Clinical trials: sponsored by Xijing Hospital
Breast Cancer
Research on the Potential Mechanisms Underlying the Efficacy Differences in Specific Neoadjuvant Treatment Regimens for Different Subtypes of Breast Cancer
This study is a single-center, open-label, prospective, clinical cohort study. It enrolled patients in three subgroups: triple negative, HR+HER2-, or HR-HER2+ subtypes, who will receive neoadjuvant treatment according to…
- Trial name
- NCT07012720
- Testing
- Single-cell sequencing and spatial transcriptome
- Where
- China
- Volunteers
- 71 people
- Sponsor
- Xijing Hospital
Breast Cancer, Breast Reconstruction
3D-printed Biodegradable Breast Implants for Breast Restoration
The purpose of this clinical trial is to evaluate the cosmetic effect of breast reconstruction based on 3D-printed biodegradable material breast implants in personalized breast reconstruction and the quality of life of patients…
- Trial name
- NCT06993714
- Testing
- Breast restoration surgery based on 3D printed degradable biological implants, Traditional breast-conserving surgery, Traditional silicone prosthesis breast reconstruction
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Immune-related Adverse Event, Chemotherapeutic Toxicity
Efficacy and Safety of Neoadjuvant Nivolumab Plus SOX Versus Nivolumab Plus FLOT in Patients With HER2-negative Gastric and Gastroesophageal Junction Adenocarcinoma
The goal of the study is to learn about Safety and efficacy of preoperative adjuvant SOX regimen combined with nivolumab versus FLOT Regimen with nivolumab in HER2-negative Gastric or Gastroesophageal Junction Adenocarcinoma.
- Conditions
- Immune-related Adverse Event, Chemotherapeutic Toxicity, Gastric or Gastroesophageal Junction Adenocarcinoma
- Trial name
- NCT06440811
- Where
- 3 sites in China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Hypertrophic Obstructive Cardiomyopathy (HOCM)
Clinical Outcomes of PIMSRA Treating for Hypertrophic Obstructive Cardiomyopathy: A Large-Sample Study
The Hypertrophic Cardiomyopathy Center of Xijing Hospital pioneered percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) as an innovative treatment for hypertrophic obstructive cardiomyopathy (HOCM) to relieve…
- Trial name
- NCT07003945
- Testing
- Percutaneous Intramyocardial Septal Radiofrequency Ablation
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Xijing Hospital
Ischemic Stroke, Acute, Minocycline
Minocycline for Acute Ischemic Stroke Undergoing Endovascular Treatment Due to Basilar Artery Occlusion (MIST-B)
This is a multi-center, evaluator-blinded, randomized, open-label, proof of concept trial to explore possible beneficial effect of adjunctive oral minocycline on acute ischemic stroke (AIS) undergoing endovascular treatment due…
- Conditions
- Ischemic Stroke, Acute, Minocycline, Endovascular Treatment, Basilar Artery Occlusion
- Trial name
- MIST-B (NCT05512910)
- Testing
- Minocycline
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Inflammatory Bowel Diseases, Colitis, Ulcerative
Investigation of the Correlation Between Polyamine Levels and Their Key Enzymatic Activities in Association With Inflammatory Bowel Disease Progression
Inflammatory Bowel Disease (IBD), encompassing Ulcerative Colitis (UC) and Crohn's Disease (CD), significantly impairs patients' quality of life.
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease, Polyamines
- Trial name
- NCT06995170
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Xijing Hospital
Ulcerative Colitis
Transcutaneous Electrical Acustimulation in the Treatment of Mild to Moderate Ulcerative Colitis
The aim of this study was to evaluate the efficacy and safety of transcutaneous electrical acustimulation in patients with mild to moderate ulcerative colitis.
- Trial name
- NCT06231264
- Testing
- transcutaneous electrical acustimulation at treatment sites
- Where
- 4 sites in China
- Volunteers
- 96 people
- Sponsor
- Xijing Hospital
Psoriasis (PsO), Randomised Controlled Trial
Sulodexide in Controlling the Recurrence of Psoriasis
This is a multicenter, randomized, double-blinded，controlled clinical trial. The purpose of the study is to evaluate the efficacy and safety of Sulodexide versus placebo in preventing psoriasis recurrence in patients with plaque…
- Trial name
- NCT06982196
- Testing
- Sulodexide
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Xijing Hospital
Intestinal Cancer
Investigating Multigene Methylation Dynamics in Treatment Response Surveillance for Intestinal Carcinoma
The primary objective is to determine whether pretreatment-to-posttreatment changes in circulating multigene methylation levels correlate with objective response rates (ORR) assessed by contrast-enhanced CT/MRI and levels of…
- Trial name
- NCT06979882
- Testing
- Multi-gene methylation testing
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Xijing Hospital
Non-suicidal Self-injury (NSSI), Adolescent
Clinical and Psychosocial Characteristics of Adolescent Patients With Non-Suicidal Self-Injury
The overall objective of this study is to explore the social and clinical psychological characteristics of adolescents with depression accompanied or not accompanied by non-suicidal self-harm. This is an observational study.
- Conditions
- Non-suicidal Self-injury (NSSI), Adolescent, Depression
- Trial name
- NCT06885749
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Breast Cancer
Clinical Efficacy and Safety Assessment of Breast-Conserving Surgery for Central Breast Cancer: A Prospective Randomized Controlled Trial
This study enrolled 158 patients with primary central early-stage breast cancer and randomly assigned them to two groups. The control group underwent total mastectomy (with optional prosthetic implantation or autologous tissue…
- Trial name
- NCT06938360
- Testing
- breast-conserving surgery combined with radiotherapy
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Xijing Hospital
Premature Ejaculation
Brain Activity During Sexual Behavior in Patients With Primary Premature Ejaculation a Clinical Trial
This is a controlled study of patients with and without primary premature ejaculation. It is based on near-infrared spectroscopy (NIRS) functional brain imaging to detect and compare changes in brain activity in resting and task…
- Trial name
- NCT06570135
- Testing
- Detecting Brain Activity with Functional Near Infrared Spectroscopy
- Where
- 2 sites in China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Disorders of Consciousness, Severe Brain Injury
Transcranial Temporal Interference Stimulation In Severely Brain Injured Patients With Disorders of Consciousness
The purpose of this academic lead study is to explore the effect of noninvasive neuromodulation of the CM-pf via tTIS for patients with disorders of consciousness.
- Conditions
- Disorders of Consciousness, Severe Brain Injury, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- NCT06851156
- Testing
- tTIS
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Xijing Hospital
COVID-19, Surgery
The Effect of COVID-19 Infection on Post-operative Complications
We did an multi-centre, observational cohort study in patients who had surgery in 2023. We included participants who underwent surgery after the COVID-19 to lift the lockdown in China.
- Conditions
- COVID-19, Surgery, Postoperative Complications
- Trial name
- NCT05677815
- Testing
- Underwent Surgery from 2019 to 2022
- Where
- China
- Volunteers
- 3,350 people
- Sponsor
- Xijing Hospital
AKI - Acute Kidney Injury, Delirium, Postoperative
Metabolomics Analysis of Acute Kidney Injury and Delirium After Cardiac Surgery
Clinical evidence suggests that renal injury leads to changes in the structure of the cerebral cortex in patients, suggesting the existence of the renal brain axis.
- Trial name
- NCT06508593
- Testing
- Serum metabolic profile
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Prostatic Neoplasms, Glioma
PET/CT Imaging Study With Simultaneous Dual-nuclide Imaging Technique
This is a study using a parallel control approach and is expected to recruit 35 volunteers, including 8 prostate cancer patients, 8 neuroendocrine tumour patients, 8 glioma patients, 8 Parkinson's syndrome patients, and 3 normal…
- Conditions
- Prostatic Neoplasms, Glioma, PARKINSON DISEASE (Disorder)
- Trial name
- NCT06914427
- Testing
- PET/CT
- Where
- China
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Drug-resistant Epilepsy, Transcranial Magnetic Stimulation
Long Term Efficacy and Safety of TMS Targeting Cerebellum to Treat DRE
This study aims to observe the long term efficacy and safety of cerebellar continuous θ burst stimulation (cTBS) for drug-resistant Epilepsy during enhanced and maintenance phase，in order to provide a new treatment for long-term…
- Trial name
- NCT06832813
- Testing
- cTBS
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Hyperuricemia
The Effect of Exercise at Different Time Intervals on Hyperuricemia
The study aim is to explore the correlation between exercise and hyperuricemia, find out the metabolic rule of uric acid after exercise, and provide scientific evidence and clinical guidance for how to exercise scientifically and…
- Trial name
- NCT06315569
- Testing
- Run 3000 meters
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Colorectal Neoplasms, Confocal Laser Endomicroscopy
Clinical Validation of Multimodal Digestive Endoscopy
According to the latest global cancer epidemiological data published by the International Agency for Research on Cancer, colorectal cancer (CRC) ranks 3rd in total incidence and 2nd in total mortality among all malignancies…
- Conditions
- Colorectal Neoplasms, Confocal Laser Endomicroscopy, Endoscopy, Digestive System, Molecular Imaging
- Trial name
- NCT05575765
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Adolescent, Depression - Major Depressive Disorder
Efficacy and Mechanism of Transcranial Temporal Interference Stimulation (tTIS) in the Treatment of Adolescent Depression
This trial is a single-center, single-blind, randomized, sham-stimulation controlled clinical trial. The primary objective of the trial is to detect the targeted effect of tTIS on the nucleus accumbens of adolescent depression…
- Trial name
- NCT06902064
- Testing
- Transcranial temporal interference stimulation
- Volunteers
- 30 people
- Sponsor
- Xijing Hospital