Clinical trials: sponsored by University of Virginia
Myelomeningocele, Neurogenic Bladder
Efficacy of Contrast Enhanced Voiding Urosonography for Urodynamic Studies
The investigators will assess the feasibility of replacing fluoroscopy/iodinated contrast with ultrasound/sulfur hexafluoride lipid-type A microspheres during routine urodynamic studies.
- Conditions
- Myelomeningocele, Neurogenic Bladder, Tethered Cord Syndrome, Bladder, Neurogenic
- Trial name
- NCT04738539
- Testing
- Contrast Enhanced Voiding Urosonography with Urodynamic Testing, Urodynamic Testing
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Resident Education, Patient Communication, Breaking Bad News to Patients Remotely, Telemedicine
Breaking Bad News to Family Members in a Pandemic
Resident education on breaking bad news and conducting end of life conversations has been shown to improve comfort levels with having these conversations.
- Trial name
- NCT04638530
- Testing
- Education on breaking bad news to family members remotely
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Mild Cognitive Impairment, Cognitive Impairment
Use of an Internet-Based Insomnia Intervention to Prevent Cognitive Decline in Adults With Mild Cognitive Impairment
The purpose of the study is to determine feasibility of an online program providing cognitive behavioral therapy for insomnia in adults with cognitive impairment.
- Conditions
- Mild Cognitive Impairment, Cognitive Impairment, Insomnia
- Trial name
- SHUTi OASIS (NCT04382365)
- Testing
- Sleep Health Using the Internet for Older Adult Sufferers of Insomnia and Sleeplessness
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Sleep Disorders, Circadian Rhythm
The Impact of Night Float on Anesthesiology Resident Sleep Patterns
Residency training requires hospital presence twenty-four hours a day. At times this necessitates working extended shifts, including night shifts, resulting in altered sleep patterns and sleep deprivation.
- Trial name
- NCT03325244
- Testing
- EEG monitor, FitBit
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Allergy;Food
Alpha-gal Pork Challenge
This study is investigating the hypothesis that alpha-gal is responsible for the gastrointestinal symptoms that occur in some alpha-gal syndrome subjects following the consumption of mammalian meat.
- Trial name
- NCT04828317
- Testing
- Pork Challenge
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Idiopathic Pulmonary Fibrosis, Diffuse Parenchymal Lung Disease
Double-blind Placebo-controlled Pilot Study of Sirolimus in Idiopathic Pulmonary Fibrosis (IPF)
Idiopathic pulmonary fibrosis (IPF) is an illness characterized by progressive decline in lung function and premature death from respiratory failure.
- Conditions
- Idiopathic Pulmonary Fibrosis, Diffuse Parenchymal Lung Disease, Interstitial Lung Disease
- Trial name
- NCT01462006
- Testing
- sirolimus
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 2
Benefits of Continuous Glucose Monitoring With GEM Lifestyle Modification for Adults With Type 2 Diabetes
The purpose of this study is to determine if the use of continuous glucose monitoring with the GEM lifestyle modification program (Glycemic load, Exercise and Monitoring glucose) will result in better diabetes control than…
- Trial name
- NCT03207893
- Testing
- GEM lifestyle modification & continuous glucose monitoring, Routine Care
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Growth Failure, Stunting
ELICIT 2.0: Pilot Study of the Effect of Maternal Protein Supplementation During Lactation on Childhood Growth
Haydom Global Health Research Center in north central Tanzania represents an important rural setting for performing high-quality medical research in sub-Saharan Africa.
- Conditions
- Growth Failure, Stunting, Malnutrition, Protein Malnutrition
- Trial name
- NCT04565314
- Testing
- Plumpy'Mum
- Where
- Tanzania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Heart Failure, Heart Failure With Reduced Ejection Fraction
Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance
The primary objective of the study is to compare efficacy of metolazone and chlorothiazide as add-on therapy in patients refractory to loop diuretics with heart failure with a reduced ejection fraction (HFrEF).
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure Acute, Cardiovascular Diseases
- Trial name
- NCT03574857
- Testing
- Metolazone Oral Tablet, Chlorothiazide Injection
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Virginia
Multiple Sclerosis
Impaired Glucose Tolerance and Cognition in MS
This is a pilot study to compare cognitive performance in two groups of subjects with multiple sclerosis; those with normal glucose tolerance and those with impaired glucose tolerance.
- Trial name
- NCT04748302
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Virginia
Anesthesia Intubation Complication
Propofol for Pediatric Tracheal Intubation With Deep Anesthesia During Sevoflurane Induction
The purpose of this study is to determine the amount of propofol required to achieve 50% of patients obtaining a perfect ("excellent") intubation score of 5 on the Steyn modification of the Helbo-Hansen Intubation Score, when…
- Trial name
- NCT01150838
- Testing
- propofol
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Virginia
Noise; Adverse Effect
Noise in the OR: A Quality Improvement Program
During Phase I, disguised SoundEar noise devices will be used to record the noise levels in the operating rooms on Labor and Delivery during Cesarean births.
- Trial name
- NCT04722497
- Testing
- Sound Education
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Type 1 Diabetes Mellitus, Cognitive Change
The VRIF Trial: Hypoglycemia Reduction With Automated-Insulin Delivery System
The objective of this pilot study is (i) to test the use of an Artificial Pancreas (AP) System as a viable therapy treatment for two vulnerable populations: 6 to 10 year-old and adults older ≥65 years old with T1D; (ii) to assess…
- Trial name
- NCT03674281
- Testing
- SAP, CLC
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome, Hyperandrogenism
Effect of Metformin on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone
Many, but not all, girls with high levels of the male hormone testosterone go on to develop polycystic ovary syndrome (PCOS) as adults.
- Trial name
- NCT01427595
- Testing
- Metformin, Progesterone, estrace
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Virginia
Hyperandrogenemia, Polycystic Ovary Syndrome
Assessment of Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition
Gonadotropin-releasing hormone (GnRH) is a hormone that regulates the ability of the pituitary to secrete two hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
- Trial name
- JCM026 (NCT01428245)
- Testing
- Progesterone, Estrace (estrogen)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Virginia
E-Cig Use
Hyperpolarized Xenon-129 MR Imaging of the Lung
Over the past 10 years, electronic cigarettes (e-cigarettes, EC) have been commercialized as a "less harmful" alternative to traditional cigarettes.1,2 However, e-cigarettes are believed to cause pulmonary epithelial, endothelial…
- Trial name
- e-cigarette (NCT04662658)
- Testing
- Hyperpolarized Xenon -129 MRI
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Constipation
Trial of Alvimopan in Major Spine Surgery
The Investigator has chosen to study the reconstructive spinal surgery patient population because it is believed that the use of alvimopan in these patients at the University of Virginia will give the scientific community…
- Trial name
- NCT02789111
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Virginia
Occupational Exposure
Effectiveness of Respiratory Protection During Simulated Resuscitation: a Prospective Cohort Study
The study hypothesizes that EHMRs with P100 filters will provide superior respiratory protection during simulated CPR compared to disposable N95 FFRs as measured by qualitative fit testing.
- Trial name
- NCT04591756
- Testing
- Qualitative Fit Testing
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Heart Failure
A Tele-Health Symptom Management Program for Patients With Heart Failure: Pall-Heart
Heart failure is common in adults and is the most common hospital diagnosis in older adults. Patients with heart failure suffer numerous distressing symptoms daily.
- Trial name
- Pall-Heart (NCT04120857)
- Testing
- Gentle Stretching
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Pulmonary Disease, Chronic Obstructive
New Technology to Assess Treatment for Chronic Obstructive Pulmonary Disease (COPD)
First, the investigators will image patients with hyperpolarized xenon (Xe) magnetic resonance imaging (MRI) to develop the technique of hyperpolarized xenon MRI at the University of Virginia (UVA).
- Trial name
- NCT02826343
- Testing
- Xenon129 MRI imaging, Gadolinium MRI, Advair (250mcg/50mcg) one puff twice a day
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia