Clinical trials: sponsored by University of Washington
Metastatic Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma
SX-682 With Pembrolizumab for the Treatment of Metastatic or Recurrent Stage IIIC or IV Non-Small Cell Lung Cancer
This phase II trial tests whether CXCR1/2 inhibitor SX-682 (SX-682) with pembrolizumab works to treat patients with stage IIIC or IV non-small cell lung cancer that has spread to other parts of the body (metastatic) or that has…
- Conditions
- Metastatic Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma, Stage IIIC Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8
- Trial name
- NCT05570825
- Testing
- Biopsy, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
Stage III Merkel Cell Carcinoma AJCC v8, Stage IIIB Merkel Cell Carcinoma AJCC v8
Adjuvant Avelumab in Merkel Cell Cancer
This randomized phase III trial studies how well avelumab works in treating patients with Merkel cell cancer that has spread to the lymph nodes and have undergone surgery and/or radiation therapy.
- Conditions
- Stage III Merkel Cell Carcinoma AJCC v8, Stage IIIB Merkel Cell Carcinoma AJCC v8, Stage IIIA Merkel Cell Carcinoma AJCC v8
- Trial name
- ADAM (NCT03271372)
- Testing
- Avelumab, Peripheral Blood Collection
- Where
- 9 sites in United States
- Volunteers
- 101 people
- Sponsor
- University of Washington
HIV Infections
The Women TDF-FTC Benchmark Study
The study seeks to define the expected blood levels of pre-exposure prophylaxis (PrEP) medications (tenofovir) for cisgender women taking directly observed oral PrEP therapy to understand the frequency of PrEP dosing associated…
- Trial name
- NCT05057858
- Testing
- co-formulated 300 mg TDF/ 200mg FTC
- Where
- Kenya
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Washington
Recurrent B-Cell Non-Hodgkin Lymphoma, Recurrent Diffuse Large B-Cell Lymphoma
Loncastuximab Tesirine for the Treatment of Relapsed or Refractory B-Cell Malignancies
This phase II trial tests whether loncastuximab tesirine works to shrink tumors in patients with B-cell malignancies that have come back (relapsed) or does not respond to treatment (refractory).
- Conditions
- Recurrent B-Cell Non-Hodgkin Lymphoma, Recurrent Diffuse Large B-Cell Lymphoma, Recurrent Follicular Lymphoma, Recurrent Mantle Cell Lymphoma
- Trial name
- NCT05453396
- Testing
- Loncastuximab Tesirine, Bone Marrow Biopsy, Bone Marrow Aspiration
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Washington
Diverticulitis
Investigation of Medical Management to Prevent Episodes of Diverticulitis Trial
This is a randomized trial (n=75) of a Mediterranean style Food Pattern and versus standardized guidance on fiber intake for patients with diverticulitis to evaluate the feasibility of this dietary intervention including…
- Trial name
- IMPEDE (NCT05681559)
- Testing
- Medi for All, Standard Fiber Supplementation
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Washington
Axial Spondyloarthritis
Physical Activity Through Health Technology in Axial Spondyloarthritis
The purpose of this study is to find out whether a mobile app called the ExerciseRx app is a practical and helpful way for people with axial spondyloarthritis (axSpA) to receive exercise recommendations as part of their regular…
- Trial name
- NCT07642622
- Testing
- Physical activity program intervention, Usual Care Group
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Social Phobia
Social Safety Learning in the Brain Oxytocin System
The investigators are conducting this research study to examine whether oxytocin enhances social safety learning (learning safety through the experience of another individual) in people with social anxiety disorder (SAD) compared…
- Trial name
- NCT05968651
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Washington
Extreme Heat, Heat Health
Study to Assess the Effectiveness of a Heat Risk Reduction Decision Support Platform and the Barriers and Facilitators of Its Implementation With 30 US Local Health Department Sites
The goal of this clinical trial is to learn if an innovative online decision support tool (Chart) that provides localized health risk assessment for extreme heat at the census tract level helps local health departments plan and…
- Conditions
- Extreme Heat, Heat Health, Extreme Heat Waves, Heat
- Trial name
- NCT06971978
- Testing
- Online decision support platform to support evidence-based heat health risk assessment and extreme heat event preparedness planning, Heat and health risk assessment and preparedness information
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Washington
Multiple Sclerosis, Multiple Sclerosis (MS)
My MS Toolkit: An Internet-Based Depression Self-Management Program for Adults Living With Multiple Sclerosis
We are conducting this study to test if the new Toolkit depression module is accessible and helpful for people with multiple sclerosis (MS) in decreasing depression severity.
- Trial name
- NCT07636434
- Testing
- My MS Toolkit
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Washington
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
A Conversational Agent (Cecebot) to Improve Insomnia in Stage I-III Breast Cancer Survivors
This clinical trial evaluates the effect of conversational agent, Cecebot, on improving insomnia in stage I-III breast cancer survivors.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Insomnia
- Trial name
- NCT06392789
- Testing
- Cognitive Behavior Therapy for Insomnia, Internet-Based Intervention, Medical Device Usage and Evaluation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Washington
Cerebral Palsy
Gait Adaptation and Biofeedback for Cerebral Palsy
This research aims to evaluate walking function in children with cerebral palsy (CP). The researchers want to understand how children with CP adapt and learn new ways of moving.
- Trial name
- NCT05899153
- Testing
- Biomotum Spark: Robotic ankle resistance, Audiovisual Biofeedback, Multilevel Orthopedic Surgery
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cancer Survivorship, Loneliness
Adapting and Pilot Testing a Loneliness Intervention for Cancer Survivors
Loneliness, which is the perceived lack of social support and connection, has increased substantially in the past decade and is adversely affecting the health and wellbeing of cancer survivors.
- Trial name
- NCT07418437
- Testing
- Social Prescribing Group, Usual Care
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Washington
Grade 1 Follicular Lymphoma, Grade 2 Follicular Lymphoma
Pirtobrutinib and Mosunetuzumab for the Treatment of Relapsed/Refractory Grades 1-3A Follicular Lymphoma, PROMOTE-FL Trial
This phase II trial tests how well pirtobrutinib and mosunetuzumab work in treating patients with grade 1-3a follicular lymphoma (FL) that has come back after a period of improvement (relapsed) or that has not responded to…
- Conditions
- Grade 1 Follicular Lymphoma, Grade 2 Follicular Lymphoma, Grade 3a Follicular Lymphoma, Recurrent Follicular Lymphoma
- Trial name
- NCT06948786
- Testing
- Pirtobrutinib, Mosunetuzumab, Biospecimen Collection
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Washington
Chronic Pain
Mechanisms of Mindfulness Meditation and Self-Hypnosis for Pain in Older Adults With Chronic Pain
The goal of this study is to better understand how two common psychological treatments for pain work in the brain of older adults living with chronic pain. This study will: 1.
- Trial name
- NCT06957743
- Testing
- Mindfulness Meditation, Therapeutic Hypnosis, Story Listening
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- University of Washington
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Effect of HSD3B1 (1245C) Gene Mutation on Treatment of Stage I-III Breast Cancer
This stage IV trial examines how a mutation in HSD3B1 (1245C) gene affects treatment of stage I-III breast cancer. This trial may help researchers determine if mutations in HSD3B1 decreases the efficacy of aromatase inhibitor…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Breast Adenocarcinoma
- Trial name
- NCT05183828
- Testing
- Biospecimen Collection, Letrozole, Questionnaire Administration
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Washington
Cannabis Use
Feasibility/Acceptability of a Brief Motivational Intervention for Frequent/High-Intensity Cannabis Use
The study aims to develop a novel brief motivational mobile health (mHealth) intervention for frequent and/or high-intensity cannabis use for non-collegiate young adults.
- Trial name
- NCT07011615
- Testing
- Brief Motivational Mobile Health (mHealth) Intervention, Psychoeducational Attention Control (AC)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Washington
Diabetic Kidney Disease, Type 1 Diabetes
Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes
The primary objective of this study is to determine the effects of semaglutide on change in albuminuria from baseline to 26 weeks in type 1 diabetes.
- Trial name
- RT1D (NCT05822609)
- Testing
- Semaglutide
- Where
- 4 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- University of Washington
Kidney Stones, Nephrolithiasis
Safety and Effectiveness of the Ultrasonic Propulsion of Kidney Stones
This study tests moving kidney stones using focused ultrasound (referred to as ultrasonic propulsion). The study includes multiple population groups to investigate the ability of our technology to: a) move stone fragments to a…
- Conditions
- Kidney Stones, Nephrolithiasis, Urolithiasis
- Trial name
- NCT02028559
- Testing
- Propulse 1 with C5-2 probe, Propulse 1 with SC-X probe
- Where
- 2 sites in United States
- Volunteers
- 172 people
- Sponsor
- University of Washington
Alcohol; Use, Problem, Posttraumatic Stress Disorder
Understanding and Testing Recovery Processes for PTSD and Alcohol Use Following Sexual Assault
Sexual assault can lead to devastating consequences including the development of chronic conditions including posttraumatic stress disorder (PTSD) and alcohol use disorders (AUD).
- Trial name
- NCT04124380
- Testing
- Imaginal Exposure, Alcohol Skills Training, Supportive Telehealth
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Washington
Artificial Intelligence (AI), Physician Burnout
Ambient AI Clinical Trial
This is a single-site pragmatic randomized control trial studying the effect of ambient artificial intelligence (AI) scribes on the delivery of medical care to patients in the ambulatory setting.
- Conditions
- Artificial Intelligence (AI), Physician Burnout, Physician Work Environment
- Trial name
- NCT07598721
- Testing
- Use of Ambient AI scribe tool on participant's mobile device
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- University of Washington
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