Clinical trials: sponsored by Uppsala University
Spinal Stenosis, Spinal Stenosis Lumbar
Decompression vs Physical Training for the Treatment of Lumbar Spinal Stenosis
Lumbar spinal stenosis (LSS) is characterized by low back and leg pain, walking disturbances and sometimes instability, impaired balance and numbness of the lower limbs.
- Conditions
- Spinal Stenosis, Spinal Stenosis Lumbar, Degeneration Lumbar Spine, Degeneration Spine
- Trial name
- UppSten (NCT03495661)
- Testing
- Decompression
- Where
- Sweden
- Volunteers
- 156 people
- Sponsor
- Uppsala University
Sepsis, Severe, Acute Kidney Injury
MR-Evaluation of Renal Function In Septic Patients
A study of renal blood flow and renal oxygenation measured by magnetic resonance after a standardized fluid challenge in critically ill, resuscitated, patients with sepsis due to COVID-19 or other agents.
- Conditions
- Sepsis, Severe, Acute Kidney Injury, COVID-19
- Trial name
- MERSEP (NCT02765191)
- Testing
- Plasma expansion with Ringer's Acetate
- Where
- Sweden
- Volunteers
- 22 people
- Sponsor
- Uppsala University
Postintensive Care Syndrome, Anxiety Disorder
Is Invasive ICU-treatment Associated With Mental Illness?
Understanding long-term complications after intensive care is important to be able to offer prophylactic and therapeutic measures to post-intensive care unit (ICU) patients.
- Conditions
- Postintensive Care Syndrome, Anxiety Disorder, Depression, PTSD
- Trial name
- NCT05137977
- Testing
- Intensive Care
- Volunteers
- 1,048,576 people
- Sponsor
- Uppsala University
Chronic Pain
Requirements and Functional Schedule as a Part of Painrehabilitation.
Requirements and functional Schedule also calen Demand Ability Protocol (DAP) is an intervention that has been tested and found useful in occupational health service.
- Trial name
- NCT05080062
- Testing
- Requirements and functional Schedule, No intervention
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Uppsala University
COVID19, ARDS
Follow-up of Critical COVID-19 Patients
The study will follow COVID-19 patients who required intensive care after 3-6 months and one year after discharge from the ICU with functional level as well as organ function to assess recovery after COVID-19.
- Conditions
- COVID19, ARDS, AKI, Circulatory Failure
- Trial name
- FUP-COVID (NCT04474249)
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Uppsala University
B-cell Leukemia, B-Cell Lymphoma
CD19-targeting, 3rd Generation CAR T Cells for Refractory B Cells Malignancy
Treatment of patients with B cell lymphoma or leukemia with two doses of CD19-targeting chimeric antigen receptor (CAR) T cells to evaluate for safety and efficacy.
- Trial name
- NCT03068416
- Testing
- CAR T cells
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Uppsala University
Blood Pressure, Perioperative/Postoperative Complications
SOMNOmedics Clinical Validation Trial
Observational study in which pulse transit time (PTT) as a method and the device to register this data is compared with arterial blood pressure.
- Trial name
- NCT03307889
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University
Healthy
Imagery Vividness and Arousal Responses to Prospective Imagery
Research has shown that mental imagery appears to carry emotion better than verbal communication. One way this can be noted is that emotional mental imagery trigger physiological arousal responses.
- Trial name
- NCT04370613
- Testing
- Prospective Imagery visualization task
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Ovarian Cancer Recurrent
Hyperthermic Intraperitoneal Chemotherapy for Treatment of Relapsed Ovarian Cancer
This is a feasibility single-center study to investigate the tolerability, toxicity, quality of life, morbidity, mortality of the HIPEC treatment following cytoreductive surgery for treatment of recurrent ovarian, peritoneal, and…
- Trial name
- NCT03717610
- Testing
- radical surgery with HIPEC
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Uppsala University Hospital
Posttraumatic Stress
PTSD Coach Sweden: Evaluating a Self-help Mobile App for Posttraumatic Stress in a Community Sample
Individuals who experience potentially traumatic events might develop long-lasting mental health problems. Limitations to health care resources, particularly in the context of mass disasters, indicate that self-help interventions…
- Trial name
- NCT04094922
- Testing
- Swedish PTSD Coach smartphone app
- Where
- Sweden
- Volunteers
- 174 people
- Sponsor
- Uppsala University
Physical Activity
Fall Prevention for Old Community-dwelling People
Fall-related injuries are a major health problem in the growing older population. Most older people are not aware of that physical training can decrease the risk of falling.
- Trial name
- NCT01778972
- Testing
- Otago home exercise programme, Motivational interviewing plus Otago
- Where
- 2 sites in Sweden
- Volunteers
- 420 people
- Sponsor
- Uppsala University
Hypertension
The Precision Hypertension Care Study
The PHYSIC study aims to investigate the potential for precision medicine in the treatment of high blood pressure. It is a double-blind, randomized, repeated cross-over trial with six treatment periods: four classes of blood…
- Trial name
- PHYSIC (NCT02774460)
- Testing
- Zestril®, Atacand®, Norvasc®
- Where
- Sweden
- Volunteers
- 280 people
- Sponsor
- Uppsala University
Permanent Hypoparathyroidism
Quality in Patients With Permanent Hypoparathyroidism After Total Thyroidectomy
Quality of life study. The study with include all patients operated with total thyroidectomy between 2005-2015 in Uppsala-Örebro healthcare region, Sweden.
- Trial name
- NCT04998968
- Where
- Sweden
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Fistula Vagina, Fistula;Rectal
Rectovaginal Fistula Repair
This study is a prospective evaluation of quality-of-life after rectovaginal fistula repair at our institution
- Trial name
- NCT05006586
- Where
- Sweden
- Volunteers
- 55 people
- Sponsor
- Uppsala University
Acute Coronary Syndrome (ACS)
PROSPECT II & PROSPECT ABSORB - an Integrated Natural History Study and Randomized Trial.
The present study has two components, an overall prospective observational study using multimodality imaging (PROSPECT II) that will examine the natural history of patients with unstable atherosclerotic coronary artery disease…
- Trial name
- P2 (NCT02171065)
- Testing
- ABSORB BVS
- Where
- Sweden
- Volunteers
- 902 people
- Sponsor
- Uppsala University
Fracture
Early Mobilization of Spiral Metacarpal Fractures Compared With Operative Treatment
Spiral metacarpal fractures (metacarpal II-V) can be treated conservatively or with operation. With minimal displacement this fracture is usually treated with immobilisation or early mobilisation.
- Trial name
- NCT03067454
- Testing
- Early mobilisation, Operation
- Where
- 2 sites in Sweden
- Volunteers
- 42 people
- Sponsor
- Uppsala University
Breast Disease, Breast Cancer
PREMs on PROMs in Breast Disease (PREMs_PROMs)
In recent years, large interest in the conduct and focus of clinical trials has focused to patient related outcomes and value-based healthcare.
- Conditions
- Breast Disease, Breast Cancer, Breast Neoplasms
- Trial name
- PREMs_PROMs (NCT04718324)
- Testing
- e-PROMS, p-PROMS
- Where
- Sweden
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Healthy Participants, Intrusive Memories
Understanding Reactions to Emotional Material in the Media During COVID-19
This feasibility study aims to adapt a protocol usually run in the laboratory in the Psychology Department for healthy participants (including the trauma film paradigm (James et al., 2016) and a simple cognitive task…
- Trial name
- NCT04608097
- Testing
- Simple cognitive task intervention
- Where
- Sweden
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Vulvodynia
An Internet-based Information Platform for Vulvodynia Patients
Vulvodynia is a very common but vastly under-diagnosed and under-treated gynaecological condition that leads to extreme suffering for both the women involved but also their partners.
- Trial name
- EMBLA (NCT02809612)
- Testing
- Internet-based platform
- Where
- Sweden
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Sepsis, Corona Virus Infection
The Impact of Premorbid Illnesses on the Risk of ICU Admission and Short-term Outcome
The Corona virus disease 2019 (COVID-19) pandemic is currently involving all parts of the world. Several risk factors for critical illness and death from the disease have been proposed.
- Conditions
- Sepsis, Corona Virus Infection, ARDS, Human
- Trial name
- NCT04542538
- Testing
- No intervention, observational study
- Where
- Sweden
- Volunteers
- 9,905 people
- Sponsor
- Uppsala University