Clinical trials: sponsored by Xuanwu Hospital, Beijing
Disorders of Consciousness
Advancing Assessment for Disorders of Consciousness
Over the past two decades, major progress has been made in detecting, predicting and promoting recovery of consciousness in patients with disorders of consciousness (DOC) caused by severe brain injuries.
- Trial name
- AADOC (NCT07180589)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer Disease
An Exploratory Study of Near-infrared Light Therapy for Mild to Moderate Alzheimer's Disease
This is an exploratory clinical study to evaluate the efficacy and safety of near-infrared light therapeutics in the treatment of mild to moderate Alzheimer's disease.
- Trial name
- NCT06836180
- Testing
- Near infrared light therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xuanwu Hospital, Beijing
Intracerebral Haemorrhage, Intracerebral Hemorrhage
Timing and Outcomes of Recovery After intraCerebral Hemorrhage
The TORCH registry is a prospective, observational cohort study, which will collect detailed, longitudinal data on the clinical characteristics, treatment modalities, and outcomes of patients with ICH.
- Trial name
- TORCH (NCT07166146)
- Testing
- Surgical interventions
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer Disease
Near-Infrared Light Therapy Combined With Lecanemab for Mild Alzheimer's Disease
The goal of this study is to explore the efficacy and safety of near-infrared light combined with lecanemab in patients with mild Alzheimer's disease (AD).
- Trial name
- NCT06992804
- Testing
- NirsCure with Lecanemab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke
An Application That Can Provide Early Warning of Temperature Health Risks and Give Protective Suggestions or Personalized Suggestions Based on Patients' Own Secondary Prevention Risk Factors Was Applied to Intervene, and the Intervention Effect of APP on Stroke Recurrence Risk Was Analyzed
This study employs individualized temperature health risk early warning and risk factor management interventions for stroke, and explores their actual intervention effects.
- Trial name
- NCT06904664
- Testing
- Individualized temperature health risk early warning and risk factor management, Temperature health risk early warning, Risk factor management
- Volunteers
- 10,184 people
- Sponsor
- Xuanwu Hospital, Beijing
Vascular Malformations
An Open-Label, Single-Arm Exploratory Clinical Study of Everolimus for the Treatment of Vascular Malformations
This study is a single-arm exploratory trial conducted by Xuanwu Hospital, Capital Medical University, aiming to evaluate the efficacy and safety of everolimus monotherapy in adult patients with vascular malformations.
- Trial name
- NCT07037238
- Testing
- Everolimus 10mg daily
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Asymptomatic Intracranial Atherosclerotic Stenosis Patients
Assessing Vulnerability and Outcomes of Intracranial Atherosclerotic Plaques
This prospective cohort study aims to establish a large-scale cohort for primary stroke prevention in asymptomatic intracranial atherosclerosis (ICAS).
- Trial name
- NCT07156344
- Testing
- Progression and Outcome of Intracranial Atherosclerosis
- Where
- China
- Volunteers
- 3,849 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke
An Application Provides Personalized Suggestions Based on Secondary Prevention Risk Factors to Stroke Patients
This study applied an application that provides personalized suggestions and explore the effect of this actual intervention on reducing the risk of stroke recurrence
- Trial name
- NCT07098143
- Testing
- Risk factor management
- Volunteers
- 5,092 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke
An Application Provides Temperature-related Health Risk Warnings and Protective Recommendations on Stroke
This study applied an application to provide early warnings and advice for stroke patients and explored the impact of this intervention on reducing the risk of stroke recurrence
- Trial name
- NCT07097428
- Testing
- Temperature health risk early warning
- Volunteers
- 5,092 people
- Sponsor
- Xuanwu Hospital, Beijing
COVID-19, Brain Fog
Transcranial Ultrasound Stimulation for Cognitive Function Modulation in Patients With Post COVID-19 Brain Fog
This study aims to investigate whether a specific brain region mediates the cognitive deficit in long COVID brain fog, and whether targeted modulation of this region can improve cognition.
- Conditions
- COVID-19, Brain Fog, Long COVID, Transcranial Ultrasound Stimulation
- Trial name
- NCT07154199
- Testing
- real transcranial ultrasound stimulation
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Xuanwu Hospital, Beijing
Multimorbidity, Hypertension
Development and Validation of a Comprehensive Management Service Package for Older Adults With Multimorbidity
This study aims to test a new comprehensive management service package for older adults with two or more chronic conditions (multimorbidity).
- Conditions
- Multimorbidity, Hypertension, Diabetes Mellitus, Coronary Artery Disease
- Trial name
- COMPASS (NCT07151430)
- Testing
- Service Package Group
- Volunteers
- 358 people
- Sponsor
- Xuanwu Hospital, Beijing
Ischemic Stroke, Acute
Human Induced Neural Stem Cell-derived Exosomes for Treating Acute Ischemic Stroke
A phase I/IIa clinical trial investigating the safety and preliminary efficacy of intravenous administration of human induced neural stem cell-derived exosomes for acute ischemic stroke
- Trial name
- NSAIS (NCT07143786)
- Testing
- iNSC-EV01
- Volunteers
- 38 people
- Sponsor
- Xuanwu Hospital, Beijing
Cerebral Infarction, Mechanical Ventilation
Phrenic Nerve Stimulation for Reducing Ventilation Duration in Acute Cerebral Infarction: A Multicenter Randomized Controlled Trial
The goal of this clinical trial is to learn if non-invasive phrenic nerve stimulation works in adult acute cerebral infarction participants undergoing mechanical ventilation.
- Conditions
- Cerebral Infarction, Mechanical Ventilation, Acute Cerebrovascular Accident, Adult
- Trial name
- EDP-VENT (NCT07133932)
- Testing
- Transcutaneous electrical phrenic nerve stimulation
- Where
- 9 sites in China
- Volunteers
- 590 people
- Sponsor
- Xuanwu Hospital, Beijing
Autoimmune Encephalitis
hUC-MSC-Exo Therapy for Autoimmune Encephalitis
This is a phase I/IIa study to investigate the safety and preliminary efficacy of intranasal admnistration of human umbilical mesenchymal stem cell-derived exosome (hUC-MSC-Exo) for patients with autoimmune encephalitis.
- Trial name
- MESAE (NCT07131683)
- Testing
- Human umbilical cord mesenchymal stem cell derived exosomes
- Volunteers
- 38 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy, Drug Resistant
Piriform Cortex Electrical Stimulation for Temporal Lobe Epilepsy With Biliteral Hippocampus Sclerosis
The primary objective of this research is to study the efficacy and safety of deep brain stimulation (DBS) of Piriform cortex as adjunctive therapy for reducing the frequency of seizures in drug-resistant temporal lobe epilepsy…
- Trial name
- NCT07128563
- Testing
- piriform cortex-DBS
- Volunteers
- 5 people
- Sponsor
- Xuanwu Hospital, Beijing
Ischemic Stroke, Carotid Stenosis
Research on Ultrasound Diagnostic Criteria for Intracranial and Extracranial Arterial Serial Stenosis
This study utilized different hemodynamic parameters of transcranial color-coded Doppler (TCCD) and transcranial Doppler (TCD) to conduct ultrasonic grading evaluation on middle cerebral artery (MCA) stenosis severity in patients…
- Trial name
- NCT06947720
- Testing
- stenting
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke, Arterial Thrombosis
Intra-arterial Thrombolysis After Successful Thrombectomy for Acute Ischemic Stroke in the Posterior Circulation (IAT-TOP)
The CHOICE study suggested that the use of adjunct intra-arterial alteplase after successful endovascular reperfusion in large vessel occlusion acute ischemic strokes may result in a greater likelihood of excellent neurological…
- Conditions
- Acute Ischemic Stroke, Arterial Thrombosis, Posterior Circulation Brain Infarction
- Trial name
- NCT05897554
- Testing
- intra-arterial alteplase
- Where
- China
- Volunteers
- 247 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer Disease
Biomarker-based Alzheimer's Disease Cohort Study (BASIC)
This study adopts a prospective cohort design, constructing a single-center cohort by recruiting patients with Alzheimer's disease (AD) who are positive for AD biomarkers.
- Trial name
- NCT07109999
- Where
- China
- Volunteers
- 2,835 people
- Sponsor
- Xuanwu Hospital, Beijing
Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System, MS (Multiple Sclerosis)
Assessment of Transcranial Alternating Current Stimulation's Clinical Efficacy in Treating Cognitive Impairment of Idiopathic Inflammatory Demyelinating Diseases
This study aims to explore the imaging and electrophysiological characteristics of idiopathic inflammatory demyelinating diseases (IIDDs), and their correlation with clinical manifestations.
- Conditions
- Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System, MS (Multiple Sclerosis), NMOSD, Acute Disseminated Encephalomyelitis
- Trial name
- TACS-CI-IIDDs (NCT07087873)
- Testing
- Neuroelectrical modulation group, Pseudo-neuromodulation group
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Xuanwu Hospital, Beijing
Cerebral Venous Sinus Thrombosis
Glymphatic Function and White Matter Integrity in Cerebral Venous Disorders
Cerebral venous disorders, including cerebral venous sinus stenosis (CVSS) and cerebral venous sinus thrombosis (CVST), can obstruct venous blood drainage, leading to intracranial hypertension.
- Trial name
- NCT07072663
- Testing
- Baseline and 3-month follow-up, Baseline
- Where
- China
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing