Clinical trials: sponsored by Vrije Universiteit Brussel
Neoplasms, Cancer Survivorship
Effectiveness of a Guided, Web-based, Stepped-care-approach to Cognitive Behavioral Therapy for Insomnia in Cancer Survivors
The goal of this multicenter randomized clinical trial is to develop and evaluate a web-based stepped-care approach to Cognitive Behavioral Therapy for Insomnia (CBT-I), specifically tailored to adult cancer survivors…
- Conditions
- Neoplasms, Cancer Survivorship, Insomnia
- Trial name
- eNightfall (NCT07876661)
- Testing
- Stepped-care Cognitive Behavioral Therapy for Insomnia, Standard web-based Cognitive Behavioral Therapy for Insomnia, Control arm - Care as usual with sleep hygiene leaflet
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- Vrije Universiteit Brussel
Social Isolation, Isolated Confined and Extreme Conditions
The Impact of Long-term Isolation in Antarctica on Social Touch and Its Underlying Biological Mechanisms in Winter-over Crew Members, Assessed During Their Stay Using Standardized Touch Stimulation, Computer-based Touch Sensitivity Tests, Questionnaires and Biological Markers.
TACTICE investigates how long-term isolation and reduced social touch during an Antarctic winter-over affect the way people perceive and respond to touch.
- Trial name
- TACTICE (NCT07858240)
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 28 people
- Sponsor
- Vrije Universiteit Brussel
Psychiatric Disorder
Cognitive Model for Behavioral Interventions as a Personalized Intervention for Patients With Serious Mental Illness
The aim of this clinical study is to investigate whether CoMBI-SMI helps to reduce behavioral problems and psychiatric complaints in Serious Mental Illness (SMI) populations complaints and to reduce the burden on informal…
- Trial name
- NCT05820360
- Testing
- CoMBI-SMI
- Where
- Netherlands
- Volunteers
- 94 people
- Sponsor
- Vrije Universiteit Brussel
Fatigue, Older Adults (65 Years and Older)
Exploring the Effect of the Hypershell Hip Exoskeleton on Fatiguing, Everyday Activities in Older Adults
The goal of this clinical trial is to learn how wearing the Hypershell lower-limb exoskeleton affects perceived fatigue during everyday mobility activities in adults aged 65 years and older.
- Conditions
- Fatigue, Older Adults (65 Years and Older), Exoskeleton Device
- Trial name
- Hypershell (NCT07840872)
- Testing
- Performance test, Hypershell assistance (EXO-ON Actuation)
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Healthy Adolescents in School-based Population, Emotional Neglect
Recognizing Emotional Neglect and Help-Seeking Intention Among Adolescents in Brussels
The goal of this study is to find out how well adolescents in Dutch-speaking secondary schools in Brussels can recognize emotional neglect, and how this relates to their intention to seek help. The main research questions are: 1.
- Conditions
- Healthy Adolescents in School-based Population, Emotional Neglect, Help-Seeking Behavior
- Trial name
- NCT07365891
- Testing
- Emotional neglect vignettes
- Where
- Belgium
- Volunteers
- 749 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Childhood Cancer
Pain, Body Composition and Physical Activity in Childhood Cancer.
Comparing baseline assessments of children with cancer and their parents with baseline assessments of healthy children and their parents in a case-control study will allow the investigators to make the comparison in terms of…
- Trial name
- NCT04004455
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Children Living Beyond Cancer (i.e. Child Cancer Survivor)
Co-creation of Pain Science Education for Children Living Beyond Cancer
A pain science education (PSE) intervention for children (8-12y) living beyond cancer (CBC) will be developed through a co-creational approach with CBC, their parents and pediatric oncology clinicians.
- Trial name
- PANACEA (NCT06345391)
- Testing
- Co-creation, Concept Mapping
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Hospital Associated Disability, Immobility
Targeting Muscle Strength Loss Due to Hospitalization in Older Adults by Blood-flow Restriction Combined With an Electromyography-driven Serious Game.
This study investigates a new training method designed to help older adults preserve their muscle strength during hospitalization.
- Conditions
- Hospital Associated Disability, Immobility, Older Adults (65 Years and Older)
- Trial name
- GHOSTLY+ (NCT07294131)
- Testing
- Gamified isometric strength training with blood flow restriction, Standard Physiotherapy
- Where
- 3 sites in Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Sleep Problems, Parasomnias
Sleep in Children Placed in Out-of-home Care
This project aims to contribute to the existing literature on sleep in children placed in out-of-home care by addressing current gaps and integrating the investigation of sleep and associated risk factors, including adverse…
- Conditions
- Sleep Problems, Parasomnias, Enuresis Nocturnal
- Trial name
- NCT07820683
- Testing
- Sleep and Adjustment in Foster care Environments (SAFE) intervention, Sleep Education Support
- Volunteers
- 730 people
- Sponsor
- Vrije Universiteit Brussel
Chronic Diseases in Children
Using a Humanoid Robot to Distract Children With Chronic Conditions Undergoing Painful Procedures
The aim of this study is to examine the effect of using a humanoid robot during a painful puncture procedure (e.g., portal catheter punction, IV punctures, blood withdrawal, etc.) in children with chronic conditions (e.g.…
- Trial name
- NCT04003701
- Testing
- Usual care, Robot-assisted puncture procedure
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Vrije Universiteit Brussel
Childhood Cancer Survivors
Pain and Sleep Disturbances in Children Living Beyond Cancer: A Case-Control Study
Children living beyond cancer (CBC) represent a unique and growing population of young people in need of long-term clinical support.
- Trial name
- NCT07120646
- Testing
- Questionnaire, actigraphy measurement and sleep diary
- Where
- 2 sites in Belgium
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Acute Heart Failure, Diuretics Drug Reactions
Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment
This is a pragmatic, multicenter, interventional, parallel-arm, randomized, open-label trial to investigate whether a diuretic regimen, based on serial assessment of sodium concentration (UNa) on spot urine samples after diuretic…
- Trial name
- DECONGEST (NCT05411991)
- Testing
- UNa measurement after intravenous loop diuretic bolus, Intravenous acetazolamide 500 mg OD, Intravenous bumetanide TID
- Where
- 2 sites in Belgium
- Volunteers
- 107 people
- Sponsor
- Vrije Universiteit Brussel
Cataract
Bilateral Monofocal Versus Monofocal-EDOF IOL Implantation: Quality of Vision Comparison
The goal of this clinical trial is to compare visual quality after cataract surgery between two groups: bilateral monofocal intraocular lenses (IOL) and monofocal and contralateral extended depth-of-focus (EDOF) IOL implantation.
- Trial name
- COMEDI (NCT06002399)
- Testing
- cataract surgery
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Pterygium
The Use of Lidocaine Gel Versus Subconjunctival Xylocaine Injection in Pterygium Excision
In pterygium excision procedures, the subconjunctival injection of xylocain is regarded as an uncomfortable and painful step in the procedure.
- Trial name
- LIDPTER (NCT05978687)
- Testing
- OPHTESIC LIDOCAINE HYDROCHLORIDE 20MG/G, Xylocaine with Epinephrine
- Where
- Belgium
- Volunteers
- 41 people
- Sponsor
- Vrije Universiteit Brussel
Parkinson Disease, Parkinson
tDCS of the Primary Motor Cortex to Improve Implicit Motor Sequence Learning in Parkinson's Disease
Implicit motor sequence learning (IMSL) is a form of cognitive function that is known to be directly associated with impaired motor function in Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Parkinson, Healthy
- Trial name
- NCT04606979
- Testing
- 1x1 Low Intensity Transcranial Direct Current Stimulation (tDCS)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Chronic Low-back Pain, Overweight or Obesity
Weight Reduction in CLBP
We will recruit overweight/ obese participants between the age of 18 and 65 with chronic nonspecific low back pain . The participants will be randomly assigned to one of two interventions (each lasting 10 weeks).
- Trial name
- NCT04824248
- Testing
- Pain Neuroscience Education, Cognition-targeted exercise therapy, Behavioral weight reduction program
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 84 people
- Sponsor
- Vrije Universiteit Brussel
Overweight or Obesity, Chronic Low-back Pain
Lifestyle Intervention in Overweight/Obese Chronic Low Back Pain (CLBP) Patients: an International Multi-center RCT
Chronic low back pain (CLBP) is the most expensive cause of workrelated disability: it causes the highest number of years lived with disability.
- Trial name
- BO2WL (NCT05811624)
- Testing
- Physiotherapy intervention, including behavioral weight reduction program combined with pain neuroscience education and cognition-targeted exercise therapy., Physiotherapy intervention, including pain neuroscience education and cognition-targeted exercise therapy alone.
- Where
- 2 sites in Belgium, Switzerland
- Volunteers
- 252 people
- Sponsor
- Vrije Universiteit Brussel
Osteoarthritis, Knee, Insomnia
Added Value of Cognitive Behavioural Therapy for Insomnia in Persons With Knee Osteoarthritis
Knee osteoarthritis (KOA) is the leading and fastest increasing cause of disability in older adults. It is a serious health issue related with a high health care utilisation.
- Trial name
- PREMEO (NCT05387473)
- Testing
- Cognitive behavioral therapy for insomnia (CBT-I) integrated in best-evidence usual care (CBTi-UC), Best-evidence usual care (UC) plus information sessions
- Where
- Belgium
- Volunteers
- 128 people
- Sponsor
- Vrije Universiteit Brussel
Behavioral and Psychological Symptoms of Dementia
Cognitive Model for Behavioral Interventions as a Non-pharmacological Intervention for Behavioral and Psychological Symptoms of Dementia
The goal of this study is to evaluate whether the Cognitive Model for Behavioral Interventions (CoMBI), a person-centered, non-pharmacological intervention, can reduce behavioral and psychological symptoms of dementia (BPSD) in…
- Trial name
- NCT07356336
- Testing
- CoMBI
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Vrije Universiteit Brussel
Behavioural Problems
Flemish Foster Parents' Satisfaction With Foster Care and Their Extra Support Needs With Parenting
From foster parents' perspectives, this study aims to shine light on the (problem) behaviour children in Flemish foster care have.
- Trial name
- NCT07775222
- Testing
- Questionnaire and Physical Exam
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel