Clinical trials: sponsored by University of Washington
Chronic Pain, Posttraumatic Stress Disorder
CIH Stepped Care for Co-occurring Chronic Pain and PTSD
The goal of this clinical trial is to evaluate the feasibility, acceptability, appropriateness, and retention of patient participants of a CIH Stepped Care approach for co-occurring chronic pain and PTSD vs.
- Trial name
- NCT06219408
- Testing
- CIH Stepped Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Washington
Trauma, Psychological, Trauma and Stressor Related Disorders
Systematic Redesign of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT)
Trauma-focused cognitive behavior therapy (TF-CBT) has the strongest evidence of any clinical intervention for youth trauma but is rarely adopted in the education sector - the most common setting for youth mental healthcare.
- Trial name
- NCT06941428
- Testing
- Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), School-Adapted TF-CBT (S-TF)
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Washington
Transition of Care
Pharmacy Transitional Team: Evaluating the Value for Patients With Limited English Proficiency
The overall goal of this proposed study is to characterize the experiences, barriers and facilitators related to providing effective care transitions from hospital to post-acute care settings to elucidate the failures that drive…
- Trial name
- NCT07437508
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Washington
Surgery, Non Diabetic Hyperglycemia
Prevention and Treatment of Common Hyperglycemia in Surgery Pilot
The PATCH pilot trial aims to establish feasibility and determine the sample size of a future, large-scale, multi-site RCT, as well as reinforce the long-standing known safety profile of glucose, insulin, and potassium (GIK) and…
- Trial name
- PATCHS Pilot (NCT06624956)
- Testing
- glucose, insulin, and potassium (GIK), Crystalloid Infusion
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Washington
Opioid Use Disorder, HIV Infections
Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washington
The investigators will implement a non-randomized observational clinical trial that will include a pop-up clinic for women who inject drugs (WWID) near venues for exchange sex and drug use in north Seattle.
- Conditions
- Opioid Use Disorder, HIV Infections, Chlamydia, Gonorrhea
- Trial name
- NCT06187064
- Testing
- Mobile Van Clinic
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV/AIDS, HIV-1-infection
Simplifying Treatment and Monitoring for HIV (STREAM HIV)
This study seeks to determine the clinical efficacy and cost effectiveness of implementing an integrated model for HIV monitoring using point of care (POC) tenofovir (TFV) adherence testing and POC viral load (VL) monitoring in…
- Trial name
- NCT04341779
- Testing
- Point-of-care viral load testing and tenofovir adherence testing
- Where
- South Africa
- Volunteers
- 539 people
- Sponsor
- University of Washington
Diverticulitis
Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial
The COSMID (Comparison of Surgery and Medicine on the Impact of Diverticulitis) trial is a pragmatic, patient-level randomized superiority trial of elective colectomy vs.
- Trial name
- COSMID (NCT04095663)
- Testing
- Partial Colectomy, Medical Management
- Where
- 29 sites in United States
- Volunteers
- 255 people
- Sponsor
- University of Washington
Narcissism
MDMA-Assisted Therapy for Pathological Narcissism
This open-label, proof-of-concept pilot study will assess the efficacy and safety of midomafetamine (MDMA) - assisted therapy (AT) for participants diagnosed with pathological narcissism.
- Trial name
- NCT06565494
- Testing
- midomafetamine (MDMA)-Assisted Therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Washington
Social Anxiety Disorder, Body Dysmorphic Disorder
Individual Factors of CBT Underlying Success
The purpose of this study is to understand why some individuals respond fully to cognitive behavioral therapy and others do not, based on multiple sources of data such as neural, neurocognitive, clinical, and self-report data.
- Trial name
- I-FOCUS (NCT06678295)
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hemophilia A, Hemophilia A, Severe
Hemophilia A Research Program
This study longitudinally observes the intergenerational (mother-child) continuum in hemophilia A from pregnancy through early childhood.
- Conditions
- Hemophilia A, Hemophilia A, Severe, Factor VIII (FVIII), FVIII Deficiency
- Trial name
- HARP (NCT07414511)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Washington
HER2 Negative Breast Carcinoma, Recurrent Breast Carcinoma
Vaccine Therapy in Treating Patients With HER2-Negative Stage III-IV Breast Cancer
This phase I trial studies the side effects and best dose of multiantigen deoxyribonucleic acid (DNA) plasmid-based vaccine in treating patients with human epidermal growth factor receptor 2 (HER2)-negative stage III-IV breast…
- Conditions
- HER2 Negative Breast Carcinoma, Recurrent Breast Carcinoma, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer
- Trial name
- NCT02157051
- Testing
- CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Washington
Prostate Cancer
Buffered Lidocaine for Reducing Pain in Patients Undergoing Prostate Biopsy, BURN Trial
This phase I/II trial examines if buffered lidocaine reduces the pain that patients may experience during prostate biopsy. Prostate biopsies are typically performed awake, in the office, with only local anesthetic.
- Trial name
- BURN (NCT06661902)
- Testing
- Buffered Lidocaine (1% Lidocaine + 8.4% Sodium Bicarbonate, in a 3:1 ratio), Lidocaine, Biopsy of Prostate
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Washington
Chronic Low Back Pain (CLBP)
A Superiority Trial of Radiofrequency Ablation for Low Back Pain
The purpose of the ASTRAL Study is to evaluate the effectiveness of LRFA (Lumbar radiofrequency ablation) against a control procedure.
- Trial name
- ASTRAL (NCT07222462)
- Testing
- Lumbar radiofrequency ablation with conventional electrodes (LRFA-C), Lumbar radiofrequency ablation with multi-tined electrodes (LRFA-M), Simulated lumbar radiofrequency ablation
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Washington
Parent Child Relationship, Child Social-Emotional Development
The Impact of an Evidence-Based Parenting Service on Maternal Sensitivity and Infant Cellular Aging in a Population of Under-Resourced Families
The goal of this clinical trial study is to learn how stress in childhood, or Early Life Adversity (ELA), gets "under the skin" and influences long-term health.
- Conditions
- Parent Child Relationship, Child Social-Emotional Development, Telomere Length, Epigenetic Aging
- Trial name
- NCT06740266
- Testing
- Promoting First Relationships in Primary Care (PFR-PC)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hiv, Contraception
Mobile Phone Messaging to Improve Reproductive Health for Women Living With HIV in Kenya (Mobile WACh Empower)
Use of a mobile health (mHealth) intervention to provide reproductive life counseling to women living with HIV may improve delivery of integrated reproductive health/HIV services and prevent adverse reproductive health outcomes.
- Conditions
- Hiv, Contraception, Fertility Issues
- Trial name
- NCT05285670
- Testing
- Digital counseling plus interactive two-way SMS dialogue
- Where
- 10 sites in Kenya
- Volunteers
- 3,310 people, healthy volunteers welcome
- Sponsor
- University of Washington
Critical Illness, Cognitive Impairment
Optimal Timing of Computerized Cognitive Training for Older Intensive Care Unit Survivors
More than 60% of intensive care unit (ICU) patients are adults ages 60 and older, who are at high risk for ICU-acquired cognitive impairment.
- Conditions
- Critical Illness, Cognitive Impairment, Circadian Dysrhythmia, Intensive Care Unit Delirium
- Trial name
- OPTIMIZE (NCT05467410)
- Testing
- COG-AM, COG-PM
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Perinatal Depression, Perinatal Anxiety
Peer Mentor Texting
This study tested whether a peer mentor text message program (called the Nurture program) could help support mental health during pregnancy and after birth.
- Conditions
- Perinatal Depression, Perinatal Anxiety, Parenting Stress
- Trial name
- NCT07380061
- Testing
- Peer mentor texting, Control
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hiv
PrEPARE-SCALE: Scaling up Integrated PrEP Delivery in Kenyan Maternal and Child Health Clinics
This project aims to develop a community of practice; then test a combination of community of practice, quality improvement, and a training toolkit, to enhance implementation and clinical outcomes; and identify patterns…
- Trial name
- NCT06526507
- Testing
- Implementation strategy package
- Where
- 5 sites in Kenya
- Volunteers
- 17,000 people
- Sponsor
- University of Washington
Psychological Stress, Alcohol Intoxication
Stress-motivated Alcohol Use as a Value-based Decision-making Process
The goal of this experimental study is to improve our understanding of the effects of stress on the decision to consume (more) alcohol in regular drinkers.
- Trial name
- NCT06264791
- Testing
- Stress, Alcohol
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Washington
Sexually Transmitted Infections (Not HIV or Hepatitis), HIV Infections
Sexual Health Access at Retail Pharmacies: Advancing Pharmacy-based Delivery of Primary STI and HIV Prevention for Cisgender Women
This proposed 3-arm randomized study will compare different pharmacy based approaches that include HIV prevention medication (PrEP and PEP), routine STI testing, and preventive antibiotic (doxycycline) for STIs.
- Trial name
- SHARP (NCT07361926)
- Testing
- doxy-PEP, Serial STI testing, HIV PEP/PrEP
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- University of Washington
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