Clinical trials: sponsored by University of Zurich
Premature Birth, Electrical Impedance Tomography (EIT)
Lung Volume Changes in Stable Preterm Infants Positioned in Car Seats
Premature infants (infants born <37 weeks' gestational age) are discharged from the hospital and transported home in car seats designed for term babies. The safe transport of these premature infants is an important concern.
- Conditions
- Premature Birth, Electrical Impedance Tomography (EIT), Lung Volume, Car Seat Transition for At-risk Infants
- Trial name
- CarSeat (NCT06724601)
- Testing
- Electrical Impedance Tomography
- Where
- Switzerland
- Volunteers
- 51 people
- Sponsor
- University of Zurich
Gait Analysis in Neurological Disorders
Investigation of Gait Parameters in Health and Neurological Disease Under Varying Locomotor Conditions
In the cross-sectional component of this study, our overall objective is to gather a large pool of data from which we can generate gait "profiles".
- Trial name
- NCT02165787
- Where
- Switzerland
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Spinal Cord Injury
Impact of Assistive Forces on Activities of Daily Living
This study is a cross-sectional study investigating the impact of assistive forces applied by the body-weight support system "the FLOAT" on the study participants.
- Trial name
- FLOAT-ADL (NCT03004144)
- Testing
- FLOAT
- Where
- Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Spinal Cord Diseases
Body Weight Supported Training Study
Successful ambulation at home and in the community is the main goal of gait training after incomplete spinal cord injury. Many different treatment approaches have been recommended to achieve this goal.
- Trial name
- NCT03534518
- Testing
- BWS overground training, BWS treadmill training
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- University of Zurich
Aging, Kidney Disease
Assessing How the Body Responds to Increased Phosphate Intake, and How This Response Depends on Age and Sex.
Kidney function declines with age and this could affect phosphate balance after an acute phosphate load (increased phosphate intake). In daily life, we regularly experience acute phosphate loads through our diet.
- Conditions
- Aging, Kidney Disease, Mineral Metabolism
- Trial name
- NCT07149337
- Testing
- Oral phosphate load
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Ischemic Stroke
Microclots and Neutrophil Activation as Potential Indicators for Stroke Risk and Reperfusion Failure
Stroke remains a major health burden worldwide. Many patients are severely disabled and stay in need of care. Mechanical thrombectomy has dramatically improved outcomes for stroke patients with large vessel occlusions, yet 40-50%…
- Trial name
- CLOTSAFE (NCT06530927)
- Testing
- 3D rotational digital tomography, Atomic Force Microscopy, Micro-Computertomography
- Where
- Switzerland
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Kidney Failure, Presence of Donor Specific Antibodies
Nanoparticle for DSA Removal
Magnetic nanoparticles, coated with human leukocyte antigens (HLA) to capture anti-HLA antibodies with donor specificity (donor-specific antibodies, DSA), will be tested ex-vivo.
- Trial name
- NCT04277377
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Gait, Stumbling, Gait, Perturbation
Mimicking Slipping Responses Using a Novel Mechanical Perturbation Algorithm
Healthy subjects will be invited to fill out a questionnaire regarding falls and balance skills followed by normal walking trials on a treadmill at 9 different speeds (0.28-1.4 m/s).
- Trial name
- NCT05890755
- Testing
- Mechanical pertubation
- Where
- Switzerland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Neurogenic Bladder Dysfunction
Bladder and TranscUtaneous Tibial Nerve Stimulation for nEurogenic Lower Urinary Tract Dysfunction
Many patients with neurological diseases suffer from neurogenic lower urinary tract dysfunction (NLUTD), which often severely impairs quality of life, due to urinary urgency with or without incontinence and voiding dysfunction.
- Trial name
- bTUNED (NCT04315142)
- Testing
- Experimental TTNS
- Where
- 12 sites in Belgium, Brazil and 2 more
- Volunteers
- 48 people
- Sponsor
- University of Zurich
Primary Lung Cancer or Secondary Lung Metastases
MR-informed Stereotactic Radiotherapy for Treatment of Ultracentral Lung Tumours Utilising a Dedicated MR-simulator for Daily Adaptation Followed by CBCT-guided Treatment Delivery
Stereotactic body radiotherapy (SBRT) is the preferred treatment for inoperable early-stage non-small cell lung cancer (NSCLC) and for operable cases when patients decline surgery, offering local control (LC) rates of 80-97%.
- Trial name
- MUSIC (NCT06815289)
- Testing
- MR-informed stereotactic radiotherapy
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- University of Zurich
Female Stress Urinary Incontinence
Stress Urinary Incontinence Study to Assess Safety and Efficacy of Muvon's Muscle Precursor Cell Therapy
The objective of the SUISSE MPC 2 study is to treat stress urinary incontinence in adult women.
- Trial name
- SUISSE MPC2 (NCT05534269)
- Testing
- autologous muscle precursor cells
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Parkinson Disease
Personalized Stimulation Loop for Neurorehabilitation in Parkinson: a Proof-of-principle Study
Parkinson's disease (PD) is a neurodegenerative disease that affects about 1% of the elderly population and accounts for substantial disability and health care costs.
- Trial name
- StimuLOOP_PD-S (NCT07082595)
- Testing
- TASS Intervention (Verum)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Terminal Illness, Terminal Cancer
Differences in Acceptability of Music Therapy Sessions Played Live Compared to a Recording Thereof
The present study seeks to assess differences in feasibility and acceptability of music therapy played live and listening to a recording thereof at the palliative care ward of the University Hospital Zurich.
- Trial name
- NCT06108375
- Testing
- music therapy, recording
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- University of Zurich
Atopic Dermatitis
Atopic Dermatitis: Sub-Saharan Africa vs. Central Europe
Many people are affected by atopic dermatitis (AD) worldwide. However, clinical studies on AD in Sub-Saharan Africa are rare and there is a lack of knowledge about possible differences in pathogenesis between European and African…
- Trial name
- NCT05363904
- Testing
- Observation
- Where
- 3 sites in Madagascar, Switzerland and 1 more
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Ischemic Stroke
Effects of Cerebrospinal Fluid Drainage on Cerebral Hemodynamics
This pilot interventional study investigates whether continuous cerebrospinal fluid (CSF) drainage via lumbar drain can improve cerebrovascular reactivity (CVR) in patients with acute ischemic stroke and hemodynamic failure, as…
- Trial name
- NCT07056907
- Testing
- Lumbar drain placement
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Left Heart Failure
Visa-versa! Breaking Instead of Pushing the Pedals-C
Eccentric muscle work is defined as lengthening of a muscle while applying force. It was shown that with eccentric work, muscles are able to perform four times as much power compared to usual concentric work, which results in…
- Trial name
- NCT05204693
- Testing
- 15 minutes eccentric cycling, 15 minutes concentric (normal) cycling
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- University of Zurich
Spinal Cord Injuries, Gait Disorders, Neurologic
Validity and Reliability of the 12-item Multiple Sclerosis Walking Scale (12-WS) in Subjects With Spinal Cord Injury
Established gait assessments for subjects with spinal cord injury (SCI) (6MWT, 10MWT, TUG, SCIM III and WISCI II) are widely used in the clinical and research setting.
- Trial name
- 12-WS SCI (NCT06256159)
- Testing
- 12 MSWS questionnaire
- Where
- 2 sites in Switzerland
- Volunteers
- 67 people
- Sponsor
- University of Zurich
Hypersensitivity, Hay Fever
Immunological Analysis of Lymph Node Tissue After Intralymphatic Immunotherapy: A Prospective Case Control Study
Allergy is a public health problem as more than 20% of western society is affected by it. Symptomatic treatment of allergy suffices with less severe allergy.
- Conditions
- Hypersensitivity, Hay Fever, Rhinitis, Allergic, Seasonal, Rhinoconjunctivitis
- Trial name
- ILIT-FNA (NCT05960266)
- Testing
- Polvac Grass+Rye
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Rhinitis, Allergic, Seasonal, Rhinitis; Allergic, With Asthma
Intralymphatic Immunotherapy With Polvac Grass & Rye Allergen Extract
The primary goal is to investigate the efficacy of intralymphatic immunotherapy (ILIT) for the treatment of allergic rhinitis and allergic asthma due to sensitisation to grass pollen allergens.
- Conditions
- Rhinitis, Allergic, Seasonal, Rhinitis; Allergic, With Asthma, Allergic Rhinitis, Allergic Rhinitis Due to Grass Pollen
- Trial name
- NCT05297760
- Testing
- Polvac Grass+Rye, Saline 0.9%
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Zurich
Prostate Cancer
Value of Ultra-fast Prostate MRI in Prostate Cancer
This study aims to assess the value of ultra-fast MRI sequences in the assessment of prostate cancer, compared to the full multiparametric/biparametric protocol as the clinical standard.
- Trial name
- NCT05903781
- Testing
- Prostate MRI
- Where
- Switzerland
- Volunteers
- 536 people
- Sponsor
- University of Zurich
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