Clinical trials: sponsored by University of Washington
Myocardial Ischemia, Coronary Artery Disease
Diagnostic Accuracy of Cardiac CT Perfusion Compared to PET Imaging
This purpose of this research project is to test the diagnostic accuracy (i.e., sensitivity, specificity, positive and negative predictive value, and receiver operator curve area under the curve) of cardiac computed tomography…
- Conditions
- Myocardial Ischemia, Coronary Artery Disease, Myocardial Infarction
- Trial name
- NCT01434043
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Washington
Appendicitis
The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial
For the past 130 years, appendectomy has been the standard treatment for appendicitis. Recent studies from Europe have challenged the notion that surgery is the best option, showing that antibiotics alone can treat appendicitis…
- Trial name
- CODA (NCT02800785)
- Testing
- Cefoxitin, Ertapenem, Moxifloxacin, Tigecycline, Ticarcillin-Clavulanic Acid; Metronidazole plus Cefazolin, Cefuroxime, Ceftriaxone, Cefotaxime, Ciprofloxacin, or Levofloxacin, Appendectomy
- Where
- 25 sites in United States
- Volunteers
- 1,552 people
- Sponsor
- University of Washington
Lower Limb Amputation Below Knee (Injury)
Auto Control of Volume Management for Limb Loss
The aim of this research is to create a prosthetic system that will automatically adjust the fit of the socket and create a well-fitting prosthesis for people with leg amputations who experience volume fluctuations when using…
- Trial name
- NCT03550118
- Testing
- Adjustable socket
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Washington
Transtibial Amputee
Bioimpedance as a Diagnostic Tool for Assessing the Need for Socket Modification in Transtibial Amputees
The purpose of the proposed study is to conduct research on individuals with lower limb amputation, evaluating if residual limb fluid volume data collected using a novel non-invasive device is beneficial towards prosthetic…
- Trial name
- NCT03164356
- Testing
- Bioimpedance monitor
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hodgkin's Lymphoma
Umbralisib and Pembrolizumab in Treating Patients With Relapsed or Refractory Classical Hodgkin Lymphoma
This phase II trial studies how well umbralisib and pembrolizumab work in treating patients with classical Hodgkin lymphoma that has come back (relapsed) or does not respond to treatment (refractory).
- Trial name
- NCT03776864
- Testing
- Pembrolizumab, Umbralisib
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Washington
Tuberculosis
Infant TB Infection Prevention Study
Randomized controlled trial (RCT) of isoniazid (INH) vs. no INH to prevent Mycobacterium tuberculosis infection in HIV-exposed uninfected (HEU) infants.
- Trial name
- iTIPS (NCT02613169)
- Testing
- Isoniazid
- Where
- Kenya
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Washington
Osteoarthritis
Mobile Motivational Physical Activity Targeted Intervention
More than 50% of older persons with osteoarthritis (OA) experience disrupted sleep and insomnia symptoms of difficulty falling asleep, awakening during the night, and awakening too early and being unable to fall back to sleep.
- Trial name
- MobMPATI (NCT03160287)
- Testing
- Motivaltional interviews and infrequent motivational text messages
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Washington
Vitamin D and Calcium Homeostasis
CYP3A4 Activity and Mineral Homeostasis
The purpose of this study is to determine whether changes in the activity of the enzyme CYP3A4 can change the Vitamin D and bone mineral homeostasis.
- Trial name
- NCT02019875
- Testing
- Rifampin, Clarithromycin, Grapefruit Juice
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Washington
Lower Limb; Fusion, Congenital, Lower Limb Fracture
Investigating Auto Adjusting Dynamic AFO
Offloading Ankle Foot Orthoses (AFOs) are devices designed for people following lower-limb reconstruction to restore mobility by reducing mechanical loading through the injury site and redistributing it proximally.
- Conditions
- Lower Limb; Fusion, Congenital, Lower Limb Fracture, Ankle Foot Injury
- Trial name
- NCT04623853
- Testing
- Variable Stiffness AFO
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Washington
HER2/Neu Positive, Recurrent Breast Carcinoma
Vaccine Therapy With or Without Polysaccharide-K in Patients With Stage IV HER2 Positive Breast Cancer Receiving HER2-Targeted Monoclonal Antibody Therapy
This randomized phase I/II trial studies the side effects of vaccine therapy with or without polysaccharide-K and to see how well it works in treating patients with stage IV human epidermal growth factor receptor 2 (HER2)…
- Conditions
- HER2/Neu Positive, Recurrent Breast Carcinoma, Stage IV Breast Cancer
- Trial name
- NCT01922921
- Testing
- HER-2/neu Intracellular Domain Protein, Laboratory Biomarker Analysis, Pertuzumab
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Washington
Urinary Tract Infection
Intravaginal LACTIN-V for Prevention of Recurrent Urinary Tract Infection
Recurrent urinary tract infections (RUTIS) continue to be a major health problem in women and are now complicated by increasing antibiotic resistance. New preventive approaches are needed.
- Trial name
- NCT00305227
- Testing
- Lactin-V
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Osteomyelitis, Methicillin-resistant Staphylococcus Aureus
Vancomycin Or Trimethoprim/Sulfamethoxazole for Methicillin-resistant Staphylococcus Aureus Osteomyelitis
The primary question of this study is to understand if trimethoprim-sulfamethoxazole (TMP-SMX) is as effective as vancomycin for treating methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis.
- Trial name
- NCT00324922
- Testing
- trimethoprim-sulfamethoxazole, vancomycin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Washington
Chronic Pain
Strategies to Improve Pain and Enjoy Life
In the Strategies to Improve Pain and Enjoy Life (STRIPE) study, the effectiveness of a multicomponent intervention will be tested, compared with usual care, on opioid dose and pain outcomes among patients on high dose (≥ 40 mg…
- Trial name
- STRIPE (NCT03743402)
- Testing
- Pain self-management training, video education, motivational interviewing, voluntary self-paced opioid taper
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- University of Washington
Advanced Hepatocellular Carcinoma, BCLC Stage B Hepatocellular Carcinoma
Cabozantinib and Pembrolizumab for the First-Line Treatment of Advanced Liver Cancer
This phase II trial studies how well cabozantinib and pembrolizumab work for the first-line treatment of patients with liver cancer who are not eligible for local therapy (i.e. advanced stage).
- Conditions
- Advanced Hepatocellular Carcinoma, BCLC Stage B Hepatocellular Carcinoma, BCLC Stage C Hepatocellular Carcinoma
- Trial name
- NCT04442581
- Testing
- Cabozantinib S-malate, Pembrolizumab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Washington
Dental Plaque
Efficacy of Plaque Removal of a Novel Brushing Device
The purpose of this research study is to compare how a novel, automated mouthpiece-based toothbrushing device removes dental plaque compared to a manual toothbrush.
- Trial name
- NCT05038293
- Testing
- Automated mouthpiece-based toothbrush, Manual toothbrush
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Washington
COVID-19, Vaccine Hesitancy
Testing a Personalized Normative Feedback Intervention for Vaccine Hesitancy
Rationale: The highest rates of coronavirus disease (i.e., COVID-19) vaccine hesitancy in the US are among young adults (YAs) aged 18-25.
- Trial name
- NCT05787015
- Testing
- Vaccine Norms Feedback, Alcohol Norms Feedback
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Washington
Mild Traumatic Brain Injury, Cognitive Impairment
Brief Telehealth Cognitive Rehabilitation Following Mild TBI
In the United States, more than a million people sustain a mild traumatic brain injury (mTBI) every year. Although many recover fully, emerging literature suggests a high number of individuals report chronic, and functionally…
- Trial name
- On-TRACC (NCT05315453)
- Testing
- Brief Cognitive Rehabilitation
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Washington
Chronic Rhinosinusitis (Diagnosis)
Effect of Post-operative Ibuprofen After Surgery for Chronic Rhinosinusitis
Endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) is a common procedure in the US, with about 250,000 cases performed annually.
- Trial name
- NCT03055507
- Testing
- Ibuprofen 400 mg, Acetaminophen 650 mg, OxyCODONE 5 Mg Oral Tablet
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cough, Dyspnea
Chest Ultrasound of ER Patients With Cough or SOB
Acute dyspnea (shortness of breath) is a common complaint for patients presenting to the Emergency Department (ED). The chest radiograph (CXR) has been the mainstay in evaluating patients with shortness of breath and often…
- Conditions
- Cough, Dyspnea, Wheezing
- Trial name
- NCT02269761
- Testing
- Nuvis Diagnostic Ultrasound System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Genital Herpes
Effect of HSV-2 Suppressive Therapy on Sexual Behavior
The purpose of this study is to determine what effect suppressive therapy has on sexual behavior and quality of life among persons with genital herpes (HSV) who have multiple sex partners.
- Trial name
- NCT00495716
- Testing
- acyclovir
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Washington
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