Clinical trials: sponsored by University of Virginia
Adrenal Insufficiency, Cirrhosis
Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients?
The hepatoadrenal syndrome has been well described in the literature and is known to be associated with poorer outcomes in both stable and critically ill cirrhotic patients.
- Conditions
- Adrenal Insufficiency, Cirrhosis, Spur Cell Anemia, Lecithin Acyltransferase Deficiency
- Trial name
- NCT03368066
- Testing
- Cosyntropin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Virginia
Breast Cancer, Estrogen Receptor-positive Breast Cancer
COX Inhibition and Biomarkers During Neoadjuvant Chemoendocrine Therapy for ER+, HER2- Stage I-III Breast Cancer
This study is designed to assess the safety and clinical activity of tamoxifen and the COX inhibitor, aspirin, given in combination with standard AC-T chemotherapy (doxorubicin, cyclophosphamide, and paclitaxel) for the treatment…
- Trial name
- Breast 51 (NCT04038489)
- Testing
- Aspirin, Tamoxifen Pill, Doxorubicin
- Where
- United States
- Sponsor
- University of Virginia
Growth Failure, Intestinal Infection
MAL-ED Metabolic: A Follow-Up of Chronic Disease at Puberty
The concept that the roots of cardiometabolic disease start in early life was established by Dr. David Barker, who documented relationships between low birthweight (as a marker for challenges during gestation) and later…
- Conditions
- Growth Failure, Intestinal Infection, Metabolic Syndrome, Glucose Intolerance
- Trial name
- NCT05121935
- Volunteers
- 254 people
- Sponsor
- University of Virginia
Cocaine Dependence
New Medication Treatment for Stimulant Dependence
This study will evaluate the efficacy of ondansetron compared with placebo in the treatment of cocaine dependence.
- Trial name
- NCT00689572
- Testing
- Ondansetron
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of Virginia
Type 1 Diabetes, Insulin-requiring Type 2 Diabetes Mellitus
Use of Closed Loop Insulin Delivery for Glucose Control in Patients With Insulin Dependent Diabetes Mellitus After Kidney Transplantation
This study will be a prospective, single center, randomized controlled parallel group open-label trial. Participants with insulin requiring diabetes mellitus who have been offered an organ for living or deceased donor kidney…
- Conditions
- Type 1 Diabetes, Insulin-requiring Type 2 Diabetes Mellitus, End Stage Renal Disease (ESRD)
- Trial name
- NCT04189510
- Testing
- Artificial Pancreas, Multiple Daily Injections
- Sponsor
- University of Virginia
Tobacco Use
Smartphone Application Smoking Cessation Study
The purpose of the study is to determine if using the smartphone application quitSTART can help people quit smoking and to understand how use of specific smartphone application features when trying to quit smoking is associated…
- Trial name
- NCT04623736
- Testing
- quitSTART
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Stimulant Use, Contingency Management
Contingency Management for Stimulant Use Disorders
The invetigators' objective is to implement Medication Assisted Treatment (MAT) and contingency management in patients affected by co-occurring opioid use disorder and stimulant use disorder.
- Trial name
- NCT05097547
- Testing
- Contingency Management
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Tobacco Use, Tobacco Smoking
Evaluation of a Brief Tobacco Intervention in the US Military
While the military has taken steps to reduce tobacco use over the past two decades, over a quarter of new military recruits report regular tobacco use prior to enlistment.
- Conditions
- Tobacco Use, Tobacco Smoking, Smoking, Cigar, Smoking, Pipe
- Trial name
- NCT03196102
- Testing
- BTI, Cigarette smoking military tailored pamphlet, Standard smoking cessation intervention
- Where
- United States
- Volunteers
- 2,999 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Astigmatism
Evaluating and Improving Functional Driving Vision of Patients With Astigmatism: Phase 3
It is a common clinical practice to leave small amounts of astigmatism uncorrected in contact lens wearers. Therefore, some drivers who have astigmatism and wear contact lenses may experience blur while driving.
- Trial name
- NCT02950545
- Testing
- Spherical Lenses, Toric Lenses
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Glucose-Galactose Malabsorption, Enteropathy
Labelled Carbon Sucrose Breath Test (13C-SBT) as a Marker of Environmental Enteropathy
Linear growth failure, a manifestation of chronic undernutrition in early childhood, is a recalcitrant problem in resource constrained settings.
- Conditions
- Glucose-Galactose Malabsorption, Enteropathy, Malnutrition, Child, Intestinal Permeability
- Trial name
- SBT4EE (NCT04109352)
- Where
- 9 sites in Australia, Bangladesh and 6 more
- Volunteers
- 600 people
- Sponsor
- University of Virginia
Type 1 Diabetes, Hypoglycemia
Identifying Driving Risk Factors in Type 1 Diabetes and Their Reduction Via Internet Program (DiabetesDriving.Com)
This study will recruit drivers with Type 1 diabetes from across the U.S. and assign them to four groups based on their presumed risk level- routine care low risk, routine care high risk, or to one of two Internet interventions…
- Trial name
- NCT01563887
- Testing
- DD.com, DD.com + MI
- Where
- United States
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 2
The Use of Libre to Improve Metabolic Control and Reduce Reliance on Medication
GEM (Glycemic Excursion Minimization) is a new lifestyle treatment for type 2 diabetes that aims to lower glucose levels after meals and snacks. This is different from the current lifestyle treatment, which is to lose weight.
- Trial name
- NCT04632849
- Testing
- GEM + CGM
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 2
Treating Type 2 Diabetes by Reducing Postprandial Glucose Elevations: A Paradigm Shift in Lifestyle Modification
Conventional lifestyle modification in the management of type 2 diabetes focuses on weight loss, through caloric restriction and exercise, to reduce insulin resistance.
- Trial name
- NCT03196895
- Testing
- Weight reduction training, PPG training, discrete BG feedback
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- University of Virginia
Antenatal Hydronephrosis, Post-natal Hydronephrosis
Minimizing the Utilization of Voiding Cystourethrography for Patients With Antenatal Hydronephrosis
It has previously been found that there is no correlation between degree of hydronephrosis and presence of reflux; however this is oftentimes the criteria physicians use to obtain a VCUG.
- Trial name
- NCT02825485
- Testing
- Voiding cystourethrogram
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Ureteral Obstruction, Stricture Ureter
Use of SPY Fluorescent Angiography to Reduce Ureteroenteric Stricture Rate Following Urinary Diversion
Ureteroenteric anastomotic stricture is a well-known complication of urinary diversion which occurs in 4-25% of patients. Recent study has yielded that radiation is a significant risk factor for development of ureteroenteric…
- Trial name
- NCT05022199
- Testing
- SPY fluorescent angiography
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Benzodiazepine Refractory Status Epilepticus
Established Status Epilepticus Treatment Trial
The primary objective is to determine the most effective and/or the least effective treatment of benzodiazepine-refractory status epilepticus (SE) among patients older than 2 years.
- Trial name
- ESETT (NCT01960075)
- Testing
- Fosphenytoin, Levetiracetam, Valproic acid
- Where
- 65 sites in United States
- Volunteers
- 478 people
- Sponsor
- University of Virginia
Coronary Microvascular Disease
Microvascular Disease Exercise Trial
For part of this study, we are collecting information from patients that have been experiencing the symptoms mentioned above. We are taking this information and creating a chest pain registry to follow trends and compare…
- Trial name
- MOVE (NCT02045459)
- Testing
- Exercise Program
- Where
- 2 sites in United States
- Volunteers
- 79 people
- Sponsor
- University of Virginia
Respiratory Sounds, Thoracic Surgery
Waveform and Spectral Characteristics of Perioperative Wheezing
With the aid of computerized sound analysis, digital acoustic monitoring could provide a more sensitive, specific, and quantifiable indicator for perioperative respiratory abnormalities including wheezing.
- Trial name
- NCT04873882
- Testing
- Acoustic ventilation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
HIV Prevention, PrEP
Using Smart Phone Technology to Support PrEP Uptake and Adherence
This is a single arm pilot study of a new smartphone app to support adherence to PrEP medication for HIV prevention in public clinics in Virginia.
- Conditions
- HIV Prevention, PrEP, Adherence, Medication
- Trial name
- prep'd (NCT04868383)
- Testing
- Use of smart phone technology to support medication adherence and uptake
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Virginia
Insomnia, Sleep Initiation and Maintenance Disorders
Sleep Healthy Using The Internet for Older Adult Sufferers of Insomnia and Sleeplessness
This study will compare the efficacy of an interactive internet intervention for older adults with insomnia called SHUTi OASIS (Sleep Healthy Using the Internet for Older Adult Sufferers of Insomnia and Sleeplessness) accessed at…
- Trial name
- SHUTiOASIS (NCT03213132)
- Testing
- SHUTi (Sleep Health Using the Internet), Patient Education
- Where
- United States
- Volunteers
- 311 people, healthy volunteers welcome
- Sponsor
- University of Virginia