Clinical trials: sponsored by VA Office of Research and Development
Dementia
Prazosin and Cerebrospinal Fluid (CSF) Biomarkers in Mild Traumatic Brain Injury (mTBI)
Mild traumatic brain injury (mTBI) from explosions is the "signature injury" of Veterans who have deployed to the wars in Afghanistan and Iraq.
- Trial name
- PoND (NCT03221751)
- Testing
- prazosin hydrochloride
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
Stroke, Hemiparesis
Plantarflexor PAS - Stroke
The current project investigates a method called paired associative stimulation (PAS) which is known to influence nervous system function through a process called neuroplasticity.
- Conditions
- Stroke, Hemiparesis, Gait Dysfunction
- Trial name
- PAS - Stroke (NCT04515407)
- Testing
- PAS at Rest, PAS - Active, PAS - Walking
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder (PTSD)
The Impact of Vocational Rehabilitation on Mentally III Veterans
To study the impact of Individual Placement and Support (IPS) supported employment (SE) compared to treatment-as-usual vocational rehabilitation program (VRP) for veterans with posttraumatic stress disorder (PTSD).
- Trial name
- NCT00333801
- Testing
- Vocational Rehabilitation Program (VRP), Individual Placement and Support (IPS)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Stroke
Post-stroke Psychosocial Recovery
Stroke is a neurological injury that adversely impacts psychosocial functioning and quality of life. This may occur due to direct insult to the brain circuits integral to adaptive psychosocial functioning, and/or indirectly via…
- Trial name
- NCT05380037
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Osteoarthritis, Knee
STepped Exercise Program for Knee OsteoArthritis
Knee osteoarthritis (OA) is one of the most common chronic conditions and a leading cause of disability among Veterans. Although exercise is known to improve pain, physical abilities, and other outcomes for patients who have knee…
- Trial name
- STEP-KOA (NCT02653768)
- Testing
- Stepped Exercise Program, Arthritis Education
- Where
- United States
- Volunteers
- 345 people
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment
Exercise Training to Improve Cognitive Function
This project is assessing the feasibility of a novel home-based exercise intervention to improve episodic memory in individuals with mild cognitive impairment.
- Trial name
- NCT03824639
- Testing
- Structured exercise, Health Education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Cardiovascular Disease
PCI Alternative Using Sustained Exercise
Cardiovascular disease remains the leading cause of morbidity and mortality in the U.S. and is a major cause of disability in Veterans. Most of these deaths are due to coronary artery disease (CAD).
- Trial name
- PAUSE (NCT03520400)
- Testing
- Exercise Therapy
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- VA Office of Research and Development
Transhumeral Amputation
EFS Functional Expectations of Transhumeral Percutaneous OI Patients
An FDA Early Feasibility Study (EFS) allows for early clinical evaluation of devices to provide proof of principle and initial clinical safety data.
- Trial name
- AEA PODS (NCT03824444)
- Testing
- PODS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Suicide
REACH VET Implementation Program Evaluation
The VA's Office of Mental Health and Suicide Prevention implemented an new program to increase suicide prevention outreach for Veterans at highest risk for suicide.
- Trial name
- REACH VET (NCT03280225)
- Testing
- External facilitation
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Geriatric Syndrome
Expanding Access to Comprehensive Geriatrics Care Via Telehealth
The overall objective of the TeleGRACE project is to improve the care and outcomes of older Veterans with a recent inpatient stay by expanding access to the evidence-based GRACE program, by evaluating a telehealth implementation.
- Trial name
- TeleGRACE (NCT05166603)
- Testing
- TeleGRACE
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- VA Office of Research and Development
Peripheral Arterial Disease, Intermittent Claudication
Exercise Rehabilitation in Veterans With PAD
Peripheral artery disease (PAD) results in blockages of arteries (blood vessels) and decreased blood flow to the legs. This may cause difficulty or pain with walking or other activities that use leg muscles.
- Trial name
- NCT02607046
- Testing
- Exercise training, NMES
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury (mTBI), Post-traumatic Stress Disorder
Transcranial Electrical Stimulation for mTBI
mTBI is a leading cause of sustained physical, cognitive, emotional, and behavioral deficits in OEF/OIF/OND Veterans and the general public.
- Trial name
- TESmTBI (NCT03244475)
- Testing
- TES
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cocaine Addiction, Opioid Addiction
sTMS for Substance Use-disordered Veterans
The purpose of this study is to determine if synchronized transcranial magnetic stimulation is safe and tolerable in individuals with cocaine, opioid, or alcohol use disorders.
- Conditions
- Cocaine Addiction, Opioid Addiction, Alcohol Addiction
- Trial name
- NCT04336293
- Testing
- sTMS
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Stroke
Effect of Constraint-Induced Gaming Therapy in an Acute Care Setting
Current protocols for therapy on a rehabilitation unit call for intensive rehabilitation composed of high intensity, long duration therapy.
- Trial name
- CIT (NCT03578536)
- Testing
- Recovery Rapids
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- VA Office of Research and Development
Homelessness, Mental Health Conditions
ASPIRE Cognitive Enhancement Study
Cognitive impairments are present in up to 80% of homeless individuals, and may contribute to homelessness in Operation Enduring Freedom / Operation Iraqi Freedom / Operation New Dawn (OEF/OIF/OND) Veterans.
- Trial name
- ACES (NCT02657954)
- Testing
- CCT, HCE
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- VA Office of Research and Development
Depressive Disorder, Major
VA Aripiprazole vs Esketamine for Treatment Resistant Depression
This is an open-label, parallel-group, randomized clinical trial of up to 6 months treatment of adjunctive intranasal (IN) esketamine (ESK) vs.
- Trial name
- VAST-D II (NCT05554627)
- Testing
- Esketamine, Aripiprazole
- Where
- 26 sites in United States
- Sponsor
- VA Office of Research and Development
Parkinson's Disease
Amyloidopathy, Cholinopathy, Dopamine Responsiveness and Freezing of Gait in PD
Early stage Parkinson disease (PD) is characterized by a 'honeymoon' phase in terms of responsiveness of motor symptoms, including gait, to dopaminergic pharmacotherapy.
- Trial name
- FOG (NCT03647137)
- Testing
- Detailed motor testing, including FoG, in PD subjects
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- VA Office of Research and Development
Upper Extremity Hemiplegia, Stroke
Contralaterally Controlled Functional Electrical Stimulation Plus Video Games for Hand Therapy After Stroke
Determine if adding a video game component to an electrical stimulation therapy improves hand function in stroke patients
- Trial name
- NCT03058796
- Testing
- Contralaterally Controlled Functional Electrical Stimulation (CCFES), Hand Therapy Video Games
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VA Office of Research and Development
Substance Use Disorder
Virtual MOUD Treatment- Virtual POC Toxicology
Care for Substance use disorders (SUD) such as Medication treatment of Opioid Use Disorder (MOUD) saves lives and is increasingly delivered virtually. Currently, 60% of VA outpatient addiction treatment occurs over video.
- Trial name
- NCT05448118
- Testing
- Virtual POC Toxicology Test
- Where
- 2 sites in United States
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic, Depression
Development of a Patient Centered Mental Health Intervention for Recent Veterans
Recent Veterans of the OIF/OEF/OND conflicts are presenting in VA care with high rates of: PTSD, depression, anxiety, and alcohol abuse, reporting significant difficulties with community reintegration, and dropping out of mental…
- Conditions
- Stress Disorders, Post-Traumatic, Depression, Anxiety, Substance-Related Disorders
- Trial name
- PCC MH (NCT02943408)
- Testing
- person-centered mental health intervention, health and wellness
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development