and Treat Early Metastatic Recurrence of TNBC
This is a prospective phase 2 study to use Functional Precision Oncology (FPO) to predict, prevent and treat early metastatic recurrence in subjects with HR-low/Her2 negative or triple negative breast cancer.
- Trial name
- TOWARDS-II (NCT05464082)
- Testing
- Functional Precision Oncology
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Scleroderma, Systemic, Morphea
Patient Reported Outcomes With UVA-1 Therapy for Treatment of Sclerosing Skin Diseases
The purpose of this study is to assess the degree of improvement seen patient reported outcomes after 30 sessions of UVA-1 therapy in treating systemic scleroderma, morphea, and sclerodermatous Graft-Versus-Host Disease.
- Conditions
- Scleroderma, Systemic, Morphea, Graft Vs Host Disease
- Trial name
- NCT04922736
- Testing
- UVA-1 Phototherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Utah
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis
Genicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Pilot Randomized Sham-Controlled Study (SHAM-PAIN) is a NIH-NIAMS funded project designed to assess enrollment feasibility and detect any…
- Conditions
- Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
- Trial name
- SHAM-PAIN (NCT06859164)
- Testing
- Genicular Artery Embolization, Lipiodol, Simple angiogram
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Skin Cancer Prevention, Sun Safety
Regional Efforts to Advance School-based Sun Safety Through Collaboration for Skin Health
This project will deliver a sun safety education presentation to high schools in the mountain west (e.g., Montana, Wyoming, and Idaho) who are at high melanoma risk.
- Trial name
- REACH West (NCT07904572)
- Testing
- REACH West
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Utah
HPV Vaccination, Uptake Vaccination
PREVENT HPV -Related Cancers Trial
This study will serve as one of the first to develop and test the effectiveness of strategies to promote HPV vaccination among diverse rural parents and caregivers of children ages 9-17 years in the Mountain West.
- Conditions
- HPV Vaccination, Uptake Vaccination, Series Completion
- Trial name
- NCT07217145
- Testing
- PREVENT
- Where
- United States
- Volunteers
- 1,455 people, healthy volunteers welcome
- Sponsor
- University of Utah
Myelofibrosis
AlloHCT With PegINFa for Myelofibrosis
This is a single site, open-label, dose de-escalation, Phase 1 study of pegylated interferon alfa-2a administered after alloHCT in subjects with primary or secondary myelofibrosis.
- Trial name
- ATIOM (NCT05535764)
- Testing
- Pegylated interferon alpha2a
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Utah
Serious Games, Transition-age Youth
Aim 3: Pilot Study of a Serious Game to Promote Transition Readiness Skills
This study involves testing a new video game designed to support adolescents with congenital heart disease (CHD) in preparing to manage their health independently.
- Conditions
- Serious Games, Transition-age Youth, Transition to Adult Care, Congenital Heart Defect
- Trial name
- NCT07042334
- Testing
- Serious game for transition readiness
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Utah
Menopause, Vasomotor Symptoms (VMS)
Waning Moon: A Whole Person Health Intervention Designed by and for Urban Menopausal American Indian/Alaska Native Women
This study tests the feasibility and acceptability of Waning Moon, a culturally tailored menopause health intervention developed in partnership with the Urban Indian Center of Salt Lake (UICSL) for American Indian/Alaska Native…
- Conditions
- Menopause, Vasomotor Symptoms (VMS), Women's Health, Health Disparities
- Trial name
- NCT07713095
- Testing
- Waning Moon
- Volunteers
- 30 people
- Sponsor
- University of Utah
Erythrocytosis, Pulmonary Hypertension
Phase IIA Study of Belzutifan in EPAS1-, EGLN1-, or VHL-Mutant Erythrocytosis
Some people develop erythrocytosis, a condition characterized by having too many red blood cells, because of inherited changes (mutations) in genes such as EPAS1, EGLN1, or VHL.
- Conditions
- Erythrocytosis, Pulmonary Hypertension, Thrombosis
- Trial name
- NCT07895966
- Testing
- Belzutifan
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Utah
Chronic Myelomonocytic Leukemia (CMML)
Cobimetinib in Newly Diagnosed or HMA-treated CMML Patients With RAS Pathway Mutations
This is an open-label, nonrandomized phase 2 trial to assess the efficacy of cobimetinib in RAS pathway activated CMML. All eligible patients will be treated daily with cobimetinib in 28-day cycles.
- Trial name
- CONCERTO (NCT04409639)
- Testing
- Cobimetinib
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Utah
Multiple Myeloma, Plasma Cell Leukemia
Use of Isatuximab, Dexamethasone and Lenalidomide in a Go-Slow Fashion for Ultra-Frail Patients With Multiple Myeloma
Historically, the frailest patients with multiple myeloma are under-represented in clinical trials, and have very high rates of treatment discontinuation, and early treatment mortality.
- Trial name
- UltraFrailMM (NCT06517017)
- Testing
- Isatuximab
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Stroke
A Novel Multimodal Approach to Promote Motor Recovery and Plasticity After Stroke
Upper extremity (UE) paresis or weakness is one of the most frequent impairments after stroke. Despite intense rehabilitation, motor and functional recovery of patients with severe hand impairments is poor.
- Trial name
- NCT07887880
- Testing
- tRNS (Transcranial Random Noise Stimulation), FES (Functional Electrical Stimulation)-assisted task-specific practice
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Utah
Myelofibrosis
Tolerability of Ropeginterferon Alfa-2b Add-on to Ongoing Ruxolitinib Therapy in Myelofibrosis
The purpose of this clinical trial is to learn if the study drug ropeginterferon alfa- 2b added to, standard of care, ruxolitinib is safe and effective in treating patients with Myelofibrosis.
- Trial name
- RopeRux (NCT07521046)
- Testing
- ropeginterferon alfa- 2b, Ruxolitinib
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Utah
Relapsed or Refractory Large B-cell Lymphoma
Loncastuximab Tesirine and Rituximab as Bridging Therapy Before Standard-of-care CAR-T Therapy in Patients With Large B-cell Lymphoma (CORAL)
The purpose of this clinical trial is to learn if the study treatment Loncastuximab tesirine and Rituximab is safe and efficient before standard of care chimeric antigen receptor T-cell (CAR-T) therapy in patients with relapsed…
- Trial name
- CORAL (NCT06788964)
- Testing
- Loncastuximab Tesirine, Rituximab
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- University of Utah