Clinical trials: sponsored by Uppsala University
Epidermolysis Bullosa Simplex
Botulinumtoxin A Treatment in Epidermolysis Bullosa Simplex and Pachyonychia Congenita
This study evaluates the clinical effect of foot injection of the bacteria protein Botulinum toxin A on plantar pain in patients with EBS (epidermolysis bullosa simplex) or PC (pachyonychia congenita).
- Trial name
- NCT00936533
- Testing
- Dysport® (Botulinumtoxin A (Btx A))
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Uppsala University
Stable Angina Pectoris
Prevalence and Prognostic Value of Unrecognized Myocardial Injury in Stable Coronary Artery Disease (PUMI)
This study includes patients with stable coronary artery disease without previously known myocardial infarction, and investigates the prevalence of clinically unrecognized myocardial damage and its prognostic implication.
- Trial name
- PUMI (NCT01257282)
- Where
- 6 sites in Sweden
- Volunteers
- 275 people
- Sponsor
- Uppsala University
Health Care Quality, Health Care Evaluation
A Study Comparing Imatinib and Imatinib/Pegylated Interferon in Chronic Myeloid Leukemia
Patients with chronic myeloid leukemia in imatinib induced CHR are randomized between imatinib 400 mg daily and imatinib 400 mg daily + PegIntron 30 ug weekly.
- Trial name
- NCT01227356
- Testing
- imatinib and pegylated interferon
- Where
- 3 sites in Sweden
- Volunteers
- 112 people
- Sponsor
- Uppsala University
IGA Nephropathy
Diet Intervention in Food Sensitive Patients With IgA Nephropathy
The purpose of this study is to assess whether a tailored diet, eliminating antigens to which IgA nephropathy patients have demonstrated sensitivity, will have an effect on proteinuria, renal function and other immunological…
- Trial name
- DIIGA (NCT01203007)
- Testing
- Tailored diet, Low antigen content diet
- Where
- 3 sites in Norway, Sweden
- Volunteers
- 40 people
- Sponsor
- Uppsala University Hospital
Obesity, Diabetes
Role of Dietary Fatty Acids in Fatty Liver and Insulin Resistance
The purpose of this study is to investigate whether substituting saturated fats with polyunsaturated fats reduces fatty liver and improves insulin action and other metabolic variables in abdominally obese subjects
- Conditions
- Obesity, Diabetes, Insulin Resistance, Fatty Liver
- Trial name
- HEPFAT (NCT01038102)
- Testing
- PUFA Diet, SFA diet
- Where
- Sweden
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Coronary Artery Disease, Myocardial Infarction
Tailoring Of Platelet Inhibition to Avoid Stent Thrombosis
The primary objective of this study is to establish a cut off level of platelet inhibition that separates patients with or without previous stent occlusion with acute clinical onset while on aspirin and clopidogrel treatment…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Stent Thrombosis, Heart Diseases
- Trial name
- TOPAS-1 (NCT00914368)
- Testing
- Clopidogrel
- Where
- Sweden
- Volunteers
- 450 people
- Sponsor
- Uppsala University
Physiology, Gastroenterology
GIP and GLP-1 on Gastric Emptying, Appetite and Insulin-glucose
Academic phase 1 study which investigates the effects of the two incretin hormones glucose-insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) on gastric emptying, appetite, insulin release and glucose disposal in…
- Conditions
- Physiology, Gastroenterology, Endocrinology
- Trial name
- GIP-GLP-gas (NCT01079624)
- Testing
- Glucose-insulinotropic peptide, Glucagon-like peptide-1
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Parkinson Disease
Pharmacokinetics of Levodopa/Carbidopa Infusion With and Without Oral Catechol-O-methyl Transferase (COMT) Inhibitors
The purpose of this study is to determine whether oral intake of COMT inhibitors affects the smooth plasma levodopa levels achieved by intestinal levodopa/carbidopa infusion in advanced Parkinson's disease patients.
- Trial name
- DuoCOMT (NCT00906828)
- Testing
- levodopa/carbidopa, entacapone, tolcapone
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Uppsala University
Bladder Cancer
Safety Study on AdCD40L Gene Therapy for Bladder Cancer
The study objective is to evaluate the feasibility of three instillations of immunostimulating gene therapy (AdCD40L) in patients with urinary bladder cancer.
- Trial name
- NCT00891748
- Testing
- AdCD40L
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Uppsala University
Fibromyalgia
Cognitive Behavioral Therapy Trial in Fibromyalgia
Previous studies have shown that the disorder fibromyalgia often is preceded by long-term stress. Moreover, an association has been shown between stress, pain and co-morbidity in these patients.
- Trial name
- (FIBCOG) (NCT01004458)
- Testing
- Cognitive behavioral therapy, Waiting list
- Where
- Sweden
- Volunteers
- 48 people
- Sponsor
- Uppsala University
Peritoneal Carcinomatosis
Single-photon Emission Computed Tomography (SPECT) to Predict Peritoneal Chemotherapy
SPECT was performed in 51 patients after cytoreductive surgery in combination with intraperitoneal chemotherapy. The detected volume was compared to the number of subsequent sequential postoperative intraperitoneal chemotherapy…
- Trial name
- NCT00997633
- Where
- Sweden
- Volunteers
- 51 people
- Sponsor
- Uppsala University
Pilonidal Sinus
Comparison Between Laying Open and Sinus Excision of Pilonidal Sinus - a Randomized Study
A pilonidal sinus is a cyst or abscess near or on the natal cleft of the buttocks that often contains hair and skin debris. The condition is common and requires surgery to be cured.
- Trial name
- NCT00997048
- Testing
- Laying open, Sinus excision
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Uppsala University
Fecal Incontinence
Pilot Study of NASHA/Dx Gel for Fecal Incontinence
The study is an open, prospective, single-site study where 16 patients suffering from fecal incontinence will be included. Change in fecal incontinence episodes after intersphincteric injection of NASHA/Dx gel 4x2 ml and…
- Trial name
- NCT00971269
- Testing
- Solesta (Nasha/Dx)
- Where
- Sweden
- Volunteers
- 16 people
- Sponsor
- Uppsala University Hospital
Subacute Low Back Pain
Trial on Subacute Low Back Pain
A randomized controlled trial over a 10-week period with a two-year follow-up. The objectives were to compare effects of manual therapy in addition to the stay-active concept versus the stay-active concept only in low back pain…
- Trial name
- Justina (NCT00923429)
- Testing
- Stay-active care, Stay-active care+stretching, Stay-active+stretching+manual therapy
- Where
- Sweden
- Volunteers
- 160 people
- Sponsor
- Uppsala University
Parkinson Disease, Dyskinesias
Different Dyskinesias in Parkinson's Disease and Their Relation to Levodopa Pharmacokinetics
The purpose of this study is to study different kinds of dyskinesias in advanced Parkinson's disease appearing at different levels of levodopa infusion dose.
- Trial name
- DYSK-PD-2007 (NCT00888186)
- Testing
- levodopa/carbidopa
- Where
- Sweden
- Volunteers
- 5 people
- Sponsor
- Uppsala University
Coronary Heart Disease
Randomized Trial of Behavioral Intervention Versus Standard Treatment
The purpose of this study is to determine the possible preventive effect of behavioural modification versus standard treatment after hospital discharge in CHD patients.
- Trial name
- SUPRIM (NCT00888485)
- Testing
- Behavioral interventional program
- Volunteers
- 362 people
- Sponsor
- Uppsala University
Lateral Epicondylitis
Tennis Elbow Trial
Epi-X is a multicentered randomized controlled clinical trial of chronic lateral epicondylitis with parallel group design and two phases.
- Trial name
- Epi-X (NCT00888225)
- Testing
- Eccentric exercise, Concentric exercise
- Where
- 2 sites in Sweden
- Volunteers
- 205 people
- Sponsor
- Uppsala University
Primary Hyperparathyroidism
Open Versus Video-Assisted Minimal-Invasive Parathyroid Surgery
The aim of the present study was to compare open minimal-invasive parathyroid surgery with video-assisted parathyroidectomy in primary hyperparathyroidism (PHPT) patients with a positive sestamibi scan in a multicentre randomized…
- Trial name
- NCT00877981
- Testing
- Minimal invasive Parathyroid surgery
- Where
- 3 sites in Denmark, Sweden
- Volunteers
- 143 people
- Sponsor
- Uppsala University
Drug-Related Problems
Optimizing Drug-Therapy in Patients 80 Years and Older
The purpose of this study is to measure the effects of an enhanced service where a pharmacists is part of the healthcare team on the ward (focusing on drug-related problems and transferring information between primary and…
- Trial name
- NCT00661310
- Testing
- Drug review 80+ -To reduce usage of hospital care
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Uppsala University Hospital
Anastomotic Leak, Rectal Cancer
Comparative Study of Circular Stapling Instruments
After removing the rectum at surgery, bowel continuity can sometimes be restored by an anastomosis between the anus and the bowel. This anastomosis is most commonly created by the use of surgical circular stapling instruments.
- Trial name
- NCT00399009
- Testing
- AutoSuture Premium Plus CEEA/Ethicon Proximate ILS
- Where
- Sweden
- Volunteers
- 880 people
- Sponsor
- Uppsala University Hospital