Clinical trials: sponsored by Xuanwu Hospital, Beijing
Mild Cognitive Impairment (MCI)
Effect of Intranasal Negative Pressure Therapy on Cognitive Function in Patients With Mild Cognitive Impairment and Obstructive Sleep Apnea
This study is a randomized controlled trial with two phases: pre-trial and formal trial. The pre-trial will include 5 participants to observe the 4-week adherence (≥4 hours/night) and safety (adverse event rate) of the iNAP…
- Trial name
- NCT07353359
- Testing
- Intranasal Negative Pressure
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke
Study on the Accuracy of Determining the Responsible Vessel in Medium Vessel Occlusive Stroke Based on Multi-type CT Evaluation
To evaluate the accuracy of diagnosing the qualifying artery in patients with medium vessel occlusion stroke based on multimodal CT
- Trial name
- NCT07347587
- Where
- China
- Volunteers
- 622 people
- Sponsor
- Xuanwu Hospital, Beijing
ICU Patients, Surgical
Implementation of Clinical Nutrition Practice Guidelines in Surgical ICUs
The goal of this interventional clinical trial is to evaluate whether the implementation of an evidence-based, context-adapted clinical nutrition practice guideline can improve clinical nutrition management in surgical intensive…
- Conditions
- ICU Patients, Surgical, Nutrition Intervention, Enteral Nutrition
- Trial name
- NCT07337798
- Testing
- Guideline Implementation
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer Disease
Investigator Initiated Trial of Galcanezumab Treatment in Alzheimer's Disease
This single-arm, open-label clinical study systematically evaluates the efficacy and safety of Galcanezumab in patients with mild-to-moderate Alzheimer's disease (AD).
- Trial name
- NCT07323927
- Testing
- Galcanezumab
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Orthostatic Hypotension
Research, Development, and Application of Intelligent Diagnostic System for Orthostatic Hypotension
Orthostatic hypotension (OH) has a high incidence rate of 30%-50% in the elderly and populations with neurodegenerative diseases.
- Trial name
- NCT07309666
- Testing
- Intelligent diagnostic system for orthostatic hypotension
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer Disease
Clinical Analgesic Management in Dementia
This study is designed to assess the efficacy and safety of oxycodone in managing moderate to severe pain in patients with Alzheimer's disease.
- Trial name
- CALM-D (NCT07323914)
- Testing
- Tylex
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Aneurysmal Subarachnoid Hemorrhage (aSAH)
DIND in Patients With aSAH : Real World Study
In recent years, with the active application of clinical monitoring and treatment methods, the survival rate of patients with aneurysmal subarachnoid hemorrhage (SAH) has improved, but still a certain proportion of patients…
- Trial name
- NCT07160088
- Testing
- Observational
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Intracranial Atherosclerosis ICAS, Hemodynamic
Digital Angiography-Derived Fractional Flow Assessment for Intracranial Stenosis
The goal of this observational study is to learn whether a digital angiography derived fractional flow reserve (DPR) measurement can improve the prediction of stroke risk in adults with symptomatic intracranial atherosclerotic…
- Conditions
- Intracranial Atherosclerosis ICAS, Hemodynamic, Stroke
- Trial name
- CASSISS-DPR (NCT07309705)
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Adult Spinal Deformity, Degenerative Scoliosis
Gait and Paraspinal sEMG in Degenerative Spinal Diseases
This cross-sectional observational study aims to quantitatively compare three-dimensional gait parameters, surface electromyography (EMG) patterns, and radiological parameters among patients with different degenerative spinal…
- Conditions
- Adult Spinal Deformity, Degenerative Scoliosis, Sagittal Deformity, Sagittal Imbalance
- Trial name
- TDGKSEPDSD (NCT07309926)
- Testing
- Gait analysis and surface electromyography analysis
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
ICAS - Intracranial Atherosclerosis, Stroke Ischemic
MPR for Stroke Risk Assessment of ICAS
Intracranial atherosclerotic stenosis (ICAS) carries substantial stroke risk despite optimal medical treatment. Current risk stratification relies primarily on stenosis severity, but novel hemodynamic markers may improve…
- Conditions
- ICAS - Intracranial Atherosclerosis, Stroke Ischemic, Hemodynamic
- Trial name
- NCT07309718
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Refractory Epilepsy, Neuromodulation
Characterising the Network-Specific Effects of Piriform Cortex Stimulation Via SEEG
The prospective study aims to characterize the network-specific modulatory effects of piriform cortex stimulation in patients undergoing stereotactic EEG for drug-resistant epilepsy.
- Trial name
- NCT07305311
- Testing
- SEEG recordings and SPES
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Dementia
Biomarker-Integrated Digital Guidance for Early Alzheimer's Detection (BRIDGE-AD): A Nationwide Multicenter Study
The investigators propose a stepwise screening approach. The first step involves rapid digital pre-screening of cognitive function through three components: the SCD-9 questionnaire to capture subjective cognitive complaints, a…
- Trial name
- NCT07284264
- Where
- 6 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke
Intravenous Thrombolysis With rhTNK-tPA for Acute Non-large Vessel Occlusion in Extended Time Window
This study is designed to evaluate the efficacy of IV rhTNK-tPA between 4.5 to 24 hours from symptom onset in patients presenting with a non-large vessel occlusion ischemic stroke.
- Trial name
- OPTION (NCT05752916)
- Testing
- rhTNK-tPA, Antiplatelet Agents
- Where
- China
- Volunteers
- 570 people
- Sponsor
- Xuanwu Hospital, Beijing
PET/MR, Stroke Ischemic
PET/MR Multimodal Quantitative Analysis of CBF and CMRGlc in Cerebral Ischemia
Research Purpose: This project focuses on clinical research issues in the diagnosis, treatment, and evaluation of patients with cephalic and carotid atherosclerosis.
- Trial name
- PMQIC (NCT07079345)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Hypertension, Hypotension
Efficacy and Safety Evaluation of Non-invasive Temporal Interference Stimulation for Blood Pressure Regulation
The primary objective of this research is to study the efficacy and safety of temporal interference stimulation for regulating the blood pressure.
- Trial name
- NCT07239492
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy, Drug Resistant
Subiculum Electrical Stimulation for Temporal Lobe Epilepsy With Biliteral Hippocampus Sclerosis(SESTB)
The primary objective of this research is to study the efficacy and safety of deep brain stimulation (DBS) of Subiculum as adjunctive therapy for reducing the frequency of seizures in drug-resistant temporal lobe epilepsy with…
- Trial name
- NCT06436547
- Testing
- Subiculum-DBS ON
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer Disease
Transcranial Alternating Current Stimulation for Patients With Mild Alzheimer's Disease II (TRANSFORM-AD II)
The goal of this study is to explore the efficacy and safety of transcranial alternating current stimulation (tACS) in patients with amnestic mild cognitive impairment due to Alzheimer's disease (AD-aMCI) and patients with mild…
- Trial name
- NCT07230158
- Testing
- transcranial alternating current stimulation
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke
Balloon Guide Catheter to Optimize Outcomes in Stroke Thrombectomy of the Internal Carotid Artery
To investigate whether using balloon guide catheter with flow arrest during mechanical thrombectomy, compared to non-flow arrest, improves the rate of first pass expanded Thrombolysis in Cerebral Infarction score (eTICI 2c-3)…
- Trial name
- NCT07192029
- Testing
- Balloon guide catheter combined with conventional thrombectomy treatment, Standard guide catheter or neurovascular sheath combined with conventional thrombectomy treatment
- Where
- 3 sites in China
- Volunteers
- 364 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer s Disease
Personalized Brain Stimulation for Cognitive Impairment in Older Adults
This study aims to develop and test new personalized treatments for older adults with cognitive impairment. Project 1: Create a personalized cognitive training program using computer algorithms to match training tasks to…
- Trial name
- NCT07208734
- Testing
- Transcranial Alternating Current Stimulation (tACS), AI-based Cognitive Training
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Xuanwu Hospital, Beijing
Spine Degeneration, Spine Fusion
Pre-operative Risk Assessment Combined With Targeted Intervention in the Chinese Elderly With Spine Surgery
With the extended life expectancy of the Chinese population and improvements in surgery and anesthesia techniques, the number of aged patients undergoing surgery has been increasing annually.
- Conditions
- Spine Degeneration, Spine Fusion, Frailty Syndrome
- Trial name
- PRACTICE (NCT06140797)
- Testing
- Multimodal prehabilitation combined with perioperative ERAS care（PREERAS）
- Where
- 3 sites in China
- Volunteers
- 164 people
- Sponsor
- Xuanwu Hospital, Beijing