Clinical trials: sponsored by University of Zurich
Allergic Rhinitis Due to Grass Pollen
ILIT: Follow-up of Rhinitis Quality of Life
Re-evaluation of patients treated with intralymphatic immunotherapy (ILIT) in terms of quality of life and therapeutic efficacy and comparison with subcutaneous immunotherapy (SCIT) 15 years post immunotherapy
- Trial name
- NCT05037955
- Where
- Switzerland
- Volunteers
- 162 people
- Sponsor
- University of Zurich
Non-melanoma Skin Cancer, Basal Cell Carcinoma
T-VEC in Non-melanoma Skin Cancer
Evaluation of the mechanism of Action of talimogene laherparepvec (T-VEC) in patients with locally advanced non-melanoma skin cancer.
- Conditions
- Non-melanoma Skin Cancer, Basal Cell Carcinoma, Squamous Cell Carcinoma, Cutaneous Lymphoma
- Trial name
- 20139157 T-VEC (NCT03458117)
- Testing
- Talimogene Laherparepvec (T-VEC)
- Where
- Switzerland
- Volunteers
- 26 people
- Sponsor
- University of Zurich
Lower Urinary Tract Dysfunction
Urodynamic Assessment of the Lower Urinary Tract: Water vs. Air
Comparison of water-perfused (WP) and air-charged (AC) catheters for invasive urodynamic investigation (UDI) regarding consistency, features and artifacts.
- Trial name
- NCT04033770
- Testing
- Urodynamic investigation
- Where
- Switzerland
- Volunteers
- 490 people
- Sponsor
- University of Zurich
Iron Deficiency (Without Anemia)
Effectiveness of Low-dose Iron Treatment in Non-anaemic Iron-deficient Women
Iron deficiency is common in Switzerland and the main reason for anaemia. Nearly one in five premenopausal women suffers from iron deficiency.
- Trial name
- NCT04636060
- Testing
- Eisen
- Where
- Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Nocturia, Sleep Disorder
Effectiveness of Bryophyllum in Nocturia-Therapy
Night-time micturition, called nocturia, is a very common problem that unfavourably influences sleep- and life-qualities. The International Continence Society (ICS) defines nocturia as micturition once or several times during the…
- Trial name
- NCT04480658
- Testing
- Bryophyllum pinnatum 50 %, tablets into capsules (verum: 2x2capsules/day)
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Hand Fracture, Hand Osteoarthritis
Italian Translation of the Michigan Hand Outcomes Questionnaire
Patient-Reported Outcome Measures (PROMs) are important clinical items for evaluating injuries and recovery of the hand. Some of the most used Questionnaires, unfortunately, are not available in Italian.
- Conditions
- Hand Fracture, Hand Osteoarthritis, Hand Injury Wrist, Hand Sprain
- Trial name
- NCT04527588
- Testing
- Questionaire Michigan
- Sponsor
- University of Zurich
Chronic Disease, Lung Diseases, Obstructive
Home-based Exercise Training for COPD Patients
The aim of this study is to assess the effectiveness of a home-based exercise training program in COPD patients who have completed a pulmonary rehabilitation.
- Conditions
- Chronic Disease, Lung Diseases, Obstructive, Respiratory Disease
- Trial name
- HOMEX-1 (NCT03461887)
- Testing
- Exercise
- Where
- 5 sites in Switzerland
- Volunteers
- 123 people
- Sponsor
- University of Zurich
Chronic Disease, Lung Diseases, Obstructive
Home-based Exercise Training for COPD Patients (HOMEX-2)
The aim of this study is to assess the effectiveness of a home-based exercise training program in COPD patients who did not participate in an inpatient or outpatient rehabilitation program within the last 2 years.
- Conditions
- Chronic Disease, Lung Diseases, Obstructive, Respiratory Disease
- Trial name
- NCT03654092
- Testing
- Exercise
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Aneurysm, Brain
Prediction of Outcomes After Surgery for Unruptured Intracranial Aneurysms
Accurate preoperative identification of patients at high risk for adverse outcomes would be clinically advantageous, as it would allow enhanced resource preparation, better surgical decision-making, enhanced patient education and…
- Trial name
- PRAEMIUM (NCT04819074)
- Testing
- Microsurgery
- Where
- 37 sites in United States, Australia and 8 more
- Volunteers
- 4,000 people
- Sponsor
- University of Zurich
Pituitary Adenoma
Multicentric Prospective Validation of the Zurich Pituitary Score
Predictive analytics for GTR, EOR and RV are useful in surgical decision-making, particularly whenever there is no unequivocal indication for surgery. Several factors have been shown to have a role in predicting GTR.
- Trial name
- NCT04076046
- Where
- 10 sites in United States, Austria and 4 more
- Volunteers
- 408 people
- Sponsor
- University of Zurich
Finger Injuries, Tendon Injury - Hand
Outcome of the Treatment of Flexor Tendon Injuries
In order to gather enough data for meaningful statistics, a multicenter register of all flexor tendon repairs was established with surgical, clinical and rehabilitation patient data.
- Trial name
- NCT04312412
- Testing
- Controlled active motion (CAM)
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Zurich
Stroke
Encouragement-induced Movement Therapy in Daily Life
Stroke places a major burden on health care and society. It often leads to a hemiparesis. Intensive stroke rehabilitation speeds up recovery.
- Trial name
- ISEAR (NCT03294187)
- Testing
- Wrist-worn wearables
- Where
- 3 sites in Switzerland
- Volunteers
- 42 people
- Sponsor
- University of Zurich
Acute Coronary Syndromes
Controlled Level EVERolimus in Acute Coronary Syndromes
Acute myocardial infarction (AMI) constitutes the major cause of death in most nations and death rates and morbidity remain substantial in the years thereafter.
- Trial name
- CLEVER-ACS (NCT01529554)
- Testing
- Everolimus
- Where
- 8 sites in Germany, Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Missing Teeth
Lateral Ridge Augmentation Using Autogenous Bone Blocks or Xenogenic Bone Block Grafts Loaded With Recombinant Human Bone Morphogenic Protein 2
Since there are no clinical studies available comparing the gold standard (autogenous bone graft plus resorbable membrane) to the promising combination of xenogenic bone graft loaded with rhBMP-2 in combination with a collagen…
- Trial name
- NCT01541345
- Testing
- Autogenous bone graft, InductOs, Augmentation surgery
- Where
- 2 sites in Austria, Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Stroke
Predicting Real World Physical Activity and Upper Limb Use After Stroke
Poststroke recovery mainly takes place within the first weeks to months and about 95% of the patients reach their maximum recovery 3 months after stroke onset.
- Trial name
- REUSE (NCT03522519)
- Testing
- Real world performance of physical activity and arm use
- Where
- Switzerland
- Volunteers
- 98 people
- Sponsor
- University of Zurich
Stroke, Healthy
Cerebral Hemodynamics During Early Verticalization After (Successful) Thrombectomy Poststroke
This is a proof-of-concept study with a prospective observational design, where the association between progressive levels of verticalization and cerebral blood flow velocity (Ultrasound) in subacute stroke patients and healthy…
- Trial name
- CHEST (NCT04573114)
- Testing
- Verticalization
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Coronary Artery Disease
Deep-Learning Image Reconstruction in CCTA
Cardiac CT allows the assessment of the heart and of the coronary arteries by use of ionising radiation. Although radiation exposure was significantly reduced in recent years, further decrease in radiation exposure is limited by…
- Trial name
- NCT03980470
- Testing
- TrueFidelity
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Multiple Sclerosis
Barriers to Physical Activity in People With MS
Multiple Sclerosis (MS) is a chronic inflammatory disease leading to the demyelination of the central nervous system. Promoting physical activity has gathered attention as an effective means to improve health-related quality of…
- Trial name
- BarKA-MS (NCT04746807)
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- University of Zurich
Stroke, Acute
Biomarker Signature of Stroke Aetiology Study: The BIOSIGNAL-Study
The three-year cumulative risk of a recurrent stroke, dependent on aetiology, is up to 25 per cent. At present, preventing recurrence relies on a broad approach to reduce risk factors associated with atherosclerosis, heart…
- Trial name
- NCT02274727
- Where
- 9 sites in Germany, Greece and 2 more
- Volunteers
- 1,800 people
- Sponsor
- University of Zurich
Nontraumatic Intracerebral Hemorrhage, Multiple Localized
Clevidipine (Cleviprex®) Compared With Urapidil (Ebrantil®)
Intracerebral hemorrhage (ICH) is responsible for 10-15% of primary strokes. ICH is a dynamic process with three phases: initial hemorrhage, followed by hematoma expansion and perihematoma edema formation.
- Trial name
- Clevidipine (NCT03300479)
- Testing
- Clevidipine, Urapidil
- Where
- Switzerland
- Sponsor
- University of Zurich
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