Clinical trials: sponsored by Uppsala University
Depression, Pregnancy Related
PREGBRAIN - Magnetic Stimulation of the Brain in Depressed Pregnant Women
Background: Depression during pregnancy is common, afflicting 10-20% of pregnant women. Nevertheless, many women want to avoid antidepressant treatment during pregnancy, due to the possible impact on the unborn child.
- Trial name
- NCT04867889
- Testing
- iTBS (intermittent theta-burst stimulation)
- Where
- Sweden
- Sponsor
- Uppsala University
Pulmonary Aspiration of Gastric Contents
A Multicentre Preoperative Fasting Audit
The new European Society of Anaesthesiology and Intensive Care (ESAIC) preoperative fasting guideline recommends a one hour minimum fasting time for clear fluids.
- Trial name
- EUROFAST (NCT05519969)
- Where
- Sweden
- Volunteers
- 307,162 people
- Sponsor
- Uppsala University
Mental Health Issue, Depression, Anxiety
A Study on Young Individuals' Mental Health in Sweden
The goal of this observational study is to increase our knowledge about the mental health of young individuals and to establish a valid and comprehensive method for assessing mental health in young individuals (15-29 years) that…
- Conditions
- Mental Health Issue, Depression, Anxiety, Well-Being, Psychological
- Trial name
- UPIC (NCT06490120)
- Testing
- sampling method
- Where
- Sweden
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Multi-antibiotic Resistance
Use of New Antibiotics in Sweden
Antibiotic resistance is a growing global health problem of great concern, especially multidrug-resistant Gram-negative bacteria. In recent years some new antibiotics targeting these bacteria have been developed.
- Trial name
- NCT05048693
- Where
- 7 sites in Sweden
- Volunteers
- 41 people
- Sponsor
- Uppsala University
Rectal Prolapse
FOAM: Functional Outcome After Ventral Mesh Rectopexy
Rectal prolapse is a protrusion of rectal wall through the anus. A surgical technique called Ventral mesh rectopexy has become a standard procedure for this condition in many centers.
- Trial name
- NCT06455501
- Testing
- Ventral mesh rectopexy
- Volunteers
- 70 people
- Sponsor
- Uppsala University
Ovarian Cancer, Fallopian Tube Cancer
Early Detection of Relapse in Ovarian Cancer Using Capillary Home-sampling and a Protein Biomarker Test
PURPOSE/AIMS There is no consensus on optimal follow-up after ovarian cancer. A recent study demonstrated eight months prolonged survival in patients with complete surgical resection.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- FOLL-OV (NCT06445621)
- Where
- Sweden
- Volunteers
- 125 people
- Sponsor
- Uppsala University Hospital
Dupuytren Contracture, Dupuytren's Disease
Effectiveness of Night Splinting After Percutaneous Needle Fasciotomy in Dupuytren's Contracture
Dupuytren's contracture (DC) is associated with progressive finger flexion and extension deficit caused by fibrosis in the palm and digits.
- Trial name
- NCT05300893
- Testing
- No night splint
- Where
- 3 sites in Sweden
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Metacarpal Fracture
Midterm (Min. 3yr) Follow-up of Patients With Single Spiral/Oblique Finger Metacarpal Fracture
Spiral metacarpal fractures (metacarpal II-V) can be treated conservatively or with operation. With minimal displacement this fracture is usually treated with immobilisation or early mobilisation.
- Trial name
- NCT05869331
- Testing
- Early mobilization, Operative treatment
- Where
- 2 sites in Sweden
- Volunteers
- 35 people
- Sponsor
- Uppsala University
Acute Kidney Injury Following Administration of Contrast Media
Incidence of Acute Kidney Injury After Administration of Iodine Contrast Media in Patients With Reduced Renal Function
This study is examining if injection of iodine contrast media increases the risk of acute kidney injury in patients with severely reduced renal function.
- Trial name
- COINCIDES (NCT06171958)
- Testing
- Iodine-containing Contrast Media
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Uppsala University
Animal Assisted Therapy
Title: Urinary Oxytocin Levels in Children Receiving Animal-Assisted Therapy
There has been growing interest in animal-assisted therapy (AAT) in recent decades due to increasing reports indicating its health benefits for adult patients.
- Trial name
- NCT06414876
- Testing
- Hospital dog
- Volunteers
- 50 people
- Sponsor
- Uppsala University
Apneic Oxygenation
Flow Rate Impact on Arterial Carbon Dioxide During THRIVE
Apneic oxygenation describes the process of continuous oxygenation of the blood without breathing efforts. This anesthesia technique has been described in the literature for more than 100 years and is sometimes used under general…
- Trial name
- ThriVent (NCT05234424)
- Testing
- THRIVE
- Where
- Sweden
- Volunteers
- 1 people
- Sponsor
- Uppsala University Hospital
Ischemic Stroke, Atrial Fibrillation
TIMING of Oral Anticoagulant Therapy in Acute Ischemic Stroke With Atrial Fibrillation
This study will compare early with late start of treatment with Non-vitamin K oral anticoagulation (NOAC) in adult patients with acute ischemic stroke and atrial fibrillation; it is a registry-based randomized clinical trial…
- Trial name
- NCT02961348
- Testing
- Early start of NOAC, Late start of NOAC
- Where
- 36 sites in Sweden
- Volunteers
- 888 people
- Sponsor
- Uppsala University
Anesthesia, Parent-Child Relations
Parental Presence at Anesthesia Induction
Parental presence during induction for young infants is still debated. There is a paucity of information on the real-world interaction between parents, infant and the anesthesia team.
- Trial name
- PPAI (NCT05787717)
- Testing
- Parental presence
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Uppsala University Hospital
Pulmonary Aspiration of Gastric Contents
Gastric Content After 6 vs 4 Hours of Preoperative Fasting in Children
The primary objective of the study is to compare the risk of increased stomach contents after tube feeding (Enteral feeding) 6 and 4 hours before anesthesia using antrum measured by ultrasound.
- Trial name
- ENGUS (NCT05695066)
- Testing
- Preoperative fasting instruction
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Uppsala University Hospital
Opioid Use, Opioid Use Disorder
Translation and Validation of the COMM and ASI-SR
The goal of this observational study is to translate the COMM (Current opinion misuse measure) form and validate it using the ASI-SR (Addiction severity score-self report)in a Swedish population of pain patients treated with…
- Conditions
- Opioid Use, Opioid Use Disorder, Alcohol Use Disorder, Pain, Chronic
- Trial name
- COMMISS (NCT06084520)
- Testing
- Current Opioid Misuse Measure (COMM)-SWE, Oral fluid drug test, PETh
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Uppsala University
Colorectal Cancer, Peritoneal Carcinomatosis, Anastomosis Insufficiency
The Impact of Gut Microbiota in Anastomoses Insufficiency After Resection and Direct Anastomosis for Colorectal Cancer.
The role of gut microbiota in anastomosis insufficiency in patients operated for colorectal cancer and for peritoneal carcinomatosis is going to be investigated. This is a pilot study.
- Trial name
- NCT04252560
- Testing
- Colectomy, CRS+HIPEC
- Where
- Sweden
- Volunteers
- 45 people
- Sponsor
- Uppsala University Hospital
B-cell Lymphoma
CAR20(NAP)-T Therapy for B Cell Lymphoma (CARMA-01 Study)
The purpose is to study the safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of CAR20(NAP)-T for patients with B-cell malignancies.
- Trial name
- CARMA-01 (NCT06002659)
- Testing
- CAR20(NAP)-T, Cyclophosphamide, Fludarabine
- Where
- 2 sites in Sweden
- Volunteers
- 18 people
- Sponsor
- Uppsala University
Pre-Eclampsia
Study for Improving Maternal, Pregnancy and Child Outcomes
The overall aims of this proposal are to improve, facilitate, optimize and equalize the existing screening system for adverse pregnancy outcomes in early pregnancy in order to limit adverse consequences for both the mother and…
- Trial name
- IMPACT (NCT03831490)
- Testing
- history
- Where
- 9 sites in Sweden
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Pain, Chronic, Mental Disorder
Evaluation of a Collaborative Intervention to Promote Employer Contact and RTW Among People With CMD or Chronic Pain
The overall aim of this cluster ranomized controlled trial is to investigate whether an intervention for collaboration between patient with CMD or chronic pain and employer (the Demand and Ability Protocol) can contribute to…
- Trial name
- NCT05216861
- Testing
- Demand and ability protocol, Collaborative interventions as usual
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Uppsala University
Acute Kidney Injury, Cancer Colorectal
Propofol and Sevoflurane Anesthesia in Colorectal Cancer Surgery: Incidence of Acute Kidney Injury
The goal of this observational study is to compare anesthetic modalities (intravenous propofol anesthesia with sevoflurane gas anesthesia) in patients who underwent colorectal cancer resection surgery regarding the outcome of…
- Trial name
- PROSACC (NCT05585866)
- Testing
- Anesthesia Agent
- Where
- Sweden
- Volunteers
- 4,000 people
- Sponsor
- Uppsala University