Clinical trials: sponsored by Zhejiang University
Consciousness Disorders
Micro-movements in Patients With Prolonged Disorders of Consciousness
The goal of this observational study is to learn about the micro-movements in patients with prolonged disorders of consciousness.
- Trial name
- NCT06406413
- Testing
- micro-movement; electroencephalogram; MRI
- Where
- China
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Locally Advanced Rectal Cancer (LARC)
SCRT Combined With Chemotherapy and Iparomlimab and Tuvonralimab in MSS or pMMR Patients With Locally Advanced Rectal Cancer
Colorectal cancer ranks as the third most prevalent malignancy worldwide and the second leading cause of cancer-related mortality.
- Trial name
- NCT06864013
- Testing
- Experimental, Control
- Where
- China
- Volunteers
- 116 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Coronary Artery Calcification, Calcific Coronary Arteriosclerosis
ClinicAL outComes of IntraVascular Lithotripsy Combined With Conventional Lesion Preparation in Patients With Moderate to Severe Coronary Artery Calcification
The goal of this clinical trial is to investigate whether the clinical outcomes of combined application of intravascular lithotripsy (IVL) following routine preconditioning are superior to those of routine preconditioning alone…
- Trial name
- CALC-IVL (NCT07340294)
- Testing
- Intensive Preconditioning Group, Routine preconditioning strategy
- Where
- 4 sites in China
- Volunteers
- 1,096 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Consciousness Disorders
Micro-expressions in Patients With Prolonged Disorders of Consciousness
The goal of this observational study is to learn about the microexpressions in patients with prolonged disorders of consciousness.
- Trial name
- NCT06088628
- Testing
- Facial expression; Electroencephalogram; MRI
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
TNBC, Triple Negative Breast Cancer
Neoadjuvant Chemotherapy Combined With Toripalimab for TNBC (NEOTORCH-BREAST02)
This study is a prospective, single arm, multi-center phase II clinical trial. The primary study objective is to evaluate the pathologic complete response（PCR） of Adjuvant treatment of TNBC breast cancer with Toripalimab combined…
- Trial name
- NCT06682195
- Testing
- Neoadjuvant chemotherapy combined with Toripalimab
- Where
- 13 sites in China
- Volunteers
- 35 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Stroke, Post Stroke Depression
A Study on the Application of Positive Psychological Counseling Based on "Dou Bao" Software in Patients With Post-stroke Depression
Patients with PSD have the characteristics of high incidence rate, difficult identification and great harm. However, the existing AI chat platforms have not developed any relevant software or programs for PSD patients.
- Trial name
- NCT07336888
- Testing
- The positive psychological counseling platform of the "Doubao" software
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Total Knee Arthroplasty
Impact of ABC-X Model Nursing on Psychological Resilience and Family Function in TKA Patients
The ABC-X model is a systematic intervention approach based on stress source analysis and adaptation theory. It emphasizes the dynamic interaction between stressors (A), coping resources (B), cognitive appraisal (C), and crisis…
- Trial name
- NCT07335809
- Testing
- Implement nursing interventions based on the ABC-X model
- Volunteers
- 117 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Electroencephalogram, Postoperative Delirium (POD)
Electroencephalogram Characteristics of Surgical Anesthetized Patients and Postoperative Dilirium
Objective: To construct a perioperative EEG database for elderly patients under general anesthesia and to explore the relationship between their EEG spectrum characteristics and the occurrence and severity of postoperative…
- Trial name
- NCT06394778
- Testing
- Delirium test scale：3D-CAM
- Where
- China
- Volunteers
- 375 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Site Preservation, Soft Tissue Healing
Site Preservation Was Performed Through an Open Healing Oral Restorative Membrane
In this study, an open healing oral restoration membrane was used for site preservation in the esthetic area after tooth extraction to maintain the space for tooth extraction and bone formation.
- Conditions
- Site Preservation, Soft Tissue Healing, Anterior Dental Aesthetic Area
- Trial name
- NCT07334067
- Testing
- site preservation surgery with open healing, site preservation surgery with close sutures
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
ORR,OS,PFS
Exploration of Sintilimab + Bevacizumab + AG Chemotherapy as First-Line Treatment for Unresectable Advanced/Metastatic Cholangiocarcinoma
Evaluation of Efficacy and Safety of Sintilimab Plus Bevacizumab and AG Regimen as First-Line Therapy in Patients with Surgically Ineligible Locally Advanced or Metastatic Cholangiocarcinoma Objectives: Primary Objective: To…
- Trial name
- NCT07328802
- Testing
- Sintilimab combined with bevacizumab and albumin-bound paclitaxel plus gemcitabine
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Herpes Simplex Keratitis, Corneal Neovascularization
Clinical Study of Intrastromal Anti-VEGF Injection for Corneal Neovascularization.
Corneal stromal injection is an emerging local drug delivery method, characterized by strong targeting, high drug concentration, and prolonged duration of action.
- Trial name
- NCT07329686
- Testing
- Intrastromal anti-VEGF injection and topical antiviral eye drops, Conventional antiviral topical ocular drops.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Idiopathic Pulmonary Fibrosis(IPF)
CAR-DC for End-Stage IPF
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fatal interstitial lung disease characterized by irreversible scarring, leading to respiratory failure.
- Trial name
- NCT07329959
- Testing
- Leukapheresis, CAR-DC
- Volunteers
- 8 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
RFS
Single-Arm Clinical Study of Icaritin Soft Capsules as Adjuvant Therapy for Hepatocellular Carcinoma Patients at High Risk of Postoperative Recurrence
Observing the Efficacy and Safety of Icaritin Soft Capsules as Postoperative Adjuvant Therapy in Hepatocellular Carcinoma Patients with High-Risk Factors for Recurrence (A Single-Arm, Single-Center, Prospective Clinical Study…
- Trial name
- NCT07328828
- Testing
- Icaritin soft capsules
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Postoperative Pain, Postoperative Pain in Orthopaedics
Effects of taVNS on Postoperative Pain in Complex Spinal Surgery
Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive, novel neuromodulation technique. Previous studies have demonstrated its safety and efficacy in chronic pain, mental disorders, and other diseases, but…
- Conditions
- Postoperative Pain, Postoperative Pain in Orthopaedics, Postoperative Pain Management
- Trial name
- taVNS-cSSPain (NCT07330973)
- Testing
- transauricular auricular vagus nerve stimulation
- Volunteers
- 98 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Basal Ganglia Hemorrhage
A Trial for Minimally Invasive Neurosurgery With AI-assisted Robotic Guidance for Moderate Basal Ganglia Hemorrhage (RAINBOW-MBH)
A nationwide, prospective, multicenter randomized controlled clinical trial to evaluate the therapeutic effects of the fiber tract-based artificial intelligence (AI) Robot Guiding System on the perioperative and long-term…
- Trial name
- RAINBOW-MBH (NCT06465719)
- Testing
- Minimally invasive basal ganglion hematoma evacuation with Tract-based AI Robot Guiding System, Patients will be managed with guideline-based medications
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Basal Ganglia Hemorrhage, Intraventricular Hemorrhage
RAINBOW-ICH Trial of AI Guided Minimally Invasive Neurosurgery for ICH
Intracerebral hemorrhage (ICH) is one of the most devastating forms of stroke, with high rates of death and disability worldwide. Despite advances in medical and surgical care, effective therapeutic options remain limited.
- Conditions
- Basal Ganglia Hemorrhage, Intraventricular Hemorrhage, Brainstem Stroke, Intracranial Hemorrhage, Spontaneous
- Trial name
- RAINBOW-ICH (NCT07205263)
- Testing
- AI-assisted robotic-guided endoscopic hematoma evacuation, Conventional craniotomy, AI-assisted robotic-guided puncture and hematoma evacuation
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lens Diseases
Evaluating Presbyopia-Correcting IOLs in Complex Cataract Cases With Anterior Segment Abnormalities
The goal of cataract surgery has evolved from simply restoring sight to providing clear and comfortable full-range vision. Traditionally, monofocal IOLs remain the routine choice for special cases with anterior segment…
- Trial name
- NCT07321756
- Testing
- Unilateral Posterior Chamber Implantation of Presbyopia-Correcting IOL, Unilateral Posterior Chamber Implantation of Monofocal IOL
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lens Diseases
Full 3D Eye Modeling in the Diagnosis and Treatment of Lens Diseases With Eye Structures Disorders
In patients with complex cataracts, spatial abnormalities in the lens and its surrounding tissues-including both the anterior and posterior ocular segments-are often present.
- Trial name
- NCT07321769
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pancreatic Adenocarcinoma
Multimodal Deep Learning Model Predicts Pancreatic Cancer Prognosis
This study describes the development and validation of a deep learning prediction model, which extracts deep learning features from preoperative enhanced CT scans and analyzes postoperative pathological specimens of pancreatic…
- Trial name
- NCT06760234
- Testing
- No Interventions
- Where
- China
- Volunteers
- 247 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rotator Cuff Tendinopathy
Clinical Study on the Safety and Efficacy of Tendon Stem Progenitor Cells Therapy for Rotator Cuff Tears
Tendon injury is one of the most common sports injuries, including local tissue degeneration at the tendon insertion site following inflammation caused by long-term joint movement, friction, or strain, as well as acute traumatic…
- Trial name
- NCT07320378
- Testing
- Stem cell therapy, Conventional rotator cuff repair.
- Volunteers
- 107 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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