Clinical trials: sponsored by Shirley Ryan AbilityLab
Stroke
Evaluating Error Augmentation for Neurorehabilitation
This is a sub-project of a larger NIDRR Grant. One promising form of robotic training that leverages the power of neuro-plasticity is error augmentation.
- Trial name
- VREA (NCT01574495)
- Testing
- Error Augmentation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Very Intensive Early Walking in Stroke
The purpose of this study is to demonstrate the efficacy of intensive locomotor interventions early post stroke. An intensive locomotor training (LT) program will be compared to an active control, conventional physical therapy.
- Trial name
- VIEWS (NCT01789853)
- Testing
- Intensive Walking, Conventional Physical Therapy
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Amputation Stumps, Neuroma
Pathophysiology of Post Amputation Pain
The purpose of this study is to see how Post Amputation Pain (PAP) affects the body and brain by using sensory testing (such as pinprick testing), taking pictures of your brain (using a functional magnetic resonance imaging…
- Trial name
- PPAP (NCT01632709)
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Irritable Bowel Syndrome, Ulcerative Colitis
Efficacy of Gralise® for Chronic Pelvic Pain
This study is done to investigate the pain relieving effects of the study drug Gralise (a novel long acting gabapentinoid) for people who experience chronic pelvic pain.
- Conditions
- Irritable Bowel Syndrome, Ulcerative Colitis, Interstitial Cystitis, Prostatitis
- Trial name
- NCT01678911
- Testing
- Gralise
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Shirley Ryan AbilityLab
Knee Osteoarthritis, Degenerative Joint Disease
Milnacipran for Chronic Pain in Knee Osteoarthritis
The patients are asked to take part in this study because you have chronic pain as a result of knee osteoarthritis. This study is done to investigate the pain relieving effects of the study drug Savella (milnacipran HCl) for…
- Conditions
- Knee Osteoarthritis, Degenerative Joint Disease, Chronic Pain
- Trial name
- KOA (NCT01510457)
- Testing
- Milnacipran
- Volunteers
- 46 people
- Sponsor
- Dr. Norman Harden
Spinal Cord Injury
Molecular Markers of Neuroplasticity During Exercise in People With Incomplete Spinal Cord Injury
The purpose of this study is to determine whether exercising (walking) at different intensities increases levels of factors in the blood and saliva that are known to impact neuroplasticity (how the connections in the spinal cord…
- Trial name
- NCT01538693
- Testing
- escitalopram oxalate, Cyproheptadine, sugar pill
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- T. George Hornby
Major Depressive Disorder, Dysthymia
Project to Improve Symptoms and Mood in People With Spinal Cord Injury
Depression is likely the most prevalent and disabling psychological complication associated with spinal cord injury (SCI). Yet no controlled depression treatment trials have been performed in this population.
- Conditions
- Major Depressive Disorder, Dysthymia, Spinal Cord Injuries
- Trial name
- PRISMS (NCT00592384)
- Testing
- venlafaxine XR
- Where
- 6 sites in United States
- Volunteers
- 133 people
- Sponsor
- University of Washington
Stroke
Survey on Return to Work After Stroke
Survey of survivor perspective on critical elements that either facilitate or inhibit return to work after a stroke. Critical elements are queried in areas of finances, stroke impairments, interpersonal support, therapeutic…
- Trial name
- NCT01699035
- Where
- United States
- Volunteers
- 715 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Hemiparesis
Bilateral Training Versus Unilateral Training in Stroke
This randomized, single-blind study compares the effectiveness of bilateral training to unilateral training for individuals with moderate hemiparesis.
- Trial name
- NCT00681434
- Testing
- bilateral upper extremity training, Unilateral upper extremity training
- Volunteers
- 24 people
- Sponsor
- University of Illinois Chicago
Chronic Spinal Cord Injury
Impact of Persistent Conductances on Motor Unit Firing in SCI
This study is being done to measure the differences between the electrical activity of muscles and /single muscle fibers in individuals with long-term spinal cord injury and neurologically intact individuals without spinal cord…
- Trial name
- NCT02136823
- Testing
- sugar pill, Riluzole, Isradipine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Parkinson's Disease, Poor Quality Sleep
Structured Physical Activity for Sleep Quality and Daytime Sleepiness in Patients With Parkinson's Disease
The purpose of this study is to examine the ability of a structured physical activity program to improve sleep quality and daytime sleepiness in patients with Parkinson's disease.
- Conditions
- Parkinson's Disease, Poor Quality Sleep, Hypersomnia
- Trial name
- NCT01544465
- Testing
- Structured Physical Activity, Sleep hygiene education
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Northwestern University
Low Back Pain
Effect of Milnacipran in Chronic Neuropathic Low Back Pain
Low back pain is a public health problem affecting between 70-85% of adults at some time in their life. This study is being done to study the safety and effectiveness of the drug Milnacipran in treating chronic low back pain.
- Trial name
- NCT01225068
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Nonfluent Aphasia, Stroke
Augmenting Language Therapy for Aphasia: Levodopa
The purpose of this study is to evaluate the effectiveness of the medication levodopa, in combination with speech-language treatment, on the language outcome of study subjects with nonfluent aphasia (i.e.
- Trial name
- NCT01429077
- Testing
- levodopa/carbidopa
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury
Intermittent Hypoxia Elicits Prolonged Restoration of Motor Function in Human SCI
The goal of the study is to determine whether repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) will improve limb function after spinal cord injury.
- Trial name
- NCT01272349
- Testing
- Acute intermittent hypoxia, Room air
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Emory University
Quadriplegia, Spinal Cord Injury
Evaluation of a Tongue Operated Assistive Technology for Individuals With Severe Paralysis
This study was intended to evaluate a new assistive neuro-technology, known as the Tongue Drive System (TDS), by its potential end-users, i.e.
- Conditions
- Quadriplegia, Spinal Cord Injury, ALS
- Trial name
- TDS-1 (NCT01124292)
- Testing
- Tongue Piercing, Usability assessment
- Where
- 4 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Osteoporosis, Bone Loss
Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI)
Individuals with spinal cord injury sustain significant loss of bone mass in their lower extremities (20-40% or more). This study evaluates the ability of PTH and weight-bearing, two interventions that build bone, to increase…
- Conditions
- Osteoporosis, Bone Loss, Spinal Cord Injury
- Trial name
- NCT00826228
- Testing
- teriparatide, weight-bearing
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Thomas J. Schnitzer
Ischemic Stroke
Speech and Language Therapy After Stroke
Our overall goal is to advance the state of functional brain imaging in aphasia, and then to apply the method to an intensive, imitation-based treatment for non-fluent aphasia.
- Trial name
- NCT00713050
- Testing
- Imitate Therapy
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of Chicago
Constipation
Lubiprostone (Amitiza®) Vs. Standard Care in Opioid-induced Constipation After Surgery in Inpatient Rehabilitation
Patients requiring opioids for post-operative pain control following elective orthopedic procedures which has resulted in constipation symptoms, and who are in inpatient rehabilitation will be randomized to two different…
- Trial name
- NCT00662363
- Testing
- Lubiprostone, Senna
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Anoxia
Bone Loss, Fractures, and Management of Bone Health in People With Stroke in Managed Rehabilitation Settings
The purpose of the study is to evaluate the state of bone health of brain injury patients being seen within a rehabilitation setting.
- Conditions
- Stroke, Anoxia, Brain Injury
- Trial name
- NCT00462683
- Where
- 2 sites in United States
- Volunteers
- 87 people
- Sponsor
- Northwestern University
Stroke
Walking Study for Stroke Rehabilitation
The primary purpose of this study is to determine the effects of reinforcement of walking speed on recovery of walking speed over the course of inpatient rehabilitation for people after stroke.
- Trial name
- SIRROWS (NCT00428480)
- Testing
- Daily reinforcement of walking speed (DRS), No reinforcement of walking speed (NRS)
- Where
- 24 sites in United States, Austria and 8 more
- Volunteers
- 216 people
- Sponsor
- University of California, Los Angeles