Clinical trials: sponsored by Western University, Canada
Cerebral Palsy, Spina Bifida
Evaluation of the Transitional and Lifelong Care Program
The population cared for in the Transitional and Lifelong Care (TLC) clinic is youth and adults with childhood-onset disability, of which the large majority are adults with brain-based, neurodevelopmental conditions such as…
- Conditions
- Cerebral Palsy, Spina Bifida, Developmental Disability
- Trial name
- NCT05849285
- Testing
- TLC Clinic
- Where
- Canada
- Volunteers
- 410 people
- Sponsor
- Western University, Canada
Functional Movement Disorder
Feasibility and Usability of a Mobile App for Monitoring and Managing Functional Movement Disorders
People with FMD may experience symptoms such as tremor, jerks, spasms, or difficulty walking. These symptoms are not caused by damage to the brain or nerves.
- Trial name
- NCT07372755
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Western University, Canada
Functional Movement Disorder
Action Outcome Latencies as a Measure of Sense of Agency in Functional Movement Disorders.
Functional movement disorders (FMD) are among the most common neurological conditions seen in clinical practice, yet they are poorly understood and often misdiagnosed.
- Trial name
- NCT07302308
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Head and Neck Cancer, Survivorship
Survivorship After HNC: A Randomized Controlled Trial Evaluating Patient Care and Adherence to Follow-up
Treatment summary and survivorship care plans (TSSPs) are poorly studied in Head and Neck Cancer (HNC) patients, and given the high frequency of unmet needs, this patient population has potentially the most to benefit from the…
- Trial name
- NCT06127784
- Testing
- Motivational interviewing counselling session
- Where
- Canada
- Volunteers
- 176 people
- Sponsor
- Western University, Canada
Rheumatoid Arthritis, Comorbidities and Coexisting Conditions
Comorbidity Management in Rheumatic Disease.
Rheumatoid arthritis is a disease where the immune system attacks the body by mistake, causing inflammation of the joints and other body parts.
- Trial name
- NCT06579222
- Testing
- Primary Care Rheumatology Family Physician Consultation
- Where
- Canada
- Volunteers
- 199 people
- Sponsor
- Western University, Canada
Bladder Cancer
Enhancing Patient Comfort and Reducing Anxiety During Flexible Cystoscopy and Bladder Instillation in Bladder Cancer Patients: A Randomized Controlled Trial and Observational Study
The goal of this clinical trial is to learn if certain comfort-enhancing interventions can reduce pain and anxiety during flexible cystoscopy and bladder instillation in patients with bladder cancer.
- Trial name
- Flexi-comfort (NCT07204301)
- Testing
- Optimized Timing of Intravesical Lidocaine Gel, Calming Music During Procedure, Visual Distraction with Screen Content
- Where
- Canada
- Volunteers
- 378 people
- Sponsor
- Western University, Canada
Cannabis Use, Cannabis Smoking
Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking
This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 3 years, and impacts of cannabis smoking on the lungs will be measured with magnetic…
- Conditions
- Cannabis Use, Cannabis Smoking, Marijuana Smoking, Marijuana Usage
- Trial name
- NCT03909477
- Testing
- Hyperpolarized Xenon-129 MRI of the lungs, Computed Tomography (CT), Pulmonary Function Tests (PFTs)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
E Cigarette Use
Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers
This is a longitudinal study of the long-term health impact of e-cigarette smoking on the lungs. Participants will be followed over a period of 5 years, and impacts of e-cigarette smoking on the lungs will be measured with…
- Trial name
- NCT04616313
- Testing
- Hyperpolarized Xenon-129 MRI of the lungs, Computed Tomography (CT), Pulmonary Function Tests (PFT)
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Covid19
Lung Structure-Function In Survivors of Mild and Severe COVID-19 Infection
This is a longitudinal study of the long-term impact of COVID-19 on the lungs. Participants will be followed over a period of up to 4 years and impacts of COVID-19 on the lungs will be measured with magnetic resonance imaging…
- Trial name
- LIVECOVIDFREE (NCT04584671)
- Testing
- Hyperpolarized Xenon-129 MRI of the lungs, Computed Tomography (CT), Pulmonary Function Tests (PFT)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Western University, Canada
Lung Disease
A Single-Centre Pilot Study Exploring the Utility of Magnetic Resonance Imaging in Patients With Chronic Lung Disease
Male and female subjects age 18-85 with lung disease will inhale 5ml/kg (patient body weight) hyperpolarized helium and will be scanned using MRI at 3 Tesla, to evaluate the Apparent Diffusion Coefficient (ADC), ventilation…
- Trial name
- NCT02723474
- Testing
- MRI at baseline and over time
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Western University, Canada
Healthy Volunteers
Healthy Lung Study- Development of 3T MRI Hardware and Software for 3He Gas Imaging of the Lung: Healthy Volunteer Development Study
Healthy volunteers aged 18-75 will undergo hyperpolarized 3-Helium MRI and pulmonary function testing for the development of tools to assess image signal to noise and reproducibility of spin-density and diffusion-weighted imaging.
- Trial name
- NCT03169673
- Testing
- Hyperpolarized Helium 3 Magnetic Resonance Imaging
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Healthy
Longitudinal 3He Magnetic Resonance Imaging of Healthy Lung
Healthy elderly subjects male and female aged 65-85 will undergo MRI, lung function and exercise testing for the development of tools to quantify and validate longitudinal in vivo magnetic resonance imaging phenotypes of the…
- Trial name
- NCT02483403
- Testing
- Hyperpolarized Helium-3, MRI
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Alcohol-Related Disorders
Alcohol & Exercise Study
The goal of this clinical trial is to learn if exercise can reduce alcohol craving in heavy social alcohol drinkers. The main questions this project aims to answer are 1) compared to a distraction activity (i.e., coloring), will…
- Trial name
- Alc-Excr (NCT05955911)
- Testing
- Exercise, Coloring
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- Western University, Canada
Testicular Cancer
A Clinical Trial of Primary Retroperitoneal Lymph Node Dissection in Patients With Testicular Seminoma With Limited Retroperitoneal Metastases
Testicular cancer represents 1% of adult neoplasms and is the most common solid malignancy in young men. At diagnosis, approximately 90% of cases are germ cell tumours (GCT), categorised as either seminoma (55-60%) or…
- Trial name
- RPLND-Seminoma (NCT06932458)
- Testing
- Retroperitoneal Lymph Node Dissection
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Western University, Canada
Liver Cancer, Kidney Cancer
(3D) Ultrasound Imaging Liver and Kidney
This study is to assess the addition of 3D ultrasound guidance during standard care ablation or biopsies of liver or kidney tumours.
- Trial name
- NCT03844399
- Testing
- Ablation, Biopsy
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Western University, Canada
Sudden Cardiac Death
The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest
Sudden cardiac death (SCD) remains a major cause of mortality within developed nations despite aggressive efforts to reduce its societal burden.
- Trial name
- EPS ARREST (NCT03079414)
- Testing
- Invasive Electrophysiology Study
- Where
- 21 sites in United States, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- Western University, Canada
Diabetes Mellitus, Type 2
The FreeStyle Libre Enabled Reduction of A1c Through Effective Eating and Exercise Study
This two-year multisite, real-world, before-after prospective six-month pilot study utilizing a single-group cohort design (n=184) which will first occur in London, Ontario (n=92) through the St.
- Trial name
- LIBERATE (NCT05261906)
- Testing
- LIBERATE
- Where
- Canada
- Volunteers
- 184 people
- Sponsor
- Western University, Canada
Kidney Diseases, Dialysis; Complications
PRevEnting FracturEs in REnal Disease - 1
PREFERRED-1 is a pilot study designed to determine the feasibility of a large randomized, pragmatic, open-label, comparative-effectiveness trial of denosumab for the prevention of fragility fractures in people receiving…
- Conditions
- Kidney Diseases, Dialysis; Complications, Fragility Fracture, Chronic Kidney Disease-Mineral and Bone Disorder
- Trial name
- PREFERRED-1 (NCT05096195)
- Testing
- Denosumab 60 mg/ml, Calcium and vitamin D prophylaxis, Monitoring of post-injection calcium and phosphate
- Where
- 6 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Western University, Canada
Anterior Cruciate Ligament Reconstruction, Post-traumatic Osteoarthritis
STABILITY: Physical Activity Intervention at 7 Years Post-Anterior Cruciate Ligament Reconstruction
Anterior cruciate ligament (ACL) ruptures are very common knee injuries amongst youth involved in sports and are often treated through ACL reconstruction surgeries.
- Trial name
- NCT05152758
- Testing
- PARx
- Where
- Canada
- Volunteers
- 196 people
- Sponsor
- Western University, Canada
Autism Spectrum Disorder, Suspected Autism
Caregiver Training to Support Children With Social Communication Challenges
"More Than Words® - The Hanen Program® for Parents of Autistic Children or Children Who May Benefit from Social Communication Support" is a family-focused intervention program delivered by a speech-language pathologist (SLP).
- Conditions
- Autism Spectrum Disorder, Suspected Autism, Social Communication Challenges
- Trial name
- NCT06909279
- Testing
- The Hanen Centre's More Than Words® program
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Western University, Canada